Publication date: August 2020Source: Auris Nasus Larynx, Volume 47, Issue 4Author(s):
Tue Sep 01, 2020 16:38
Abstract Head and neck ultrasound can be used as a non‐invasive image modality for the diagnosis of congenital pyriform sinus fistula (CPSF) in children. The pathognomonic ultrasonic images of CPSFs include a hypoechoic fistulous tract by the perithyroid or trans‐thyroid route, a hyperechoic gas‐line within an inflammatory mass or cystic lesion during the Valsalva maneuver or swallowing action, and thyroiditis with increasing vascular flow in the ipsilateral thyroid lobe. The diagnosis of CPSF...
Mon Aug 31, 2020 20:06
Abstract Introduction Litigation against the National Health Service (NHS) in England is rising, costing £2.4 billion in 2018/19. The aim of this study was to determine the incidence and characteristics of otorhinolaryngology clinical negligence claims in England. Methods A retrospective review was undertaken of all clinical negligence claims in England held by NHS Resolution relating to otorhinolaryngology between April 2013 and April 2018. Analysis was performed using information for...
Mon Aug 31, 2020 19:07
ABSTRACT Objectives This study aimed to compare the prognosis according to age, genotype or HPV variant in patients with recurrent respiratory papillomatosis (RRP). Design Non‐concurrent cohort. Participants 41 patients with RRP. Setting Tertiary referral hospital. Main outcome measures Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV‐6 variants were...
Mon Aug 31, 2020 18:50
Abstract Choosing the best approach for selected pathologies is always source of debates and controversies, whatever the surgical speciality. In endoscopic endonasal surgery (EES), most of surgical series have compared their outcomes with conventional procedures to assess their safety and efficacy.However, there are few objective ways to compare the technical advantages of one approach versus another.Nowadays, it is possible to generate surgical models of skull base anatomy in several identical...
Mon Aug 31, 2020 18:50
Abstract Background Endoscopic sinus surgery (ESS) is an important treatment modality for chronic rhinosinusitis (CRS). However, its effect on olfaction remains controversial. Objective of review To assess the olfactory impact of ESS in patients with CRS Type of review A meta‐analysis Search strategy A systematic literature search in the PubMed, EMBASE, and Cochrane Library databases was conducted to identify studies that assessed change in olfaction after ESS in patients with...
Mon Aug 31, 2020 13:20
Conditions: Advanced Head and Neck Squamous Cell Carcinoma; Advanced Hypopharyngeal Squamous Cell Carcinoma; Advanced Laryngeal Squamous Cell Carcinoma; Advanced Oral Cavity Squamous Cell Carcinoma; Advanced Oropharyngeal Squamous Cell Carcinoma; Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8;...
Tue Sep 01, 2020 16:50
Conditions: Plaque Psoriasis; Psoriasis Vulgaris; PsoriasisInterventions: Biological: Brodalumab; Other: Placebo; Biological: GuselkumabSponsor: LEO PharmaNot yet recruiting
Tue Sep 01, 2020 16:50
Condition: Nasopharyngeal CarcinomaIntervention: Drug: TreprilimabSponsor: Sun Yat-sen UniversityNot yet recruiting
Tue Sep 01, 2020 16:50
Conditions: Unresectable Head and Neck Squamous Cell Carcinoma; Metastatic Head and Neck Cancer; Recurrent Head and Neck CancerInterventions: Biological: BNT113; Biological: PembrolizumabSponsor: BioNTech SENot yet recruiting
Tue Sep 01, 2020 16:50
Conditions: Skin Cancer; Mucosal Neoplasm of Oral Cavity; Soft Tissue NeoplasmIntervention: Device: Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)Sponsor: Alpha Tau Medical LTD.Not yet recruiting
Tue Sep 01, 2020 16:50
Abstract Purpose The aim of this study was to evaluate the frequency of various otolaryngological symptoms in patients with COVID-19 with regard to age, gender and pneumonia-related thorax CT characteristics. Methods This is a retrospective study conducted between March 25, 2020 and April 25, 2020. The anamnesis and medical files of 155 patients who applied...
Tue Sep 01, 2020 03:00
Abstract Purpose Post-irradiation vasculopathy is a severe form of atherosclerosis and affects the prognosis of head and neck cancer survivors. Sonographic intima-media thickness (IMT) precedes stenosis, plaque formation, and cerebrovascular events. Therefore, IMT may be a valuable screening marker for post-irradiation toxicity. However, the critical irradiation dose and the onset of IMT increase remain unclear. ...
Tue Sep 01, 2020 03:00
Abstract The discovery of MRGPRX2 marks an important change in MC biology, explaining non‐IgE‐mediated clinical phenomena relying on MCs. As receptor for multiple drugs, MRGPRX2 is crucial to drug‐induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology. Here, we give a brief overview of MRGPRX2 and its regulation by microenvironmental stimuli, which support...
Mon Aug 31, 2020 21:20
Abstract The incidence of cutaneous keratinocyte derived cancers in increasing globally. Basal cell carcinoma (BCC) is the most common malignancy worldwide and cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. BCC can be classified into subtypes based on the histology, and these subtypes are classified further into low‐ and high‐risk tumors. There is an increasing need to identify new therapeutic strategies for the treatment of unresectable and metastatic cSCC,...
Mon Aug 31, 2020 21:04
Abstract Tissue homeostasis is maintained through constant, dynamic and heterogeneous communication between cells and their microenvironment. Proteins that are at the same time active at the intracellular, cell periphery and deeper extracellular levels possess the ability to on the individual molecular level influence the cells and their microenvironment in a bi‐directional manner. The transmembrane collagens are a family of such proteins, which are of notable interest for tissue development and...
Mon Aug 31, 2020 20:19
Abstract Background Mutations in GJB2 encoding Connexin26 (CX26) are associated with hearing loss and hyperproliferative skin disorders of differing severity including Keratitis Ichthyosis Deafness (KID) and Vohwinkel syndrome. A 6‐year‐old Caucasian girl who presented with recurrent skin rashes and sensorineural hearing loss harbored a heterozygous point mutation in GJB2 (c.424T>C; p.F142L). Objectives To characterise the impact of CX26F142L on cellular events. Methods Plasmids...
Mon Aug 31, 2020 14:25
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) represents a new public health problem, with a total of 10.577.263 documented COVID‐19 cases worldwide and 513.441 deaths up to the present date. Few cases of disease‐related cutaneous manifestations have been reported in the literature and such manifestations are scarce. Integumentary manifestations from COVID‐19 include exanthemas and papular dermatoses, urticarial eruptions, atopic dermatitis, vesiculobullous lesions and...
Mon Aug 31, 2020 14:19
Abstract Dermal fibroblasts are an essential population of skin cells. They are not only responsible for synthesis and remodeling of the extracellular matrix of the dermis, but also communicate with other skin cells via autocrine and paracrine interactions. Skin‐associated dermal adipocytes reside below the reticular dermis. Strong lipolysis is observed during the regression of dermal adipocytes. However, the nature of the local intercellular crosstalk in which lipids released by dermal adipocytes...
Mon Aug 31, 2020 11:59
Abstract The aim is to evaluate the accuracy of autofluorescence for screening oral cancer in comparison with toluidine blue staining and clinical examination. Oral mucosal disorders detected by autofluorescence were compared with those detected using toluidine blue staining. Methodological quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies tool. The diagnostic odds ratio (DOR) for autofluorescence was 8.197 (95% confidence interval, 4.018‐16.723). The area under the...
Mon Aug 31, 2020 22:44
Abstract Purpose To assess cancer control and patient‐reported outcomes (PROs) after de‐intensified intensity‐modulated radiotherapy (IMRT) in lateralized p16‐associated oropharyngeal cancer (p16‐OPC). Methods Lateralized p16‐OPC treated with radiotherapy and concurrent Carboplatin/5‐fluorouracil between 2011 and 2014 were enrolled. De‐intensified IMRT consisted in elective neck dose of 43.2 Gy/24 fractions and omission of contralateral retropharyngeal/level IV nodes. PROs were assessed...
Mon Aug 31, 2020 22:38
Background. Xerostomia is a common complication following radiation therapy for head and neck cancer (HNC), for which there is no single, universally accepted therapy. Coconut oil has been anecdotally suggested to provide relief for this complication. This study sought to examine the feasibility and effectiveness of coconut oil as a therapy for radiation-induced xerostomia. Methods. A feasibility study was performed among 30 patients with xerostomia subsequent to radiation for HNC. Coconut oil samples...
Tue Sep 01, 2020 06:20
Abstract Intratympanic gentamicin has become an accepted standard of care for Ménière’s disease. But there still exists controversies regarding the dosing protocol as well as the drug concentration for optimum control of vertigo and hearing preservation. To determine if 20 mg of intratympanic gentamicin administered once a month for a maximum of 2 months can alleviate intractable vertigo caused by definite Ménière’s disease with hearing preservation. Once diagnosed with definite...
Tue Sep 01, 2020 03:00
Abstract Disseminated cysticercosis is a rare manifestation of cysticercosis, a relatively common tropical disease in Asia, Africa and South America. Here the embryo of pork tapeworm Taenia Solium gets disseminated to multiple organs and tissues via hepatoportal system. we report here a 45 year gentleman with stage IV oral malignancy who was incidentally found to have disseminated cysticercosis on pre-operative work up. Along with the management of primary cancer and new found...
Tue Sep 01, 2020 03:00
Abstract Allergic rhinitis is one of the most rampant diseases in the world and many studies have been conducted to find its risk factors. Various studies have shown that there is a correlation between allergic rhinitis and increased Body Mass Index (BMI). Obesity has several effects on the immune system that could play a major role in increasing allergic disease. Allergic rhinitis is known to produce mild eosinophilia. The purpose of this study is to assess the correlation between...
Tue Sep 01, 2020 03:00
Abstract Rhabdomyosarcoma (RMS) is a highly aggressive lesion and is commonly seen in children below the age of 10 years. The survival rate is not very high as an early diagnosis is often difficult. However, the treatment involves mainly surgery followed by chemotherapy and sometimes radiotherapy.
Tue Sep 01, 2020 03:00
Abstract Computerization of health care is the only model to sustain safe health care in this COVID era particularly in overpopulated nations with limited health care providers/systems like India. Accordingly incorporation of computer-based algorithms and artificial intelligence seems very robust and practical models to assist the physician. The advantages of Computerized algorithms to facilitate better screening, diagnosis or follow-up and use of Artificial Intelligence (AI)...
Tue Sep 01, 2020 03:00
Abstract SARS-CoV-2 virus causing COVID-19 disease has brought tremendous strain on health care sectors around the world. Being a respiratory disease, COVID-19 has tremendous implications on the otolaryngology residency. Otolaryngology residents are dealing with great apprehension of getting infected while working with both COVID-19 and non-COVID patients. Further, drastic change in the routine has affected their residency training. Outpatient and Inpatient care, elective and...
Tue Sep 01, 2020 03:00
Abstract BackgroundPatient‐specific instrumentation (PSI) improves accuracy of surgical operations. PSI needs software for preoperative planning and instrument design. In this study, we explain the methodology of developing a software tool for PSI guide design and preoperative planning in reverse shoulder arthroplasty (RSA).MethodsApproaches used to prepare input data, transform them into meaningful features, and use of those features to create special guide geometries are explained by describing...
Mon Aug 31, 2020 19:50
Objective Treatment of advanced laryngeal and hypopharyngeal cancer has shifted from total laryngectomy (TL) toward laryngeal‐preserving therapies due to a general perception that TL has a significantly negative impact on the individual's life. However, whether the physical impairments related to TL translate to a reduced health‐related quality of life (HRQoL) has not yet been determined. Therefore, the objective of this systematic review was to determine how HRQoL is affected following TL. ...
Mon Aug 31, 2020 20:30
Objectives/Hypothesis A subset of patients will undergo revision endoscopic sinus surgery (ESS) with a different otolaryngologist than the one who performed their primary surgery. The purpose of this study is to report the incidence of and clinicodemographic factors associated with a change in surgeon for revision ESS. Study Design Retrospective cohort study. Methods Adult patients who underwent at least two outpatient ESS procedures between 2009 and 2014 using the State Ambulatory Surgery...
Mon Aug 31, 2020 20:23
Objectives/Hypothesis Thyroid cancer with distant metastasis (TCDM) at diagnosis has significantly worse survival rates when compared to localized/regional thyroid cancer. This study sought to report on the characteristics of patients presenting with TCDM and the potential survival advantage of surgical resection. Study Design Data were acquired from the Surveillance, Epidemiology, and End Results (SEER) database with cases from 2004 to 2015. Methods TCDM cases (n = 2,558) were identified...
Mon Aug 31, 2020 15:59
Objectives In 2009, the Food and Drug Administration approved the use of the surgical robotic system for removal of benign and malignant conditions of the upper aerodigestive tract. This novel application of robotic‐assisted surgery, termed transoral robotic surgery (TORS), places robotic instruments and camera system through the mouth to reach recessed areas of the pharynx and larynx. Over the successive decade, there was a rapid adoption of TORS with a surgical growth rate that continues to increase....
Mon Aug 31, 2020 15:55
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