Background & Aims. Chronic hepatitis (CH) has emerged as a distinct outcome of drug-induced liver injury (DILI). Combination therapy of Isoniazid (INH) and Rifampicin (RMP) which is widely used for prolonged periods can cause acute hepatotoxicity and has been also incriminated in chronic DILI. We sought evidence of the production of hepatic fibrosis on long-term INH-RMP treatment through experiments in BALB/c mice exposed to INH-RMP. Methods. A combined dose of INH (50 mg) and RMP (100 mg) per...
15h
A Value-at-Risk (VaR) forecast may be calculated for the case of a random loss alone and/or of a random loss that depends on another random loss. In both cases, the VaR forecast is obtained by employing its (conditional) probability distribution of loss data, specifically the quantile of loss distribution. In practice, we have an estimative VaR forecast in which the distribution parameter vector is replaced by its estimator. In this paper, the quantile-based estimative VaR forecast for dependent...
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Background. Out-of-hospital cardiac arrest (OHCA) survival remains low in most countries. Few studies examine OHCA outcomes out of the Middle East region. This is the first study to describe characteristics and outcomes of patients with OHCA treated by emergency medical services (EMS) in regions of Kuwait. Objectives. To describe characteristics and outcomes of adult patients affected with OHCA in regions of Kuwait. Methods. This was a retrospective observational study on all adult OHCA patients...
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Scene parsing plays a crucial role when accomplishing human-robot interaction tasks. As the “eye” of the robot, RGB-D camera is one of the most important components for collecting multiview images to construct instance-oriented 3D environment semantic maps, especially in unknown indoor scenes. Although there are plenty of studies developing accurate object-level mapping systems with different types of cameras, these methods either process the instance segmentation problem in completed mapping or...
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The study of forest fire prediction is of great environmental and scientific significance. China’s Guangxi Autonomous Region has a high incidence rate of forest fires. At present, there is little research on forest fires in this area. The application of the artificial neural network and support vector machines (SVM) in forest fire prediction in this area can provide data for forest fire prevention and control in Guangxi. In this paper, based on Guangxi’s 2010–2018 satellite monitoring hotspot data,...
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In this paper, we consider a class of boundary value problems of nonlinear fractional differential equation with integral boundary conditions. By applying the monotone iterative method and some inequalities associated with Green’s function, we obtain the existence of minimal and maximal positive solutions and establish two iterative sequences for approximating the solutions to the above problem. It is worth mentioning that these iterative sequences start off with zero function or linear function,...
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In this study, we are presenting the effect of three ripening stages of air-dried bitter gourd fruit extracts on phenolic acid composition, antioxidant, antibacterial, and anticancer activities. The results showed mature bitter gourd fruit extract in 100% methanol showing 78% DPPHº scavenging activity. Immature dried fruit extract in 80% and 100% methanol showed promising antibacterial activities, i.e., >18.5 ± 0.21 mm zone-of-inhibition against Staphylococcus aureus, while mature dried fruit...
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Background. There is a rapid deterioration in the effectiveness of antibiotics due to the global prevalence of bacterial antimicrobial resistance (AMR). AMR can cause an increase in mortality and morbidity due to treatment failures and a lack of effective therapy. Objective. The purpose of this study was to evaluate the AMR pattern of different bacterial isolates at hospitals and laboratories. Materials and Methods. A cross-sectional study from March 2019 to June 2019 was conducted at different governmental...
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The relationship between selenium and metabolic syndrome (MetS) has been discussed controversially, and limited studies have examined the associations of single nucleotide polymorphisms in selenoproteins genes with MetS. Hence, to examine the associations of plasma selenium concentrations and selenoprotein P rs7579 polymorphism with MetS, a case-control study of 1279 MetS cases and 1279 sex- and age- (±2 years) matched controls was conducted based on the baseline data of the Tongji-Ezhou Cohort study....
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Landmark model (LM) is a dynamic prediction model that uses a longitudinal biomarker in time-to-event data to make prognosis prediction. This study was designed to improve this model and to apply it to assess the cardiovascular risk in on-treatment blood pressure patients. A frailty parameter was used in LM, landmark frailty model (LFM), to account the frailty of the patients and measure the correlation between different landmarks. The proposed model was compared with LM in different scenarios respecting...
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In order to study the characteristics of high water-content materials (HWC) undergoing chloride erosion, we analyzed and summarized changes in strength, elastic modulus, and mass of HWC materials during chloride erosion using specific experimental research, and we also described the compression failure morphologies of HWC materials after erosion. The cuboid specimens developed a horizontal crack between the top and bottom, and the cylindrical specimens developed irregular encryption cracks at the...
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In the past decades, the booming growth of housing markets in China triggers the urgent need to explore how the rapid urban spatial expansion, large-scale urban infrastructural development, and fast-changing urban planning determine the housing price changes and spatial differentiation. It is of great significance to promote the existing governing policy and mechanism of housing market and the reform of real-estate system. At the level of city, an empirical analysis is implemented with the traditional...
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Heart failure (HF), a clinical syndrome with a high incidence due to various reasons, is the advanced stage of most cardiovascular diseases. Huangqi is an effective treatment for cardiovascular disease, which has multitarget, multipathway functions. Therefore, we used network pharmacology to explore the molecular mechanism of Huangqi in treating HF. In this study, 21 compounds of Huangqi, which involved 407 targets, were obtained and reconfirmed using TCMSP and PubChem databases. Moreover, we used...
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Type 2 diabetes mellitus (T2DM) has become a major disease threatening human health worldwide. At present, the treatment of T2DM cannot cure diabetes and is prone to many side effects. Psidium guajava L. leaves have been reported to possess hypoglycemic activity, and they have been widely used in diabetes treatment in the folk. However, the antidiabetic mechanism has not been clearly explained. Also, the change in amino acid profile can reflect a metabolic disorder and provide insights into system-wide...
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Arenobufagin (ARE) has demonstrated potent anticancer activity in various types of tumor, but the role and mechanism of ARE for lung cancer remain unclear. Oxidative stress exists under normal conditions and is an inevitable state in the body. A variety of noxious stimuli can break the equilibrium state of oxidative stress and promote apoptosis. Here, we used a CCK-8 assay to examine cell viability. We determined oxidative stress damage by measuring levels of intracellular ROS and levels of GSH,...
15h
In the universe of nanomaterials, silver nanoparticles (AgNPs) have attracted the attention of researchers because of their optical, catalytic, antimicrobial, fungicidal, and bactericidal properties. Recently, studies have correlated the toxicity and efficacy of antimicrobial activity with surface-volume ratio, morphology, polydispersity, ligand types, particle size, and stability of AgNPs. Soon, the need for characterization of properties such as diameter and polydispersity is clear. The methodologies...
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This study constructs an optimization model to address ski-jump energy dissipation problems in different reservoir environments. The multiobjective genetic algorithm is herein applied as the calculation method. In the process of changing the ski-jump flow model, the runoff of ski-jump flow is changed (especially the abnormal flip bucket). Water flow might go from having a single falling point to multiple falling points. Optimization is only performed after the stabilization of the fall of the water...
15h
Erchen plus Huiyanzhuyu decoction (EHD), a Chinese herbal medicine (CHM) formula that consists of Erchen decoction and Huiyanzhuyu decoction, has achieved satisfactory results in the clinic. The main function of EHD is to remove phlegm and blood stasis, and EHD is suitable for phlegm-coagulation-blood-stasis (PCBS) syndrome in laryngeal cancer (LC). In this study, a xenograft mouse model of LC with PCBS syndrome was constructed by feeding a high-fat diet, swimming in ice water, and subcutaneously...
15h
The disposal of agricultural straw has been a severe environmental concern in China and many other countries. In this study, the complex modulus of using biochar converted from straw as an alternative mineral filler in asphalt mastic was investigated through both laboratory tests and modeling. The experimental results indicated that the biochar can provide asphalt mastic higher stiffness than the conventional granite mineral filler. It was believed that the special porous structure of biochar providing...
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Purpose. To investigate the long-term outcomes of refraction, corneal tomography, and wavefront aberrations after small incision lenticule extraction (SMILE) for moderate and high myopia. Methods. Prospective, nonconsecutive case series. A total of 26 patients (26 eyes) who underwent SMILE from May 2010 to March 2013 at the Fudan University Eye and ENT Hospital (Shanghai, China) were enrolled. The periods of follow-up were 1 month, 1 year, 5 years, and 7 years after surgery. The routine eye examinations...
15h
In this paper, on the basis of multifunctional reconfigurable pixel antenna (RPA) elements, a novel linear sparse array with an attractive compound reconfigurability is presented. It has the potential advantages of its beam scanning with low gain fluctuation, low sidelobe in two orthogonal planes, and polarization reconfigurable performance. Specifically, an RPA with simultaneous polarization and pattern reconstruction capabilities, consisting of the driven patch and the parasitic pixels on the same...
15h
Objective. This study aimed to investigate the expression of collagen (types I, III, and V), heat shock protein 47 (HSP47), matrix metalloproteinase-2 (MMP-2), and tissue inhibitors of metalloproteinase-1 (TIMP-1) in the retrobulbar adipose tissues of patients with thyroid-associated orbitopathy (TAO). Materials and Methods. The retrobulbar adipose tissues were collected from 4 TAO patients undergoing orbital decompression and 4 ocular enucleation patients with atrophic eyeball caused by ocular trauma...
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This work concentrates on the fracture behaviour of the compact tension specimen under mixed-mode loading, and numerical investigation using ANSYS Mechanical APDL 19.2 finite element program with different modes of mix angles is carried out. The prediction of mixed-mode fatigue life under constant amplitude fatigue loading for the compact tension shear specimen (CTS) is employed using Paris’ law model for two different loading angles with agreement to the experimental results. The predicted values...
15h
A simplified notched design method for the Vivaldi antenna is exhibiting high frequency-band-selectivity characteristics. By suitably introducing half-wavelength resonator (HWR) and complementary capacitively loaded loop (CCLL), the notched-band selectivity is promoted while maintaining the wide impedance bandwidth of the antenna applicable for wireless communications. HWR is bent in the middle to focus the first notch pole, and the second notch pole is obtained by CCLL on the radiating patch. Additionally,...
15h
With comprehensive application of the theories of coating shear failure mechanism and fatigue cumulative damage, a life prediction method of a gun barrel is proposed based on the shear fatigue damage accumulation at the coating-substrate interface. The life of a small-caliber gun barrel is predicted by use of constant tensile strength at normal temperature and temperature-dependent tensile strength, respectively. The influence of the two kinds of tensile strength on barrel life prediction results...
15h
Boundary behavior of important functions has been an object of intensive research since the time of Riemann. Kurokawa, Kurokawa-Koyama, and Chapman studied the boundary behavior of generalized Eisenstein series which falls into this category. The underlying principle is the use of the Lipschitz summation formula. Our purpose is to show that it is a form of the functional equation for the Lipschitz–Lerch transcendent (and in the long run, it is equivalent to that for the Riemann zeta-function) and...
15h
PTS-FNN-Based Health Prediction Method for Flexible Photoelectric Film Material Processing Equipment
Roll-to-Roll (R2R) processing is a common processing method for flexible photoelectric film materials. Due to the physical properties of the materials, the change in the performance of the R2R processing equipment can easily cause deformation of the flexible film material, it is particularly important to predict the performance degradation of the processing equipment. Based on the accuracy and real-time requirements of performance degradation prediction, a PTS-FNN model for performance degradation...
15h
Grid-based Generalized Voronoi Diagrams (GVDs) are widely used to represent the surrounding environment of intelligent agents in the fields of robotics, computer games, and military simulations, which improve the efficiency of path planning of intelligent agents. Current studies mainly focus on square-grid-based GVD construction approaches, and little attention has been paid to constructing GVDs from hexagonal grids. In this paper, an algorithm named hexagon-based crystal growth (HCG) is presented...
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Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting the joints and surrounding tissue. Identification of novel proteins associated with the progression of a disease is a prerequisite for understanding the pathogenesis of RA. The present study was undertaken to identify the potential biomarkers from a less explored biological sample such as synovial fluid (SF) cells which is specific for RA and to analyze their functional aspects using proteomic approach. Two-dimensional...
15h
The aim of this study was to explore the effect of adenosine A2A receptor agonists on fracture healing and the regulation of the immunity system after bone fracture. We implanted fibrin gel containing adenosine A2A receptor agonist CGS 21680/inhibitor ZM 241385/saline locally in rat tibial fracture models, finding that the adenosine A2A receptor agonist could promote fracture healing. At the same time, the adenosine A2A receptor agonist decreased the level of IL-6 in blood and the fracture area,...
15h
We aimed to establish a quantitative analysis method of six constituents (5-caffeoylquinic acid, 3-caffeoylquinic acid, 4-caffeoylquinic acid, 1,3-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, and 4,5-dicaffeoylquinic acid) in Artemisia capillaris (Yinchen) and its decoction by using HPLC coupled with DAD. Besides, the transformation paths of the six constituents were analyzed in decoction preparation processing. The analytical method was fully validated in terms of linearity, sensitivity, precision,...
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Purpose. Microsatellite instability (MSI) caused by mismatch repair protein (MMRP) deficiency is detected in 15% of sporadic colorectal cancers (CRCs). Our aim is to investigate the frequency of MMRP deficiency in young CRC patients, using immunohistochemical analysis. Methods. This study targeted cases of CRC at King Hussein Cancer Center from 2004 until 2012 in patients 45 years of age or younger at the time of diagnosis. Clinicopathological data was obtained from 155 patients’ records. Immunohistochemistry...
15h
Wearable health monitoring system (WHMS), which helps medical professionals to collect patients’ healthcare data and provides diagnosis via mobile devices, has become increasingly popular thanks to the significant advances in the wireless sensor network. Because health data are privacy-related, they should be protected from illegal access when transmitted over a public wireless channel. Recently, Jiang et al. presented a two-factor authentication protocol on quadratic residues with fuzzy verifier...
15h
Fatigue behavior is an important factor for mechanical analysis of concrete members reinforced by basalt fiber reinforced polymer (BFRP) grid and polymer cement mortar (PCM) and plays a critical role in ensuring the safety of reinforced concrete bridges and other structures. In this study, on the basis of the static loading test results of concrete specimens reinforced by BFRP grid and PCM, a series of fatigue tests with different loading levels were conducted on interfaces between BFRP grid and...
15h
Cardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aimed at elucidating the impact of CVDRF in the oxidation responsive AMPK/SIRT1-PGC-1α-SIRT3 pathway and related miRNAs in the human corpus cavernosum. Human penile tissue fragments from individuals submitted to programmed urological surgeries (), aged 43-63 years,...
15h
Breast cancer is the most commonly diagnosed cancer among women. Difficulties in treating breast cancer are associated with the occurrence of metastases at early stages of disease, leading to its further progression. Recent studies have shown that changes in androgen receptor (AR) and microRNAs’ expressions are associated with mammary gland carcinogenesis, in particular, with the formation of metastases. Thus, to identify novel metastatic markers, we evaluated the expression levels of AR; miR-185...
15h
Purpose. This systematic review and meta-analysis was performed to determine the effectiveness of Omega-3 polyunsaturated fatty acid ( PUFA) supplement on muscle soreness after eccentric exercise. Methods. PubMed, EMBASE, CENTRAL, and ISI Web of Science were searched to identify randomized controlled trials (RCTs) that assessed the efficacy of PUFA on muscle soreness after eccentric exercise. Mean difference (MD) and the associated 95% confidence interval (95% CI) were calculated by RevMan 5.3 to...
15h
Background. Globally, computer vision syndrome is the most common eye problem which is associated with prolonged exposure to a computer. It has a great socioeconomic impact on the users due to its effect on job performance. Recently, many people in the world, including our country Ethiopia, especially bank workers, are spending most of their time in front of a computer screen to facilitate their work. Since it is assumed that knowledge is pertinent to prevent computer vision syndrome, this study...
15h
Aim. There are increasing evidence demonstrating that neutrophil-mediated inflammation plays a role in the etiology of type 2 diabetes. However, the molecular mechanisms by which neutrophils contribute to type 2 diabetes remain largely unknown. The aim of the present work was to identify possible changes in circulating neutrophils to better elucidate neutrophil involvement in human type 2 diabetes. Methods. Patients newly diagnosed with type 2 diabetes () and age- and sex-matched healthy controls...
15h
Background. Hepatocellular carcinoma (HCC) is a common cancer with an extremely high mortality rate. Therefore, there is an urgent need in screening key biomarkers of HCC to predict the prognosis and develop more individual treatments. Recently, AATF is reported to be an important factor contributing to HCC. Methods. We aimed to establish a gene signature to predict overall survival of HCC patients. Firstly, we examined the expression level of AATF in the Gene Expression Omnibus (GEO), the Cancer...
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Worldwide interest in the use of functional foods containing probiotic bacteria such as Lactobacillus and Bifidobacterium for health promotion and disease prevention has increased significantly. Probiotics have demonstrated beneficial properties including strengthening the body’s natural defense system, inhibiting the growth of pathogenic bacteria, and regulating mental activity, but their effects on the human vagina have not been fully elucidated. The primary purpose of our study was to isolate...
15h
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