CircRNAs in Oral Cancer

Cancers, Vol. 12, Pages 1041: Functional and Clinical Impact of CircRNAs in Oral Cancer:

Cancers, Vol. 12, Pages 1041: Functional and Clinical Impact of CircRNAs in Oral Cancer

Cancers doi: 10.3390/cancers12041041

Authors:
Ion Cristóbal
Cristina Caramés
Jaime Rubio
Marta Sanz-Alvarez
Melani Luque
Juan Madoz-Gúrpide
Federico Rojo
Jesús García-Foncillas


The increasing number of recently published works regarding the role of circular RNAs (circRNAs) in oral cancer highlights the key contribution of this novel class of endogenous noncoding RNAs as regulators of critical signaling pathways and their clinical value as novel biomarkers. This review summarizes and puts into context the existing literature in order to clarify the relevance of circRNAs as novel mediators of oral cancer pathogenesis as well as their potential usefulness as predictors of clinical outcome and response to therapy in this disease.