Related ArticlesModelling towards a more holistic medicine: The Virtual Physiological Human (VPH). Morphologie. 2019 Dec;103(343):127-130 Authors: Van Sint Jan S, Geris L Abstract The Virtual Physiological Human (VPH) is a European initiative, rooted in the international Physiome initiative, focusing on establishing a methodological and technological framework, enabling the collaborative investigation of the human body as a single complex system. This...
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Related ArticlesThe ageing rate of workers engaged in chrome ore processing. Work. 2019;64(3):421-426 Authors: Mussina A, Suleimenov B, Sembayev Z, Kakabayev A, Burumbayeva M, Suleimenova R, Abduldayeva A, Kazbekova A, Tuleshova G, Dosmambetova K Abstract BACKGROUND: According to the modern concept of occupational medicine adopted by the World Health Organization, relationship between health and work is fully established while the levels of physical,...
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Related ArticlesHospital ethics reflection groups: a learning and development resource for clinical practice. BMC Med Ethics. 2019 10 24;20(1):75 Authors: Bruun H, Huniche L, Stenager E, Mogensen CB, Pedersen R Abstract BACKGROUND: An ethics reflection group (ERG) is one of a number of ethics support services developed to better handle ethical challenges in healthcare. The aim of this article is to evaluate the significance of ERGs in psychiatric and...
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Related ArticlesBaseline Psychosocial and Demographic Factors Associated with Study Attrition and 12-Month Weight Gain in the DIETFITS Trial. Obesity (Silver Spring). 2019 12;27(12):1997-2004 Authors: Fielding-Singh P, Patel ML, King AC, Gardner CD Abstract OBJECTIVE: The purpose of this study was to examine correlates of failure-trial attrition and weight gain-in a randomized clinical weight-loss trial. METHODS: The Diet Intervention Examining...
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Related ArticlesForming and implementing community advisory boards in low- and middle-income countries: a scoping review. BMC Med Ethics. 2019 10 17;20(1):73 Authors: Zhao Y, Fitzpatrick T, Wan B, Day S, Mathews A, Tucker JD Abstract BACKGROUND: Community advisory boards (CABs) have expanded beyond high-income countries (HICs) and play an increasing role in low- and middle-income country (LMIC) research. Much research has examined CABs in HICs, but...
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Related ArticlesEngaging research ethics committees to develop an ethics and governance framework for best practices in genomic research and biobanking in Africa: the H3Africa model. BMC Med Ethics. 2019 10 18;20(1):69 Authors: Tindana P, Yakubu A, Staunton C, Matimba A, Littler K, Madden E, Munung NS, de Vries J, as members of the H3Africa Consortium Abstract In the past decade, there has been an increase in genomic research and biobanking activities...
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Related ArticlesHow do researchers acquire and develop notions of research integrity? A qualitative study among biomedical researchers in Switzerland. BMC Med Ethics. 2019 10 16;20(1):72 Authors: Satalkar P, Shaw D Abstract BACKGROUND: Structured training in research integrity, research ethics and responsible conduct of research is one strategy to reduce research misconduct and strengthen reliability of and trust in scientific evidence. However, how...
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Related ArticlesThe Place for Religious Content in Clinical Ethics Consultations: A Reply to Janet Malek. HEC Forum. 2019 Dec;31(4):305-323 Authors: Colgrove N, Evans KK Abstract Janet Malek (HEC Forum 31(2):91-102, 2019) argues that a "clinical ethics consultant's religious worldview has no place in developing ethical recommendations or communicating about them with patients, surrogates, and clinicians." She offers five types of arguments in support...
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Related ArticlesManagement of Malignant Pleural Effusions-What Is New. Semin Respir Crit Care Med. 2019 06;40(3):323-339 Authors: Thomas R, Roy B, Maldonado F, Lee YCG Abstract Malignant pleural effusion (MPE) is a common and challenging problem. Patients affected by MPE have a poor prognosis and suffer from breathlessness and impaired quality of life. The management of MPE has barely changed for many decades; however, recent research has driven new...
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Related ArticlesPhysiologic Basis of Symptoms in Pleural Disease. Semin Respir Crit Care Med. 2019 06;40(3):305-313 Authors: DeBiasi EM, Feller-Kopman D Abstract Pleural effusions are commonly encountered and have a significant impact on the respiratory system. The reported effect of thoracentesis on physiologic parameters including oxygenation, lung volumes, and respiratory mechanics is variable likely owing to studies with a small, heterogeneous population...
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Related ArticlesImpaired Mobility and Urinary Incontinence in Nursing Home Residents: A Multicenter Study. J Wound Ostomy Continence Nurs. 2019 Nov/Dec;46(6):524-529 Authors: Jachan DE, Müller-Werdan U, Lahmann NA Abstract PURPOSE: The purpose of this study was to evaluate associations among use of walking aids, mobility status, and occurrence of urinary incontinence (UI) in geriatric patients residing in nursing homes, and to examine associations between...
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Related ArticlesDeath by organ donation: euthanizing patients for their organs gains frightening traction. Intensive Care Med. 2019 09;45(9):1309-1311 Authors: Ely EW PMID: 31444501 [PubMed - indexed for MEDLINE]
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Related ArticlesBurden of disease in pediatric patients with hypophosphatasia: results from the HPP Impact Patient Survey and the HPP Outcomes Study Telephone interview. Orphanet J Rare Dis. 2019 08 16;14(1):201 Authors: Rush ET, Moseley S, Petryk A Abstract BACKGROUND: Hypophosphatasia (HPP) is a rare, inherited, metabolic bone disease caused by deficient tissue-non-specific isoenzyme of alkaline phosphatase activity that manifests as a broad range...
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Related ArticlesAddressing emotional and physical distress after pulmonary embolism. Thromb Res. 2019 Oct;182:184 Authors: de Wit K PMID: 31399198 [PubMed - indexed for MEDLINE]
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Related ArticlesHealth-related quality of life and its risk factors in Chinese hereditary angioedema patients. Orphanet J Rare Dis. 2019 08 08;14(1):191 Authors: Liu S, Wang X, Xu Y, Xu Q, Zhi Y Abstract BACKGROUND: Hereditary angioedema (HAE) is a rare but serious condition characterized by unpredictable and recurrent attacks affecting the skin and mucosa. HAE has wide-ranging impacts on the health-related quality of life (HRQoL) of patients. This...
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Related ArticlesPerceptions and expectations of health-related quality of life among geriatric patients seeking emergency care: a qualitative study. BMC Geriatr. 2019 08 05;19(1):209 Authors: Dresden SM, McCarthy DM, Engel KG, Courtney DM Abstract BACKGROUND: Health-related quality of life (HRQoL), encompassing social, emotional, and physical wellbeing is an important clinical outcome of medical care, especially among geriatric patients. It is unclear...
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Related ArticlesImplementation of Japan's First Clinical Research Regulatory Law: Background, Overview, and Challenges. HEC Forum. 2019 Dec;31(4):283-294 Authors: Akabayashi A, Nakazawa E, Akabayashi A Abstract In April 2018, Japan's first law regulating clinical research went into effect. The law aimed to strengthen regulations on research integrity and conflicts of interest, which had been limited under existing administrative guidelines; the law...
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Related ArticlesA systems perspective on the importance of global health strategy developments for accomplishing today's Sustainable Development Goals. Health Policy Plan. 2019 11 01;34(9):635-645 Authors: Byskov J, Maluka S, Marchal B, Shayo EH, Blystad A, Bukachi S, Zulu JM, Michelo C, Hurtig AK, Bloch P Abstract Priority setting within health systems has not led to accountable, fair and sustainable solutions to improving population health. Providers,...
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Related ArticlesA pragmatic randomised controlled trial (RCT) and realist evaluation of the interdisciplinary home-bAsed Reablement program (I-HARP) for improving functional independence of community dwelling older people with dementia: an effectiveness-implementation hybrid design. BMC Geriatr. 2019 07 29;19(1):199 Authors: Jeon YH, Simpson JM, Low LF, Woods R, Norman R, Mowszowski L, Clemson L, Naismith SL, Brodaty H, Hilmer S, Amberber AM, Gitlin LN, Szanton S ...
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Related ArticlesValidation of the Italian version of the PSP Quality of Life questionnaire. Neurol Sci. 2019 Dec;40(12):2587-2594 Authors: Picillo M, Cuoco S, Amboni M, Bonifacio FP, Bruschi F, Carotenuto I, De Micco R, De Rosa A, Del Prete E, Di Biasio F, Elifani F, Erro R, Fabbri M, Falla M, Franco G, Frosini D, Galantucci S, Lazzeri G, Magistrelli L, Malaguti MC, Milner AV, Minafra B, Olivola E, Pilotto A, Rascunà C, Rizzetti MC, Schirinzi T, Borroni B, Ceravolo R,...
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Related ArticlesQuality of life assessment in migraine and relapsing remitting multiple sclerosis: self-perceived health is similar. Neurol Sci. 2019 Dec;40(12):2549-2554 Authors: Glavor KD, Titlić M, Vuletić G, Mrđen A, Šimunić MM Abstract OBJECTIVE: The aim of this study was to compare self-perceived health between migraine and early stages of relapsing-remitting multiple sclerosis (RRMS) and to explore whether and how accurate those health domains...
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Related ArticlesIllness acceptance in adolescents: A concept analysis. Nurs Forum. 2019 Oct;54(4):545-552 Authors: Zheng K, Bruzzese JM, Smaldone A Abstract AIM: To strengthen the theoretical understanding of illness acceptance in adolescents and to inform healthcare strategies geared toward supporting adolescents with chronic illness. BACKGROUND: Illness acceptance is associated with positive health outcomes. Though well understood in adults...
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Related ArticlesLetter to the editor. Knee Surg Sports Traumatol Arthrosc. 2019 11;27(11):3733-3734 Authors: Hiemstra LA, Kerslake S, Lafave M PMID: 31286165 [PubMed - indexed for MEDLINE]
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Related ArticlesFatigue in primary Sjögren's syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study. Rheumatol Int. 2019 Nov;39(11):1867-1873 Authors: Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D, UK Primary Sjögren’s Syndrome Registry, Ng WF Abstract Primary Sjögren's syndrome (pSS) is a chronic autoimmune rheumatic disease with symptoms including dryness, fatigue, and pain. The previous...
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Related ArticlesEffectiveness of an in-home respite care program to support informal dementia caregivers: A comparative study. Int J Geriatr Psychiatry. 2019 10;34(10):1534-1544 Authors: Vandepitte S, Putman K, Van Den Noortgate N, Verhaeghe S, Annemans L Abstract OBJECTIVES: Dementia is a major public health problem with important physical, psychosocial, emotional, and financial consequences for patients, their caregivers, and society. Since patients...
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Related ArticlesQuality of life among infertile PCOS patients. Arch Gynecol Obstet. 2019 08;300(2):461-467 Authors: Angin P, Yoldemir T, Atasayan K Abstract OBJECTIVE: To investigate whether quality of life differs between PCOS and non-PCOS infertile women. STUDY DESIGN: Two questionnaire forms of quality of life (PCOSQ, SF-36) were given to 238 women. Patients were asked to answer all of the questions in both of the questionnaires. Of these...
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Related ArticlesPalliative dialysis: Addressing the need for alternative dialysis delivery modes. Semin Dial. 2019 09;32(5):391-395 Authors: Tentori F, Hunt A, Nissenson AR Abstract For some patients with kidney failure, particularly those who have limited life expectancy or severe comorbidities, the "standard" dialysis treatment regimen may be perceived as excessively burdensome and may not align well with the patient's own priorities. For such patients,...
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A review of the burden and management of mild asthma in adults - Implications for clinical practice.
Related ArticlesA review of the burden and management of mild asthma in adults - Implications for clinical practice. Respir Med. 2019 06;152:97-104 Authors: Mulgirigama A, Barnes N, Fletcher M, Pedersen S, Pizzichini E, Tsiligianni I Abstract Mild asthma is present in 50-75% of patients with asthma and is defined by the Global Initiative for Asthma as asthma that can be well controlled with low-intensity treatments (Steps 1 and 2). Despite this definition,...
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Related ArticlesImplementing volunteer peer mentoring as a supplement to professional efforts in primary rehabilitation of persons with spinal cord injury. Spinal Cord. 2019 Oct;57(10):881-889 Authors: Hoffmann DD, Sundby J, Biering-Sørensen F, Kasch H Abstract STUDY DESIGN: A feasibility study, supplemented by a noncontrolled pretest/posttest. OBJECTIVES: To examine if a nationwide volunteer peer-mentoring program for in-patients with acute/subacute...
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Related ArticlesAssociation of industry ties with outcomes of studies examining the effect of wholegrain foods on cardiovascular disease and mortality: systematic review and meta-analysis. BMJ Open. 2019 05 19;9(5):e022912 Authors: Chartres N, Fabbri A, McDonald S, Turton J, Allman-Farinelli M, McKenzie J, Bero L Abstract OBJECTIVE: To determine if observational studies examining the association of wholegrain foods with cardiovascular disease (CVD)...
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Related ArticlesUpdate on hypoparathyroidism. Curr Opin Rheumatol. 2019 07;31(4):381-387 Authors: Cusano NE, Bilezikian JP Abstract PURPOSE OF REVIEW: Hypoparathyroidism is a rare endocrine disorder characterized by low or insufficient parathyroid hormone (PTH) concentrations leading to hypocalcemia, hyperphosphatemia, and markedly reduced bone turnover. Despite being a rare disease, hypoparathyroidism has a profound impact on affected patients. ...
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Related ArticlesActivity Modification and Load Management of Adolescents With Patellofemoral Pain: A Prospective Intervention Study Including 151 Adolescents. Am J Sports Med. 2019 06;47(7):1629-1637 Authors: Rathleff MS, Graven-Nielsen T, Hölmich P, Winiarski L, Krommes K, Holden S, Thorborg K Abstract BACKGROUND: Patellofemoral pain (PFP) affects 7% of adolescents, especially those who are highly active. Exercise-focused treatments show limited effect...
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Related ArticlesIs neighbourhood social cohesion associated with subjective well-being for older Chinese people? The neighbourhood social cohesion study. BMJ Open. 2019 05 10;9(5):e023332 Authors: Yu R, Cheung O, Leung J, Tong C, Lau K, Cheung J, Woo J Abstract OBJECTIVES: To evaluate the psychometric properties of the Hong Kong version of Neighbourhood Cohesion Instrument (HK-NCI) and examine whether neighbourhood social cohesion as measured using...
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Related ArticlesA swan song for Kt/Vurea. Semin Dial. 2019 09;32(5):424-437 Authors: Vanholder R, Van Biesen W, Lameire N Abstract Dialyzer clearance of urea multiplied by dialysis time and normalized for urea distribution volume (Kt/Vurea or simply Kt/V) has been used as an index of dialysis adequacy since more than 30 years. This article reviews the flaws of Kt/V, starting with a lack of proof of concept in three randomized controlled hard outcome...
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Related ArticlesA Case Management System for Integrating Patient-reported Outcome Assessment in Clinical Practice: The Beacon Tool. Med Care. 2019 05;57 Suppl 5 Suppl 1:S73-S79 Authors: Zahrieh D, Alexander A, Fruth B, Tan AD, Le-Rademacher J, Warsame R, Croghan K, Sloan JA Abstract INTRODUCTION: What if you could only ask one question of the patient during a clinic visit? Further, suppose the patient's biggest concern can pragmatically be incorporated...
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Related ArticlesInterpreting and Acting on PRO Results in Clinical Practice: Lessons Learned From the PatientViewpoint System and Beyond. Med Care. 2019 05;57 Suppl 5 Suppl 1:S46-S51 Authors: Blackford AL, Wu AW, Snyder C Abstract INTRODUCTION: We have used several methods to aid in the interpretation of patient-reported outcome (PRO) scores, and to suggest recommendations for acting on them, both within the PatientViewpoint system and in work done...
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Related ArticlesPRO-Bookmarking to Estimate Clinical Thresholds for Patient-reported Symptoms and Function. Med Care. 2019 05;57 Suppl 5 Suppl 1:S13-S17 Authors: Cook KF, Cella D, Reeve BB Abstract INTRODUCTION: PRO-Bookmarking is an alternative to traditional methods for deriving cut scores and applying qualitative modifiers to score ranges. METHODS: In PRO-Bookmarking, a working group of stakeholders identifies ranges of scores they judge...
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Related ArticlesRandomized controlled trial of motivational interviewing for psychogenic nonepileptic seizures. Epilepsia. 2019 05;60(5):986-995 Authors: Tolchin B, Baslet G, Suzuki J, Martino S, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA Abstract OBJECTIVE: We conducted a randomized controlled trial of motivational interviewing (MI) as an intervention to improve psychotherapy adherence and outcomes, including frequency of psychogenic nonepileptic...
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Related ArticlesFalls Self-Management Interventions for People with Parkinson's Disease: A Systematic Review. J Parkinsons Dis. 2019;9(2):283-299 Authors: Owen CL, Ibrahim K, Dennison L, Roberts HC Abstract BACKGROUND: Falls are common in Parkinson's disease (PD). Increased involvement of people with Parkinson's (PwP) in their care has been associated with enhanced satisfaction. Self-management programmes in other long-term conditions (LTCs) have led...
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