Related Articles Rac1 repression reverses chemoresistance by targeting tumor metabolism. Cancer Biol Ther. 2020 Aug 31;:1-3 Authors: Ganapathy-Kanniappan S Abstract Tumor metabolism is exemplified by the increased rate of glucose utilization, a biochemical signature of cancer cells. The enhanced glucose hydrolysis enabled by the augmentation of glycolytic flux and the pentose phosphate pathway (PPP) plays a pivotal role in the growth and survival...
Tue Sep 01, 2020 14:46
Related Articles Pharmacological strategies to overcome treatment resistance in acute myeloid leukemia: increasing leukemic drug exposure by targeting the resistance factor SAMHD1 and the toxicity factor Top2β. Expert Opin Drug Discov. 2020 Aug 31;:1-5 Authors: Herold N PMID: 32866407 [PubMed - as supplied by publisher]
Tue Sep 01, 2020 13:40
Related Articles Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in Patients with Renal Anemia: A Meta-Analysis of Randomized Trials. Nephron. 2020 Aug 31;:1-11 Authors: Wen T, Zhang X, Wang Z, Zhou R Abstract BACKGROUND: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of treatment for renal anemia in patients with chronic kidney disease (CKD). This meta-analysis was designed to evaluate their efficacy...
Tue Sep 01, 2020 13:24
Related Articles Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways. Immunopharmacol Immunotoxicol. 2020 Aug 29;:1-11 Authors: Abdel-Wahab BA, Ali FEM, Alkahtani SA, Alshabi AM, Mahnashi MH, Hassanein EHM Abstract OBJECTIVES: The fact that methotrexate (MTX) is hepatotoxic is an important reason to limit its clinical use. Rebamipide...
Tue Sep 01, 2020 14:14
Related Articles Cochlear implantation in children without preoperative computed tomography diagnostics. Analysis of procedure and rate of complications. Int J Pediatr Otorhinolaryngol. 2020 Aug 28;138:110266 Authors: Ehrmann-Müller D, Shehata-Dieler W, Kaulitz S, Back D, Kurz A, Kühn H, Hagen R, Rak K Abstract INTRODUCTION: To evaluate the safety in cochlear implantation without preoperative computed tomography diagnostics, which was implemented...
Tue Sep 01, 2020 14:03
Related Articles Interrupted cochlear implant habilitation due to COVID-19 pandemic-ways and means to overcome this. Int J Pediatr Otorhinolaryngol. 2020 Aug 25;138:110327 Authors: Dham R, Arumugam SV, Dharmarajan S, Sunil Mathews, Paramasivan VK, Kameswaran M PMID: 32866796 [PubMed - as supplied by publisher]
Tue Sep 01, 2020 14:03
Related Articles Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice. J Vis Exp. 2020 Aug 13;(162): Authors: Dieterich A, Yohn CN, Samuels BA Abstract Mood disorders, including major depressive disorder, can be precipitated by chronic stress. The Y-maze barrier task is an effort-related choice test that measures motivation to expend effort and obtain reward. In mice, chronic stress exposure significantly...
Tue Sep 01, 2020 13:41
Related Articles Interactive Molecular Model Assembly with 3D Printing. J Vis Exp. 2020 Aug 13;(162): Authors: Fazelpour E, Fennell CJ Abstract With the growth in accessibility of 3D printing, there has been a growing application of and interest in additive manufacturing processes in chemical laboratories and chemical education. Building on the long and successful history of physical modeling of molecular systems, we present select models...
Tue Sep 01, 2020 13:41
Related Articles A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis. J Vis Exp. 2020 Aug 12;(162): Authors: Seman BG, Povroznik JM, Vance JK, Rawson TW, Robinson CM Abstract Neonates are at an increased risk of bacterial sepsis due to the unique immune profile they display in the first months of life. We have established a protocol for studying the pathogenesis of E. coli O1:K1:H7, a serotype responsible for high mortality rates...
Tue Sep 01, 2020 13:41
Related Articles Propagation of the Microsporidian Parasite Edhazardia aedis in Aedes aegypti Mosquitoes. J Vis Exp. 2020 Aug 13;(162): Authors: Grigsby A, Kelly BJ, Sanscrainte ND, Becnel JJ, Short SM Abstract Edhazardia aedis is a microsporidian parasite of Aedes aegypti mosquitoes, a disease vector that transmits multiple arboviruses which cause millions of disease cases each year. E. aedis causes mortality and reduced reproductive fitness...
Tue Sep 01, 2020 13:41
Related Articles Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography. J Vis Exp. 2020 Aug 16;(162): Authors: Oliver CR, Westerhof TM, Castro MG, Merajver SD Abstract Brain metastases are the most lethal cancer lesions; 10-30% of all cancers metastasize to the brain, with a median survival of only ~5-20 months, depending on the cancer type. To reduce the brain...
Tue Sep 01, 2020 13:41
Related Articles Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model. J Vis Exp. 2020 Aug 16;(162): Authors: Ellmann S, Seyler L, Gillmann C, Popp V, Treutlein C, Bozec A, Uder M, Bäuerle T Abstract Machine learning (ML) algorithms permit the integration of different features into a model to perform classification or regression tasks with an accuracy exceeding its constituents. This protocol describes...
Tue Sep 01, 2020 13:41
Related Articles Near Simultaneous Laser Scanning Confocal and Atomic Force Microscopy (Conpokal) on Live Cells. J Vis Exp. 2020 Aug 11;(162): Authors: Sandin JN, Aryal SP, Wilkop T, Richards CI, Grady ME Abstract Techniques available for micro- and nano-scale mechanical characterization have exploded in the last few decades. From further development of the scanning and transmission electron microscope, to the invention of atomic force...
Tue Sep 01, 2020 13:41
Related Articles Establishing In Situ Closed Circuit Perfusion of Lower Abdominal Organs and Hind Limbs in Mice. J Vis Exp. 2020 Aug 13;(162): Authors: Ren P, Yang C, Lofchy LA, Wang G, Chen F, Simberg D Abstract Ex vivo perfusion is an important physiological tool to study the function of isolated organs (e.g. liver, kidneys). At the same time, due to the small size of mouse organs, ex vivo perfusion of bone, bladder, skin, prostate, and...
Tue Sep 01, 2020 13:41
Related Articles Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation. J Vis Exp. 2020 Aug 14;(162): Authors: Acedo M, Gonzalez Cena JR, Kiehlbaugh KM, Ogden KL Abstract In the United States, 35% of the total carbon dioxide (CO2) emissions come from the electrical power industry, of which 30% represent natural gas electricity generation. Microalgae can biofix CO2 10 to 15 times faster...
Tue Sep 01, 2020 13:41
Related Articles Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots. J Vis Exp. 2020 Aug 16;(162): Authors: Peics J, Vishvanath L, Zhang Q, Shan B, Pedersen TÅ, Gupta RK Abstract The stromal-vascular fraction (SVF) of white adipose tissue (WAT) is remarkably heterogeneous and consists of numerous cell types that contribute functionally to the expansion and remodeling of...
Tue Sep 01, 2020 13:41
Related Articles A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies. J Vis Exp. 2020 Aug 13;(162): Authors: Cayford J, Herrera-da la Mata S, Schmiedel BJ, Chandra V, Vijayanad P, Seumois G Abstract Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) is a powerful and widely used approach to profile chromatin DNA associated with specific histone modifications, such as H3K27ac, to help identify cis-regulatory...
Tue Sep 01, 2020 13:41
Related Articles Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons. J Vis Exp. 2020 Aug 16;(162): Authors: Er S, Hlushchuk I, Airavaara M, Chmielarz P, Domanskyi A Abstract The goal of this protocol is to establish a robust and reproducible model of α-synuclein accumulation in primary dopamine neurons. Combined with immunostaining and unbiased automated image analysis, this...
Tue Sep 01, 2020 13:41
Related Articles Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans. J Vis Exp. 2020 Aug 15;(162): Authors: Palikaras K, Tavernarakis N Abstract Battling human neurodegenerative pathologies and managing their pervasive socioeconomic impact is becoming a global priority. Notwithstanding their detrimental effects on the human life quality and the healthcare system, the majority of human neurodegenerative disorders...
Tue Sep 01, 2020 13:41
Related Articles WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control. J Vis Exp. 2020 Aug 15;(162): Authors: Liu Q, Nakahira Y, Liang Z, Mohideen A, Dai A, Choi SH, Pan A, Ho DM, Doyle JC Abstract Feedback control theory has been extensively implemented to theoretically model human sensorimotor control. However, experimental platforms capable of manipulating important components of multiple feedback loops...
Tue Sep 01, 2020 13:41
Related Articles High-Resolution Mapping of Protein-DNA Interactions in Mouse Stem Cell-Derived Neurons using Chromatin Immunoprecipitation-Exonuclease (ChIP-Exo). J Vis Exp. 2020 Aug 14;(162): Authors: Montanera KN, Rhee HS Abstract Identification of specific protein-DNA interactions on the genome is important for understanding gene regulation. Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) is widely used...
Tue Sep 01, 2020 13:41
Related Articles Health-Related Quality of Life Following Total Laryngectomy: A Systematic Review. Laryngoscope. 2020 Aug 31;: Authors: Wulff NB, Højager A, Wessel I, Dalton SO, Homøe P Abstract OBJECTIVE: Treatment of advanced laryngeal and hypopharyngeal cancer has shifted from total laryngectomy (TL) toward laryngeal-preserving therapies due to a general perception that TL has a significantly negative impact on the individual's life. However,...
Tue Sep 01, 2020 14:51
Related Articles Transoral Robotic Surgical Proficiency Via Real-Time Tactile Collision Awareness System. Laryngoscope. 2020 Aug 31;: Authors: Mendelsohn AH, Kim C, Song J, Singh A, Le T, Abiri A, Berke GS, Geoghegan R Abstract OBJECTIVES: In 2009, the Food and Drug Administration approved the use of the surgical robotic system for removal of benign and malignant conditions of the upper aerodigestive tract. This novel application of robotic-assisted...
Tue Sep 01, 2020 14:51
Related Articles TLR2 favors OVA-induced allergic airway inflammation in mice through JNK signaling pathway with activation of autophagy. Life Sci. 2020 Sep 01;256:117896 Authors: Fang L, Shen Q, Wu H, He F, Ding P, Xu K, Yan X, Wang M, Li S, Liu R Abstract AIMS: Numerous studies indicate that toll-like receptor 2 (TLR2) led to divergent effects in asthma. The occurrence of autophagy in asthma pathogenesis is still incompletely understood....
Tue Sep 01, 2020 14:51
Related Articles Infection Rates After Microlaryngeal and Open Phonosurgery: The Role of Postoperative Antibiotics. Laryngoscope. 2020 05;130(5):1128-1131 Authors: Roof SA, Ferrandino RM, Villavisanis DF, Amato MV, Rubinstein BJ, Courey MS, Woo P Abstract OBJECTIVE: Although it is known that the airway has bacterial contamination that seeds the surgical site during microlaryngeal surgery, literature on the use of postoperative antibiotics is...
Tue Sep 01, 2020 14:51
Related Articles Microflap dissection with a cotton ball self-retraction technique in treating vocal cysts. Laryngoscope. 2020 05;130(5):1239-1242 Authors: Ahn HG, Jung JY, Choi HS, Kim JH PMID: 31397899 [PubMed - indexed for MEDLINE]
Tue Sep 01, 2020 14:51
Related Articles Niclosamide repurposed for the treatment of inflammatory airway disease. JCI Insight. 2019 08 08;4(15): Authors: Cabrita I, Benedetto R, Schreiber R, Kunzelmann K Abstract Inflammatory airway diseases, such as asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD), are characterized by mucus hypersecretion and airway plugging. In both CF and asthma, enhanced expression of the Ca2+-activated Cl- channel...
Tue Sep 01, 2020 14:51
Related Articles The difference between first and second harmonic amplitudes correlates between glottal airflow and neck-surface accelerometer signals during phonation. J Acoust Soc Am. 2019 05;145(5):EL386 Authors: Mehta DD, Espinoza VM, Van Stan JH, Zañartu M, Hillman RE Abstract Miniature high-bandwidth accelerometers on the anterior neck surface are used in laboratory and ambulatory settings to obtain vocal function measures. This study...
Tue Sep 01, 2020 14:51
Related Articles The clinical significance of stringent complete response in multiple myeloma is surpassed by minimal residual disease measurements. PLoS One. 2020;15(8):e0237155 Authors: Cedena MT, Martin-Clavero E, Wong S, Shah N, Bahri N, Alonso R, Barcenas C, Valeri A, Salazar Tabares J, Sanchez-Pina J, Cuellar C, Martin T, Wolf J, Lahuerta JJ, Martinez-Lopez J Abstract BACKGROUND: Stringent complete response (sCR) is used as a deeper response...
Tue Sep 01, 2020 13:40
Related Articles A population-based analysis of attributable hospitalisation costs of invasive fungal diseases in haematological malignancy patients using data linkage of state-wide registry and costing databases: 2009-2015. Mycoses. 2020 Feb;63(2):162-171 Authors: Valentine JC, Morrissey CO, Tacey MA, Liew D, Patil S, Ananda-Rajah M Abstract BACKGROUND: Invasive fungal diseases (IFD) are associated with significant treatment-related costs...
Tue Sep 01, 2020 13:40
Related Articles Call for a Multidisciplinary Effort to Map the Lymphatic System with Advanced Medical Imaging Techniques: A Review of the Literature and Suggestions for Future Anatomical Research. Anat Rec (Hoboken). 2019 10;302(10):1681-1695 Authors: Stouthandel MEJ, Veldeman L, Van Hoof T Abstract This review intends to rekindle efforts to map the lymphatic system by using a more modern approach, based on medical imaging. The structure,...
Tue Sep 01, 2020 13:40
Related Articles Microbial Triggers of Chronic Human Illness: This report is based on a colloquium, sponsored by the American Academy of Microbiology, held June 25-27, 2004, in New Orleans, Louisiana. Book. 2005 Authors: Abstract The American Academy of Microbiology convened a colloquium on June 25-27, 2004, in New Orleans, Louisiana, to deliberate the microbial causes of chronic diseases. Research professionals from the fields of microbiology, medicine, oncology,...
Tue Sep 01, 2020 13:40
Related Articles Effect of e-cigarettes on nasal epithelial cell growth, Ki67 expression, and pro-inflammatory cytokine secretion. Am J Otolaryngol. 2020 Aug 18;41(6):102686 Authors: Rouabhia M, Piché M, Corriveau MN, Chakir J Abstract OBJECTIVE: Upon use, e-cigarette aerosol comes in contact with various mucosal tissues, including the nasal epithelium, which may lead to nasal pathologies. We therefore assessed the effect of e-cigarettes on...
Tue Sep 01, 2020 14:25
Related Articles Laryngeal Langerhans Cell Histiocytosis: A Case Report and Literature Review. Ann Otol Rhinol Laryngol. 2020 Aug 30;:3489420954883 Authors: Zhou AS, Li L, Carroll TL Abstract OBJECTIVE: To describe a case of laryngeal Langerhans cell histiocytosis, discuss its characteristic features and management, and provide a review of the available literature. METHODS: A patient presenting to a tertiary care medical center...
Tue Sep 01, 2020 15:17
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου