Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.

Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.:

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Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.

Cell Prolif. 2020 Apr 07;:e12804

Authors: Peng FZ, Fan J, Ge TT, Liu QQ, Li BJ

Abstract

Major depressive disorder takes at least 3 weeks for clinical anti-depressants, such as serotonin selective reuptake inhibitors, to take effect, and only one-third of patients remit. Ketamine, a kind of anaesthetic, can alleviate symptoms of major depressive disorder patients in a short time and is reported to be effective to treatment-resistant depression patients. The rapid and strong anti-depressant-like effects of ketamine cause wide concern. In addition to ketamine, caloric restriction and sleep deprivation also elicit similar rapid anti-depressant-like effects. However, mechanisms about the rapid anti-depressant-like effects remain unclear. Elucidating the mechanisms of rapid anti-depressant effects is the key to finding new therapeutic targets and developing therapeutic patterns. Therefore, in this review we summarize potential molecular and cellular mechanisms of rapid anti-depressant-like effects based on the pre-clinical and clinical evidence, trying to provide new insight into future therapy.

PMID: 32266752 [PubMed - as supplied by publisher]