Abstract Background Cenobamate is a new, Food and Drug Administration (FDA)-approved oral antiepileptic drug for treatment of focal seizures in adults. This study examined recovery of cenobamate from suspensions administered through ex vivo enteral feeding tubes. Methods Suspensions containing 100 and 200 mg of cenobamate were prepared (five duplicates for...
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ACS NanoDOI: 10.1021/acsnano.0c00907
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ACS NanoDOI: 10.1021/acsnano.9b10083
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ACS NanoDOI: 10.1021/acsnano.9b03552
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ACS NanoDOI: 10.1021/acsnano.0c01436
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ACS NanoDOI: 10.1021/acsnano.0c01506
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ACS NanoDOI: 10.1021/acsnano.9b08805
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Publication date: Available online 23 April 2020Source: Advances in Biological RegulationAuthor(s): Alessandro Poli, Roberta Fiume, Sara Mongiorgi, Antonio Zaurito, Bhavwanti Sheth, Magdalena Castellano Vidalle, Shidqiyyah Abdul Hamid, ScottT. Kimber, Francesca Campagnoli, Stefano Ratti, Isabella Rusciano, Irene Faenza, Lucia Manzoli, Nullin Divecha
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Summary Purpose Combining small-molecule inhibitors of different targets was shown to be synergistic in preclinical studies. Testing this concept in clinical trials is, however, daunting due to challenges in toxicity management and efficacy assessment. This study attempted to evaluate the safety and efficacy of vatalanib plus everolimus in patients with advanced solid tumors and explore the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) studies as a predictive...
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Laboratories worldwide find it challenging to identify enough tissues and cases for verification and validation studies of low-incidence, rare antigens. These antigens have a low frequency of occurrence in the population, or have little or no expression in normal tissues. Validation studies are essential to assure testing standardization before introducing a new instrument, product, or test into the clinical laboratory. The College of American Pathologists has published comprehensive guidelines for...
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Meningiomas are highly vascularized tumors originating from arachnoid cap cells of the leptomeninges. The majority of meningiomas are classified as World Health Organization (WHO) grade I and display a benign clinical course with a low risk of recurrence. In contrast, WHO grade III meningiomas carry a high risk of recurrence and poor prognosis. However, it is commonly recognized that histopathologic grading does not always reliably predict recurrence or progression of meningiomas. Fatty acid-binding...
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Kawasaki disease (KD) is a systemic vasculitis of unknown etiology which predominantly affects medium- and small-sized muscular arteries. Histopathologic studies of KD vasculitis lesions have demonstrated characteristic T cell infiltration and an abundance of CD8+ T cells; however, the contribution of cytotoxic lymphocytes to KD vasculitis lesions has not been identified. Here, we histopathologically and immunohistochemically examined infiltrating inflammatory cells, particularly cytotoxic protein-positive...
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Hospitals and institutions from Belgium have banded together to create an artificial...Read more on AuntMinnieEurope.comRelated Reading: Guerbet secures distribution deal with Icometrix for icobrain Icometrix adds $18M to coffers Affidea forms AI partnership with Icometrix Icometrix names new CCO Belgium seeks to shore up defenses against cyberattack
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Chest CT can be an important tool in the management of COVID-19, but its use...Read more on AuntMinnieEurope.comRelated Reading: U.K. radiographer dies of COVID-19 Confusion reigns over payment of COVID-19 work in France What Europe can learn from China in combating COVID-19 How is global radiology bearing up in COVID-19 pandemic? ESR issues statement on imaging's role in COVID-19
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An Italian study involving cases of COVID-19 pneumonia has found that quantification...Read more on AuntMinnieEurope.comRelated Reading: France releases pediatric guidance on COVID-19 U.K. radiographer dies of COVID-19 Confusion reigns over payment of COVID-19 work in France How is global radiology bearing up in COVID-19 pandemic? Hard truths from COVID-19 front line in Paris
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An international research group plans to test the ability of artificial intelligence...Read more on AuntMinnieEurope.comRelated Reading: AI dominates at ECR 2019's technical exhibition
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While an alarming 9 per cent of insects on land are being lost each decade, the state of the world’s insects is much more nuanced than warnings of an insect apocalypse
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A bunch of asteroids near Jupiter and Neptune with orbits perpendicular to the plane of the solar system may have come here from a different star system
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A cheap, lightweight smartphone-heated device can test for DNA in blood, urine and other samples in a fraction of the time it takes to test in a lab
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The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
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AI can check satellite images of the ocean and distinguish between floating materials such as seaweed or plastics, which could help clean-up efforts
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A brain-computer interface has helped a man with a severe spinal cord injury move and feel using a hand again, letting him carefully lift light objects such as a paper cup
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A long-standing hypothesis suggests the BCG vaccine also serves to generally enhance the immune system, meaning it could protect against covid-19, and trials are underway to find out
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The coronavirus pandemic is making life feel slower than ever, but observing timescales across the universe can bring us some comfort, writes Chanda Prescod-Weinstein
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We need to scale up testing efforts to tackle the coronavirus pandemic, and looking for signs of virus RNA in our sewage could provide a shortcut
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Dingoes have been persecuted in Australia for centuries for killing livestock, but protecting them could benefit the environment and aid recovery from the devastating fires
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Publication date: Available online 23 April 2020Source: BiochimieAuthor(s): Mira A.M. Behnam, Christian D.P. Klein
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Publication date: Available online 22 April 2020Source: BiochimieAuthor(s): Michelle M. Murphy, Jean-Louis Guéant
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Publication date: Available online 22 April 2020Source: BiochimieAuthor(s): Diana Maltseva, Maria Raygorodskaya, Evgeny Knyazev, Victor Zgoda, Olga Tikhonova, Shan Zaidi, Sergey Nikulin, Ancha Baranova, Andrey Turchinovich, Sergey Rodin, Alexander Tonevitsky
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Publication date: Available online 22 April 2020Source: BiochimieAuthor(s): Sophia D. Amenyah, Amy McMahon, Mary Ward, Jennifer Deane, Helene McNulty, Catherine F. Hughes, J.J. Strain, Geraldine Horigan, John Purvis, Colum P. Walsh, Diane J. Lees-Murdock
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