Abstract Purpose PATRO adults is an ongoing, multicenter, observational, post-marketing surveillance study aimed at investigating the long-term safety (primary endpoint) and effectiveness (secondary endpoint) of the recombinant human growth hormone (rhGH) Omnitrope® during routine clinical practice. This report describes data from Italian participants in PATRO Adults with growth hormone deficiency (GHD), up to August 2017. ...
Sun Jun 07, 2020 03:00
Abstract Purpose To evaluate the changes in ocular biomechanical properties in active moderate-to-severe Graves’ orbitopathy (GO) after intravenous glucocorticoids (IVGCs), and to clarify correlations between clinical findings and ocular biomechanical properties. Methods A prospective study. A total of 20 consecutive GO patients and 20 age- and sex-matched...
Sun Jun 07, 2020 03:00
Unfortunately, the 5th author name has been publisehd incorrectly in the original publication. The complete correct name is given below.
Fri Jun 05, 2020 03:00
Abstract Purpose In this study, antihyperglycaemic and level of gene expression of glucose transporters in alloxan-induced diabetic rats administered aqueous extract of S. macrocarpon leaves were assessed. Method and results Diabetes was induced by a single intraperitoneal (I.P) injection of freshly prepared alloxan. The animals were divided into six...
Fri Jun 05, 2020 03:00
Publication date: Available online 8 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Lukas Hauer, Petra Seidlová, Vlasta Merglová, Daniel Hrusak, Hana Böhmová, Petr Posta, Jiri Gencur, Jan Netolicky
Mon Jun 08, 2020 22:29
Publication date: Available online 8 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Min Ji Kim, Dong Nyeok Jeon, Jong Woo Choi, Sung Chan Kim
Mon Jun 08, 2020 22:29
Publication date: June 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 6Author(s):
Sat Jun 06, 2020 14:12
Publication date: June 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 6Author(s):
Sat Jun 06, 2020 14:12
Publication date: June 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 6Author(s):
Sat Jun 06, 2020 14:12
Abstract Patients with pediatric cancers such as neuroblastoma (NB) are often unresponsive to checkpoint blockade immunotherapy. One major factor in pediatric tumor resistance to immunotherapy is considered to be the low mutation rate of pediatric tumors. Another factor may be the overexpression of additional inhibitory pathways. While analyzing the RNA-sequencing database TARGET, we found that human NB tumors overexpress immune checkpoint molecule CD200. To determine its significance...
Mon Jun 08, 2020 03:00
Abstract The cross-talk between cancer cells and monocyte-derived alveolar macrophages (Mo-AMs) promotes non-small cell lung carcinoma (NSCLC) progression. In this study, we report that both cancer cells and Mo-AMs robustly express beta 3-adrenergic receptor (ADRB3) in NSCLC. ADRB3 supports lung cancer cells proliferation and promotes chronic inflammation. Genetic and pharmacologic inhibition of ADRB3 reverses tumor growth and inflammation in mouse. Furthermore, we demonstrate...
Mon Jun 08, 2020 03:00
Abstract Preclinical assessment of novel therapies to fight cancer requires models that reflect the human physiology and immune response. Here, we established an in vitro three-dimensional (3D) reconstructed organotypic human melanoma-in-skin (Mel-RhS) model to investigate cellular and molecular features of tumor formation over a period of 6 weeks. Tumor nests developed over time at the epidermal–dermal junction and spread towards the dermis, in places disrupting the basement...
Sun Jun 07, 2020 03:00
Abstract Background Perturbation of the CDK4/6 pathway is frequently observed in advanced bladder cancer. We investigated the potential of targeting this pathway alone or in combination with chemotherapy or immunotherapy as a therapeutic approach for the treatment of bladder cancer Methods The genetic alterations of the CDK4/6 pathway in bladder cancer...
Sat Jun 06, 2020 03:00
Abstract Due to its high ability to disseminate, ovarian cancer remains one of the largest threats to women’s health, worldwide. Evidence showed that the immune cells infiltrating the tumor microenvironment are crucial in mediating metastasis. Therefore, it is necessary to understand which types of immune cells are involved in metastasis, and to determine the mechanisms by which they influence the process. By immunohistochemistry, we found that higher concentrations of intratumoral...
Fri Jun 05, 2020 03:00
Abstract AKT-inhibition is a promising approach to improve T cell therapies; however, its effect on CD4+ T cells is insufficiently explored. Previously, we and others showed that AKT-inhibition during ex vivo CD8+ T cell expansion facilitates the generation of polyfunctional T cells with stem cell memory-like traits. However, most therapeutic T cell products are generated from lymphocytes, containing CD4+ T cells that can affect CD8+ T cells dependent on the Th-subset. Here, we...
Fri Jun 05, 2020 03:00
Abstract Target expression heterogeneity and the presence of an immunosuppressive microenvironment can hamper severely the efficiency of immunotherapeutic approaches. We have analyzed the potential to encounter and overcome such conditions by a combinatory two-target approach involving a bispecific antibody retargeting T cells to tumor cells and tumor-directed antibody-fusion proteins with costimulatory members of the B7 and TNF superfamily. Targeting the tumor-associated antigens...
Fri Jun 05, 2020 03:00
This method describes the steps to improve the quality and quantity of sequence data that can be obtained from formalin-fixed paraffin-embedded (FFPE) RNA samples. We describe the methodology to more accurately assess the quality of FFPE-RNA samples, prepare sequencing libraries, and analyze the data from FFPE-RNA samples.
Mon Jun 08, 2020 22:15
We present an optimized tandem mass tag (TMT) labeling protocol that includes detailed information for each of the following steps: protein extraction, quantification, precipitation, digestion, labeling, submission to a proteomics facility, and data analyses.
Mon Jun 08, 2020 21:15
Conventional BODIPY conjugates can be used for live-cell single-molecule localization microscopy (SMLM) through exploitation of their transiently forming, red-shifted ground state dimers. We present an optimized SMLM protocol to track and resolve subcellular neutral lipids and fatty acids in living mammalian and yeast cells at the nanoscopic length scale.
Mon Jun 08, 2020 20:14
The presented diagnostic FL-DNA kit is a time-saving and user-friendly method to determine the reliable probability of the presence of colorectal cancer lesions.
Mon Jun 08, 2020 20:00
Presented here is a protocol of tracheal intubation over an intubating tube introducer using a rigid tube for laryngoscopy with an attached light source. The main characteristics of this maneuver are the retromolar approach and the use of the thyroid cartilage as a landmark while advancing the rigid tube.
Sat Jun 06, 2020 21:05
This manuscript describes a genome-scale cell-based screening approach to identify extracellular receptor-ligand interactions.
Sat Jun 06, 2020 21:00
This article shows how to perform the external cephalic version (ECV) by two experienced obstetricians in the obstetric operating room in the presence of an anesthesiologist and a midwife. The ECV is carried out with analgesia and tocolysis. Two attempts are made under ultrasonography control.
Sat Jun 06, 2020 20:04
Oncologically safe left pancreatectomy requires radical resection (R0), Gerota’s (perirenal) fascia resection, and adequate lymph node dissection. This study describes the technical details of laparoscopic radical left pancreatectomy (LRLP), used in the first international multicenter randomized trial comparing minimally invasive with open left pancreatectomy for pancreatic cancer, the DIPLOMA trial.
Sat Jun 06, 2020 20:00
Public parks serve as spaces within neighborhoods for encouraging a variety of physical and mental health-related behaviors. Over the past decade, there have been a number of interventions conducted in public ...
Mon Jun 08, 2020 03:00
Metabolic syndrome is a constellation of various cardiovascular and type 2 diabetes risk factors, such as abdominal obesity, atherogenic dyslipidemia, high blood pressure, and high blood glucose, but its preva...
Mon Jun 08, 2020 03:00
Community-based peer and community health worker-led diabetes self-management programs (COMP-DSMP) can benefit diabetes care, but the supporting evidence has been inadequately assessed. This systematic review ...
Sat Jun 06, 2020 03:00
Network meta-analyses (NMAs) of psoriasis treatments, undertaken as part of the NICE Single Technology Appraisal (STA) process, have included heterogeneous studies. When there is inconsistency or heterogeneity...
Fri Jun 05, 2020 03:00
Delirium is an acute confusional state, common in critical illness and associated with cognitive decline. There is no effective pharmacotherapy to prevent or treat delirium, although it is scientifically plaus...
Fri Jun 05, 2020 03:00
Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions. The o...
Fri Jun 05, 2020 03:00
Abstract Background The clinical significance of emergence delirium remains unclear. The purpose of this study was to investigate the association between emergence delirium and postoperative delirium in elderly after general anesthesia and surgery. Methods This prospective observational study was done in a tertiary hospital in Beijing, China. Elderly...
Sun Jun 07, 2020 03:00
Abstract Monoamine oxidase (MAO) deficiency is an X-linked hereditary disease characterized by spontaneous deletion of MAO-A and/or MAO-B on the X chromosome. Here, we describe the first reported case of a patient with MAO-A and MAO-B deficiency managed under general anesthesia in dental treatment. The patient was aged 11 years old when he was scheduled for dental treatment. He was diagnosed with MAO-A and MAO-B deficiency on genetic testing at 2 years of age. He was not given...
Fri Jun 05, 2020 03:00
Telehealth use has been increasing over the last decade. Studies have shown that patients have a positive attitude towards incorporating telehealth into their healthcare. Significant uncertainty remains over reimbursement policies that vary widely between states and by payer.
Mon Jun 08, 2020 03:00
Atopic diseases such as allergic rhinitis and asthma have become common in westernized countries1. These conditions occur when there is dysregulation in the immune system and can be influenced by genetic and environmental factors1. Exposure to air polluting factors have been associated with allergy and asthma outcomes in children2–5. Additionally, differences have been reported in concentrations of T helper (Th) 2, Th17 and regulatory T cells (Tregs) type cytokines in atopic individuals6,7.
Mon Jun 08, 2020 03:00
In children <2 years old, studies evaluating the value of skin prick tests (SPT) and specific immunoglobulin E (sIgE) results to predict persistence or resolution of egg allergy (EA) are limited. Additionally, the value of egg yolk (EY) sIgE and fresh egg (FE) SPT has not been well characterized.
Sun Jun 07, 2020 03:00
VitD-axis, which includes VitD, VitD-binding protein (VDBP), and the VitD receptor, has been found to regulate immunomodulatory functions that may be of particular relevance in asthma.[1] Serum (Se) VitD is the most commonly used surrogate of the VitD-axis to explore the impact of the axis on clinical asthma expression. However, the findings are controversial.[2]
Sun Jun 07, 2020 03:00
A young woman from an Echinococcus-endemic area with progressive abdominal distension: a case report
Cystic echinococcosis is a zoonotic infection caused by Echinococcus granulosus. This case report shows the difficulty in differential diagnosis in a patient with highly suspected hydatid disease.
Mon Jun 08, 2020 03:00
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