Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity
Publication date: Available online 22 April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Seung-Joo Yang, Seung-Je Jeon, Thang Van Nguyen, Raymond J. Deshaies, Chul-Seung Park, Kwang Min Lee
10h
Help kids learn about the geology of the Pacific Northwest in a fun, informative geology book with easy projects. -- Read more on ScientificAmerican.com
11h
African-Americans are already afflicted disproportionately by COVID-19, but economic collapse could make things even worse for them -- Read more on ScientificAmerican.com
14h
The deadly fungal pathogen Candida auris may have developed drug resistance on farms -- Read more on ScientificAmerican.com
19h
Abstract Orthohantaviruses are re-emerging rodent-borne pathogens distributed all over the world. Here, we report the isolation of a Puumala orthohantavirus (PUUV) strain from bank voles caught in a highly endemic region around the city Osnabrück, north-west Germany. Coding and non-coding sequences of all three segments (S, M, and L) were determined from original lung tissue, after isolation and after additional passaging in VeroE6 cells and a bank vole-derived kidney cell line....
11h
Abstract Great strides over the past few decades have increased our understanding of the pathophysiology of hypophosphatemic disorders. Phosphate is critically important to a variety of physiologic processes, including skeletal growth, development and mineralization, as well as DNA, RNA, phospholipids, and signaling pathways. Consequently, hypophosphatemic disorders have effects on multiple systems, and may cause a variety of nonspecific signs and symptoms. The acute effects of...
11h
In Tanzania, there is no national trauma registry. The World Health Organization (WHO) has developed a data set for injury that specifies the variables necessary for documenting the burden of injury and patien...
11h
Abstract Warthin tumor is one of the most common benign salivary gland tumors. Overt lymphoma is known to occur in the lymphoid stroma of Warthin tumor. In situ follicular neoplasia is difficult to identify in routine histologic examination of lymphoid tissue and has not been reported in association with Warthin tumor. Our objective is to determine the prevalence of overt malignant lymphoma and in situ follicular neoplasia in Warthin tumor. We conducted a retrospective histological...
12h
TGen contributes to international studies identifying cell-types susceptible to SARS-CoV-2 infection
PHOENIX, Ariz. — April 23, 2020 — Two significant international studies involving hundreds of scientists, including a human geneticist at the Translational Genomics Research Institute (TGen) , an affiliate of City of Hope , suggest that specific cells in the human nasal passage shaped like a champagne glass, known as goblet cells, may play a significant role in enabling COVID-19 infections. Two studies, one published today in Nature Medicine and a similar study published April 22 in the journal...
12h
by Sheng Tong, Maolian Li, Nemat O. Keyhani, Yu Liu, Min Yuan, Dongmei Lin, Dan Jin, Xianbi Li, Yan Pei, Yanhua Fan Competition is one of the fundamental driving forces of natural selection. Beauveria bassiana is a soil and plant phylloplane/root fungus capable of parasitizing insect hosts. Soil and plant environments are often enriched with other fungi against which B. bassiana competes for survival. Here, we report an antifungal peptide (BbAFP1), specifically expressed and localized to the...
12h
by Kenta Takahashi, Yuko Sato, Tsuyoshi Sekizuka, Makoto Kuroda, Tadaki Suzuki, Hideki Hasegawa, Harutaka Katano JC polyomavirus (JCPyV, JCV) causes progressive multifocal leukoencephalopathy (PML) in immunocompromised hosts. JCPyV replicates in oligodendrocytes within the brain tissue of patients with PML. The JCPyV genome encodes a microRNA (miRNA) in the region encoding the large T antigen. JCPyV-encoded miRNA (miR-J1) has been detected in the tissue and cerebrospinal fluid samples of patients...
13h
by Virginia E. Glazier, Damian J. Krysan
13h
by Chikara Kaito, Hirono Yoshikai, Ai Wakamatsu, Atsushi Miyashita, Yasuhiko Matsumoto, Tomoko Fujiyuki, Masaru Kato, Yoshitoshi Ogura, Tetsuya Hayashi, Takao Isogai, Kazuhisa Sekimizu The molecular mechanisms that allow pathogenic bacteria to infect animals have been intensively studied. On the other hand, the molecular mechanisms by which bacteria acquire virulence functions are not fully understood. In the present study, we experimentally evaluated the evolution of a non-pathogenic strain...
13h
by E. Ashley Moseman
13h
by Vitor E. Fernandes, Giuseppe Ercoli, Alan Bénard, Carolin Brandl, Hannah Fahnenstiel, Jennifer Müller-Winkler, Georg F. Weber, Paul Denny, Lars Nitschke, Peter W. Andrew Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal...
13h
Publication date: Available online 23 April 2020Source: Cellular SignallingAuthor(s): Caroline R. Sussman, Xiaofang Wang, Fouad T. Chebib, Vicente E. Torres
12h
Publication date: Available online 22 April 2020Source: Cellular SignallingAuthor(s): Louis Fréchette, Chantal Binda, Samuel Génier, Jade Degrandmaison, Marilou Boisvert, Jean-Luc Parent
12h
Publication date: Available online 22 April 2020Source: Cellular SignallingAuthor(s): Mingyuan Chen, Maotuan Huang, Weihong Chen, Xiaojie Jiang, Wei Su, Xiaoqian Wang, Nanhong Tang, Feifei She, Yanling Chen
12h
by Courtney W. Hanna As the maternal–foetal interface, the placenta is essential for the establishment and progression of healthy pregnancy, regulating both foetal growth and maternal adaptation to pregnancy. The evolution and functional importance of genomic imprinting are inextricably linked to mammalian placentation. Recent technological advances in mapping and manipulating the epigenome in embryogenesis in mouse models have revealed novel mechanisms regulating genomic imprinting in placental...
12h
by Oliver Leicht, Muriel C. F. van Teeseling, Gaël Panis, Celine Reif, Heiko Wendt, Patrick H. Viollier, Martin Thanbichler The Alphaproteobacteria show a remarkable diversity of cell cycle-dependent developmental patterns, which are governed by the conserved CtrA pathway. Its central component CtrA is a DNA-binding response regulator that is controlled by a complex two-component signaling network, mediating distinct transcriptional programs in the two offspring. The CtrA pathway has been studied...
12h
by Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R. Cavener, Masayuki Yamamoto, Ken Itoh Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters, as constituents in proteins and as nutrients. GCN2-mediated phosphorylation of eukaryotic initiation factor 2 alpha (elF2α) restores homeostasis in response...
12h
by Wei Yung Ding, Jiawen Huang, Hongyan Wang Neural stem cells (NSCs) are crucial for development, regeneration, and repair of the nervous system. Most NSCs in mammalian adult brains are quiescent, but in response to extrinsic stimuli, they can exit from quiescence and become reactivated to give rise to new neurons. The delicate balance between NSC quiescence and activation is important for adult neurogenesis and NSC maintenance. However, how NSCs transit between quiescence and activation remains...
12h
by Abdul Khalique, Sandy Mattijssen, Alexander F. Haddad, Shereen Chaudhry, Richard J. Maraia The tRNA isopentenyltransferases (IPTases), which add an isopentenyl group to N6 of A37 (i6A37) of certain tRNAs, are among a minority of enzymes that modify cytosolic and mitochondrial tRNAs. Pathogenic mutations to the human IPTase, TRIT1, that decrease i6A37 levels, cause mitochondrial insufficiency that leads to neurodevelopmental disease. We show that TRIT1 encodes an amino-terminal mitochondrial...
12h
by Anil Chougule, François Lapraz, István Földi, Delphine Cerezo, József Mihály, Stéphane Noselli Left-Right (LR) asymmetry is essential for organ positioning, shape and function. Myosin 1D (Myo1D) has emerged as an evolutionary conserved chirality determinant in both Drosophila and vertebrates. However, the molecular interplay between Myo1D and the actin cytoskeleton underlying symmetry breaking remains poorly understood. To address this question, we performed a dual genetic screen to identify...
12h
Antibiotics, Vol. 9, Pages 204: Development of Antimicrobial Stewardship Programmes in Low and Middle-Income Countries: A Mixed-Methods Study in Nigerian Hospitals Antibiotics doi: 10.3390/antibiotics9040204 Authors: Eneyi E. Kpokiri David G. Taylor Felicity J. Smith Antimicrobial resistance (AMR) is a major concern facing global health today, with the greatest impact in developing countries where the burden of infectious diseases is much higher. The inappropriate prescribing...
12h
Antibiotics, Vol. 9, Pages 205: Acinetobacter baumannii Resistance: A Real Challenge for Clinicians Antibiotics doi: 10.3390/antibiotics9040205 Authors: Rosalino Vázquez-López Sandra Georgina Solano-Gálvez Juan José Juárez Vignon-Whaley Jorge Andrés Abello Vaamonde Luis Andrés Padró Alonzo Andrés Rivera Reséndiz Mauricio Muleiro Álvarez Eunice Nabil Vega López Giorgio Franyuti-Kelly Diego Abelardo Álvarez-Hernández Valentina Moncaleano Guzmán Jorge...
14h
Antibiotics, Vol. 9, Pages 203: Risk Factors of Initial Inappropriate Antibiotic Therapy and the Impacts on Outcomes of Neonates with Gram-Negative Bacteremia Antibiotics doi: 10.3390/antibiotics9040203 Authors: Shih-Ming Chu Jen-Fu Hsu Mei-Yin Lai Hsuan-Rong Huang Ming-Chou Chiang Ren-Huei Fu Ming-Horng Tsai Background: Timely appropriate empirical antibiotic plays an important role in critically ill patients with gram-negative bacteremia. However, the relevant...
18h
Antibiotics, Vol. 9, Pages 202: Antibiotics and Environment Antibiotics doi: 10.3390/antibiotics9040202 Authors: Rosa Alduina Since the discovery of penicillin by Alexander Fleming in 1928, the use of antibiotics has become the golden standard in the treatment of bacterial infections of all kinds [...]
20h
Antibiotics, Vol. 9, Pages 201: Hyponatremia Associated with Prophylactic Low-Dose Trimethoprim during Systemic Corticosteroid Therapy for AQP4-Positive Optic Neuritis in a Diabetic Patient Antibiotics doi: 10.3390/antibiotics9040201 Authors: Masahiro Takubo Sho Tanaka Masaru Kushimoto Jin Ikeda Katsuhiko Ogawa Yutaka Suzuki Masanori Abe Hisamitsu Ishihara Midori Fujishiro Hyponatremia associated with low-dose trimethoprim in patients on concomitant...
20h
Doctors treating patients with known or suspected covid-19 should be vigilant for signs of acute myocardial injury, a new rapid guideline from the National Institute for Health and Care Excellence...
12h
Deaths from malaria in sub-Saharan Africa could return to levels last seen 20 years ago because of severe disruptions in access to nets and medicines during the covid-19 pandemic, a new modelling...
12h
The UK government has launched a nationwide surveillance study to track the prevalence of infection with SARS-CoV-2 in the general population. The study will include swab testing and serology testing...
12h
The BMA has written to the chancellor of the exchequer calling for all NHS workers to receive full death in service cover.After an announcement by the Scottish government of a comprehensive death in...
12h
Doctors treating patients with known or suspected covid-19 should be vigilant for signs of acute myocardial injury, a new rapid guideline from the National Institute for Health and Care Excellence...
14h
Deaths from malaria in sub-Saharan Africa could return to levels last seen 20 years ago because of severe disruptions in access to nets and medicines during the covid-19 pandemic, a new modelling...
15h
The UK government has launched a nationwide surveillance study to track the prevalence of infection with SARS-CoV-2 in the general population. The study will include swab testing and serology testing...
16h
The BMA has written to the chancellor of the exchequer calling for all NHS workers to receive full death in service cover.After an announcement by the Scottish government of a comprehensive death in...
17h
The Indian government has given an ordinance that makes violence against healthcare workers a non-bailable offence, punishable by up to seven years imprisonment, amid concerns that the covid-19...
17h
The Indian government has given an ordinance that makes violence against healthcare workers a non-bailable offence, punishable by up to seven years imprisonment, amid concerns that the covid-19...
19h
Two thirds of healthcare workers who have died from covid-19 were from an ethnic minority background, and at least half were not born in the UK, researchers have found.Tim Cook, professor of...
20h
The reason I write this letter is to take a small step towards helping readers with evidence based decision making by keeping them up to date with the rapidly growing number of covid-19 studies in...
20h
Safety of new treatments for multiple sclerosisImmunomodulating treatments help people with multiple sclerosis by reducing relapse rate and slowing disease progression. However, they are not without...
20h
Critics of covid-19 management say that something should have been done weeks before it was,1 forgetting that most aspects of the infection were unknown before January. If tests haven’t been...
20h
Greenhalgh and colleagues discuss the potential use of video consultations for covid-19 and outline some of the system level challenges for implementation and scale-up.1 Despite the limited evidence,...
20h
Two thirds of healthcare workers who have died from covid-19 were from an ethnic minority background, and at least half were not born in the UK, researchers have found.Tim Cook, professor of...
21h
The reason I write this letter is to take a small step towards helping readers with evidence based decision making by keeping them up to date with the rapidly growing number of covid-19 studies in...
21h
Safety of new treatments for multiple sclerosisImmunomodulating treatments help people with multiple sclerosis by reducing relapse rate and slowing disease progression. However, they are not without...
21h
Critics of covid-19 management say that something should have been done weeks before it was,1 forgetting that most aspects of the infection were unknown before January. If tests haven’t been...
21h
Greenhalgh and colleagues discuss the potential use of video consultations for covid-19 and outline some of the system level challenges for implementation and scale-up.1 Despite the limited evidence,...
22h
Covid-19Care home residents and staff are promised testsThe pledge to boost covid-19 testing for staff in UK care homes must be delivered promptly and be matched with greater transparency about the...
23h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου