Background: Transorbital ultrasonographic measurement of optic nerve sheath diameter (ONSD) is an important technique for bedside assessment of raised intracranial pressure (ICP). However, developing competency for this clinical skill requires practice scans on both normal subjects and patients with raised ICP. The aim of this study is to develop a high-fidelity training model capable of measuring dynamic changes in ONSD and to test the reliability and reproducibility of the model at different...
07:14
Background: In the evolving research into cervical spine mechanics during airway intervention, new devices are being constantly added to the armamentarium of anesthesiologists. In this study we compared cervical spine movement during orotracheal intubation using an intubating laryngeal mask airway (LMA Fastrach) assisted flexible bronchoscope or video laryngoscope. Materials and Methods: In total, 40 consenting patients without history of abnormalities of cervical spine and planned for elective...
07:14
Background: Awake surgeries for cerebral lesion resection have several limitations including patient fear, discomfort, or pain. This study aimed to determine whether components of language function could be measured under general anesthesia. In this study, the occurrence of mismatch negativity (MMN) was searched in evoked potentials for phonological sounds. Materials and Methods: Five normal hearing, French native speaker, awake volunteers participated in evaluating the phonological task...
07:14
The pandemic of coronavirus disease 2019 (COVID-19) has unique implications for the anesthetic management of endovascular therapy for acute ischemic stroke. The Society for Neuroscience in Anesthesiology and Critical Care appointed a task force to provide timely, consensus-based expert recommendations using available evidence for the safe and effective anesthetic management of endovascular therapy for acute ischemic stroke during the COVID-19 pandemic. The goal of this consensus statement is to provide...
07:14
No abstract available
07:14
The pandemic of coronavirus disease 2019 (COVID-19) has several implications relevant to neuroanesthesiologists, including neurological manifestations of the disease, impact of anesthesia provision for specific neurosurgical procedures and electroconvulsive therapy, and health care provider wellness. The Society for Neuroscience in Anesthesiology and Critical Care appointed a task force to provide timely, consensus-based expert guidance for neuroanesthesiologists during the COVID-19 pandemic. The...
07:14
Background: Cervical spine movement during intubation with direct laryngoscopy can predispose to new-onset neurological deficits in patients with cervical spine instability. While fiberoptic-guided intubation (FGI) is mostly preferred in such patients, this is not always possible. Videolaryngoscopy results in less cervical spine movement than direct laryngoscopy and may be an alternative to FGI in patients with cervical spine instability. The objective of this study was to compare cervical spine...
07:14
Perioperative stroke is associated with considerable morbidity and mortality. Stroke recognition and diagnosis are challenging perioperatively, and surgical patients receive therapeutic interventions less frequently compared with stroke patients in the outpatient setting. These updated guidelines from the Society for Neuroscience in Anesthesiology and Critical Care provide evidence-based recommendations regarding perioperative care of patients at high risk for stroke. Recommended areas for future...
07:14
Background: Pulse pressure variation (PPV) and plethysmographic variability index (PVI), dynamic indicators of preload dependence based on heart-lung interactions, are used to predict fluid responsiveness in mechanically ventilated patients in the supine position. The sitting position for neurosurgery, by changing intrathoracic blood volume, could affect the capacity of PPV and PVI to predict fluid responsiveness. The aim of the study was to assess the ability of PPV and PVI to predict fluid responsiveness...
07:14
Background: Intravenous and inhalational anesthesia might have different associations with long-term outcome in cancer patients, with reports of adverse effects of inhalation anesthesia. However, the effects of anesthesia in patients with high-grade glioma (HGG) are not known. Methods: This study investigated 154 patients who received propofol and 140 patients who received sevoflurane for maintenance of anesthesia during HGG tumor resection. The primary outcomes were progression-free survival...
07:14
Background: Hypotension and/or hypocapnia might increase general anesthesia (GA)-related neuromorbidity in infants, but safe levels of perioperative blood pressure are poorly defined. Serum protein S100b has been used as screening, monitoring, and prediction tool in the management of patients with traumatic brain injury. Using an animal model, we investigated serum S100b as an acute biomarker of cerebral hypoperfusion and cerebral cell dysfunction during hypotension, hypocapnia, or combined hypotension/hypocapnia...
07:14
Objective: Outcome prediction in comatose patients with acute brain injury remains challenging. Regional cerebral oxygenation (rSO2) derived from near-infrared spectroscopy (NIRS) is a surrogate for cerebral blood flow and can be used to calculate cerebral autoregulation (CA) continuously at the bedside from the derived cerebral oximetry index (COx). We hypothesized that COx derived thresholds for CA are associated with outcomes in patients with acute coma from neurological injury. Methods:...
07:14
No abstract available
07:14
Abstract The use of waterjet technology is now prevalent in medical applications including surgery, soft tissue resection, bone cutting, waterjet steerable needles, and wound debridement. The depth of the cut (DOC) of a waterjet in soft tissue is an important parameter that should be predicted in these applications. For instance, for waterjet-assisted surgery, selective cutting of tissue layers is a must to avoid damage to deeper tissue layers. For our proposed fracture-directed...
03:00
Abstract Flows through medical devices as well as in anatomical vessels despite being at moderate Reynolds number may exhibit transitional or even turbulent character. In order to validate numerical methods and codes used for biomedical flow computations, the US Food and Drug Administration (FDA) established an experimental benchmark, which was a pipe with gradual contraction and sudden expansion representing a nozzle. The experimental results for various Reynolds numbers ranging...
Sun Jun 07, 2020 03:00
Abstract Muscle fatigue negatively affects gait, and the changes in gait pattern due to muscle fatigue is influenced by which muscles are fatigued and pre-existing physical activity levels. However, how these factors alter gait stability and variability, measures related to risk of fall, remains unclear. To explore how muscular fatigue affects linear and nonlinear gait features in young adults, the effects of triceps surae fatigue and weight training level on gait variability and...
Fri Jun 05, 2020 03:00
Abstract Lung cancer is the deadliest cancer worldwide. It has been shown that early detection using low-dose computer tomography (LDCT) scans can reduce deaths caused by this disease. We present a general framework for the detection of lung cancer in chest LDCT images. Our method consists of a nodule detector trained on the LIDC-IDRI dataset followed by a cancer predictor trained on the Kaggle DSB 2017 dataset and evaluated on the IEEE International Symposium on Biomedical Imaging...
Fri Jun 05, 2020 03:00
Radiation therapy (RT) may be curative, adjuvant or palliative for treating a variety of cancers and most patients receive RT as part of a complex multimodal treatment strategy including surgery, chemotherapy and targeted therapies. There are gains and risks from RT; the gains are improved cure of cancer and often improved overall survival, and at the same time, the organ is usually preserved. The risks comprise a broad spectrum from loco-regional radiation-induced normal tissue effects (e.g. fibrosis,...
Mon Jun 08, 2020 03:00
We read the letter to the editor with great interest and would firstly like to thank the authors for their kind appraisal of our review on behalf of all authors [1,2]. Indeed, ePROM based follow-up not only relying on the patients’ input results in high completion rates. Especially the last finding, which is flexible and pragmatic, should be a priority in this diverse and often frail population[1]. In our review we excluded papers using by-proxy assessment in the follow-up. Studies have shown that...
Mon Jun 08, 2020 03:00
Given the large number of degrees of freedom in intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT), the optimisation of a radiotherapy treatment plan is an iterative and time-consuming process. Reducing the number of iterations to explore the patient-specific trade-offs is crucial to reduce the time to commence with therapy.
Mon Jun 08, 2020 03:00
In recent years, there has been a growing interest in combinatorial approaches of utilizing radiation therapy (RT) and immunotherapies as part of oncologic management. RT has the putative ability to potentiate immune-mediated tumor regression through a variety of cellular mechanisms and abscopal effects that have been better characterized in recent years [1].
Sun Jun 07, 2020 03:00
Global COVID-19 pandemic has significant, far-reaching impact on almost all sector of industries and services worldwide.[1] The infection was fatal in small percentage but significant number of cases. The mortality rate generally ranged from 3% to up to 10%. In Indonesia the mortality rate was on the upper range, around 8%.[2] Due to the highly infectious nature of this COVID-19 resulting in significant amount of people infected, it is necessary to anticipate transmission of infection by regulating...
Fri Jun 05, 2020 03:00
The outbreak of the novel coronavirus disease-19 (COVID-19) has rapidly and drastically impacted worldwide the healthcare system. Despite an increasing number of recommendations becoming available in the last two months, measures adopted in radiation-oncology departments to overcome this situation are rapidly changing and may differ largely based on institutional and national practices.
Fri Jun 05, 2020 03:00
In France, as in most countries, strict strategies were implemented in cancer hospitals to reduce the spread of coronavirus (COVID-19), but to maintain as much as possible the capacity of oncology health services [1,2]. These strategies included the reduction of elective services, an emphasis on remote visits, and the use of personal protective equipment [3–7]. International radiation therapy (RT) academic societies proposed to restrict the indications for treatment [8], to delay as long as possible...
Fri Jun 05, 2020 03:00
Under the current pandemic of the coronavirus disease 2019(COVID-19) , cancer patients are considered to be one of the high-risk infected population[1].[2] As a radiation oncology center in general hospital, the influence of fever patients during the treatment are largely unknown. So we retrospectively studied the clinical characteristics of febrile patients who received radiation therapy during the period of covid-19 infection, from Peking Union Medical College Hospital of China, analyzed the clinical...
Fri Jun 05, 2020 03:00
Genomic selection has been successfully implemented in plant and animal breeding. The transition of parental selection based on phenotypic characteristics to genomic selection (GS) has reduced breeding time and cost while accelerating the rate of genetic progression. Although breeding methods have been adapted to include genomic selection, parental selection often involves truncation selection, selecting the individuals with the highest genomic estimated breeding values (GEBVs) in the hope that favorable...
Mon Jun 08, 2020 23:21
The mutation rate and mutations' effects on fitness are crucial to evolution. Mutation rates are under selection due to linkage between mutation rate modifiers and mutations' effects on fitness. The linkage between a higher mutation rate and more beneficial mutations selects for higher mutation rates, while the linkage between a higher mutation rate and more deleterious mutations selects for lower mutation rates. The net direction of selection on mutations rates depends on the fitness landscape,...
Fri Jun 05, 2020 23:30
Pat1 promotes the activation and assembly of multiple proteins during mRNA decay. After deadenylation, the Pat1/Lsm1-7 complex binds to transcripts containing oligo(A) tails, which can be modified by the addition of several terminal uridine residues. Pat1 enhances Lsm1-7 binding to the 3' end, but it is unknown how this interaction is influenced by nucleotide composition. Here we examine Pat1/Lsm1-7 binding to a series of oligoribonucleotides containing different A/U contents using recombinant purified...
Mon Jun 08, 2020 18:44
Understanding the functional connection that occurs for the three nuclear RNA polymerases to synthesize ribosome components during the ribosome biogenesis process has been the focal point of extensive research. To preserve correct homeostasis on the production of ribosomal components, cells might require the existence of proteins that target a common subunit of these RNA polymerases to impact their respective activities. This work describes how the yeast prefoldin-like Bud27 protein, which physically...
Fri Jun 05, 2020 21:51
Ribosome footprint profiling is a high throughput sequencing based technique that provides detailed and global views of translation in living cells. An essential part of this technology is removal of unwanted, normally very abundant, ribosomal RNA sequences that dominate libraries and increase sequencing costs. The most effective commercial solution (Ribo-Zero) has been discontinued as a standalone product and a number of new, experimentally distinct commercial applications have emerged on the market....
Fri Jun 05, 2020 20:11
The paper of Huang et al. (Nucleic Acids Res., 2020, vol. 48, pp. 4396-4404) claims that proteins translated in different reading frames from the same mRNA can have similar functions. This conclusion is possibly incorrect due to the possibility that the wild type protein could still be expressed.
Fri Jun 05, 2020 19:33
Olivier Oth, Maria Fernanda Orellana, Régine GlineurAnnals of Maxillofacial Surgery 2020 10(1):178-181 Introduction: Mental nerve injuries with neurosensory deficits, asymmetries, and intra-operative bleeding are the main immediate complications of genioplasty. Following a recent systematic review, three-dimensional (3D)-printed cutting guide could improve the predictability and accuracy of this surgical technique avoiding postoperative asymmetries. Furthermore, anatomical structures in the surgical...
Mon Jun 08, 2020 00:00
Payal Dilipkumar Mehta, Nimisha Desai, Kalpesh Makwana, Yama PatelAnnals of Maxillofacial Surgery 2020 10(1):251-253 Leiomyoma is a benign smooth muscle tumor that occurs most frequently in the uterine myometrium, gastrointestinal tract, skin, and lower extremities. Leiomyoma rarely affects the oral cavity. Angioleiomyoma (vascular leiomyoma) is a histological subtype of the leiomyoma. The diagnosis is commonly determined by histopathological studies. This case report shows a 57-year-old male...
Mon Jun 08, 2020 00:00
Chingiz R Rahimov, Sirajaddin G Ahmadov, Masuma Ch Rahimli, Ismayil M FarzaliyevAnnals of Maxillofacial Surgery 2020 10(1):3-9 Introduction: Orbital floor fractures are common among mid-face fractures. The general aim of treatment is to restore orbital volume and anatomy with grafts or reconstructive materials. Malpositioning of the implants and inadequate volume restorations are common complications of these procedures. The aim of our study is to present the surgical outcomes of orbital reconstruction...
Mon Jun 08, 2020 00:00
Stefan Ihde, Olga SipicAnnals of Maxillofacial Surgery 2020 10(1):213-216 The technology of the Strategic Implant® has expanded the indications for tooth and bone removal. This case report shows what kind of results are possible and how much the appearance of a patient can be changed within a few days if both teeth and bone are removed. The treatment option explained here could be considered by patients with a gummy smile. This treatment conflicts with the traditional thinking of dentists, who...
Mon Jun 08, 2020 00:00
Shishir Kaushik, Iqbal Ali, Manish Dubey, Neha BajpaiAnnals of Maxillofacial Surgery 2020 10(1):10-15 Aim: The aim of this study was to compare 2 mm conventional miniplates with three-dimensional (3D) strut plates in the treatment of mandibular fractures treated in the Department of Oral and Maxillofacial Surgery of a college in India, during 2012–2015. Materials and Methods: All 20 patients with mandible fracture requiring open reduction and internal fixation of the fracture were reported and...
Mon Jun 08, 2020 00:0
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