Ori Blanc, Dekel Shilo, Efi Weitman, Tal Capucha, Adi RachmielAnnals of Maxillofacial Surgery 2020 10(1):127-132 Background: Limited bone quality in the posterior maxilla results in low success rates for dental implants. Various bone augmentation methods have been described, yet most require two-step surgical procedures with relatively high rates of resorption and failure. An alternative for these patients is zygomatic implants. Zygomatic implants utilize the basal craniofacial bone. Materials...
Mon Jun 08, 2020 00:00
Nivedhitha Malli Sureshbabu, Aishwarya Ranganath, Benoy JacobAnnals of Maxillofacial Surgery 2020 10(1):246-250 Although endodontic therapy is typically successful, in approximately 10%–15% of the cases, symptoms can persist or reoccur. Periapical surgery is the preferred treatment of choice in failed root canal therapy, chronic periapical lesion, persistent apical periodontitis, etc., i.e., when conventional treatment modalities fail. Over the past few decades, although the list of indications...
Mon Jun 08, 2020 00:00
Amin Rahpeyma, Saeedeh KhajehahmadiAnnals of Maxillofacial Surgery 2020 10(1):133-135 Introduction: Donor site morbidity is an important factor for selecting a flap for reconstruction. Submental flap using submentum skin for reconstruction has low donor site morbidity. Up to now, donor site morbidity of submental flap in Caucasians has not been evaluated. Materials and Methods: In a retrospective study, donor site morbidity of the submental flap including changes in hair direction, hypertrophic...
Mon Jun 08, 2020 00:00
Akhilesh Prathap, Ravi Rajan Areekkal, Eapen Thomas, Nithin Pratap, Vinesh UdayakumarAnnals of Maxillofacial Surgery 2020 10(1):254-257 Eosinophilic granuloma (EG) is a rare histiocytic disorder resulting from clonal proliferation of Langerhans cells. Eosinophilic granuloma, the most benign of the three entities of Langerhans cell histiocytosis, may be multiple or solitary. This lesion can affect any bones but commonly involves the mandible when the jaws are affected. It is difficult to make...
Mon Jun 08, 2020 00:00
Adi Rachmiel, Shahar Turgeman, Dekel Shilo, Omri Emodi, Dror AizenbudAnnals of Maxillofacial Surgery 2020 10(1):136-141 Background: Transverse maxillomandibular discrepancies are widespread. Treatment is comprised of orthodontic expansion in patients younger than 15 years or by surgically assisted rapid palatal expansion (SARPE) in skeletally mature patients where the possibility of successful orthodontic maxillary expansion decreases as sutures close and resistance to mechanical forces increases....
Mon Jun 08, 2020 00:00
Sujeeth Kumar Shetty, Saubhik Dasukil, Geetanjali AroraAnnals of Maxillofacial Surgery 2020 10(1):262-266 The aggressive ossifying fibroma is an uncommon benign fibro-osseous lesion which has been described in the literature under a variety of terms. This tumor is distinguished from standard ossifying fibroma based on its more clinically aggressive biological behavior, occurrence in children and young adults, and tendency to occur in different anatomic sites. We report a case of a 45-year-old...
Mon Jun 08, 2020 00:00
Fares KablanAnnals of Maxillofacial Surgery 2020 10(1):142-148 Introduction: Posterior mandibular ridges with extreme atrophy are usually combined with superficial location of the mental nerve and inferior alveolar nerves (IAN) and with a short residual mandibular ridge. As a result, dental implants cannot be placed in conjunction with IAN transposition alone. The aim of this paper is to introduce a new treatment approach to treat those patients. Patients and Methods: Eleven patients with 18...
Mon Jun 08, 2020 00:00
Vaibhav Shukla, Anmol Agarwal, Gaurav Mittal, Uday Kiran Uppada, Abhishek RathiAnnals of Maxillofacial Surgery 2020 10(1):272-274 Cartilaginous tumors are commonly encountered tumors that can involve almost any bone and very rarely found in the maxillofacial region. These tumors may have varied presentations ranging from a simple enchondroma to a high-grade osteo or chondrosarcoma. Owing to their membranous development they are reported to occur usually in the cartilage bearing areas of the jaws...
Mon Jun 08, 2020 00:00
Ankush Puri, Pradhuman Verma, Princy Mahajan, Amit Bansal, Shivani Kohli, Samar Ali FarazAnnals of Maxillofacial Surgery 2020 10(1):149-157 Background: Oral implants are considered safe in the mandibular anterior region, but complications often occur if vital structures such as inferior alveolar nerve, mandibular incisive canal (MIC), anterior mental loop (AL), or mental foramen (MF) are not properly identified. Aim: The aim was to evaluate vital anatomical structures in the mandibular interforaminal...
Mon Jun 08, 2020 00:00
Omisakin Olatunde Oluleke, Kache Stephen Akau, Ayuba Iko Godwin, Aghadi Ifeanyi Kene, Ajike Olusegun SundayAnnals of Maxillofacial Surgery 2020 10(1):279-283 Background: Dermoid cyst is a benign congenital lesion of ectodermal origin. They are commonly found throughout the body but rare in the oral cavity. It is a developmental lesion and usually due to retention of germinal epithelium during growth of brachial arches and lower jaw. It is commonly present in the sublingual region as a swelling...
Mon Jun 08, 2020 00:00
Accurate disease monitoring is essential following transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) due to potential for profound adverse event and large variation in survival outcome. Post-treatment changes on conventional imaging can confound determination of residual/recurrent disease, magnifying the clinical challenge. Based on increased expression of thymidylate synthase (TYMS), thymidine kinase-1 (TK-1) and SLC29A1 (Equilibrative nucleoside transporter 1, ENT1) in HCC...
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Glycoprotein CD44 and alternative splice variants are overexpressed in many cancers and cancer stem cells. Binding of hyaluronic acid (HA) to CD44 activates cell signaling pathways, inducing cell proliferation, cell survival, and invasion. As such, CD44 is regarded an excellent target for cancer therapy when this interaction can be blocked. In this study, we developed a CD44-specific antibody fragment and evaluated it for imaging CD44-positive cancers utilizing positron emission tomography (PET)....
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IgG4-related disease (IgG4-RD) is characterized by lymphoplasmacytic infiltration enriched in IgG4-positive plasma cells and variable degrees of fibrosis with a characteristic storiform pattern. Since fibrosis is an important feature of IgG4-RD, we performed a prospective cohort study to evaluate the performance of 68Ga-FAPI, a recently introduced PET agent targeting fibroblast activation protein, in IgG4-RD. Methods: Twenty-six patients with IgG4-RD were recruited. All patients underwent both...
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Background: Given the high frequency of liver metastases in neuroendocrine tumor patients, we aimed to determine whether hepatic intra-arterial (IA) injection of 90Y-DOTATOC Peptide Receptor Radionuclide Therapy (PRRT) would achieve higher intratumoral concentrations than intravenous (IV) injection, thus maintaining efficacy while reducing systemic toxicity. Methods: PRRT-naïve adult NET patients with liver-dominant metastases involving <70% of the liver were enrolled in a prospective pilot,...
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Purpose: Preclinical studies demonstrated that a DNA vaccine (pTVG-AR, MVI-118) encoding the androgen receptor ligand-binding domain (AR LBD) augmented antigen-specific CD8+ T cells, delayed prostate cancer progression and emergence of castration-resistant disease, and prolonged survival of tumor-bearing mice. This vaccine was evaluated in a multicenter phase 1 trial. Experimental Design: Patients with metastatic castration sensitive prostate cancer (mCSPC) who had recently begun androgen deprivation...
Mon Jun 08, 2020 16:27
Purpose: TIGIT blockade could represent an alternative therapeutic option to release the immune response in patients with multiple myeloma (MM). Here we analyzed the expression of TIGIT and its ligands PVR and nectin-2 in the bone marrow (BM) of patients with monoclonal gammopathies and the efficacy of TIGIT blockade activating anti-myeloma immunity. Experimental Design: Expression levels of TIGIT and its ligands were characterized by flow cytometry and ELISA. TIGIT blockade was analyzed in in vitro...
Mon Jun 08, 2020 16:27
The novel coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global health threat.1 Cancer patients are one of the most vulnerable populations. During this pandemic clinical trial accrual to NCI studies has fallen dramatically. Investigators quickly turned to regulatory bodies to simplify treatment schedules, facilitate telemedicine and to decrease required data collection Going forward the oncology research community must use the lessons...
Fri Jun 05, 2020 16:11
Facial Plast SurgDOI: 10.1055/s-0040-1712469A novel treatment approach to address the nasolabial fold is the insertion facial suspension threads. However, there is a paucity of data available to guide insertion techniques and material selection. Three female and two male cephalic specimens of Caucasian ethnicity (73.6 ± 6.5 years; 21.41 ± 2.2 kg/m2) were included into this experimental split-face study. One facial side was treated with polycaprolactone (PCL) thread: 180 mm, bidirectional, 18G 100 mm...
Mon Jun 08, 2020 02:00
Facial Plast SurgDOI: 10.1055/s-0040-1712160Repair of nasal defects is technically challenging due to inelastic nasal skin and unforgiving nasal geometry. The bilobe flap is a double transposition flap that can transpose skin from cephalad to caudad to repair defects of the lower third of the nose. However, pincushioning may complicate this flap, yielding untoward aesthetic outcomes. We review our single surgeon series of patients who underwent bilobe flap reconstruction of nasal defects, and describe...
Mon Jun 08, 2020 02:00
Facial Plast SurgDOI: 10.1055/s-0040-1712159In lip reconstructive surgery, knowledge of orolabial dimensions and position according to ethnicity, age, and gender are important to obtain satisfactory results. Unfortunately, there is a dearth of information related to these values in South Indians. The objective of the present study was to quantify the orolabial dimensions and position in South Indians. Evaluation of orolabial features was performed on standardized frontal and lateral of 400 South...
Mon Jun 08, 2020 02:00
Facial Plast SurgDOI: 10.1055/s-0040-1712474Guidelines for pain management following septorhinoplasty are lacking, leading to a wide range of therapy regimes even including opioid medication. Thus, the presented study strived to investigate and compare postoperative pain intensities after external and endonasal septorhinoplasty and evaluate whether pain perception is potentially related to patient satisfaction with the aesthetic result. In addition, the effectiveness of an escalating pain treatment...
Mon Jun 08, 2020 02:00
Facial Plast SurgDOI: 10.1055/s-0040-1712468Shape, tip projection, and position can be controlled by the use of septal extension grafts (SEG). A retrospective cohort study of patients undergoing primary and secondary rhinoplasty was reviewed. The purpose of this study was to analyze maintenance of nasal length, dorsal length, and nasolabial angle postoperatively comparing different types of SEG using standardized photography and digital measurement. Two-hundred twenty-one patients undergoing rhinoplasty...
Mon Jun 08, 2020 02:00
Horm Metab ResDOI: 10.1055/a-1172-1352COVID-19 was declared a global pandemic by the WHO and has affected millions of patients around the world. COVID-19 disproportionately affects persons with endocrine conditions, thus putting them at an increased risk for severe disease. We discuss the mechanisms that place persons with endocrine conditions at an additional risk for severe COVID-19 and review...
Mon Jun 08, 2020 02:00
Horm Metab ResDOI: 10.1055/a-1169-0307Patients with craniopharyngioma are susceptible to autonomic dysfunction as a result of hypothalamic damage. We evaluated indices of heart rate variability (HRV) in patients with childhood-onset craniopharyngioma to investigate autonomic function and its relationship with components of the metabolic syndrome (MetS). This cross-sectional, case-only study included...
Mon Jun 08, 2020 02:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01824
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01747
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00575
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00794
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01158
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01106
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01504
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00799
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00925
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01265
Mon Jun 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01044
Mon Jun 08, 2020 07:00
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