We report a case of tick-borne relapsing fever caused by Borrelia persica in a traveler returning to Switzerland from central Asia. After the disease was diagnosed by blood smear microscopy, the causative Borrelia species was confirmed by shotgun metagenomics sequencing. PCR and sequencing techniques provide highly sensitive diagnostic tools superior to microscopy.
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The live-attenuated yellow fever vaccine (YFV) is generally contraindicated in immunosuppressed patients. Our aim was to investigate if immunosuppressive therapy impairs the long-term protection against yellow fever virus in patients who had received YFV prior to the start of their immunosuppressive therapy.; Our study examined 35 healthy individuals and 40 immunosuppressed patients with autoimmune diseases or organ transplants. All individuals had received YFV prior to the onset of their immunosuppression....
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Rationale:; Most studies determining the prevalence of airway obstruction are limited to short time periods.; Objectives:; Because temporal trends of obstruction in populations are largely unknown, we determined the prevalence of airway obstruction over 20 years in yearly general population samples in Switzerland between 1993 and 2012.; Methods:; We analyzed data of 85,789 participants aged 35 years and older who provided spirometric measurements as part of the LuftiBus lung function campaign. We...
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Bats are important wildlife to their ecologic system, but they are also a zoonotic disease reservoir. Close bat-human interaction can lead to pathogen spillover. We conducted a qualitative study in two districts of Bangladesh and interviewed 30 bat hunters who hunt bats primarily for consumption, to understand the process and their reasons for hunting bats and their perceptions about bats and bat-borne disease. Most hunters catch bats during winter nights, using a net. Bat meat is used for household...
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Low- and middle-income countries have been undertaking health finance reforms to address shortages of medicines. However, data are lacking on how medicine availability and stock-outs influence access to health services in Tanzania. The current study assesses the effects of medicine availability and stock-outs on healthcare utilization in Dodoma region, Tanzania. We conducted a cross-sectional study that combined information from households and healthcare facility surveys. A total of 4 hospitals and...
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To compare early motor and language development of children <3 years of age growing up in high-income and low-income contexts.; Cross-sectional study.; We analysed differences in motor and language skills across study sites in Cambodia, Chile, Ghana, Guatemala, Lebanon, Pakistan, the Philippines and the USA.; Cognitive and language development assessed with the Caregiver Reported Early Development Instruments (CREDI) tool.; 4649 children aged 0-35 months (mean age=18 months) were analysed. On...
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Exposure to traffic noise is associated with stress and sleep disturbances. The World Health Organization (WHO) recently concluded that road traffic noise increases the risk for ischemic heart disease and potentially other cardiometabolic diseases, including stroke, obesity, and diabetes. The WHO report focused on whole-day noise exposure, but new epidemiological and translational field noise studies indicate that nighttime noise, in particular,is an important risk factor for cardiovascular disease...
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The Philippines decentralized government health services through devolution to local governments in 1992. Over the years, opinions varied on the impact of devolved governance to decision-making for local health services. The objective of this study was to analyze decision-makers' perspectives on who should be making decisions for local health services and on their preferred structure of health service governance should they be able to change the situation.; We employed a mixed methods approach that...
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Lavanya Tandon, Pankaj Thakur, Kultar Singh, Poonam Khullar, Gurinder Kaur Ahluwalia, Mandeep Singh Bakshi
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Wenjing Zhang, Chanjuan Liu, Mingren Qu, Ke Pan, Kehui OuYang, Xiaozhen Song, Xianghui Zhao
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Ehsan Moradi, Motahareh Hashemi Moosavi, Seydeh Marzieh Hosseini, Leila Mirmoghtadaie, Maryam Moslehishad, Mohammad Reza Khani, Narges Jannatyha, Saeedeh Shojaee-Aliabadi
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Publication date: 15 July 2020Source: International Journal of Biological Macromolecules, Volume 155Author(s): Talat Baran, Idris Sargin
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Publication date: 15 July 2020Source: International Journal of Biological Macromolecules, Volume 155Author(s): Quanxin Gao, Qiongying Tang, Ming Zhao, Minghua Min, Qian Wang, Shiming Peng, Lingbo Ma
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Publication date: 15 July 2020Source: International Journal of Biological Macromolecules, Volume 155Author(s): M. Monier, Abeer Abdulaziz H. Bukhari, Nadia H. Elsayed
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Publication date: 15 July 2020Source: International Journal of Biological Macromolecules, Volume 155Author(s): Sundus Mehboob, Tahira Mohsin Ali, Marium Sheikh, Abid Hasnain
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Study of the Enzymatic Capacity of <b><i>Kluyveromyces marxianus</i></b> for the Synthesis of Esters
Recently, biotechnological opportunities have been found in non-Saccharomyces yeasts because they possess metabolic characteristics that lead to the production of compounds of interest. It has been observed that Kluyveromyces marxianus has a great potential in the production of esters, which are aromatic compounds of industrial importance. The genetic bases that govern the synthesis of esters include a large group of enzymes, among which the most important are alcohol acetyl transferases (AATases)...
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JPM, Vol. 10, Pages 29: Pharmacogenomic (PGx) Counseling: Exploring Participant Questions about PGx Test Results Journal of Personalized Medicine doi: 10.3390/jpm10020029 Authors: Tara Schmidlen Amy C. Sturm Laura B. Scheinfeldt As pharmacogenomic (PGx) use in healthcare increases, a better understanding of patient needs will be necessary to guide PGx result delivery. The Coriell Personalized Medicine Collaborative (CPMC) is a prospective study investigating the utility of personalized...
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Publication date: Available online 22 April 2020Source: GeneAuthor(s): Panagiotis G. Adamopoulos, Fotini Ε. Koukouzeli, Christos K. Kontos, Andreas Scorilas
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Publication date: Available online 22 April 2020Source: GeneAuthor(s): Zhi Zou, Meiying Li, Ruizong Jia, Hui Zhao, Pingping He, Yuliang Zhang, Anping Guo
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Publication date: Available online 22 April 2020Source: GeneAuthor(s): Thomas A. Owen, Chandni Patel, Shanqiao Wei, Chi S. Ho, Kaylah Birmingham, Samuel Sanchez, Natalie Chung, Alexa Cahill, James P. O'Malley, Stephen D. Barrett, María Inés Morano
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Abstract Aside from well-characterized immune-mediated ataxias with a clear trigger and/or association with specific neuronal antibodies, a large number of idiopathic ataxias are suspected to be immune mediated but remain undiagnosed due to lack of diagnostic biomarkers. Primary autoimmune cerebellar ataxia (PACA) is the term used to describe this later group. An International Task Force comprising experts in the field of immune ataxias was commissioned by the Society for Research...
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