Brain Sciences, Vol. 10, Pages 356: A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis Brain Sciences doi: 10.3390/brainsci10060356 Authors: Catherine Koukoulitsa Eleni Chontzopoulou Sofia Kiriakidi Andreas G. Tzakos Thomas Mavromoustakos Multiple sclerosis (MS) is a serious central nervous system (CNS) disease responsible for disability problems and deterioration of the quality of life. Several approaches have been applied...
Mon Jun 08, 2020 03:00
Brain Sciences, Vol. 10, Pages 355: Cerebrospinal Fluid Findings of 36 Adult Patients with Autism Spectrum Disorder Brain Sciences doi: 10.3390/brainsci10060355 Authors: Kimon Runge Ludger Tebartz van Tebartz van Elst Simon Maier Kathrin Nickel Dominik Denzel Miriam Matysik Hanna Kuzior Tilman Robinson Thomas Blank Rick Dersch Katharina Domschke Dominique Endres Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by difficulties...
Mon Jun 08, 2020 03:00
Brain Sciences, Vol. 10, Pages 354: Can Trauma Condition Vulnerable Individuals to Develop Catatonic Symptoms? Brain Sciences doi: 10.3390/brainsci10060354 Authors: Jackson Hortenstine Nagy Youssef Limited research has been done on the risk and predisposing factors of catatonic symptoms induced by traumatic events. There seem to be two types or constructs of conditioning that predispose an individual to catatonic symptoms in response to traumatic events: external conditioning and...
Mon Jun 08, 2020 03:00
Brain Sciences, Vol. 10, Pages 353: Brain Network Underlying Executive Functions in Gambling and Alcohol Use Disorders: An Activation Likelihood Estimation Meta-Analysis of fMRI Studies Brain Sciences doi: 10.3390/brainsci10060353 Authors: Alessandro Quaglieri Emanuela Mari Maddalena Boccia Laura Piccardi Cecilia Guariglia Anna Maria Giannini Background: Neuroimaging and neuropsychological studies have suggested that common features characterize both Gambling Disorder...
Sun Jun 07, 2020 03:00
Brain Sciences, Vol. 10, Pages 351: Adaptive Skills in FXS: A Review of the Literature and Evaluation of the PEDI-Computer Adaptive Test (PEDI-CAT) to Measure Adaptive Skills Brain Sciences doi: 10.3390/brainsci10060351 Authors: Lisa Cordeiro Adrienne Villagomez Deanna Swain Sophia Deklotz Nicole Tartaglia As adaptive skills (AS) are dynamic and may indicate the success of an intervention, they are a common domain measured in clinical trials. Typical interview tools for measuring...
Sat Jun 06, 2020 03:00
Brain Sciences, Vol. 10, Pages 352: The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG Study Brain Sciences doi: 10.3390/brainsci10060352 Authors: Mina Kheirkhah Philipp Baumbach Lutz Leistritz Stefan Brodoehl Theresa Götz Ralph Huonker Otto W. Witte Carsten M. Klingner The processing of emotions in the human brain is an extremely complex process that extends...
Sat Jun 06, 2020 03:00
Brain Sciences, Vol. 10, Pages 350: From Correlational Signs to Markers. Current Trends in Neuroelectric Research on Visual Attentional Processing Brain Sciences doi: 10.3390/brainsci10060350 Authors: Alberto Zani Traditionally, electroencephalographic (EEG) and event-related brain potentials (ERPs) research on visual attentional processing attempted to account for mental processes in conceptual terms without reference to the way in which they were physically realized by the anatomical...
Sat Jun 06, 2020 03:00
Brain Sciences, Vol. 10, Pages 349: Complex Repetitive Discharges: A Sign of Motor Axonal Reinnervation? Brain Sciences doi: 10.3390/brainsci10060349 Authors: Andreas Posa Izabela Niśkiewicz Alexander Emmer Frank Hanisch Malte E. Kornhuber Complex repetitive discharges (CRDs) are poorly understood phenomena in needle electromyography (EMG) recordings. The data presented here suggest that CRDs may mainly be a sign of motor unit reinnervation. EMG “video”...
Fri Jun 05, 2020 03:00
Brain Sciences, Vol. 10, Pages 348: Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation Brain Sciences doi: 10.3390/brainsci10060348 Authors: Rodolfo Thome Alexandra Boehm Larissa Lumi Watanabe Ishikawa Giacomo Casella Jaqueline Munhoz Bogoljub Ciric Guang-Xian Zhang Abdolmohamad Rostami Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) are...
Fri Jun 05, 2020 03:00
Cancers, Vol. 12, Pages 1498: Flavonoids in Cancer Metastasis Cancers doi: 10.3390/cancers12061498 Authors: Alena Liskova Lenka Koklesova Marek Samec Karel Smejkal Samson Mathews Samuel Elizabeth Varghese Mariam Abotaleb Kamil Biringer Erik Kudela Jan Danko Mehdi Shakibaei Taeg Kyu Kwon Dietrich Büsselberg Peter Kubatka Metastasis represents a serious complication in the treatment of cancer. Flavonoids are plant secondary metabolites exerting various...
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1499: Detection of Circulating Tumor Plasma Cells in Monoclonal Gammopathies: Methods, Pathogenic Role, and Clinical Implications Cancers doi: 10.3390/cancers12061499 Authors: Luzalba Sanoja-Flores Juan Flores-Montero Martín Pérez-Andrés Noemí Puig Alberto Orfao Cancer dissemination and distant metastasis most frequently require the release of tumor cells into the blood circulation, both in solid tumors and most hematological malignancies, including...
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1495: Improved Outcome Prediction for Appendiceal Pseudomyxoma Peritonei by Integration of Cancer Cell and Stromal Transcriptional Profiles Cancers doi: 10.3390/cancers12061495 Authors: Claudio Isella Marco Vaira Manuela Robella Sara Erika Bellomo Gabriele Picco Alice Borsano Andrea Mignone Consalvo Petti Roberta Porporato Alexandra Ambra Ulla Alberto Pisacane Anna Sapino Michele De Simone Enzo Medico In recent years, cytoreductive...
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1494: What Is the Role of Imaging in Cancers? Cancers doi: 10.3390/cancers12061494 Authors: Laura Evangelista Stefano Fanti In the issue entitled “Role of Medical Imaging in Cancers”, 33 papers have been collected (23 original articles, 8 reviews, 1 brief report and 1 perspective) [...]
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1496: Prognostic Significance of CHIP and RIPK3 in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12061496 Authors: Jisup Kim Joon-Yong Chung Young Soo Park Se Jin Jang Hyeong Ryul Kim Chang-Min Choi Joon Seon Song RIPK3 is a key regulator of necroptosis, which plays a double-edged sword role in tumor progression. CHIP is an E3 ubiquitin ligase that regulates necroptosis by degrading RIPK3. Here, we investigated the prognostic value of...
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1497: Diagnosis and Treatment of Primary Cutaneous B-Cell Lymphomas: State of the Art and Perspectives Cancers doi: 10.3390/cancers12061497 Authors: Maëlle Dumont Maxime Battistella Caroline Ram-Wolff Martine Bagot Adèle de Masson Primary cutaneous B-cell lymphomas are rare entities that develop primarily in the skin. They constitute a heterogeneous group that represents around a quarter of primary cutaneous lymphomas. The 2018 update of the World...
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1493: Diffusion-Weighted Imaging in Oncology: An Update Cancers doi: 10.3390/cancers12061493 Authors: Carmelo Messina Rodolfo Bignone Alberto Bruno Antonio Bruno Federico Bruno Marco Calandri Damiano Caruso Pietro Coppolino Riccardo De Robertis Francesco Gentili Irene Grazzini Raffaele Natella Paola Scalise Antonio Barile Roberto Grassi Domenico Albano Albano To date, diffusion weighted imaging (DWI) is included...
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1492: Development of a VLP-Based Vaccine Displaying an xCT Extracellular Domain for the Treatment of Metastatic Breast Cancer Cancers doi: 10.3390/cancers12061492 Authors: Valeria Rolih Jerri Caldeira Elisabetta Bolli Ahmad Salameh Laura Conti Giuseppina Barutello Federica Riccardo Jolanda Magri Alessia Lamolinara Karla Parra Paloma Valenzuela Giulio Francia Manuela Iezzi Federica Pericle Federica Cavallo Metastatic breast...
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1491: Hepatocellular Carcinoma Emergence in Diabetic Mice with Non-Alcoholic Steatohepatitis Depends on Diet and Is Delayed in Liver Exhibiting an Active Immune Response Cancers doi: 10.3390/cancers12061491 Authors: Mélanie Simoes Eugénio Muhammad Farooq Sarah Dion Christelle Devisme Céline Raguenes-Nicol Claire Piquet-Pellorce Michel Samson Marie-Thérèse Dimanche-Boitrel Jacques Le Seyec The increase of the sedentary lifestyle and high-calorie...
Mon Jun 08, 2020 03:00
Cancers, Vol. 12, Pages 1490: Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons Cancers doi: 10.3390/cancers12061490 Authors: Eirini Terpsi Vitti Andrzej Kacperek Jason L. Parsons The response of head and neck squamous cell carcinoma (HNSCC) to radiotherapy depends on human papillomavirus type 16 (HPV) status, and where improved outcome and survival is observed in HPV-positive...
Sun Jun 07, 2020 03:00
Cancers, Vol. 12, Pages 1489: c-Src and EGFR Inhibition in Molecular Cancer Therapy: What Else Can We Improve? Cancers doi: 10.3390/cancers12061489 Authors: Stefania Belli Daniela Esposito Alberto Servetto Ada Pesapane Luigi Formisano Roberto Bianco The proto-oncogene c-Src is a non-receptor tyrosine kinase playing a key role in many cellular pathways, including cell survival, migration and proliferation. c-Src de-regulation has been observed in several cancer types, making...
Sun Jun 07, 2020 03:00
Cancers, Vol. 12, Pages 1488: First-In-Class CD13-Targeted Tissue Factor tTF-NGR in Patients with Recurrent or Refractory Malignant Tumors: Results of a Phase I Dose-Escalation Study Cancers doi: 10.3390/cancers12061488 Authors: Christoph Schliemann Mirjam Gerwing Hauke Heinzow Saliha Harrach Christian Schwöppe Moritz Wildgruber Anna A. Hansmeier Linus Angenendt Andrew F. Berdel Ursula Stalmann Björna Berning Karsten Kratz-Albers Kristina Middelberg-Bisping...
Sun Jun 07, 2020 03:00
Cancers, Vol. 12, Pages 1486: Liver Tumor Burden in Pancreatic Neuroendocrine Tumors: CT Features and Texture Analysis in the Prediction of Tumor Grade and 18F-FDG Uptake Cancers doi: 10.3390/cancers12061486 Authors: Alessandro Beleù Giulio Rizzo Riccardo De Robertis Alessandro Drudi Gregorio Aluffi Chiara Longo Alessandro Sarno Sara Cingarlini Paola Capelli Luca Landoni Aldo Scarpa Claudio Bassi Mirko D’Onofrio Pancreatic neuroendocrine tumors (p-NETs)...
Sun Jun 07, 2020 03:00
Cancers, Vol. 12, Pages 1487: Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations Cancers doi: 10.3390/cancers12061487 Authors: Kathy-Ann Secker Lukas Bruns Hildegard Keppeler Johan Jeong Thomas Hentrich Julia M. Schulze-Hentrich Barbara Mankel Falko Fend Dominik Schneidawind Corina Schneidawind Mixed lineage leukemia (MLL) (KMT2A) rearrangements (KMT2Ar) play a crucial role in leukemogenesis....
Sun Jun 07, 2020 03:00
Cancers, Vol. 12, Pages 1484: TGFα Promotes Chemoresistance of Malignant Pleural Mesothelioma Cancers doi: 10.3390/cancers12061484 Authors: Staumont Jamakhani Costa Vandermeers Sriramareddy Redouté Mascaux Delvenne Hubert Safari Willems Background: There is no standard chemotherapy for refractory or relapsing malignant pleural mesothelioma (MPM). Our previous reports nevertheless indicated that a combination of an anthracycline (doxorubicin) and...
Sat Jun 06, 2020 03:00
Cancers, Vol. 12, Pages 1485: T1 Glottic Cancer: Does Anterior Commissure Involvement Worsen Prognosis? Cancers doi: 10.3390/cancers12061485 Authors: Giuditta Mannelli Lara Valentina Comini Roberto Santoro Alessandra Bettiol Alfredo Vannacci Isacco Desideri Pierluigi Bonomo Cesare Piazza Radiotherapy (RT) and transoral laser microsurgery (TLM) represent the main treatment modalities for early glottic carcinoma. Local failure is notoriously more frequent in T1b glottic...
Sat Jun 06, 2020 03:00
Cancers, Vol. 12, Pages 1482: Detection of Colorectal Cancer and Advanced Adenoma by Liquid Biopsy (Decalib Study): The ddPCR Challenge Cancers doi: 10.3390/cancers12061482 Authors: Audelaure Junca Gaëlle Tachon Camille Evrard Claire Villalva Eric Frouin Lucie Karayan-Tapon David Tougeron Background: In most countries, participation in colorectal cancer (CRC) screening programs with the immunological fecal occult blood test (iFOBT) is low. Mutations of RAS and BRAF...
Sat Jun 06, 2020 03:00
Cancers, Vol. 12, Pages 1481: Shallow Whole-Genome Sequencing from Plasma Identifies FGFR1 Amplified Breast Cancers and Predicts Overall Survival Cancers doi: 10.3390/cancers12061481 Authors: Chantal Bourrier Jean-Yves Pierga Laura Xuereb Hélène Salaun Charlotte Proudhon Michael R. Speicher Jelena Belic Ellen Heitzer Brian Paul Lockhart Nolwen Guigal-Stephan Background: Focal amplification of fibroblast growth factor receptor 1 (FGFR1) defines a subgroup of...
Sat Jun 06, 2020 03:00
Cancers, Vol. 12, Pages 1483: Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression Cancers doi: 10.3390/cancers12061483 Authors: Anqi Xiong Ananya Roy Argyris Spyrou Holger Weishaupt Voichita D. Marinescu Tommie Olofsson Ola Hermanson Fredrik J. Swartling Karin Forsberg-Nilsson Pseudokinases, comprising 10% of the human kinome, are emerging as regulators of canonical kinases and their functions...
Sat Jun 06, 2020 03:00
Cancers, Vol. 12, Pages 1480: A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles Cancers doi: 10.3390/cancers12061480 Authors: Elisa Rodrigues Sousa Eugenio Zoni Sofia Karkampouna Federico La Manna Peter C. Gray Marta De Menna Marianna Kruithof-de Julio Cripto is a small glycosylphosphatidylinisitol (GPI)-anchored and secreted oncofetal protein that plays important roles in regulating...
Fri Jun 05, 2020 03:00
Cancers, Vol. 12, Pages 1479: Oncogenic Properties of the EBV ZEBRA Protein Cancers doi: 10.3390/cancers12061479 Authors: Diego Germini Fatimata Bintou Sall Anna Shmakova Wiels Dokudovskaya Drouet Vassetzky Epstein Barr Virus (EBV) is one of the most common human herpesviruses. After primary infection, it can persist in the host throughout their lifetime in a latent form, from which it can reactivate following specific stimuli. EBV reactivation is triggered by transcriptional...
Fri Jun 05, 2020 03:00
Cancers, Vol. 12, Pages 1476: Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells Cancers doi: 10.3390/cancers12061476 Authors: Mingtian Che Soo-Mi Kweon Jia-Ling Teo Yate-Ching Yuan Laleh G. Melstrom Richard T. Waldron Aurelia Lugea Raul A. Urrutia Stephen J. Pandol Keane K. Y. Lai Background: Although cyclic AMP-response element binding protein-binding protein (CBP)/β-catenin signaling is known...
Fri Jun 05, 2020 03:00
Cancers, Vol. 12, Pages 1477: Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers12061477 Authors: Assunta Sellitto Ylenia D’Agostino Elena Alexandrova Jessica Lamberti Giovanni Pecoraro Domenico Memoli Domenico Rocco Elena Coviello Giorgio Giurato Giovanni Nassa Roberta Tarallo Alessandro Weisz Francesca Rizzo Estrogen receptors (ERα and ERβ) are ligand-activated transcription...
Fri Jun 05, 2020 03:00
Cancers, Vol. 12, Pages 1478: Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma Cancers doi: 10.3390/cancers12061478 Authors: Huiyuan Zhang Lin Qi Yuchen Du L. Frank Huang Frank K. Braun Mari Kogiso Yanling Zhao Can Li Holly Lindsay Sibo Zhao Sarah G. Injac Patricia A. Baxter Jack M. Su Clifford Stephan Charles Keller Kent A. Heck Akdes Harmanci Arif O. Harmanci Jianhua Yang Tiemo J. Klisch...
Fri Jun 05, 2020 03:00
Cancers, Vol. 12, Pages 1475: Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 Antibodies Cancers doi: 10.3390/cancers12061475 Authors: Mariacarmela Santarpia Andrés Aguilar Imane Chaib Andrés Felipe Cardona Sara Fancelli Fernando Laguia Jillian Wilhelmina Paulina Bracht Peng Cao Miguel Angel Molina-Vila Niki Karachaliou Rafael Rosell Treatment of advanced (metastatic) non-small-cell lung cancer (NSCLC) is currently mainly based...
Fri Jun 05, 2020 03:00
Cancers, Vol. 12, Pages 1474: EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region Cancers doi: 10.3390/cancers12061474 Authors: Victor M. Baart Chayenne van Duijn Sylvia L. van Egmond Willem A. Dijckmeester Jeroen C. Jansen Alexander L. Vahrmeijer Cornelis F. M. Sier Danielle Cohen R0 resection is paramount in cutaneous squamous cell carcinoma (CSCC) and head and neck squamous cell...
Fri Jun 05, 2020 03:00
Cancers, Vol. 12, Pages 1473: BCMA-Targeting Therapy: Driving a New Era of Immunotherapy in Multiple Myeloma Cancers doi: 10.3390/cancers12061473 Authors: Shih-Feng Cho Liang Lin Lijie Xing Yuyin Li Tengteng Yu Kenneth C Anderson Yu-Tzu Tai The treatment of multiple myeloma (MM) has entered into a new era of immunotherapy. Novel immunotherapies will significantly improve patient outcome via simultaneously targeting malignant plasma cell (PC) and reversing immunocompromised...
Fri Jun 05, 2020 03:00
Cells, Vol. 9, Pages 1424: Glycogen Synthase Kinase-3β Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4+ T Lymphocytes Cells doi: 10.3390/cells9061424 Authors: Cheng-Chieh Tsai Chin-Kun Tsai Po-Chun Tseng Chiou-Feng Lin Chia-Ling Chen Cytokines are the major immune regulators secreted from activated CD4+ T lymphocytes that activate adaptive immunity to eradicate nonself cells, including pathogens, tumors, and allografts....
Mon Jun 08, 2020 03:00
Cells, Vol. 9, Pages 1425: Megalencephalic Leukoencephalopathy with Subcortical Cysts Disease-Linked MLC1 Protein Favors Gap-Junction Intercellular Communication by Regulating Connexin 43 Trafficking in Astrocytes Cells doi: 10.3390/cells9061425 Authors: Angela Lanciotti Maria Stefania Brignone Marcello Belfiore Sandra Columba-Cabezas Cinzia Mallozzi Olimpia Vincentini Paola Molinari Tamara Corinna Petrucci Sergio Visentin Elena Ambrosini Astrocytes, the most...
Mon Jun 08, 2020 03:00
Cells, Vol. 9, Pages 1423: Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization Cells doi: 10.3390/cells9061423 Authors: Artem V. Luzhin Bogdan Avanesyan Artem K. Velichko Victoria O. Shender Natalia Ovsyannikova Georgij P. Arapidi Polina V. Shnaider Nadezhda V. Petrova Igor I. Kireev Sergey V. Razin Omar L. Kantidze Hyperthermia has been used as an adjuvant treatment for radio- and chemotherapy...
Mon Jun 08, 2020 03:00
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