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J Clin Sleep Med. 2020 Apr 08;:
Authors: Xu J, Wei Z, Wang X, Li X, Wang W
Abstract
STUDY OBJECTIVES: To undertake a meta-analysis of literatures comparing the prevalence of cardio- and cerebrovascular comorbidities between overlap syndrome (OS) patients and chronic obstructive pulmonary disease (COPD) or obstructive sleep apnea (OSA) patients.
METHODS: Studies about the cardio- and cerebrovascular disease of OS were searched among several electronic databases from the time of database construction to June, 2019. Two independent reviewers performed the process of study screening, quality assessment and data extraction. Meta-analysis of odds ratios was carried out by RevMan5.3 under either fixed- or random- effects models. Sensitivity analysis was conducted to examine the robustness of pooled outcome.
RESULTS: A total of 17 articles were included. Compared with COPD/OSA, OS significantly increased the risk of developing hypertension (OS vs. COPD: OR=1.94, 95% CI [1.49, 2.52]; OS vs. OSA: OR=2.05, 95% CI [1.57, 2.68]) and pulmonary hypertension (OS vs. COPD: OR=2.96, 95% CI [1.30, 6.77]; OS vs. OSA: OR=5.93, 95% CI [1.84, 18.42]). There was no significant difference in the prevalence of coronary heart disease (OR=1.19，95%CI[0.67,2.11]) and cerebrovascular disease (OR=2.43, 95%CI[0.81, 7.31]) between COPD and OS patients. However, the sensitivity analysis showed that the pooled outcome of the comparison of pulmonary arterial pressure between OS and COPD patients was not stable.
CONCLUSIONS: OS significantly increased cardiovascular risk including the prevalence of hypertension and pulmonary hypertension. However, since the pooled outcome about pulmonary arterial pressure was not stable, further studies were still required.
PMID: 32267225 [PubMed - as supplied by publisher]
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