Related Articles Good Outcome of Early-Stage Rectal Cancer Diagnosed During Pregnancy. Am J Case Rep. 2020 Aug 31;21:e925673 Authors: Alkhamis WH, Naama T, Arafah MA, Abdulghani SH Abstract BACKGROUND Colorectal cancer (CRC) in pregnancy is very rare. It is often associated with poor prognosis which is contributed to delayed diagnosis due to the overlapping symptoms of CRC and pregnancy. The purpose of this case report is to highlight the importance...
Tue Sep 01, 2020 15:24
Related Articles A 57-Year-Old African American Man with Severe COVID-19 Pneumonia Who Responded to Supportive Photobiomodulation Therapy (PBMT): First Use of PBMT in COVID-19. Am J Case Rep. 2020 Aug 15;21:e926779 Authors: Sigman SA, Mokmeli S, Monici M, Vetrici MA Abstract BACKGROUND Coronavirus disease 2019 (COVID-19) is associated with lung inflammation and cytokine storm. Photobiomodulation therapy (PBMT) is a safe, non-invasive therapy...
Tue Sep 01, 2020 15:24
Related Articles Refractory Chylous Ascites with Chylothorax and an Umbilical Hernia in a Patient Ineligible for a Transjugular Intrahepatic Portosystemic Shunt. Am J Case Rep. 2020 Aug 31;21:e925026 Authors: Fatah A, Audiyanto T Abstract BACKGROUND Chylous ascites is a rare condition, which is defined by accumulation of a milky fluid due to high triglyceride levels. It is most commonly secondary to malignancy, liver cirrhosis, infection, and...
Tue Sep 01, 2020 15:24
Related Articles Physiological and histopathological alterations in male Swiss mice after exposure to titanium dioxide (anatase) and zinc oxide nanoparticles and their binary mixture. Drug Chem Toxicol. 2020 Aug 30;:1-26 Authors: Ogunsuyi O, Ogunsuyi O, Akanni O, Alabi O, Alimba C, Adaramoye O, Cambier S, Eswara S, Gutleb AC, Bakare A Abstract Existing studies have shown the systemic damage of titanium dioxide (TiO2) or zinc oxide (ZnO) nanoparticles...
Tue Sep 01, 2020 15:13
Related Articles Standardized aqueous stem bark extract of Gmelina arborea roxb. possesses nephroprotection against adriamycin-induced nephrotoxicity in Wistar rats. Drug Chem Toxicol. 2020 Aug 30;:1-11 Authors: Amarasiri SS, Attanayake AP, Arawwawala LDAM, Jayatilaka KAPW, Mudduwa LKB Abstract Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina...
Tue Sep 01, 2020 15:13
Related Articles Desensitization of metastatic melanoma cells to therapeutic treatment through repeated exposure to dacarbazine. J Photochem Photobiol B. 2020 Jul 31;211:111982 Authors: Biteghe FAN, Padayachee E, Davids LM, Chalomie NET, Ndong JC, Barth S Abstract Aberrant anti-cancer drug efflux mediated by membrane protein ABC transporters (ABCB5 and ABCG2) is thought to characterize melanoma heterogeneous chemoresistant populations,...
Tue Sep 01, 2020 13:10
Related Articles Antiproliferative effect of mitochondria-targeting allobetulin 1,2,3-triazolium salt derivatives and their mechanism of inducing apoptosis of cancer cells. Eur J Med Chem. 2020 Aug 20;207:112737 Authors: Wang R, Li Y, Dehaen W Abstract Herein we report the targeting effect of 1,2,3-triazolium salt derivatives of allobetulin on cancer cells mitochondria and their antiproliferative mechanism. A series of allobetulin derivatives...
Tue Sep 01, 2020 13:10
Related Articles In vivo experiments demonstrate the potent antileishmanial efficacy of repurposed suramin in visceral leishmaniasis. PLoS Negl Trop Dis. 2020 Aug 31;14(8):e0008575 Authors: Khanra S, Juin SK, Jawed JJ, Ghosh S, Dutta S, Nabi SA, Dash J, Dasgupta D, Majumdar S, Banerjee R Abstract BACKGROUND: Treatment failure and resistance to the commonly used drugsremains a major obstacle for successful chemotherapy against visceral leishmaniasis...
Tue Sep 01, 2020 13:10
Related Articles LMTK3 promotes tumorigenesis in bladder cancer via the ERK/ MAPK pathway. FEBS Open Bio. 2020 Aug 31;: Authors: Jiang T, Lu X, Yang F, Wang M, Yang H, Xing N Abstract Lemur tyrosine kinase 3 (LMTK3) is a key member of the serine/threonine tyrosine kinase family. It plays an important role in breast cancer tumorigenesis and progression. However, its biological role in bladder cancer remains elusive. In this study, we demonstrated...
Tue Sep 01, 2020 13:10
Related Articles CircDHDDS/miR-361-3p/WNT3A Axis Promotes the Development of Retinoblastoma by Regulating Proliferation, Cell Cycle, Migration, and Invasion of Retinoblastoma Cells. Neurochem Res. 2020 Aug 31;: Authors: Wang H, Li M, Cui H, Song X, Sha Q Abstract Retinoblastoma (RB) is a common intraocular malignant tumor. The growing evidence has reported that circular RNAs (circRNAs) play critical roles in RB development. Therefore, the...
Tue Sep 01, 2020 13:10
Related Articles Increasing the colon cancer cells sensitivity toward radiation therapy via application of Oct4-Sox2 complex decoy oligodeoxynucleotides. Mol Biol Rep. 2020 Aug 31;: Authors: Johari B, Rezaeejam H, Moradi M, Taghipour Z, Saltanatpour Z, Mortazavi Y, Nasehi L Abstract Low sensitivity of cancer stem cells toward regular cancer therapy strategies is an important issue in the field of cancer remedy. The concept of cancer stem...
Tue Sep 01, 2020 13:10
Related Articles Role for phagocytosis in the prevention of neoplastic transformation in Drosophila. Genes Cells. 2020 Aug 31;: Authors: Zhang M, Nagaosa K, Nakai Y, Yasugi T, Kushihiki M, Rahmatika D, Sato M, Shiratsuchi A, Nakanishi Y Abstract Immunity is considered to be involved in the prevention of cancer. Although both humoral and cellular immune reactions may participate, underlying mechanisms have yet to be clarified. The present...
Tue Sep 01, 2020 13:10
Related Articles FB-15 inhibits MGC-803 cells growth by regulating energy metabolism. Chem Biol Interact. 2020 Aug 25;327:109186 Authors: Deng X, Pi Y, Li Z, Xiong R, Liu J, Zhao J, Xie Z, Lei X, Tang G Abstract In this study, we scrutinized the anticancer effects of FB-15 on human gastric carcinoma MGC-803 cells in vitro and vivo, and its preliminary effect on tubulin and HIF-1α. We confirmed that FB-15 not only inhibited the proliferation...
Tue Sep 01, 2020 13:10
Related Articles PD173074 blocks G1/S transition via CUL3-mediated ubiquitin protease in HepG2 and Hep3B cells. PLoS One. 2020;15(6):e0234708 Authors: Qiao C, Qian H, Wang J, Zhao T, Ma P, Wang S, Zhang T, Liu X Abstract Fibroblast growth factor receptors (FGFRs) are frequently altered in a variety of human cancer cells and are overexpressed in hepatocellular carcinoma (HCC). Several literatures have proven that they are efficacious for HCC...
Tue Sep 01, 2020 13:10
Related Articles SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation. Life Sci. 2020 Sep 01;256:117971 Authors: Xiang Y, Fang B, Liu Y, Yan S, Cao D, Mei H, Wang Q, Hu Y, Guo T Abstract AIMS: Multiple myeloma (MM) was recently reported to rely on increased oxidative phosphorylation (OXPHOS) for survival, providing a potential opportunity for MM therapy. Herein, we aimed to propose a novel...
Tue Sep 01, 2020 13:10
Related Articles Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer. Cell Rep. 2019 08 20;28(8):2156-2168.e5 Authors: Di Mitri D, Mirenda M, Vasilevska J, Calcinotto A, Delaleu N, Revandkar A, Gil V, Boysen G, Losa M, Mosole S, Pasquini E, D'Antuono R, Masetti M, Zagato E, Chiorino G, Ostano P, Rinaldi A, Gnetti L, Graupera M, Martins Figueiredo Fonseca AR, Pereira Mestre R, Waugh...
Tue Sep 01, 2020 13:10
Related Articles microRNA-374 inhibits proliferation and promotes apoptosis of mouse melanoma cells by inactivating the Wnt signalling pathway through its effect on tyrosinase. J Cell Mol Med. 2019 08;23(8):4991-5005 Authors: Li XJ, Li ZF, Xu YY, Han Z, Liu ZJ Abstract Melanoma is one of the most malignant skin tumours with constantly increasing incidence worldwide. Previous studies have demonstrated that microRNA-374 (miR-374) is a novel...
Tue Sep 01, 2020 13:10
Related Articles MicroRNA-551b-3p inhibits tumour growth of human cholangiocarcinoma by targeting Cyclin D1. J Cell Mol Med. 2019 08;23(8):4945-4954 Authors: Chang W, Wang Y, Li W, Shi L, Geng Z Abstract MicroRNAs (miRNAs) are powerful regulators in the tumorigenesis of cholangiocarcinoma (CCA). Previous studies report that miR-551b-3p acts as an oncogenic factor in ovarian cancer, but plays a tumour suppressive role in gastric cancer. However,...
Tue Sep 01, 2020 13:10
Related Articles Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers. Carcinogenesis. 2020 04 22;41(2):214-222 Authors: Xu L, You X, Cao Q, Huang M, Hong LL, Chen XL, Lei L, Ling ZQ, Chen Y Abstract Adenosylmethionine decarboxylase 1 (AMD1) is a key enzyme involved in biosynthesis of polyamines including spermidine and spermine. The potential function of AMD1 in human gastric cancers...
Tue Sep 01, 2020 13:10
Related Articles Network meta-analysis of antiepileptic drugs in focal drug-resistant epilepsy. Epilepsy Res. 2020 Jul 25;167:106433 Authors: Hu TY, Wang HQ, Zhang WP, Tian RF, Lei GS, Deng YC, Xing JL Abstract OBJECTIVE: To compare and rank the efficacy and acceptability of new antiepileptic drugs (AEDs) for patients with focal drug-resistant epilepsy. METHODS: PubMed, EMBASE, Cochrane databases and Clinicaltrials.gov were systematically...
Tue Sep 01, 2020 14:56
Related Articles Case report: a 10-year-old girl with primary hypoparathyroidism and systemic lupus erythematosus. J Pediatr Endocrinol Metab. 2020 Aug 27;: Authors: Borysewicz-Sańczyk H, Sawicka B, Michalak J, Wójtowicz J, Dobreńko E, Konstantynowicz J, Kemp EH, Thakker RV, Allgrove J, Hannan FM, Bossowski A Abstract Objectives Hypoparathyroidism is a rare disease in children that occurs as a result of autoimmune destruction of the parathyroid...
Tue Sep 01, 2020 14:56
Related Articles Intraoperative Electrophysiologic Mapping of Medial Frontal Motor Areas and Functional Outcomes. World Neurosurg. 2020 06;138:e389-e404 Authors: Shibata S, Yamao Y, Kunieda T, Inano R, Nakae T, Nishida S, Inada T, Takahashi Y, Kikuchi T, Arakawa Y, Yoshida K, Matsumoto R, Ikeda A, Mima T, Miyamoto S Abstract OBJECTIVE: To propose a method for intraoperative mapping and monitoring of the medial frontal motor areas (MFMA). ...
Tue Sep 01, 2020 14:56
Related Articles Valproate risk form-Surveying 215 clinicians involving 4775 encounters. Acta Neurol Scand. 2020 Jun;141(6):483-490 Authors: Angus-Leppan H, Moghim MM, Cock H, Kinton L, Synnott Wells M, Shankar R Abstract OBJECTIVES: Annual completion of a Valproate Risk Acknowledgement Form (RAF) is mandated in the United Kingdom due to neurodevelopmental risks of in utero valproate exposure. The number of women of childbearing potential taking...
Tue Sep 01, 2020 14:56
Related Articles Outcomes of stereoelectroencephalography exploration at an epilepsy surgery center. Acta Neurol Scand. 2020 Jun;141(6):463-472 Authors: Peedicail JS, Almohawes A, Hader W, Starreveld Y, Singh S, Josephson CB, Murphy W, Federico P, Wiebe S, Pillay N, Calgary Comprehensive Epilepsy Program collaborators Abstract OBJECTIVES: Epilepsy surgery is offered in resistant focal epilepsy. Non-invasive investigations like scalp video EEG...
Tue Sep 01, 2020 14:56
Related Articles Multimodal pathway for brain tumor-related epilepsy patients: Observational study. Acta Neurol Scand. 2020 Jun;141(6):450-462 Authors: Maialetti A, Maschio M, Zarabla A, Polimadei C, Papa E, Villani V, Giannarelli D Abstract OBJECTIVES: Brain tumor-related epilepsy patients (BTRE) have a complex profile due to the simultaneous presence of two pathologies: brain tumor and epilepsy. That illness and their treatments could induce...
Tue Sep 01, 2020 14:56
Related Articles Evaluation of the Prognosis of Neuroglioma Based on Dynamic Magnetic Resonance Enhancement. World Neurosurg. 2020 06;138:663-671 Authors: Li F, Zhang Y, Wang N, Song C, Gao Y, Diao X, Zhang H Abstract This paper explores the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the prognosis of glioma, and judges the relevant factors affecting the prognosis of glioma. This paper used a Cox proportional...
Tue Sep 01, 2020 14:56
Related Articles Easy anchoring and smaller skin incision procedure for neuronavigation-based frameless stereoelectroencephalography. J Clin Neurosci. 2020 Apr;74:220-224 Authors: Fujimoto A, Sakakura K, Ichikawa N, Okanishi T Abstract Epilepsy surgery uses both depth electrodes (DEs) and subdural electrodes (SE). DEs have mainly been developed and used in Europe. As we are able to use the DEs safely due to the current advanced level of technology,...
Tue Sep 01, 2020 14:56
Related Articles Incorporating New Technology Into a Surgical Technique: The Learning Curve of a Single Surgeon's Stereo-Electroencephalography Experience. Neurosurgery. 2020 03 01;86(3):E281-E289 Authors: McGovern RA, Butler RS, Bena J, Gonzalez-Martinez J Abstract BACKGROUND: Technological improvements frequently outpace the publication of randomized, controlled trials in surgical patients. This makes the application of new surgical techniques...
Tue Sep 01, 2020 14:56
Related Articles Uncovering homonymous visual field defects in candidates for pediatric epilepsy surgery. Eur J Paediatr Neurol. 2020 Mar;25:165-171 Authors: Neumayr L, Pieper T, Kudernatsch M, Trauzettel-Klosinski S, Staudt M Abstract OBJECTIVES: Perimetry in children can be challenging due to low cooperation and short attention span. Especially during the pre-surgical work-up of children with pharmaco-refractory epilepsies, however, diagnosing...
Tue Sep 01, 2020 14:56
Related Articles [Use of cannabidiol oil in children]. Ned Tijdschr Geneeskd. 2019 05 03;163: Authors: Wolff D, Reijneveld SA Abstract Useof cannabidiol oil in children The use of cannabidioloil (CBD oil), a cannabis-derived chemical, is increasing. CBD oil is freely available in the Netherlands, but its composition and quality are not monitored. However, the alternative, pharmacist-prepared oil, is more expensive and difficult to acquire. Common...
Tue Sep 01, 2020 14:56
Related Articles Use, costs, and predictors of psychiatric healthcare services following an autism spectrum diagnosis: Population-based cohort study. Autism. 2019 11;23(8):2020-2030 Authors: Croteau C, Mottron L, Dorais M, Tarride JE, Perreault S Abstract A number of cross-sectional studies report extensive use of psychiatric services and high healthcare costs in autistic youths. However, little is known about how the use of these services...
Tue Sep 01, 2020 14:56
Related Articles The anticonvulsive Phenhydan® suppresses extrinsic cell death. Cell Death Differ. 2019 09;26(9):1631-1645 Authors: Moerke C, Jaco I, Dewitz C, Müller T, Jacobsen AV, Gautheron J, Fritsch J, Schmitz J, Bräsen JH, Günther C, Murphy JM, Kunzendorf U, Meier P, Krautwald S Abstract Different forms of regulated cell death-like apoptosis and necroptosis contribute to the pathophysiology of clinical conditions including ischemia-reperfusion...
Tue Sep 01, 2020 14:56
Related Articles What is the role of PARP inhibitors in pancreatic cancer? Expert Rev Anticancer Ther. 2020 Aug 30;: Authors: Halder R, Shroff R PMID: 32865047 [PubMed - as supplied by publisher]
Tue Sep 01, 2020 15:22
Related Articles The clinical significance of stringent complete response in multiple myeloma is surpassed by minimal residual disease measurements. PLoS One. 2020;15(8):e0237155 Authors: Cedena MT, Martin-Clavero E, Wong S, Shah N, Bahri N, Alonso R, Barcenas C, Valeri A, Salazar Tabares J, Sanchez-Pina J, Cuellar C, Martin T, Wolf J, Lahuerta JJ, Martinez-Lopez J Abstract BACKGROUND: Stringent complete response (sCR) is used as a deeper...
Tue Sep 01, 2020 13:21
Related Articles Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study. Lancet Glob Health. 2020 08;8(8):e1027-e1037 Authors: Heer E, Harper A, Escandor N, Sung H, McCormack V, Fidler-Benaoudia MM Abstract BACKGROUND: Breast cancer has distinct causes, prognoses, and outcomes and effects in patients at premenopausal and postmenopausal ages. We sought to assess the global burden and trends in breast...
Tue Sep 01, 2020 13:21
Related Articles Feasibility of intratumoral 165Holmium siloxane delivery to induced U87 glioblastoma in a large animal model, the Yucatan minipig. PLoS One. 2020;15(6):e0234772 Authors: Khoshnevis M, Carozzo C, Brown R, Bardiès M, Bonnefont-Rebeix C, Belluco S, Nennig C, Marcon L, Tillement O, Gehan H, Louis C, Zahi I, Buronfosse T, Roger T, Ponce F Abstract Glioblastoma is the most aggressive primary brain tumor leading to death in most...
Tue Sep 01, 2020 13:21
Related Articles The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells. Toxicol Appl Pharmacol. 2020 08 15;401:115080 Authors: Chang YC, Kondapuram SK, Yang TH, Syed SB, Cheng SM, Lin TY, Lin YC, Coumar MS, Chang JY, Leung E, Cheung CHA Abstract Upregulation of ABCB1/MDR1 (P-gp) and BIRC5/Survivin promotes multidrug resistance in a variety of human cancers. LCL161...
Tue Sep 01, 2020 13:21
Related Articles Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease. Adv Exp Med Biol. 2020;1257:85-94 Authors: Reed DR, Hingorani P, Anderson PM Abstract Osteosarcoma relapses not only herald a very poor prognosis but also opportunities to treat this genetically diverse complex cancer in new ways. This review will attempt to show that the field is a rapidly evolving one in which not only cytotoxic agents but also local...
Tue Sep 01, 2020 13:21
Related Articles Application of 2016 WHO classification in the diagnosis of paediatric high-grade MYC-negative mature B-cell lymphoma with Burkitt-like morphological features. J Clin Pathol. 2020 Sep;73(9):563-570 Authors: Zhang L, Brown LE, Bowen LM, McCarthy LC, Cooley LD, Repnikova E, Gener MA, Garola R, August KJ, Hays JA, Zwick DL, Li W Abstract AIMS: Historically, there has been no consensus on the diagnostic classification of high-grade...
Tue Sep 01, 2020 13:21
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