Πέμπτη 23 Απριλίου 2020

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The Impact of Patient Support Programs on Adherence to Disease-Modifying Therapies of Patients with Relapsing-Remitting Multiple Sclerosis in Germany: A Non-Interventional, Prospective Study
Abstract Introduction Disease-modifying therapies (DMTs) in multiple sclerosis (MS) are chronic therapies, and patients are likely to face challenges in adhering to DMT dosing regimens over time. DMT manufacturers offer patient support programs (PSPs) to increase adherence. PSPs are managed offerings typically encompassing nurse services, phone services, online resources, or mobile offerings. This study evaluated whether PSPs have a...
Advances in Therapy
1m
Developing Classifications of Laryngeal Dysplasia: The Historical Basis
Abstract During the last 60 years numerous significant attempts have been made to achieve a widely acceptable terminology and histological grading for laryngeal squamous intraepithelial lesions. While dysplasia was included in the pathology of the uterine cervix already in 1953, the term dysplasia was accepted in laryngeal pathology first after the Toronto Centennial Conference on Laryngeal Cancer in 1974. In 1963 Kleinsasser proposed a three-tier classification, and in 1971 Kambic...
Advances in Therapy
14h
Correction to: 24-Hour Efficacy and Ocular Surface Health with Preservative-Free Tafluprost Alone and in Conjunction with Preservative-Free Dorzolamide/Timolol Fixed Combination in Open-Angle Glaucoma Patients Insufficiently Controlled with Preserved Latanoprost Monotherapy
In the original article, the incorrect Open Access License type has been incuded.
Advances in Therapy
14h
The Myeloproliferative Neoplasm Landscape: A Patient’s Eye View
Abstract Patients with myeloproliferative neoplasms (MPNs), a group of rare haematological conditions including polycythaemia vera, essential thrombocythaemia, and myelofibrosis, often experience a range of symptoms which can significantly impact their quality of life (QoL). Although symptom burden is highest in myelofibrosis and high-risk patients, lower-risk patients also report symptoms impacting their daily life and ability to work. In addition to physical symptoms, MPNs affect...
Advances in Therapy
18h
Successful sparing approach between the ascending aorta and the main pulmonary artery to the giant coronary aneurysm of the left main coronary artery
Coronary aneurysm located just above the left main coronary artery (LMT) is rare and difficult to treat. How the aneurysm is accessed is very important as it determines the result of the surgery. A 70-year-old man with a large coronary aneurysm (40 mm in diameter) in the LMT underwent surgery to prevent its rupture; however, there was severe adhesion. Initially, dissection of the ascending aorta or the pulmonary artery seemed necessary to access the aneurysm; however, the process was possible with...
BMJ Case Reports Last 6 Issues
3h
Approach to exaggerated startle reflex: a case of hyperekplexia minor
A broad set of conditions may present with an exaggerated startle reflex in clinics. This, combined with the overall rarity of these disorders, may pose diagnostic uncertainty in the mind of the treating physician. Herein, we report a case of a patient who presented to us with the complaint of exaggerated startle reflex and outline a simple approach towards characterisation of these disorders.
BMJ Case Reports Last 6 Issues
3h
Pericardial relapse of multiple myeloma
In patients who experience relapse of multiple myeloma, upwards of 30% can have extramedullary disease. The presence of extramedullary multiple myeloma is typically associated with adverse cytogenetics and a poor prognosis. Organs most commonly involved include the liver, skin, central nervous system, pleural effusions, kidney, lymph nodes, and pancreas. We present the case of a 53-year-old man with IgA kappa multiple myeloma with the adverse cytogenetic findings of t(4;14) and 1q21 gain who had...
BMJ Case Reports Last 6 Issues
3h
Ovoid palatal patch: a clue to anti-TIF1{gamma} dermatomyositis
An 80-year-old woman presented with a several-year history of progressive hair loss and scalp pruritus. No other rashes or muscle weakness were noted on examination. Scalp biopsy showed interface dermatitis, dense perivascular and periadnexal lymphocytic infiltrate, mucin and scarring alopecia. Laboratory analysis did not show evidence of myositis. The patient was started on hydroxychloroquine for possible cutaneous lupus erythematosus. On follow-up, she presented with a new violaceous rash on the...
BMJ Case Reports Last 6 Issues
3h
Rare case of basilar artery aneurysm in a young child
A previously well, 14-month-old girl presented with acute decreased level of consciousness. There was no history of trauma, systemic upset or significant family history. Blood pressure was within normal range and no focal neurological deficit was elicited on examination. Neuroimaging revealed a subarachnoid haemorrhage secondary to a basilar tip aneurysm. Patient underwent endovascular embolisation with good clinical outcome. Follow-up MRI revealed anterior circulation vasospasm, and although clinically...
BMJ Case Reports Last 6 Issues
3h
ICT resources for research: an ANOVA analysis on the digital research skills of higher education teachers comparing the areas of knowledge within each gender
Abstract Research skills are part of the academic activities of Higher Education teachers. Regardless of the knowledge area they teach, there is a need to observe, reflect, select, analyse and communicate scientific results using technological advances. The aim of this study is to analyse the use that teachers make of different ICT resources for research in terms of gender, comparing within each gender the different areas of knowledge to which the teachers belong (Science and Engineering-Architecture,...
Latest Results for Education and Information Technologies
3h
Physical activity and nutrition interventions for older adults with cancer: a systematic review
Abstract Purpose The aim of this review was to summarize the current literature for the effectiveness of activity and nutritional based interventions on health-related quality of life (HRQoL) in older adults living with and beyond cancer (LWBC). Methods We conducted systematic structured searches of CINAHL, Embase, Medline, Cochrane CENTRAL databases, and...
Latest Results for Journal of Cancer Survivorship
3h
Clinical Pathway for Early Diagnosis of COVID-19: Updates from Experience to Evidence-Based Practice
Abstract The COVID-19 pandemic is a significant global event in the history of infectious diseases. The SARS-CoV-2 appears to have originated from bats but is now easily transmissible among humans, primarily through droplet or direct contact. Clinical features of COVID-19 include high fever, cough, and fatigue which may progress to ARDS. Respiratory failure can occur rapidly after this. The primary laboratory findings include lymphopenia and eosinopenia. Elevated D-dimer, procalcitonin,...
Latest Results for Clinical Reviews in Allergy
3h
Combining doxorubicin with stearylamine-bearing liposomes elicits Th1 cytokine responses and cures metastasis in a mouse model
Abstract Surface exposed phosphatidylserine (PS) of cancer aids it to evade immune surveillance and thereby results in tumor progression. Earlier, we reported that PS targeting cationic liposomes, phosphatidylcholine–stearylamine (PC-SA), alone and in combination with doxorubicin can result in complete remission of B16F10 melanoma in C57BL/6 mice without signs of toxicity. Inducing an immunogenic response is highly crucial for any cancer therapy as it is essential in improving...
Latest Results for Cancer Immunology, Immunotherapy
3h
Analysis of Stage I EFHWTs Treatment Finds Event-Free Survival and Overall Survival Rates Greater Than 95%
A recent study reported a 96.2% event-free survival rate and a 100% overall survival rate when investigating treatment option for stage I epithelial-predominant favorable-histology Wilms tumors in a population with a majority of patients under the age of 48 months. (Source: CancerNetwork)
CancerNetwork
3h
Brendan F. Kennedy, PhD, on a New Imaging Technique for Breast Cancer
Brendan F. Kennedy, PhD, discussed this study which evaluated the accuracy of quantitative micro-elastography compared to optical coherence tomography. (Source: CancerNetwork)
CancerNetwork
3h
Rapid Rollout of Telemedicine Aids Cancer Care During COVID-19 Pandemic
Clinicians from Lombardi Comprehensive Cancer Center spoke about moving cancer care to telehealth due to the COVID-19 pandemic. (Source: CancerNetwork)
CancerNetwork
3h
Use of Prophylactic Cranial Irradiation in Patients with Limited Stage SCLC
Researchers found that using prophylactic cranial irradiation after thoracic radiation in patients with limited-stage small cell lung cancer undergoing contemporary head imaging is not associated with a decrease in risk of developing new brain metastasis. (Source: CancerNetwork)
CancerNetwork
3h
FDA Grants Accelerated Approval to Sacituzumab Govitecan-hziy to Treat Metastatic TNBC
The FDA granted a breakthrough therapy designation and priority review under its Accelerated Approval Program to sacituzumab govitecan-hziy for the treatment of patients with metastatic triple-negative breast cancer. (Source: CancerNetwork)
CancerNetwork
3h
Correction to: Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats
In the original publication, the starting point in time for the three feeding trials.
Latest Results for Archives of Toxicology
4h
Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study
Abstract Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biological targets underlying the activity of alternariol, taken as the signature compound of Alternaria toxins. Combining ligand-based screening and structure-based...
Latest Results for Archives of Toxicology
17h
Effect of estrogen-active compounds on the expression of RACK1 and immunological implications
Abstract We previously demonstrated the existence of a balance among steroid hormones, i.e. glucocorticoids and androgens, in RACK1 (receptor for activated C kinase 1) expression and innate immunity activation, which may offer the opportunity to use RACK1 expression as marker to evaluate immunotoxicity of hormone-active substances. Because of the existence of close interconnections between the different steroid hormone receptors with overlapping ligand specificities and signaling...
Latest Results for Archives of Toxicology
19h
Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart [Protein Structure and Folding]
We have previously demonstrated that ischemia/reperfusion (I/R) impairs endoplasmic reticulum (ER)-based protein folding in the heart and thereby activates an unfolded protein response (UPR) sensor and effector, activated transcription factor 6α (ATF6). ATF6 then induces mesencephalic astrocyte–derived neurotrophic factor (MANF), an ER-resident protein with no known structural homologs and unclear ER function. To determine MANF’s function in the heart in vivo, here we developed a cardiomyocyte-specific...
JBC Papers in Press
4h
Sphingosine kills bacteria by binding to cardiolipin [Microbiology]
Sphingosine is a long-chain sphingoid base that has been shown to have bactericidal activity against many pathogens, including Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. We have previously demonstrated that sphingosine is present in nasal, tracheal, and bronchial epithelial cells and constitutes a central element of the defense of the airways against bacterial pathogens. Here, using assorted lipid-binding and cell biology assays, we demonstrate that exposing P. aeruginosa...
JBC Papers in Press
4h
Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation [Signal Transduction]
Increased permeability of vascular lung tissues is a hallmark of acute lung injury and is often caused by edemagenic insults resulting in inflammation. Vascular endothelial (VE)-cadherin undergoes internalization in response to inflammatory stimuli and is recycled at cell adhesion junctions during endothelial barrier re-establishment. Here, we hypothesized that phospholipase D (PLD)-generated phosphatidic acid (PA) signaling regulates VE-cadherin recycling and promotes endothelial barrier recovery...
JBC Papers in Press
4h
Swallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal Model
Abstract Feeding difficulties are especially prevalent in preterm infants, although the mechanisms driving these difficulties are poorly understood due to a lack of data on healthy infants. One potential mechanism of dysphagia in adults is correlated with bolus volume. Yet, whether and how bolus volume impacts swallow safety in infant feeding is unknown. A further complication for safe infant swallowing is recurrent laryngeal nerve (RLN) injury due to patent ductus arteriosus...
Dysphagia
4h
Thyroid function and lipid profile in euthyroid adults: the TCLSIH cohort study
Abstract Purpose Thyroid hormones (THs) have multiple effects on lipid synthesis, mobilization, and degradation, suggesting that THs may affect the development of dyslipidemia. However, prospective studies on the association between serum THs levels and incident dyslipidemia in euthyroid subjects are limited. Therefore, we conducted a cohort study (~5-year follow-up period, median: 3.0 years) to explore whether THs can affect incident...
Latest Results for Endocrine
4h
High rate incidence of post-surgical adverse events in patients with low-risk papillary thyroid cancer who did not accept active surveillance
Abstract Purpose To describe the outcomes and the incidence of adverse events following active surveillance (AS) versus immediate surgery in patients with low-risk papillary thyroid carcinoma (PTC). Methods We prospectively evaluated 286 patients who attended the Hospital de Clínicas, with a single thyroid nodule <1.5 cm classified as Bethesda category...
Latest Results for Endocrine
4h
MIlitary Combat Mental Health Framework
This paper describes a framework for understanding military combat mental health based on the possible mental ill-health consequences of exposure to ‘potential trauma events’ for members of the armed forces and after their military service as veterans. It uses a life course approach that maps an individual’s mental well-being against four ‘states’: fit, reacting, injured and ill. It then considers five categories of factors that influence the risk of mental illness from this exposure based on research...
Journal of the Royal Army Medical Corps Online First
5h
Stromal platelet-derived growth factor receptor-{beta} signaling promotes breast cancer metastasis in the brain
Platelet-derived growth factor receptor-beta (PDGFRβ) is a receptor tyrosine kinase found in cells of mesenchymal origin such as fibroblasts and pericytes. Activation of this receptor is dependent on paracrine ligand induction, and its preferred ligand PDGFB is released by neighboring epithelial and endothelial cells. While expression of both PDGFRβ and PDGFB has been noted in patient breast tumors for decades, how PDGFB-to-PDGFRβ tumor-stromal signaling mediates breast cancer (BC) initiation, progression,...
Cancer Research Online First Articles
5h
Emerging role of PTEN loss in evasion of the immune response to tumours
British Journal of Cancer, Published online: 24 April 2020; doi:10.1038/s41416-020-0834-6Emerging role of PTEN loss in evasion of the immune response to tumours
British Journal of Cancer - Issue - nature.com science feeds
5h
Emerging role of PTEN loss in evasion of the immune response to tumours
British Journal of Cancer - Issue - nature.com science feeds
8h
Liver X receptor activation induces podocyte injury via inhibiting autophagic activity
Abstract Podocyte injury plays a key role in the occurrence and development of kidney diseases. Decreased autophagic activity in podocyte is closely related to its injury and the occurrence of proteinuria. Liver X receptors (LXRs), as metabolic nuclear receptors, participate in multiple pathophysiological processes and express in several tissues, including podocytes. Although the functional roles of LXRs in the liver, adipose tissue and intestine are well established; however,...
Latest Results for Journal of Physiology and Biochemistry
5h
Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents
Planta MedDOI: 10.1055/a-1148-9000Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional...
Planta Medica
5h
Anti-biofilm and Virulence Factor-Reducing Activities of Essential Oils and Oil Components as a Possible Option for Bacterial Infection Control
Planta MedDOI: 10.1055/a-1147-4671Pathogenic biofilm-associated bacteria that adhere to biological or nonbiological surfaces are a big challenge to the healthcare and food industries. Antibiotics or disinfectants often fail in an attempt to eliminate biofilms from those surfaces. Based on selected experimental research, this review deals with the potential biofilm-inhibiting, virulence factor-reducing, and biofilm-eradicating activities of essential oils and single essential oil compounds using Staphylococcus...
Planta Medica
5h
Where Is Bacosine in Commercially Available Bacopa monnieri?
Planta MedDOI: 10.1055/a-1137-4289 Bacopa monnieri is an Ayurvedic plant with rising interest in the pharmacological effects of its extract and constituents, including flavonoids, saponins, and triterpenes such as cucurbitacins, betulinic acid, and bacosine. The latter two compounds are isomeric 3-hydroxy lupenoic acids, which vary only in the arrangement of the carboxylic acid group and the methyl group at C-27 and C-28 and the orientation of the hydroxy group at C-3. In this study, we...
Planta Medica
5h
Amyloid beta peptide is an endogenous negative allosteric modulator of leptin receptor
Introduction: Metabolic dysfunction is now recognized as a pivotal component of Alzheimer’s disease (AD), the most common dementia worldwide. However, the precise molecular mechanisms linking metabolic dysfunction to AD remain elusive. Objective: Here we investigated the direct impact of soluble oligomeric amyloid-beta (Aβ) peptides, the main molecular hallmark of AD, on leptin system, a major component of central energy metabolism regulation. Methods: We developed a new Time-Resolved Fluorescence...
NEN : Last 20 articles
5h
THE CUT-OFF LIMITS OF GH RESPONSE TO INSULIN TOLERANCE TEST RELATED TO BODY MASS INDEX FOR THE DIAGNOSIS OF ADULT GH DEFICIENCY
Introduction: The diagnosis of GH deficiency (GHD) in adults is based on a reduced GH response to provocative tests, such as the insulin tolerance test (ITT) and the GHRH + arginine (ARG) test. However, the cut-off limits of peak GH response in lean subjects are not reliable in obese patients; this is noteworthy since adult GHD is often associated with obesity. To date there are no cut-offs to ITT related to body mass index (BMI). Objective: Aim of this study was to evaluate the diagnostic cut-offs...
NEN : Last 20 articles
5h
Late effects of parasellar lesion treatment: hypogonadism and infertility
ABSTRACT Central hypogonadism, also defined as hypogonadotropic hypogonadism, is a recognized complication of hypothalamic-pituitary-gonadal axis damage following treatment of sellar and parasellar masses. In addition to radiotherapy and surgery, CTLA4-blocking antibodies and alkylating agents such as temozolomide can also lead to hypogonadism, through different mechanisms. Central hypogonadism in boys and girls may lead to pubertal delay or arrest, impairing full development of the genitalia and...
NEN : Last 20 articles
5h
Sex Differences in the Regulation of Vasopressin and Oxytocin Secretion in Bile Duct Ligated Rats
Introduction: Hyponatremia due to elevated arginine vasopressin (AVP) secretion increases mortality in liver failure patients. No previous studies have addressed sex differences in hyponatremia in liver failure animal models. Objective: This study addressed this gap in our understanding of the potential sex differences in hyponatremia associated with increased AVP secretion. Methods: This study tested the role of sex in the development of hyponatremia using adult male, female, and ovariectomized...
NEN : Last 20 articles
5h

Management and prognosis of localized duodenal neuroendocrine neoplasms
Introduction: The characteristics, prognostic factors, and management of duodenal neuroendocrine neoplasms (dNEN) are ill-defined given their rarity. Whether non-surgical management could be appropriate in good-prognosis non-metastatic dNEN, as for pancreatic NEN (pNEN), is unknown. We aimed to describe the management and prognosis of non-metastatic dNEN patients. Methods: All consecutive patients with non-metastatic dNEN managed between 1981 and 2018 in two expert centers were included. Recurrence-free...
NEN : Last 20 articles
5h
Prospective Evaluation of the NETest as a Liquid Biopsy for Gastroenteropancreatic and Bronchopulmonary Neuroendocrine Tumours: An ENETS Centre of Excellence Experience
Background: There is a substantial unmet clinical need for an accurate and effective blood biomarker for neuroendocrine neoplasms (NEN). We therefore evaluated, under real-world conditions, the clinical utility of the NETest as a liquid biopsy in an ENETS Centre of Excellence and compared its utility with chromogranin A (CgA). Methods Cohorts: Gastroenteropancreatic (GEP)-NEN (n=253), bronchopulmonary (BP)-NEN (n=64), thymic NEN (n=1), colon cancer (n=37), NSCLC (n=63), benign lung disease (n=59)...
NEN : Last 20 articles
5h

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