Abstract Household water purifiers are increasingly used to treat drinking water at the household level, but their influence on the microbiological safety of drinking water has rarely been assessed. In this study, representative purifiers, based on different filtering processes, were analyzed for their impact on effluent water quality. The results showed that purifiers reduced chemical qualities such as turbidity and free chlorine. However, a high level of bacteria (102–106 CFU/g)...
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Abstract RNA polymerases (RNAPs) carry out transcription in the three domains of life, Bacteria, Archaea, and Eukarya. Transcription initiation is highly regulated by a variety of transcription factors, whose number and subunit complexity increase during evolution. This process is regulated in Bacteria by the σ factor, while the three eukaryotic RNAPs require a complex set of transcription factors (TFs) and a TATA-binding protein (TBP). The archaeal transcription system appears...
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Abstract The methylotrophic bacterium Methylorubrum extorquens AM1 holds a great potential of a microbial cell factory in producing high value chemicals with methanol as the sole carbon and energy source. However, many gene functions remain unknown, hampering further rewiring of metabolic networks. Clustered regularly interspaced short palindromic repeat interference (CRISPRi) has been demonstrated to be a robust tool for gene knockdown in diverse...
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Abstract Aromatic prenyltransferases are known for their extensive promiscuity toward aromatic acceptor substrates and their ability to form various carbon-carbon and carbon-heteroatom bonds. Of particular interest among the prenyltransferases is NphB, whose ability to geranylate cannabinoid precursors has been utilized in several in vivo and in vitro systems. It has therefore been established that prenyltransferases can be utilized as biocatalysts for...
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Abstract Leishmaniosis is caused by the protozoa of the genus Leishmania with a wide spectrum of clinical and epidemiological manifestations which are characterized into four clinical groups: cutaneous, mucocutaneous, diffuse cutaneous, and visceral. American visceral leishmaniosis (AVL) or visceral leishmaniosis (VL) has been known as the most severe form of the disease. However, despite the growing number of people exposed to the infection risk and...
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Abstract Acetate is the main by-product from microbial succinate production. In this study, we performed acetate removal by Methanosarcina barkeri 227 for succinate fermentation by Actinobacillus succinogenes 130Z. The acetoclastic methanogen M. barkeri requires similar environmental factors to A. succinogenes, and the conditions required for co-cultivation were optimized in this study: gas used for anaerobicization, strain adaptation, medium composition, pH adjustment, and inoculation...
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Abstract “The Great Five” (GF) is an artificial bacterial consortium developed to protect potato tubers from soft rot caused by Pectobacterium spp. and Dickeya spp. To investigate the commercialization potential of the GF, we developed liquid and powder formulations of the consortium and of each of the comprising strains (Serratia plymuthica strain A294, Enterobacter amnigenus strain A167, Rahnella aquatilis strain H145, Serratia rubidaea strain H440,...
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Abstract Orange peel waste (OPW), the primary byproduct of the juice extraction process, is annually generated in massive amounts (21 Mton), and its aqueous extraction in biorefining operations yields a liquid fraction, referred to as orange peel extract (OPE). Although OPE contains significant amounts of easily assimilable carbohydrates, such as fructose, glucose, and sucrose, no investigations have been conducted yet to assess its possible use in biodiesel production by oleaginous...
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Abstract Numerous studies have shown that probiotic Bacillus could promote growth and enhance anti-disease ability in animal. In present study, the mixture of three Bacillus strains, which were isolated from rex rabbits and showed high cellulose, protease, and amylase activities, was added into the diet for investigating its effects on young and weaning rex rabbits. For experiment 1, 40 young rex rabbits (9 weeks old) were randomly divided into four...
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Abstract More than 100 years have passed since the discovery of Mycobacterium tuberculosis, in 1882, as the pathogen that causes tuberculosis (TB). However, globally, TB is still one of the leading causes of death by infectious diseases. In 2018, approximately 10.0 million people were diagnosed with TB owing to the development of advanced strategies by M. tuberculosis to resist antibiotics, including the development of a dormant state. The World Health Organization (WHO) and...
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Publication date: Available online 25 April 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Jakub Miletin, Andrej Sukop, Vaclav Baca, David Kachlik
Tue Apr 28, 2020 13:40
Publication date: Available online 25 April 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Robert Haładaj, R. Shane Tubbs, Piotr Brzeziński, Łukasz Olewnik, Michał Polguj
Tue Apr 28, 2020 13:40
Related ArticlesBreast Tumor Microenvironment: Emerging target of therapeutic phytochemicals. Phytomedicine. 2020 Apr 16;70:153227 Authors: Malla RR, Deepak K, Merchant N, Dasari VR Abstract Triple negative breast cancer (TNBC) is the most aggressive and challenging form of breast cancers. Tumor microenvironment (TME) of TNBC is associated with induction of metastasis, immune system suppression, escaping immune detection and drug resistance. TME is highly...
Tue Apr 28, 2020 14:29
EMA Review of Axicabtagene Ciloleucel (Yescarta) for the Treatment of Diffuse Large B-Cell Lymphoma.
Related ArticlesEMA Review of Axicabtagene Ciloleucel (Yescarta) for the Treatment of Diffuse Large B-Cell Lymphoma. Oncologist. 2020 Apr 27;: Authors: Papadouli I, Mueller-Berghaus J, Beuneu C, Ali S, Hofner B, Petavy F, Tzogani K, Miermont A, Norga K, Kholmanskikh O, Leest T, Schuessler-Lenz M, Salmonson T, Gisselbrecht C, Garcia JL, Pignatti F Abstract On June 28, 2018, the Committee for Advanced Therapies and the Committee for Medicinal Products...
Tue Apr 28, 2020 14:29
Related ArticlesA Semi-parametric Bayesian approach to population finding with time-to-event and toxicity data in a randomized clinical trial. Biometrics. 2020 Apr 27;: Authors: Morita S, Müller P, Abe H Abstract A utility-based Bayesian population finding (BaPoFi) method was proposed by Morita and Müller (2017, Biometrics, 1355-1365) to analyze data from a randomized clinical trial with the aim of identifying good predictive baseline covariates for...
Tue Apr 28, 2020 14:29
Related ArticlesManagement of pleomorphic dermal sarcoma. ANZ J Surg. 2020 Apr 27;: Authors: Lonie S, Yau B, Henderson M, Gyorki D, Angel C, Webb A Abstract BACKGROUND: Pleomorphic dermal sarcoma (PDS) is a rare, poorly defined skin neoplasm with features similar to atypical fibroxanthoma, but with adverse histopathological characteristics indicating metastatic potential such as tumour necrosis, invasion beyond superficial subcutis or vascular and/or...
Tue Apr 28, 2020 14:29
Related ArticlesReal-world treatment duration in ALK-positive non-small-cell lung cancer patients receiving brigatinib through the early access program. Future Oncol. 2020 Apr 27;: Authors: Lin HM, Pan X, Hou P, Allen S, Baumann P, Hochmair MJ Abstract Aim: To assess time-to-treatment discontinuation (TTD) of brigatinib following treatment with ALK tyrosine kinase inhibitor(s) (TKIs) in patients with ALK-positive (ALK+) non-small-cell lung cancer (NSCLC)...
Tue Apr 28, 2020 14:29
Related ArticlesThe Development and Implementation of a Novel Electronic Consult System by a Laboratory Medicine Service: Experience From the First 2 Years of Use. Arch Pathol Lab Med. 2020 Apr 27;: Authors: Stendahl K, Siddon AJ, Peaper DR, Hauser RG, Campbell S, Tormey CA Abstract CONTEXT.—: A novel electronic consult (e-consult) system for a pathology and laboratory medicine service (PLMS) was implemented in 2015 at a high-complexity Veterans Administration...
Tue Apr 28, 2020 14:29
Related ArticlesCardiotoxicity of Sequential Aromatase Inhibitors Use in Women with Breast Cancer. Am J Epidemiol. 2020 Apr 27;: Authors: Khosrow-Khavar F, Bouganim N, Filion KB, Suissa S, Azoulay L Abstract The association between aromatase inhibitors and cardiovascular outcomes is controversial. While some observational studies have assessed their cardiovascular safety as up-front treatments, their cardiotoxic effects as sequential treatments with...
Tue Apr 28, 2020 14:29
Related ArticlesIdasanutlin as a new treatment option in improving the therapeutic odyssey of relapsed/refractory AML. Future Oncol. 2020 Apr 27;: Authors: Corbali MO, Eskazan AE PMID: 32338053 [PubMed - as supplied by publisher]
Tue Apr 28, 2020 14:29
Related ArticlesTherapeutic status and the prospect of CRISPR/Cas9 gene editing in multiple myeloma. Future Oncol. 2020 Apr 27;: Authors: Hong L, Zhang C, Jiang Y, Liu H, Huang H, Guo D Abstract In recent years, CRISPR/Cas9, a novel gene-editing technology, has shown considerable potential in the design of novel research methods and future options for treating multiple myeloma (MM). The use of CRISPR/Cas9 promises faster and more accurate identification...
Tue Apr 28, 2020 14:29
Related ArticlesThe future of radiation-induced abscopal response: beyond conventional radiotherapy approaches. Future Oncol. 2020 Apr 27;: Authors: Tubin S, Yan W, Mourad WF, Fossati P, Khan MK Abstract Advances in the immunological pharmaceuticals, such as checkpoint inhibitors and agonists, have positive implications for the future of the radiotherapy abscopal response. A once rare phenomenon, whereby distant nonirradiated tumor sites regressed after...
Tue Apr 28, 2020 14:29
Related ArticlesPatient-centeredness in acute stroke care - A qualitative study from the perspectives of patients, relatives and staff. Eur J Neurol. 2020 Apr 26;: Authors: Busetto L, Stang C, Hoffmann J, Amiri H, Seker F, Purrucker J, Ringleb PA, Nagel S, Bendszus M, Wick W, Gumbinger C, Stroke Consortium Rhine-Neckar Abstract BACKGROUND: Although patient-centeredness is considered a key component of high-quality neurological care, it is unclear to...
Tue Apr 28, 2020 13:35
Related ArticlesOn the implementation of the plan-class specific reference field using multidimensional clustering of plan features and alternative strategies for improved dosimetry in modulated clinical linear accelerator treatments. Med Phys. 2020 Apr 26;: Authors: Desai VK, Labby ZE, DeWerd LA, Culberson WS Abstract PURPOSE: The plan-class specific reference field concept could theoretically improve the calibration of radiation detectors in a beam...
Tue Apr 28, 2020 13:35
Related ArticlesEffect of China's Universal Two-child Policy on the Rate of Cesarean Delivery: A Case Study of a Big Childbirth Center in China. Curr Med Sci. 2020 Apr;40(2):348-353 Authors: Du SG, Tang F, Zhao Y, Sun GQ, Lin Y, Tan ZH, Wu XF Abstract China's universal two-child policy was released in October of 2015. How would this new policy influence the rate of overall cesarean delivery (CD) in China? The objective of this paper is to investigate...
Tue Apr 28, 2020 13:35
Fruit and vegetable consumptions in relation to frequent mental distress in breast cancer survivors.
Related ArticlesFruit and vegetable consumptions in relation to frequent mental distress in breast cancer survivors. Support Care Cancer. 2020 Apr 26;: Authors: Zhang D, Feng Y, Li N, Sun X Abstract PURPOSE: Evidence suggests that fruit and vegetable consumptions may improve mental health among general population. However, their associations among breast cancer survivors are unclear. We planned to investigate this association via a nationwide survey...
Tue Apr 28, 2020 13:35
Related ArticlesToronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations. JNCI Cancer Spectr. 2019 Dec;3(4):pkz050 Authors: Dowling RJO, Kalinsky K, Hayes DF, Bidard FC, Cescon DW, Chandarlapaty S, Deasy JO, Dowsett M, Gray RJ, Henry NL, Meric-Bernstam F, Perlmutter J, Sledge GW, Bratman SV, Carey LA, Chang MC, DeMichele A, Ennis M, Jerzak KJ, Korde LA, Lohmann AE, Mamounas...
Tue Apr 28, 2020 13:35
Related ArticlesToronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions. JNCI Cancer Spectr. 2019 Dec;3(4):pkz049 Authors: Dowling RJO, Sparano JA, Goodwin PJ, Bidard FC, Cescon DW, Chandarlapaty S, Deasy JO, Dowsett M, Gray RJ, Henry NL, Meric-Bernstam F, Perlmutter J, Sledge GW, Thorat MA, Bratman SV, Carey LA, Chang MC, DeMichele A, Ennis M, Jerzak KJ, Korde LA,...
Tue Apr 28, 2020 13:35
Related ArticlesThe Data set for Patient Information Based Algorithm to Predict Mortality Cause by COVID-19. Data Brief. 2020 Apr 24;:105619 Authors: Li J, Wang L, Guo S, Xie N, Yao L, Cao Y, Day SW, Howard SC, Graff JC, Gu T, Ji J, Gu W, Sun D Abstract The data of COVID-19 disease in China and then in South Korea were collected daily from several different official websites. The collected data included 33 death cases in Wuhan city of Hubei province...
Tue Apr 28, 2020 13:35
Related ArticlesDual EGFR blockade with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial. Exp Hematol Oncol. 2020;9:7 Authors: Subbiah V, Dumbrava EI, Jiang Y, Thein KZ, Naing A, Hong DS, Fu S, Piha-Paul SA, Tsimberidou AM, Janku F, Meric-Bernstam F, Kurzrock R, Falchook G Abstract Background: Angiogenesis and activation of the epidermal growth factor (EGFR)...
Tue Apr 28, 2020 13:35
Related ArticlesCoordinating Care for Reproductive Health Malignancies in the Veterans' Health Administration: Promising Practices, Ongoing Challenges, and Future Research. Semin Reprod Med. 2019 01;37(1):32-42 Authors: Cordasco KM, Moreau JL, Chawla N Abstract In cancer care, communication and coordination across the cancer continuum is paramount for delivering effective, high-quality, patient-centered care. However, achieving optimally coordinated...
Tue Apr 28, 2020 13:35
Related ArticlesPD-1/PD-L1 blockade in paediatric cancers: What does the future hold? Cancer Lett. 2019 08 10;457:74-85 Authors: Moreno-Vicente J, Beers SA, Gray JC Abstract Checkpoint blockade (CPB) immunotherapy has shown unprecedented success in a wide range of adult malignancies, and is increasingly being employed in the treatment of advanced cancers. However, the experience in the paediatric population remains limited and the small number of single...
Tue Apr 28, 2020 13:35
Related ArticlesIdentification and Quantification of Proteoforms by Mass Spectrometry. Proteomics. 2019 05;19(10):e1800361 Authors: Schaffer LV, Millikin RJ, Miller RM, Anderson LC, Fellers RT, Ge Y, Kelleher NL, LeDuc RD, Liu X, Payne SH, Sun L, Thomas PM, Tucholski T, Wang Z, Wu S, Wu Z, Yu D, Shortreed MR, Smith LM Abstract A proteoform is a defined form of a protein derived from a given gene with a specific amino acid sequence and localized post-translational...
Tue Apr 28, 2020 13:35
Publication date: Available online 28 April 2020Source: Magnetic Resonance ImagingAuthor(s): Wenyuan Qiu, Dongxiao Li, Xinyu Jin, Fan Liu, Bin Sun
Tue Apr 28, 2020 13:31
Publication date: Available online 28 April 2020Source: Magnetic Resonance ImagingAuthor(s): Kenneth Wengler, Jason Ha, Olga Syritsyna, Lev Bangiyev, Patricia K. Coyle, Tim Q. Duong, Mark E. Schweitzer, Xiang He
Tue Apr 28, 2020 13:31
Publication date: Available online 27 April 2020Source: Magnetic Resonance ImagingAuthor(s): Niccolo Fuin, Aurelien Bustin, Thomas Küstner, Ilkay Oksuz, James Clough, Andrew P. King, Julia A. Schnabel, René M. Botnar, Claudia Prieto
Tue Apr 28, 2020 13:31
Publication date: Available online 27 April 2020Source: Magnetic Resonance ImagingAuthor(s): Sanqian Li, Jinjie Zhou, Dong Liang, Qiegen Liu
Tue Apr 28, 2020 13:31
Related ArticlesA time course metabolism comparison among Saccharomyces cerevisiae, S. uvarum and S. kudriavzevii species in wine fermentation. Food Microbiol. 2020 Sep;90:103484 Authors: Minebois R, Pérez-Torrado R, Querol A Abstract In this study, we presented the first metabolome time course analysis performed among a set of S. uvarum, S. kudriavzevii and S. cerevisiae strains under winemaking conditions. Extracellular and intracellular metabolites,...
Tue Apr 28, 2020 13:27
Related ArticlesCombined NaCl and DTT diminish harmful ER-stress effects in the sorghum seedlings CSF 20 variety. Plant Physiol Biochem. 2020 Feb;147:223-234 Authors: Queiroz CS, Pereira IMC, Lima KRP, Bret RSC, Alves MS, Gomes-Filho E, Carvalho HH Abstract Plants have developed mechanisms to avoid harmful effects of Na+ accumulation, such as the signaling pathway of carrier proteins Na+/H+ (NHX) and salt overly sensitive (SOS). Besides, endoplasmic...
Tue Apr 28, 2020 13:27
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