IJMS, Vol. 21, Pages 4055: The MNK1/2-eIF4E Axis as a Potential Therapeutic Target in Melanoma International Journal of Molecular Sciences doi: 10.3390/ijms21114055 Authors: Prabhu Moussa Wilson H. Miller Sonia V. del Rincón : Melanoma is a type of skin cancer that originates in the pigment-producing cells of the body known as melanocytes. Most genetic aberrations in melanoma result in hyperactivation of the mitogen activated protein kinase (MAPK) and phosphoinositide 3-kinase...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4050: Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo International Journal of Molecular Sciences doi: 10.3390/ijms21114050 Authors: Fu-Kai Chuang Ching-Len Liao Ming-Kuan Hu Yi-Lin Chiu An-Rong Lee Shih-Ming Huang Yu-Lung Chiu Pei-Ling Tsai Bo-Cyuan Su Tsung-Hsien Chang Chang-Chi Lin Chih-Chin Shih Li-Chen Yen Dengue virus (DENV) and Zika virus (ZIKV) are mosquito-borne flaviviruses that...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4047: The Mitochondrial Pentatricopeptide Repeat Protein PPR18 Is Required for the cis-Splicing of nad4 Intron 1 and Essential to Seed Development in Maize International Journal of Molecular Sciences doi: 10.3390/ijms21114047 Authors: Rui Liu Shi-Kai Cao Aqib Sayyed Chunhui Xu Feng Sun Xiaomin Wang Bao-Cai Tan Pentatricopeptide repeat (PPR) protein comprises a large family, participating in various aspects of organellar RNA metabolism in land plants....
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4049: A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21114049 Authors: Hui Shu Sufang Liu Yuanyuan Tang Brian L. Schmidt John C. Dolan Larry L. Bellinger Phillip R. Kramer Steven D. Bender Feng Tao Migraine is commonly reported among patients with temporomandibular...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4048: Facile Histamine Detection by Surface-Enhanced Raman Scattering using SiO2@Au@Ag Alloy Nanoparticles International Journal of Molecular Sciences doi: 10.3390/ijms21114048 Authors: Kim-Hung Huynh Xuan-Hung Pham Eunil Hahm Jaehyun An Hyung-Mo Kim Ahla Jo Bomi Seong Yoon-Hee Kim Byung Sung Son Jaehi Kim Won-Yeop Rho Bong-Hyun Jun Histamine intoxication associated with seafood consumption represents a global health problem. The...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4043: Anticancer and Antiangiogenic Activities of Novel α-Mangostin Glycosides in Human Hepatocellular Carcinoma Cells via Downregulation of c-Met and HIF-1α International Journal of Molecular Sciences doi: 10.3390/ijms21114043 Authors: Sung Min Kim Jang Mi Han Tuoi Thi Le Jae Kyung Sohng Hye Jin Jung Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is a leading cause of cancer-related death worldwide. Therefore, exploring...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4051: Genetically Modified Mesenchymal Stem Cells: The Next Generation of Stem Cell-Based Therapy for TBI International Journal of Molecular Sciences doi: 10.3390/ijms21114051 Authors: Rami Ahmad Shahror Chung-Che Wu Yung-Hsiao Chiang Kai-Yun Chen Mesenchymal stem cells (MSCs) are emerging as an attractive approach for restorative medicine in central nervous system (CNS) diseases and injuries, such as traumatic brain injury (TBI), due to their relatively...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4044: The C-Terminus Tail Regulates ERK3 Kinase Activity and Its Ability in Promoting Cancer Cell Migration and Invasion International Journal of Molecular Sciences doi: 10.3390/ijms21114044 Authors: Lobna Elkhadragy Hadel Alsaran Weiwen Long Extracellular signal-regulated kinase 3 (ERK3) is an atypical member of the mitogen-activated protein kinase (MAPK) family. It harbors a kinase domain in the N-terminus and a long C-terminus extension. The C-terminus extension...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4045: Gut–Brain Axis and Neurodegeneration: State-of-the-Art of Meta-Omics Sciences for Microbiota Characterization International Journal of Molecular Sciences doi: 10.3390/ijms21114045 Authors: Bruno Tilocca Luisa Pieroni Alessio Soggiu Domenico Britti Luigi Bonizzi Paola Roncada Viviana Greco Recent advances in the field of meta-omics sciences and related bioinformatics tools have allowed a comprehensive investigation of human-associated microbiota...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4042: Gadolinium Complexes as Contrast Agent for Cellular NMR Spectroscopy International Journal of Molecular Sciences doi: 10.3390/ijms21114042 Authors: Nat Sakol Ayako Egawa Toshimichi Fujiwara Aqua Gd3+ and Gd-DOTA (gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacete) complexes were studied as a contrast agent in cellular NMR (nuclear magnetic resonance) spectroscopy for distinguishing between intracellular and extracellular spaces. The contrast...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4046: Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21114046 Authors: Nikoletta Almási Szilvia Török Szabolcs Dvorácskó Csaba Tömböly Ákos Csonka Zoltán Baráth Zsolt Murlasits Zsuzsanna Valkusz Anikó Pósa Csaba Varga Krisztina Kupai Inflammatory Bowel Disease (IBD) is an autoimmune ailment of the gastrointestinal (GI) tract,...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4039: Elastography Techniques for the Assessment of Liver Fibrosis in Non-Alcoholic Fatty Liver Disease International Journal of Molecular Sciences doi: 10.3390/ijms21114039 Authors: Yasushi Honda Masato Yoneda Kento Imajo Atsushi Nakajima Non-alcoholic fatty liver disease (NAFLD) is expected to increase in prevalence because of the ongoing epidemics of obesity and diabetes, and it has become a major cause of chronic liver disease worldwide. Liver fibrosis...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4041: The Role of P2X7 Purinergic Receptors in the Renal Inflammation Associated with Angiotensin II-induced Hypertension International Journal of Molecular Sciences doi: 10.3390/ijms21114041 Authors: Rocio Bautista-Pérez Oscar Pérez-Méndez Agustina Cano-Martínez Ursino Pacheco José Santamaría Fernando Rodríguez-Sámano Bernardo Rodríguez-Iturbe L. Gabriel Navar Martha Franco Purinergic receptors play a central role in the renal pathophysiology...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4040: Genome Editing in Cereals: Approaches, Applications and Challenges International Journal of Molecular Sciences doi: 10.3390/ijms21114040 Authors: Waquar A. Ansari Sonali U. Chandanshive Vacha Bhatt Altafhusain B. Nadaf Sanskriti Vats Jawahar L. Katara Humira Sonah Rupesh Deshmukh Over the past decades, numerous efforts were made towards the improvement of cereal crops mostly employing traditional or molecular breeding approaches. The current...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4038: Single and Combined Fe and S Deficiency Differentially Modulate Root Exudate Composition in Tomato: A Double Strategy for Fe Acquisition? International Journal of Molecular Sciences doi: 10.3390/ijms21114038 Authors: Stefania Astolfi Youry Pii Tanja Mimmo Luigi Lucini Maria B. Miras-Moreno Eleonora Coppa Simona Violino Silvia Celletti Stefano Cesco Fe chlorosis is considered as one of the major constraints on crop growth and yield worldwide,...
Fri Jun 05, 2020 03:00
IJMS, Vol. 21, Pages 4037: Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21114037 Authors: Francesca Destefanis Valeria Manara Paola Bellosta The biogenesis of ribosomes is a finely regulated multistep process linked to cell proliferation and growth—processes which require a high rate of protein synthesis. One of the master regulators of ribosome biogenesis is Myc, a well-known...
Fri Jun 05, 2020 03:00
JCM, Vol. 9, Pages 1789: Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review Journal of Clinical Medicine doi: 10.3390/jcm9061789 Authors: Przemyslaw Kosinski Pawel Krajewski Miroslaw Wielgos Aleksandra Jezela-Stanek The aim of this paper is to review the outcomes and discuss the genetic and non-genetic aetiology of nonimmune hydrops fetalis in order to support differential ultrasound and genetic evaluations and family counselling....
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1787: Trends and Between-Physician Variation in Laboratory Testing: A Retrospective Longitudinal Study in General Practice Journal of Clinical Medicine doi: 10.3390/jcm9061787 Authors: Lisa D. Schumacher Levy Jäger Rahel Meier Yael Rachamin Oliver Senn Thomas Rosemann Stefan Markun Laboratory tests are frequently ordered by general practitioners (GPs), but little is known about time trends and between-GP variation of their use. In this retrospective...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1788: The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9061788 Authors: Karolina Skonieczna-Żydecka Karolina Kaźmierczak-Siedlecka Mariusz Kaczmarczyk Joanna Śliwa-Dominiak Dominika Maciejewska Katarzyna Janda Ewa Stachowska Beata Łoniewska Damian Malinowski...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1785: Sperm Antioxidant Biomarkers and Their Correlation with Clinical Condition and Lifestyle with Regard to Male Reproductive Potential Journal of Clinical Medicine doi: 10.3390/jcm9061785 Authors: Wirginia Krzyściak Monika Papież Ewelina Bąk Eva Morava Paweł Krzyściak Anna Ligęzka Agnieszka Gniadek Palina Vyhouskaya Jarosław Janeczko Measurement of sperm oxidative-antioxidant indicators is widely used in the assessment and detection of biochemical...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1783: Impaired Mitochondrial Morphology and Functionality in Lonp1wt/− Mice Journal of Clinical Medicine doi: 10.3390/jcm9061783 Authors: Anna De Gaetano Lara Gibellini Elena Bianchini Rebecca Borella Sara De Biasi Milena Nasi Federica Boraldi Andrea Cossarizza Marcello Pinti LONP1 is a nuclear-encoded mitochondrial protease crucial for organelle homeostasis; mutations of LONP1 have been associated with Cerebral, Ocular, Dental, Auricular, and...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1784: The Predictive Value of the Cervical Consistency Index to Predict Spontaneous Preterm Birth in Asymptomatic Twin Pregnancies at the Second-Trimester Ultrasound Scan: A Prospective Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9061784 Authors: Johannes van der Merwe Isabel Couck Francesca Russo Xavier P. Burgos-Artizzu Jan Deprest Montse Palacio Liesbeth Lewi Novel transvaginal ultrasound (TVU) markers have been proposed to improve...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1786: Reproductive Effects of Exposure to Low-Dose Ionizing Radiation: A Long-Term Follow-Up of Immigrant Women Exposed to the Chernobyl Accident Journal of Clinical Medicine doi: 10.3390/jcm9061786 Authors: Julie Cwikel Ruslan Sergienko Gil Gutvirtz Rachel Abramovitz Danna Slusky Michael Quastel Eyal Sheiner The Chernobyl accident in 1986 spread ionizing radiation over extensive areas of Belarus and Ukraine, leading to adverse health effects in exposed...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1781: Non-Overt Coagulopathy in Non-ICU Patients with Mild to Moderate COVID-19 Pneumonia Journal of Clinical Medicine doi: 10.3390/jcm9061781 Authors: Daniela Mazzaccaro Francesca Giacomazzi Matteo Giannetta Alberto Varriale Rosa Scaramuzzo Alfredo Modafferi Giovanni Malacrida Paolo Righini Massimiliano M. Marrocco-Trischitta Giovanni Nano Introduction: Aim of the study is to assess the occurrence of early stage coagulopathy and disseminated...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1779: Diabetic Foot Infections: The Diagnostic Challenges Journal of Clinical Medicine doi: 10.3390/jcm9061779 Authors: Chiara Lauri Antonio Leone Marco Cavallini Alberto Signore Laura Giurato Luigi Uccioli Diabetic foot infections (DFIs) are severe complications of long-standing diabetes, and they represent a diagnostic challenge, since the differentiation between osteomyelitis (OM), soft tissue infection (STI), and Charcot’s osteoarthropathy...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1780: Prevalence, Clinical Aspects and Outcomes in a Large Cohort of Persons with Diabetic Foot Disease: Comparison between Neuropathic and Ischemic Ulcers Journal of Clinical Medicine doi: 10.3390/jcm9061780 Authors: Marco Meloni Valentina Izzo Laura Giurato José Luis Lázaro-Martínez Luigi Uccioli This study aims to evaluate clinical and ulcer characteristics as well the outcomes of patients with diabetic foot ulcers (DFUs). The study group was composed...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1782: L-Arginine/NO Pathway Metabolites in Colorectal Cancer: Relevance as Disease Biomarkers and Predictors of Adverse Clinical Outcomes Following Surgery Journal of Clinical Medicine doi: 10.3390/jcm9061782 Authors: Iwona Bednarz-Misa Mariusz G. Fleszar Marek Zawadzki Bartosz Kapturkiewicz Agnieszka Kubiak Katarzyna Neubauer Wojciech Witkiewicz Małgorzata Krzystek-Korpacka The L-Arginine/NO pathway is involved in carcinogenesis and immunity....
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1778: Herbal Medicines (Danggui Liuhuang Decoctions) for Management of Menopausal Symptoms: A Systematic Review of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9061778 Authors: Ji Hee Jun Hye Won Lee Junhua Zhang Fengwen Yang Myeong Soo Lee Danggui Liuhuang (DLH) decoctions are traditional herbal medicines that are widely used for menopausal symptoms. The objective of this systematic review was to investigate evidence of the...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1777: Pathogenesis and Clinical Management of Mesenteric Fibrosis in Small Intestinal Neuroendocine Neoplasms: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9061777 Authors: Anna Koumarianou Krystallenia I. Alexandraki Göran Wallin Gregory Kaltsas Kosmas Daskalakis Mesenteric fibrosis (MF) constitutes an underrecognized sequela in patients with small intestinal neuroendocrine neoplasms (SI-NENs), often complicating the disease clinical...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1776: Optimal Endoscopic Resection Technique for Selected Gastric GISTs. The Endoscopic Suturing System Combined with ESD—a New Alternative? Journal of Clinical Medicine doi: 10.3390/jcm9061776 Authors: Katarzyna M. Pawlak Artur Raiter Katarzyna Kozłowska-Petriczko Joanna Szełemej Jan Petriczko Katarzyna Wojciechowska Anna Wiechowska-Kozłowska Background and Study Aim: In terms of therapeutic management, gastrointestinal stromal tumors (GISTs) seem...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1774: COVID-19 and Congenital Heart Disease: Results from a Nationwide Survey Journal of Clinical Medicine doi: 10.3390/jcm9061774 Authors: Jolanda Sabatino Paolo Ferrero Massimo Chessa Francesco Bianco Paolo Ciliberti Aurelio Secinaro Lilia Oreto Martina Avesani Valentina Bucciarelli Giuseppe Calcaterra Maria Pia Calabrò Maria Giovanna Russo Pier Paolo Bassareo Paolo Guccione Ciro Indolfi Giovanni Di Salvo Background. The...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1775: Leveraging Fitness Tracker and Personalized Exercise Prescription to Promote Breast Cancer Survivors’ Health Outcomes: A Feasibility Study Journal of Clinical Medicine doi: 10.3390/jcm9061775 Authors: Nan Zeng Ning Liao Chunyuan Han Wenxi Liu Zan Gao Purpose: This feasibility study investigated whether a year-long combined fitness wristband-based and personalized exercise prescription intervention improves Chinese breast cancer survivors’...
Mon Jun 08, 2020 03:00
JCM, Vol. 9, Pages 1771: Effectiveness and Nephrotoxicity of Long-Term Tacrolimus Administration in Patients with Ulcerative Colitis Journal of Clinical Medicine doi: 10.3390/jcm9061771 Authors: Keiichi Haga Tomoyoshi Shibuya Kei Nomura Koki Okahara Osamu Nomura Dai Ishikawa Naoto Sakamoto Taro Osada Akihito Nagahara Background: Tacrolimus (TAC) is used for the management of ulcerative colitis (UC). However, there are few reports on the effectiveness of its long-term...
Sun Jun 07, 2020 03:00
JCM, Vol. 9, Pages 1772: Different Toxicity Profiles Predict Third Line Treatment Efficacy in Metastatic Colorectal Cancer Patients Journal of Clinical Medicine doi: 10.3390/jcm9061772 Authors: Unseld Fischöder Jachs Drimmel Siebenhüner Bianconi Kieler Puhr Minichsdorfer Winder Prager The nucleoside trifluridine/tipiracil (TAS-102) and the multikinase inhibitor regorafenib significantly improved survival in metastatic colorectal cancer patients...
Sun Jun 07, 2020 03:00
JCM, Vol. 9, Pages 1773: Sleep in the Supine Position during Pregnancy Is Associated with Fetal Cerebral Redistribution Journal of Clinical Medicine doi: 10.3390/jcm9061773 Authors: Robertson Okano Kumar : The supine sleep position in late pregnancy is a major risk factor for stillbirth, with a population attributable risk of 5.8% and one in four pregnant women reportedly sleeping in a supine position. Although the mechanisms linking the supine sleep position and late stillbirth...
Sun Jun 07, 2020 03:00
JCM, Vol. 9, Pages 1770: Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients Journal of Clinical Medicine doi: 10.3390/jcm9061770 Authors: Joaquim Bosch-Barrera Begoña Martin-Castillo Maria Buxó Joan Brunet José Antonio Encinar Javier A. Menendez COVID-19, the illness caused by infection with the novel coronavirus SARS-CoV-2, is a rapidly spreading global pandemic in urgent need of...
Sun Jun 07, 2020 03:00
JCM, Vol. 9, Pages 1769: Efficacy and Safety of Pembrolizumab for Gemcitabine/Cisplatin-Refractory Biliary Tract Cancer: A Multicenter Retrospective Study Journal of Clinical Medicine doi: 10.3390/jcm9061769 Authors: Sang Hoon Lee Hee Seung Lee Sang Hyub Lee Sang Myung Woo Dong Uk Kim Seungmin Bang Pembrolizumab, an anti-programmed cell death (PD)-1 monoclonal antibody, is an anticancer agent showing substantial benefit in lung cancer and melanoma treatment. Biliary tract...
Sun Jun 07, 2020 03:00
JCM, Vol. 9, Pages 1768: Ocular Blood Flow Changes Impact Visual Acuity Gain after Surgical Treatment for Idiopathic Epiretinal Membrane Journal of Clinical Medicine doi: 10.3390/jcm9061768 Authors: Felix Rommel Max P. Brinkmann Jan A. M. Sochurek Michelle Prasuhn Salvatore Grisanti Mahdy Ranjbar Background: Idiopathic epiretinal membrane (iERM) is a common eye disease, which can be treated by surgical removal of the fibrotic tissue. Morphological outcome is generally...
Sun Jun 07, 2020 03:00
JCM, Vol. 9, Pages 1767: Predicting Acute Kidney Injury after Cardiac Surgery by Machine Learning Approaches Journal of Clinical Medicine doi: 10.3390/jcm9061767 Authors: Charat Thongprayoon Panupong Hansrivijit Tarun Bathini Saraschandra Vallabhajosyula Poemlarp Mekraksakit Wisit Kaewput Wisit Cheungpasitporn Cardiac surgery-associated AKI (CSA-AKI) is common after cardiac surgery and has an adverse impact on short- and long-term mortality. Early identification of...
Sun Jun 07, 2020 03:00
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