Abstract The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a cornucopia of activities and regulatory pathways have been associated with it. In this review, we will raise questions about Mdm2 and its cousin Mdm4 that we consider worth pursuing in future research, reaching from molecular structures and intracellular activities all the way to development, evolution, and cancer therapy. We anticipate that such research will not only close a few gaps in our knowledge...
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Antibiotics, Vol. 9, Pages 217: Natural Compounds as Antimicrobial Agents Antibiotics doi: 10.3390/antibiotics9050217 Authors: Carlos Manuel Franco Beatriz I. Vázquez During the first two decades of this century, conventional antimicrobial compounds have been found out to have more bacterial resistance. What has also been worrying is the rediscovery of the so-called “natural compounds”, which in turn have a good name among the average citizen because of the former’s...
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Antibiotics, Vol. 9, Pages 216: Efficacy of A Poly(MeOEGMA) Brush on the Prevention of Escherichia coli Biofilm Formation and Susceptibility Antibiotics doi: 10.3390/antibiotics9050216 Authors: Patrícia Alves Luciana Calheiros Gomes Cesar Rodríguez-Emmenegger Filipe José Mergulhão Urinary tract infections are one of the most common hospital-acquired infections, and they are often associated with biofilm formation in indwelling medical devices such as catheters and stents. This...
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