Abstract Introduction Disuse-induced bone loss is caused by a suppression of osteoblastic bone formation and an increase in osteoclastic bone resorption. There are few data available for the effects of environmental conditions, i.e., atmospheric pressure and/or oxygen concentration, on osteoporosis. This study examined the effects of mild hyperbaric oxygen at 1317 hPa with 40% oxygen on unloading-induced osteoporosis. ...
03:00
Accentuation influences selective attention and the depth of semantic processing during online speech comprehension. We investigated the processing of semantically congruent and incongruent words in a language that presents cues to prosodic prominences in the region of the utterance occurring after the focussed information (the post-focal region). This language is Italian, in particular the variety spoken in Bari. In this variety, questions have a compressed, post-focal accent, whereas in statements...
Mon Apr 27, 2020 03:00
Thyroid, Ahead of Print.
Mon Apr 27, 2020 10:00
Surgical Infections, Ahead of Print.
Mon Apr 27, 2020 10:00
Stem Cells and Development, Ahead of Print.
Mon Apr 27, 2020 10:00
Stem Cells and Development, Ahead of Print.
Mon Apr 27, 2020 10:00
Stem Cells and Development, Ahead of Print.
Mon Apr 27, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Apr 24, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Apr 24, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Apr 24, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Apr 24, 2020 10:00
Knockdown of circAPLP2 Inhibits Progression of Colorectal Cancer by Regulating miR-485-5p/FOXK1 Axis
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Apr 24, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Apr 27, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Apr 24, 2020 10:00
Over the past few decades, obesity has become a public health issue of global concern. Even though disparities exist between human populations, e.g., the higher liver fat content of the Japanese despite a lower body mass index (BMI), studies on the genetics of obesity still largely focus on populations of European descent, leading to a dearth of genetic data on non-European populations. In this context, this study aimed to establish a broad picture of the genetic attributes of the Japanese population,...
01:12
Ascochyta rabiei is the causal organism of ascochyta blight of chickpea and is present in chickpea crops worldwide. Here we report the release of a high-quality PacBio genome assembly for the Australian A. rabiei isolate ArME14. We compare the ArME14 genome assembly with an Illumina assembly for Indian A. rabiei isolate, ArD2. The ArME14 assembly has gapless sequences for nine chromosomes with telomere sequences at both ends and 13 large contig sequences that extend to one telomere. The total length...
01:12
As the SARS-CoV-2 (COVID19) pandemic spreads and the number of Bruton's tyrosine kinase inhibitor (BTKi)-treated COVID19 affected patients grows, we must consider the pros and cons of BTKi discontinuation for our patients. In favor of BTKi continuation, BTK plays an active role in macrophage polarization. By modulating key transcription factors, BTK may regulate macrophage polarization downstream of classic M1 and M2 polarizing stimuli and mitigate the hyperinflammatory state associated with COVID19....
Tue Apr 28, 2020 16:44
Purpose: Incomplete oncologic resections and damage to vital structures during colorectal cancer surgery increases morbidity and mortality. Moreover, neoadjuvant chemoradiotherapy has become the standard treatment modality for locally advanced rectal cancer, where subsequent downstaging can make identification of the primary tumor more challenging during surgery. Near-infrared (NIR) fluorescence imaging can aid surgeons by providing real-time visualization of tumors and vital structures during surgery....
Tue Apr 28, 2020 16:44
Purpose: Resistance to anti-PD1 based immune checkpoint blockade (ICB) remains a problem for the treatment of metastatic melanoma. Tumor cells as well as host myeloid cells can express the immune checkpoint ligand CD155 to regulate immune cell function. However, the effect of tumor CD155 on the immune context of human melanoma has not been well described. This observational study characterizes tumor CD155 ligand expression by metastatic melanoma tumors and correlates results with differences in immune...
Tue Apr 28, 2020 16:44
Purpose: With the increased prevalence in checkpoint therapy resistance, there remains a significant unmet need for additional therapies for relapsing or refractory cancer patients. We have developed FS222, a bispecific tetravalent antibody targeting CD137 and PD-L1 to induce T cell activation to eradicate tumours without the current toxicity and efficacy limitations seen clinically. Experimental Design: A bispecific antibody (FS222) was developed by engineering CD137 binding sites into the Fc region...
Tue Apr 28, 2020 16:44
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations for evaluation or treatment.…
Tue Apr 28, 2020 03:00
Dozens of candidate orphan riboswitch classes have been discovered previously by using comparative sequence analysis algorithms to search bacterial genomic sequence databases. Each orphan is classified by the presence of distinct conserved nucleotide sequences and secondary structure features, and by its association with particular types of genes. One previously reported orphan riboswitch candidate is the ‘NMT1 motif’, which forms a hairpin structure with an internal bulge that includes numerous...
Tue Apr 28, 2020 20:22
A major challenge for RNA-seq analysis of gene expression is to achieve sufficient coverage of informative non-ribosomal transcripts. In eukaryotic samples, this is typically achieved by selective oligo(dT)-priming of messenger RNAs to exclude ribosomal RNA (rRNA) during cDNA synthesis. However, this strategy is not compatible with prokaryotes in which functional transcripts are generally not polyadenylated. To overcome this, we adopted DASH (Depletion of Abundant Sequences by Hybridization), initially...
Tue Apr 28, 2020 18:54
Pancreatic cancer remains one of the most rapidly progressive and deadly malignancies worldwide. Current treatment regimens only result in small improvements in overall survival for patients with this cancer t...
Tue Apr 28, 2020 03:00
In the original publication of this manuscript [1], Fig. 5a needs to be revised, and adjustments have also been made to the captions for Figs. 2, 4, 5 and S1 to improve clarity for the reader.
Tue Apr 28, 2020 03:00
Abstract Introduction Metastatic breast cancer (MBC) with leptomeningeal metastases (LM) has dismal survival. We aim to determine if modern systemic therapy, especially the bevacizumab, cisplatin, and etoposide (BEEP) regimen, is beneficial to MBC LM patients. Methods We excerpted data from a prospectively collected cytopathology database for MBC patients...
03:00
Abstract Purpose Unplanned readmission of post-operative brain tumor patients is often attributed to hospital and patient characteristics and is associated with higher mortality and cost. Previous studies demonstrate multiple patient outcome disparities in safety net hospitals (SNHs) when compared to non-SNHs. This study uses the Nationwide Readmissions Database (NRD) to determine if initial brain tumor resection at SNHs is associated...
Tue Apr 28, 2020 03:00
Abstract Purpose Several studies describe sleep–wake disturbances in pediatric craniopharyngioma, but none have determined the prevalence or associated predictors of excessive sleepiness in this group after diagnosis and prior to post-operative observation or adjuvant radiotherapy. In this study, we report sleep–wake disturbances in children and adolescents with craniopharyngioma and associated clinical and treatment variables. ...
Tue Apr 28, 2020 03:00
Pulmonary alveolar microlithiasis (PAM) is an uncommon hereditary lung disease characterized by widespread deposition of calcium phosphate microliths within the alveolar spaces. It is considered an autosomal recessive disease with a mutation in a gene encoding a sodium phosphate cotransporter. The imaging findings in the early phase of disease can be mistaken for miliary tuberculosis or sarcoidosis. However, the classic radiologic findings in the later phases of disease show numerous opacities causing...
Tue Apr 28, 2020 18:50
Introduction. Neuroendocrine differentiation in colorectal cancer is reportedly associated with poorer grade of tumor differentiation, nodal and distant metastasis, and other unfavorable features, contributing to a worse clinical outcome. Colorectal cancer with osteoclast-like giant cells (OGCs) is extremely rare. Case Presentation. An 86-year-old woman was diagnosed as double cancer of the transverse and sigmoid colon. Both tumors were simultaneously removed. The transverse colon cancer directly...
Tue Apr 28, 2020 17:05
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05176
Tue Apr 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00810
Tue Apr 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01003
Tue Apr 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05620
Tue Apr 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04699
Tue Apr 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00600
Tue Apr 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00907
Tue Apr 28, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00508
Tue Apr 28, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01023
Tue Apr 28, 2020 07:00
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