Related ArticlesA potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019. Histol Histopathol. 2020 Apr 27;:18223 Authors: Zhou H, Liu LP, Fang M, Li YM, Zheng YW Abstract The novel coronavirus disease 2019 (COVID-19) outbreak began in the city of Wuhan, whereupon it rapidly spread throughout China and subsequently across the world. Rapid transmission of COVID-19 has caused wide-spread panic....
Tue Apr 28, 2020 16:09
Related ArticlesChanges in Diet Quality over 10 Years Are Associated with Baseline Sociodemographic and Lifestyle Factors in the Multiethnic Cohort Study. J Nutr. 2020 Apr 27;: Authors: Park SY, Shvetsov YB, Kang M, Setiawan VW, Wilkens LR, Le Marchand L, Boushey CJ Abstract BACKGROUND: Trends in diet quality among US adults indicate a steady improvement, but data on longitudinal individual-level changes in diet quality are still limited. OBJECTIVE:...
Tue Apr 28, 2020 15:07
Related ArticlesDietary Intake and Biomarkers of Folate and Cobalamin Status in Norwegian Preschool Children: The FINS-KIDS Study. J Nutr. 2020 Apr 27;: Authors: Solvik BS, Strand TA, Kvestad I, Markhus MW, Ueland PM, McCann A, Øyen J Abstract BACKGROUND: Folate and cobalamin (vitamin B-12) are essential for growth and development. However, few population-based studies have investigated B-vitamin status in children. OBJECTIVES: This study aimed...
Tue Apr 28, 2020 15:07
Related ArticlesSpeech Perception and Sound-Quality Rating with an Adaptive Nonlinear Frequency Compression Algorithm in Mandarin-Speaking Hearing-Aid Users. J Am Acad Audiol. 2020 Apr 27;: Authors: Xu L, Voss SC, Yang J, Wang X, Lu Q, Rehmann J, Kuehnel V, Qian J Abstract BACKGROUND: Mandarin Chinese has a rich repertoire of high-frequency speech sounds. This may pose a remarkable challenge to hearing-impaired listeners who speak Mandarin Chinese...
Tue Apr 28, 2020 14:34
Related ArticlesNeural Coding of Syllable-Final Fricatives with and without Hearing Aid Amplification. J Am Acad Audiol. 2020 Apr 27;: Authors: Miller SE, Zhang Y Abstract BACKGROUND: Cortical auditory event-related potentials are a potentially useful clinical tool to objectively assess speech outcomes with rehabilitative devices. Whether hearing aids reliably encode the spectrotemporal characteristics of fricative stimuli in different phonological...
Tue Apr 28, 2020 14:34
Related ArticlesComplaints of People with Hyperacusis. J Am Acad Audiol. 2020 Apr 27;: Authors: Ke J, Du Y, Tyler RS, Perreau A, Mancini PC Abstract BACKGROUND: Hyperacusis is a prevalent auditory disorder that causes significant distress and negatively affects quality of life for many patients. Patients with hyperacusis often have different complaints about the sounds and situations that they experience. Audiologists may have few patients with...
Tue Apr 28, 2020 14:34
Related ArticlesEffect of Microphone Configuration and Sound Source Location on Speech Recognition for Adult Cochlear Implant Users with Current-Generation Sound Processors. J Am Acad Audiol. 2020 Apr 27;: Authors: Dwyer RT, Roberts J, Gifford RH Abstract BACKGROUND: Microphone location has been shown to influence speech recognition with a microphone placed at the entrance to the ear canal yielding higher levels of speech recognition than top-of-the-pinna...
Tue Apr 28, 2020 14:34
Related ArticlesBilateral Cochlear Implants Allow Listeners to Benefit from Visual Information When Talker Location is Varied. J Am Acad Audiol. 2020 Apr 27;: Authors: Dorman MF, Natale S, Knickerbocker A Abstract BACKGROUND: Previous research has found that when the location of a talker was varied and an auditory prompt indicated the location of the talker, the addition of visual information produced a significant and large improvement in speech...
Tue Apr 28, 2020 14:34
Related ArticlesAuditory Gating in Hearing Loss. J Am Acad Audiol. 2020 Apr 27;: Authors: Campbell J, Nielsen M, Bean C, LaBrec A Abstract BACKGROUND: Sensory gating is a measure used to evaluate inhibitory deficits underlying neurological disorders. However, the effects of hearing loss (HL), thought to decrease inhibition, remain unknown on gating function. PURPOSE: The goal of this study was to investigate gating performance in HL....
Tue Apr 28, 2020 14:34
Related ArticlesVestibular Test Results of a Patient with Cerebral Microangiopathy and Idiopathic Thrombocytopenia. J Am Acad Audiol. 2020 Apr 27;: Authors: Myers B, Creegan D, Hoyos E Abstract BACKGROUND: Cerebral microangiopathy (CM) is a general term for small ischemic changes related to small blood vessels in the brain. Immune thrombocytopenia (ITP) is a rare acquired autoimmune disease that is characterized by low platelet count and increased...
Tue Apr 28, 2020 14:34
Publication date: Available online 25 April 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Thomas A. Buckley, Barry A. Munkasy, David A. Krazeise., Jessie R. Oldham, Kelsey M. Evans, Brandy Clouse
Tue Apr 28, 2020 13:02
Publication date: Available online 25 April 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Yumi Kim, Tapan Mehta, Byron Lai, Robert W. Motl
Tue Apr 28, 2020 13:02
Related ArticlesAligned soy protein isolate-modified poly(L-lactic acid) nanofibrous conduits enhanced peripheral nerve regeneration. J Neural Eng. 2020 Apr 27;: Authors: Zhang Q, Tong Z, Chen F, Wang X, Ren M, Zhao Y, Wu P, He X, Chen P, Chen Y Abstract Repair and regeneration of peripheral nerve defect by engineered conduits has greatly advanced in the past decades while still facing great challenges. In this work, we fabricated a new highly oriented...
Tue Apr 28, 2020 15:04
Related ArticlesPlacental fatty acid transport across late gestation in a baboon model of intrauterine growth restriction. J Physiol. 2020 Apr 27;: Authors: Chassen SS, Ferchaud-Roucher V, Palmer C, Li C, Jansson T, Nathanielsz PW, Powell TL Abstract KEY POINTS: Intrauterine growth restriction (IUGR) is associated with perinatal morbidity and increased risk of lifelong disease, including neurodevelopmental impairment. Fatty acids (FA) are critical for...
Tue Apr 28, 2020 14:57
Related ArticlesIntracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca2+ dependent manner. J Physiol. 2020 Apr 27;: Authors: Thakur DP, Wang Q, Jeon J, Tian JB, Zhu MX Abstract KEY POINTS: Receptor-operated activation of TRPC4 cation channels requires Gi/o proteins and phospholipase-Cδ1 (PLCδ1) activation by intracellular Ca2+ Concurrent stimulation of Gq/11 pathway accelerates Gi/o activation of TRPC4, which...
Tue Apr 28, 2020 14:57
Zusammenfassung Der Lupus erythematodes (LE) ist eine Autoimmunerkrankung, bei der die Immuntoleranz gegenüber Nukleinsäuren verloren geht und es unter anderem durch ein enthemmtes Typ-I-Interferon-System zu einer chronischen Immunaktivierung kommt. Geradezu typisch für den LE ist seine große Heterogenität von klinischen Symptomen und Verläufen zwischen Patienten. Die LE-Manifestationen auf der Haut können mit Beteiligung innerer Organe verbunden sein oder auch isoliert auftreten...
Tue Apr 28, 2020 03:00
Abstract Purpose of Review The present paper aims to highlight clinical implications of elevated cardiac biomarkers and associated myocardial dysfunction in a variety of cardiac and non-cardiac scenarios in patients with an asthma exacerbation, and to propose a basic algorithm for cardiovascular evaluation and triage (and hence, for further management) of these patients primarily based on evaluation of cardiac biomarkers along...
Tue Apr 28, 2020 03:00
Publication date: June 2020Source: Cancer Epidemiology, Volume 66Author(s): Joseph Lubega, M. David Hallman, Philip J. Lupo, Yunxin Fu, Leif Peterson, Michael E. Scheurer
Tue Apr 28, 2020 12:49
Publication date: June 2020Source: Cancer Epidemiology, Volume 66Author(s): Kristen D. Brantley, Anders H. Riis, Rune Erichsen, Ole Thorlacius-Ussing, Holger Jon Møller, Timothy L. Lash
Tue Apr 28, 2020 12:49
Publication date: Available online 25 April 2020Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): A. Torrado-Carvajal
Tue Apr 28, 2020 12:40
The Journal of Antibiotics, Published online: 28 April 2020; doi:10.1038/s41429-020-0312-7In vitro synergistic effect of retapamulin with erythromycin and quinupristin against Enterococcus faecalis
Tue Apr 28, 2020 03:00
Zusammenfassung Hintergrund Die Differenzialdiagnose des Schwindels mit Hörminderung erfordert standardisiertes Vorgehen bei Erkennung und Klassifikation seltener kongenitaler und erworbener Fehlbildungen des Felsenbeins. Fragestellung Ziel ist die Darstellung von Physiologie und Pathophysiologie der endo- und perilymphatischen Druckregulation,...
Tue Apr 28, 2020 12:34
Adolescent pregnancies are a global health problem with over 16 million children born to this age group globally. Adolescent females also represent almost half of all adolescent global migrants. Adolescent pregnancy by itself is associated with poor health care access and morbidities; the additional risk of social insecurity in the case of undocumented adolescent migrants leads to higher risks for the mother and newborn. According to the CDC, adolescents comprise half of all new sexually transmitted...
Tue Apr 28, 2020 08:05
Respiratory support of the critically ill neonate has steadily shifted from invasive to noninvasive forms of support. There have recently been a number of important advances in our understanding of the changes to neonatal resuscitation practices as they pertain to clinically important outcomes, mechanisms of gas exchange for high-flow nasal cannula, and best use of noninvasive ventilation and predicting response. Although the proportion of infants requiring intubation and mechanical ventilation has...
Tue Apr 28, 2020 10:42
PEEP Titration to Minimize Driving Pressure in Subjects With ARDS: A Prospective Physiological Study
BACKGROUND:Observational studies report that lower driving pressure (ie, the difference between plateau pressure and PEEP) is associated with improved survival in patients with ARDS and may be a key mediator of lung-protective ventilation strategies. The primary objective of this study was to characterize reductions in driving pressure that could be achieved through changes in PEEP.METHODS:In this prospective physiological pilot study, 10 subjects with ARDS were placed on PEEP according to the ARDS...
Tue Apr 28, 2020 10:42
BACKGROUND:The N95 filtering facepiece respirator (FFR) is the most popular individual protective device to reduce exposure to particulate matter. However, concerns have been raised with regard to its use because it can increase respiratory resistance and dead space. Therefore, this study assessed the safety of N95 use in patients with COPD and air-flow limitation.METHODS:This prospective study was performed at a tertiary hospital and enrolled 97 subjects with COPD. The subjects were monitored for...
Tue Apr 28, 2020 10:42
BACKGROUND:Electrical impedance tomography (EIT) is a noninvasive, portable lung imaging technique that provides functional distribution of ventilation. We aimed to describe the relationship between the distribution of ventilation by mode of ventilation and level of oxygenation impairment in children who are critically ill. We also aimed to describe the safety of EIT application.METHODS:A prospective observational study of EIT images obtained from subjects in the pediatric ICU. Images were categorized...
Tue Apr 28, 2020 10:42
BACKGROUND:Assisted coughing via mechanical in-exsufflation (MI-E) is a first-line treatment for secretion management in patients with amyotrophic lateral sclerosis (ALS) with unassisted CPF < 4.25 L/s. Some devices enable oscillations to be added to MI-E (MI-E+O). We sought to determine whether adding oscillations to MI-E enables a reduction in the use of invasive secretion management procedures (ie, bronchoscopy or tracheostomy) in subjects with ALS.METHODS:We conducted a 12-month, prospective,...
Tue Apr 28, 2020 10:42
BACKGROUND:Ventilator-associated pneumonia (VAP) is a common and serious complication of mechanical ventilation. We conducted a meta-analysis of published randomized controlled trials to evaluate the efficacy and safety of probiotics for VAP prevention in patients who received mechanical ventilation.METHODS:We searched a number of medical literature databases to identify randomized controlled trials that compared probiotics with controls for VAP prevention. The results were expressed as odds ratios...
Tue Apr 28, 2020 10:42
BACKGROUND:The threshold of the lower limit of the normal range of lung function has been suggested to be more accurate than the 0.7 fixed ratio (FEV1/FVC < 0.7) for a diagnosis of COPD. We aimed to explore the health status and risk factors of patients overdiagnosed with COPD when using the lower limit of the normal range as a diagnostic reference.METHODS:Subjects with COPD diagnosed by a pulmonologist according to guidelines of the Global Initiative for Chronic Obstructive Lung Disease were...
Tue Apr 28, 2020 10:42
“E-cigarettes” are a class of consumer devices designed to deliver drugs, primarily nicotine or marijuana oils, to the lung by vaporization. Regulation of the devices in the United States is relatively minimal, and research on both epidemiology and potential toxicity has focused on nicotine devices. In 2019, an outbreak of an acute respiratory illness in the United States was traced back to the contamination of e-cigarette fluids with vitamin E acetate, which had been used to disguise the dilution...
Tue Apr 28, 2020 10:42
BACKGROUND:High-flow nasal cannula (HFNC) therapy may reduce the re-intubation rate compared with conventional oxygen therapy. However, HFNC has not been sufficiently compared with conventional oxygen therapy with a heated humidifier, even though heated humidification is beneficial for facilitating airway clearance.METHODS:This study was a single-center, open-label, randomized controlled trial. We randomized subjects with respiratory failure after extubation to either HFNC group or to a large-volume...
Tue Apr 28, 2020 10:42
BACKGROUND:Field walking tests are commonly used in patients with chronic pulmonary diseases for assessment of functional capacity. However, the physiological demands and magnitude of desaturation on 6-min walk test (6MWT), incremental shuttle walk test (ISWT), and endurance shuttle walk test (ESWT) have not been investigated in patients with bronchiectasis. The objective of this study was to compare the physiological responses and the magnitude of desaturation of subjects with bronchiectasis when...
Tue Apr 28, 2020 10:42
BACKGROUND:In this study, we aimed to validate the agreement between pulmonary function measurements obtained with a portable spirometer and measurements obtained with conventional spirometry in Chinese pediatric and adult populations.METHODS:Pulmonary function testing was performed to evaluate subjects enrolled at Shanghai Zhongshan Hospital (n = 104) and Shanghai Children's Medical Center (n = 103). The portable spirometers and conventional devices were applied to each subject with a 20-min quiescent...
Tue Apr 28, 2020 10:42
BACKGROUND:Pneumoperitoneum and Trendelenburg position affect respiratory system mechanics and oxygenation during elective pelvic robotic surgery. The primary aim of this randomized pilot study was to compare the effects of a conventional low tidal volume ventilation with PEEP guided by gas exchange (VGas-guided) versus low tidal volume ventilation tailoring PEEP according to esophageal pressure (VPes-guided) on oxygenation and respiratory mechanics during elective pelvic robotic surgery.METHODS:This...
Tue Apr 28, 2020 10:42
BACKGROUND:Radiotherapy for breast cancer has been implicated in the development of bronchiolitis obliterans organizing pneumonia (BOOP). Patients may be asymptomatic or may have pulmonary and constitutional symptoms that are moderate or severe. Postradiotherapy BOOP usually develops during the 12 months after completion of radiotherapy and is characterized by ground-glass opacities in the radiation-exposed lung and frequently in the non-irradiated lung.METHODS:An updated literature search and review...
Tue Apr 28, 2020 10:42
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