Cancers, Vol. 12, Pages 1084: Multimodal Targeted Deep Sequencing of Circulating Tumor Cells and Matched Cell-Free DNA Provides a More Comprehensive Tool to Identify Therapeutic Targets in Metastatic Breast Cancer Patients Cancers doi: 10.3390/cancers12051084 Authors: Corinna Keup Markus Storbeck Siegfried Hauch Peter Hahn Markus Sprenger-Haussels Oliver Hoffmann Rainer Kimmig Sabine Kasimir-Bauer Cell-free DNA (cfDNA) and circulating tumor cells (CTCs)...
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Cancers, Vol. 12, Pages 1086: FAK Inhibition Induces Glioblastoma Cell Senescence-Like State through p62 and p27 Cancers doi: 10.3390/cancers12051086 Authors: Lía Alza Mireia Nàger Anna Visa Carles Cantí Judit Herreros Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor that has a poor prognosis....
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Cancers, Vol. 12, Pages 1082: Differences of the Immune Phenotype of Breast Cancer Cells after Ex Vivo Hyperthermia by Warm-Water or Microwave Radiation in a Closed-Loop System Alone or in Combination with Radiotherapy Cancers doi: 10.3390/cancers12051082 Authors: Michael Hader Deniz Pinar Savcigil Andreas Rosin Philipp Ponfick Stephan Gekle Martin Wadepohl Sander Bekeschus Rainer Fietkau Benjamin Frey Eberhard Schlücker Udo S. Gaipl The treatment...
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Cancers, Vol. 12, Pages 1085: Ribosomal Protein S27/Metallopanstimulin-1 (RPS27) in Glioma—A New Disease Biomarker? Cancers doi: 10.3390/cancers12051085 Authors: Jonas Feldheim Almuth F. Kessler Dominik Schmitt Ellaine Salvador Camelia M. Monoranu Julia J. Feldheim Ralf-Ingo Ernestus Mario Löhr Carsten Hagemann Despite its significant overexpression in several malignant neoplasms, the expression of RPS27 in the central nervous system (CNS) is widely...
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Cancers, Vol. 12, Pages 1083: Crosstalk Between Prostate Cancer Cells and Tumor-Associated Fibroblasts Enhances the Malignancy by Inhibiting the Tumor Suppressor PLZF Cancers doi: 10.3390/cancers12051083 Authors: Kum Hee Noh Ae Jin Jeong Haeri Lee Song-Hee Lee Eunhee Yi Pahn-Shick Chang Cheol Kwak Sang-Kyu Ye Although prostate cancer is clinically manageable during the early stages of progression, metastatic progression severely compromises the prognosis...
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Cancers, Vol. 12, Pages 1087: Application of a Biphasic Mathematical Model of Cancer Cell Drug Response for Formulating Potent and Synergistic Targeted Drug Combinations to Triple Negative Breast Cancer Cells Cancers doi: 10.3390/cancers12051087 Authors: Jinyan Shen Li Li Niall G. Howlett Paul S. Cohen Gongqin Sun Triple negative breast cancer is a collection of heterogeneous breast cancers that are immunohistochemically negative for estrogen receptor, progesterone...
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Cancers, Vol. 12, Pages 1081: Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors Cancers doi: 10.3390/cancers12051081 Authors: Xiaowen Wang Matias Bustos Xiaoqing Zhang Romela Ramos Cong Tan Yuuki Iida Shu-Ching Chang Matthew Salomon Kevin Tran Rebecca Gentry Yelena Kravtsova-Ivantsiv Daniel Kelly Gordon Mills Aaron Ciechanover Ying Mao Dave Hoon...
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The author names and family names of the originally published article was inversed. Correct presentation is presented here.
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Abstract Purpose To develop and validate an integrated model for discriminating tumor recurrence from radiation necrosis in glioma patients. Methods Data from 160 pathologically confirmed glioma patients were analyzed. The diagnostic model was developed in a primary cohort (n = 112). Textural features were extracted from postoperative...
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The Table 2 in the original version of this article contained a mistake in the alignment. Correct Table 2 presentation is presented here.
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Funding information from the original version of this article was incomplete. Complete information is presented here.
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Abstract Purpose The purpose of this study was to perform a prospective integrated analysis of 18F-fluorodeoxyglucose (18F-FDG)-positron emission tomography (PET)/computed tomography (CT) and circulating tumor DNA (ctDNA) to assess responses to multimodal chemotherapy in children and adolescents suffering from Ewing sarcoma (EwS). Methods ...
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The correct administered activity of 18F-FCH is 0.1–0.14 mCi/Kg, which is equivalent to 3.7–5.2 MBq/kg.
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Abstract Introduction Influenza in hospitalized intensive care unit (ICU) patients with respiratory failure is associated with 25% mortality, despite timely oseltamivir treatment. A systematic review of randomized controlled trials (RCTs) was conducted to evaluate the efficacy and safety of alternative neuraminidase inhibitor (NAI) regimens compared to standard of care in patients hospitalized for H1N1, H3N2, or B influenza. ...
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Abstract Introduction Sublingual immunotherapy (SLIT) with birch pollen extract has been shown to be an efficacious treatment of allergic rhinitis (AR). An as-yet unanswered question is whether and how clinical benefit translates into patient benefit, i.e. what benefit patients derive from this treatment. Methods This 1-year, open, prospective, multicenter,...
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Objective: Helicobacter pylori (H. pylori) is responsible for a wide spectrum of diseases. Due to ease of use and access, the standard triple therapy is being used as a first-line eradication in many areas. Intestinal metaplasia (IM) is a precancerous lesion that requires eradication therapy. Our aim is to investigate the effect of IM on the standard triple therapy success in H. pylori positive patients. Subject and Methods: The patients who referred to Düzce University Hospital and Avrasya Hospital...
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Objective: Acute kidney injury (AKI), which is prevalent in ST-segment elevated myocardial infarction (STEMI) patients undergone primary percutaneous coronary intervention (PCI), is associated with poor cardiovascular outcome. As high pulse pressure (PP) is associated with adverse cardiovascular events, the present study’s aim was to evaluate the relationship between fractional PP (PPf) and AKI in patients with STEMI who underwent primary PCI. Subject and methods: All laboratory findings as well...
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The original version of this article unfortunately contained a mistake. The second sentence of the section “irAEs and ICI efficacy” should read as.
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Abstract The effectual clinical benefits of immune checkpoint inhibitor (ICI) are hampered by a high rate of innate resistance, and VEGFA may contribute to ICI treatment resistance. In this study, we endeavored to assess the tumor microenvironment (TME) in VEGFA-overexpressed human tumors and mouse tumor models, and to explore whether anti-angiogenesis therapy can overcome the innate resistance to ICI in hyperangiogenesis mouse tumor models and the underlying mechanism. Effect...
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Abstract Targeted immunotherapy has improved the outcome of patients with high-risk neuroblastoma (NB). However, immune escape of tumor cells still occurs and about 40% of NB patients relapse and die from their disease. We previously showed that natural killer (NK) cell stimulation by Toll-like receptor (TLR)-activated plasmacytoid dendritic cells (pDC) increases the efficacy of dinutuximab-based immunotherapy against NB cell lines via the TRAIL death-receptor pathway. With the...
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Publication date: June 2020Source: European Journal of Cancer, Volume 132Author(s): Koen J. Hartemink, Alexander C.J. van Akkooi, Aletta P.I. Houwink, Emile E. Voest
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Publication date: June 2020Source: European Journal of Cancer, Volume 132Author(s): Eileen M. O'Reilly, Diletta Barone, Devalingam Mahalingam, Tanios Bekaii-Saab, Spencer H. Shao, Julie Wolf, Molly Rosano, Silva Krause, Donald A. Richards, Kenneth H. Yu, James M. Roach, Keith T. Flaherty, David P. Ryan
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Zusammenfassung Hintergrund Häufig suchen Patienten mit Krebserkrankungen nach komplementären Behandlungsmöglichkeiten. Die Nachfrage diesbezüglich scheint ständig zuzunehmen. 40–50 % aller Krebspatienten wenden komplementäre und alternative Medizin (KAM) an. Insbesondere Frauen und vor allem Frauen mit Brustkrebs sind besonders aktiv in dieser Richtung. Fragestellung ...
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Zusammenfassung Hintergrund Die individuellen Therapiemöglichkeiten der Patientin mit einem metastasierten Brustkrebs werden immer spezifischer. Für Therapieentscheidungen in der metastasierten Situation liegt keine ausreichende Evidenz aus klinischen Studien für alle Behandlungssituationen und Subgruppen vor. Dieses macht die Erhebung und systematische Auswertung von Real-World-Daten zur Erstellung von Real-World-Evidenz sinnvoll. ...
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Zusammenfassung Hintergrund Die Entdeckung der BRAF-Mutation und ihrer Rolle in der Pathogenese des Melanoms führte zur Etablierung der zielgerichteten Therapie mit sog. BRAF- und MEK-Inhibitoren, welche den Krankheitsverlauf und die Prognose von Patienten mit metastasiertem Melanom mit BRAF-Mutationen deutlich verbesserten. Material und Methoden Relevante...
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Zusammenfassung Hintergrund Brustkrebs ist die häufigste Krebsart bei Frauen in Deutschland. Ungefähr 6 % der Patientinnen haben bereits bei Diagnose Fernmetastasen. Fragestellung Berechnung aktueller Schätzer und Trends des relativen Überlebens nach primär metastasiertem Brustkrebs Material und...
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Background: Large vessel occlusion (LVO) leads to debilitating stroke and responds modestly to recombinant tissue plasminogen activator (rt-TPA). Early thrombectomy improves functional outcomes in selected patients with proximal occlusion but it is not available in all medical facilities. The best imaging modality for triage in an acute stroke setting in drip-and-ship models is still the subject of debate. Objectives: We aimed to assess the diagnostic value of millimeter-sliced noncontrast computed...
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Objectives: Mechanical thrombectomy (MT) is an effective treatment for acute ischemic stroke (AIS) caused by large vessel occlusion. Recanalization time is a key factor in the treatment of AIS. It has previously been suggested that intravenous thrombolysis (IVT) may be associated with a shorter recanalization time. The aim of our study was to investigate whether IVT or other factors could be associated with shorter or longer MT procedure times. Methods: We performed a retrospective analysis of a...
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Publication date: Available online 25 April 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): L. Salwey, V. L’Huillier, M. Zaid, Y. Vené, L. Tavernier, O. Mauvais
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Publication date: Available online 28 April 2020Source: Cancer LettersAuthor(s): Shan Kong, Mei Tao, Xianjuan Shen, Shaoqing Ju
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Publication date: Available online 28 April 2020Source: Cancer LettersAuthor(s): Wolong Zhou, Yuanqi Liu, Yang Gao, Yuanda Cheng, Ruimin Chang, Xizhe Li, Yanwu Zhou, Shaoqiang Wang, Lubiao Liang, Chaojun Duan, Chunfang Zhang
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Publication date: Available online 27 April 2020Source: Cancer LettersAuthor(s): Pei-Hua Peng, Joseph Chieh-Yu Lai, Kai-Wen Hsu, Kou-Juey Wu
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Publication date: Available online 26 April 2020Source: Cancer LettersAuthor(s): Sanjay Gupta, Atul Kumar Singh, Kumari Sunita Prajapati, Prem Prakash Kushwaha, Mohd Shuaib, Shashank Kumar
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Publication date: Available online 25 April 2020Source: Cancer LettersAuthor(s): Surendra K. Shukla, Spas D. Markov, Kuldeep S. Attri, Enza Vernucci, Ryan J. King, Aneesha Dasgupta, Paul M. Grandgenett, Michael A. Hollingsworth, Pankaj K. Singh, Fang Yu, Kamiya Mehla
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