Nature Communications, Published online: 28 April 2020; doi:10.1038/s41467-020-15887-5Cytosine base editors have been reported to induce off-target mutations in DNA and RNA. Here the authors identify next-generation CBEs with reduced guide-independent off-target editing profiles and retain high on-target editing activity.
Tue Apr 28, 2020 03:00
Nature Communications, Published online: 28 April 2020; doi:10.1038/s41467-020-15793-wPublisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations
Tue Apr 28, 2020 03:00
Nature Communications, Published online: 28 April 2020; doi:10.1038/s41467-020-15928-zSpatial contexts are often predictive of the tasks to be performed in them (e.g., a kitchen predicts cooking). Here the authors show that the retrieval of task demand when encountering a spatial context depends on hippocampal-prefrontal interactions.
Tue Apr 28, 2020 03:00
Nature Communications, Published online: 28 April 2020; doi:10.1038/s41467-020-15960-zTargeted mass spectrometry enables reproducible and accurate lipid quantification but dedicated software tools to develop targeted lipidomics assays are lacking. Here, the authors develop a targeted lipidomics workbench and lipid knowledgebase for the streamlined generation of targeted assays.
Tue Apr 28, 2020 03:00
Nature Communications, Published online: 28 April 2020; doi:10.1038/s41467-020-15954-xIn meiosis, BRCA2 associates to MEILB2 localising at DNA double-strand breaks (DSBs). Here, the authors identify BRCA2 and MEILB2- associating protein 1 termed BRME1 to work together in regulating meiotic recombination.
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Related ArticlesNightly Hypoxia Does Not Seem to Lead to Otolith Dysfunction in Patients With Obstructive Sleep Apnea. Ear Nose Throat J. 2020 Apr 27;:145561320922126 Authors: Birk R, Dietz M, Sommer JU, Stuck BA, Hörmann K, Rotter N, Maurer JT, Kramer B, Hülse R, Schell A Abstract OBJECTIVES: Obstructive sleep apnea (OSA) is a common sleep disorder, which is associated with recurrent oxygen desaturation during sleep. It has already been shown that...
Tue Apr 28, 2020 14:13
Related ArticlesThe Effect of External Auditory Canal Packing Duration on Healing After Endoscopic Cartilage Myringoplasty. Ear Nose Throat J. 2020 Apr 27;:145561320922117 Authors: Lou Z Abstract INTRODUCTION: The external auditory canal (EAC) packing is widely used in otosurgery and is considered to promote hemostasis and to support tympanic membrane grafts. However, few studies have investigated the effects of packing removal time on healing. ...
Tue Apr 28, 2020 14:13
Related ArticlesEffects of Peripheral Vertigo on Inflammatory and Immunologic Laboratory Markers. Ear Nose Throat J. 2020 Apr 27;:145561320920149 Authors: Temirbekov D, Sakallı E Abstract The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) are markers of subclinical inflammation and atherothrombosis. We investigated whether these easily accessible blood count parameters are affected by peripheral...
Tue Apr 28, 2020 14:13
Related ArticlesTracheobronchopathia Osteochondroplastica: Five Cases Report and Literature Review. Ear Nose Throat J. 2020 Apr 27;:145561319897982 Authors: Wang W, Hu H, Liu M, Wang J Abstract Tracheobronchopathia osteochondroplastica (TO) is a rare disease. Here, we report 5 TO cases treated at our hospital. Bronchoscopy showed typical multiple firm and glossy nodules in all the 5 cases. Conservative treatment effectively alleviated the symptoms....
Tue Apr 28, 2020 14:13
Related ArticlesHost defence cryptides from human apolipoproteins: applications in medicinal chemistry. Curr Top Med Chem. 2020 Apr 26;: Authors: Gaglione R, Pizzo E, Notomista E, de la Fuente-Nunez C, Arciello A Abstract Several eukaryotic proteins with defined physiological roles may act as precursors of cryptic bioactive peptides released upon protein cleavage by host and/or bacterial proteases. Based on this, the term "cryptome" has been used to...
Tue Apr 28, 2020 14:13
Related ArticlesAntimicrobial Peptides and Their Multiple Effects at Sub-Inhibitory Concentrations. Curr Top Med Chem. 2020 Apr 26;: Authors: Casciaro B, Cappiello F, Verrusio W, Cacciafesta M, Mangoni ML Abstract The frequent occurrence of multidrug-resistant strains to conventional antimicrobials has led to a clear decline of antibiotic therapies. Therefore, new molecules with different mechanisms of action are extremely necessary. Due to their unique...
Tue Apr 28, 2020 14:13
Related ArticlesTrans-diagnostic Validation in Neuro-psychiatry: Towards Biological Signatures of Disease. Curr Top Med Chem. 2020;20(7):517 Authors: Stoyanov DS PMID: 32336262 [PubMed - in process]
Tue Apr 28, 2020 14:13
Related ArticlesReal-World Data of Pyrotinib-Based Therapy in Metastatic HER2-Positive Breast Cancer: Promising Efficacy in Lapatinib-Treated Patients and in Brain Metastasis. Cancer Res Treat. 2020 Apr 24;: Authors: Lin Y, Lin M, Zhang J, Wang B, Tao Z, Du Y, Zhang S, Cao J, Wang L, Hu X Abstract Purpose: Pyrotinib is a newly-developed irreversible pan-ErbB receptor tyrosine kinase inhibitor. This study reported the first real-world data of pyrotinib-based...
Tue Apr 28, 2020 14:11
Related ArticlesAntibody-PROTAC conjugates enable HER2-dependent targeted protein degradation of BRD4. ACS Chem Biol. 2020 Apr 27;: Authors: Maneiro M, Forte N, Shchepinova MM, Kounde CS, Chudasama V, Baker JR, Tate EW Abstract Targeting protein degradation with Proteolysis-Targeting Chimeras (PROTACs) is an area of great current interest in drug discovery. Nevertheless, although the high effectiveness of PROTACs against a wide variety of targets has...
Tue Apr 28, 2020 14:11
Related ArticlesOlfactory and rhinological evaluations in SARS-CoV-2 patients complaining of olfactory loss. Rhinology. 2020 Apr 27;: Authors: Ottaviano G, Carecchio M, Scarpa B, Marchese-Ragona R Abstract Since December 2019, a novel coronavirus SARS-CoV-2 (Covid-19) outbreak emerged in China and spread rapidly in several countries. As of April 5, 2020, 1.218.474 cases were confirmed with 65.884 deaths worldwide (1). The clinical manifestations of Covid-19...
Tue Apr 28, 2020 14:10
4048 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/04/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Apr 28, 2020 14:09
Related ArticlesTherapeutic effects of ephrin B receptor 2 inhibitors screened by molecular docking on cutaneous squamous cell carcinoma. J Dermatolog Treat. 2020 Apr 27;:1-7 Authors: Li Y, Zhang X Abstract Background: Cutaneous squamous cell carcinoma (CSCC) is the most known form type of metastatic skin cancer. Activation of ephrin B receptor 2 (EphB2) signaling can promote the metastasis, invasion, and angiogenesis of CSCC cells. Therefore, EphB2...
Tue Apr 28, 2020 14:08
Related ArticlesReal-world treatment duration in ALK-positive non-small-cell lung cancer patients receiving brigatinib through the early access program. Future Oncol. 2020 Apr 27;: Authors: Lin HM, Pan X, Hou P, Allen S, Baumann P, Hochmair MJ Abstract Aim: To assess time-to-treatment discontinuation (TTD) of brigatinib following treatment with ALK tyrosine kinase inhibitor(s) (TKIs) in patients with ALK-positive (ALK+) non-small-cell lung cancer (NSCLC)...
Tue Apr 28, 2020 16:06
Related ArticlesIdasanutlin as a new treatment option in improving the therapeutic odyssey of relapsed/refractory AML. Future Oncol. 2020 Apr 27;: Authors: Corbali MO, Eskazan AE PMID: 32338053 [PubMed - as supplied by publisher]
Tue Apr 28, 2020 16:06
Related ArticlesTherapeutic status and the prospect of CRISPR/Cas9 gene editing in multiple myeloma. Future Oncol. 2020 Apr 27;: Authors: Hong L, Zhang C, Jiang Y, Liu H, Huang H, Guo D Abstract In recent years, CRISPR/Cas9, a novel gene-editing technology, has shown considerable potential in the design of novel research methods and future options for treating multiple myeloma (MM). The use of CRISPR/Cas9 promises faster and more accurate identification...
Tue Apr 28, 2020 16:06
Related ArticlesThe future of radiation-induced abscopal response: beyond conventional radiotherapy approaches. Future Oncol. 2020 Apr 27;: Authors: Tubin S, Yan W, Mourad WF, Fossati P, Khan MK Abstract Advances in the immunological pharmaceuticals, such as checkpoint inhibitors and agonists, have positive implications for the future of the radiotherapy abscopal response. A once rare phenomenon, whereby distant nonirradiated tumor sites regressed after...
Tue Apr 28, 2020 16:06
Related ArticlesA new clinical entity in T704M mutation in periodic paralysis. J Clin Neurosci. 2020 Apr 23;: Authors: Gun Bilgic D, Aydin Gumus A, Gerik Celebi HB, Bilgic A, Unaltuna Erginel N, Cam FS Abstract Periodic paralyses (PPs) are a group of rare disorders characterized by episodic, sudden-onset, flaccid paralysis of skeletal muscles usually resulting in complete recovery after the attacks. PPs are caused by abnormal, mostly potassium-sensitive...
Tue Apr 28, 2020 14:04
Related ArticlesPlasma cytokine profile in synucleinophaties with dementia. J Clin Neurosci. 2020 Apr 23;: Authors: Usenko TS, Nikolaev MA, Miliukhina IV, Bezrukova AI, Senkevich KA, Gomzyakova NA, Beltceva YA, Zalutskaya NM, Gracheva EV, Timofeeva AA, Petrova OA, Semenov AV, Lubimova NE, Totolyan AA, Pchelina SN Abstract Immune response may play a pivotal role in the pathogenesis of the common synucleinopathy as Parkinson's disease (PD) and could be...
Tue Apr 28, 2020 14:04
Related ArticlesVertebral-carotid bypass for common carotid artery occlusion. J Clin Neurosci. 2020 Apr 23;: Authors: Li LF, Tsang FC, Cheng KK, Lui WM, Tsang AC, Leung GK Abstract One of the treatment options for long segment common carotid artery (CCA) occlusion is bypass surgery with different combinations of donors and receipts. Using vertebral artery (VA) as the donor for CCA occlusion was uncommonly reported. The reported cases were using jump...
Tue Apr 28, 2020 14:04
Related ArticlesThoracoscopic delivery of therapeutics in the swine sympathetic chain: Implications for future neuromodulation. J Clin Neurosci. 2020 Apr 23;: Authors: Texakalidis P, Tora MS, Federici T, Javidfar JJ, Boulis NM Abstract The thoracic sympathetic chain is implicated in several disease processes including palmar hyperhidrosis and complex regional pain syndrome. These diseases are often medically refractory and require surgical treatments...
Tue Apr 28, 2020 14:04
Related ArticlesLarge-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. J Clin Neurosci. 2020 Apr 23;: Authors: Gummadavelli A, Dinauer C, McGuone D, Vining EM, Erson-Omay EZ, Omay SB Abstract Gigantism (early-onset acromegaly) is a rare pediatric disorder caused by a growth hormone (GH)-secreting pituitary adenoma. Approximately 50% patients of gigantism have a germline...
Tue Apr 28, 2020 14:04
Related ArticlesSoleus nerve transfer to deep peroneal nerve for treatment of foot drop. J Clin Neurosci. 2020 Apr 23;: Authors: Emamhadi M, Naseri A, Aghaei I, Ashrafi M, Emamhadi R, Andalib S Abstract Different mechanisms including knee dislocation, replacement surgery, nerve tumor, lumbar disc herniation, sharp injury, and gunshot wound lead to foot drop. Several surgical techniques have been used for treatment of foot drop, however, they have had...
Tue Apr 28, 2020 14:04
Related ArticlesEpendymoma and pilocytic astrocytoma: Differentiation using radiomics approach based on machine learning. J Clin Neurosci. 2020 Apr 23;: Authors: Li M, Wang H, Shang Z, Yang Z, Zhang Y, Wan H Abstract Mandatory accurate and specific diagnosis demands have brought about increased challenges for radiologists in pediatric posterior fossa tumor prediction and prognosis. With the development of high-performance computing and machine learning...
Tue Apr 28, 2020 14:04
Related ArticlesCorrespondence: Pituitary tumors and diaphragma sellae. Re: Cabuk B, Anik I, Kokturk S, Ceylan S, Ceylan S: Anatomic and histologic features of diaphragma sellae that effects the suprasellar extension. Journal of Clinical Neuroscience 71(2020) 234-244. J Clin Neurosci. 2020 Apr 23;: Authors: Goel A PMID: 32336635 [PubMed - as supplied by publisher]
Tue Apr 28, 2020 14:04
Related ArticlesFirst line transradial access for posterior circulation stroke intervention; initial 12-month experience at a high volume thrombectomy center. J Clin Neurosci. 2020 Apr 23;: Authors: Crockett MT, Selkirk GD, Chiu AHY, Singh TP, McAuliffe W, Phillips TJ Abstract BACKGROUND: The Neurointerventional Surgery Standards and Guidelines Committee has advocated the use of transradial access in the setting of posterior circulation stroke intervention,...
Tue Apr 28, 2020 14:04
Related ArticlesClinico-radiological profile of CVT patients and its correlation with D-dimer. J Clin Neurosci. 2020 Apr 23;: Authors: Pathak A, Nath Chaurasia R, Kumar Singh V, Shukla U, Joshi D, Nath Mishra V Abstract Cerebral Venous Thrombosis (CVT) is a well-known disease with diverse clinical presentation and causes. With advances in neuroimaging and changing lifestyles, the clinical profile and causes of CVT are changing. D-dimer has been studied...
Tue Apr 28, 2020 14:04
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