The bone thickness of the human mandibular ramus is an important parameter in mandibular surgeries. The aim of this study was to systematically measure the bicortical bone thickness, the ramus dimensions and t...
Mon Jun 08, 2020 03:00
Abstract Purpose The incidence of primary congenital hypothyroidism (CH) has grown progressively and literature data indicate an association between CH and congenital malformations. The purpose of this study is to establish the current incidence of CH in the Italian Region of Piedmont and verify the relationship between CH diagnostic categories and associated malformations. ...
Sun Jun 07, 2020 03:00
Abstract The novel coronavirus disease COVID-19 is produced by SARS-CoV-2. WHO has declared COVID-19 as a public health emergency, with the most susceptible populations (requiring ventilation) being the elderly, pregnant women and people with associated co-morbidities including heart failure, uncontrolled diabetes, chronic obstructive pulmonary disease, asthma and cancer. However, such general guidance does not provide information regarding COVID-19 risks in patients with suffering...
Sun Jun 07, 2020 03:00
Abstract Purpose The identification of somatic mutations in cancer specimens enables detection of molecular markers for personalized treatment. We recently developed a novel molecular assay and evaluated its clinical performance as an ancillary molecular method for indeterminate thyroid nodule cytology. Herein we describe the analytical validation of the novel targeted next-generation sequencing (NGS) assay in thyroid samples from different...
Sat Jun 06, 2020 03:00
Abstract Purpose Distant metastasis from papillary thyroid cancer is rare, and the more frequent site is neck and bone. During follow-up after surgery new distant lesions could appear, while Tg levels remain normal. When suspicious lesions are superficial, fine needle aspiration is the first choice. In case of deeper localization, the diagnosis could need more invasive procedure, such as in case of lung nodules. ...
Sat Jun 06, 2020 03:00
Abstract Purpose We aimed to evaluate the performance of structural magnetic resonance imaging (MRI)-based quantitative measurements at extraocular muscle (EOM), orbital fat (OF), and especially lacrimal gland (LG) in predicting response to glucocorticoid (GC) in patients with active and moderate–severe thyroid-associated ophthalmopathy (TAO). Methods ...
Fri Jun 05, 2020 03:00
Abstract Purpose Short stature is a common clinical presentation, thus it is widely accepted that it is a polygenic trait. However, genome wide association and next generation sequencing studies have recently challenged this view, suggesting that many of the children classified as idiopathic short stature could instead have monogenic defects. Linear growth is determined primarily by chondrogenesis at the growth plate. This process results...
Fri Jun 05, 2020 03:00
Abstract Purpose To evaluate how self-care maintenance, self-care monitoring, and self-care management affect glycated haemoglobin in type 2 diabetes mellitus patients and to set cut-off points of the Self-Care of Diabetes Inventory scales using glycated haemoglobin as outcome of interest. Methods A secondary analysis of a previous multicentre observational...
Fri Jun 05, 2020 03:00
Publication date: Available online 6 June 2020Source: Cancer/RadiothérapieAuthor(s): Antoine Talbot, Laura Devos, François Dubus, Maximilien Vermandel
Sun Jun 07, 2020 17:09
Publication date: Available online 4 June 2020Source: Cancer/RadiothérapieAuthor(s): Isabelle Gardin
Fri Jun 05, 2020 14:24
Publication date: Available online 6 June 2020Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): M. Jafari, L. Schneider-Bordat, B. Hersant
Sun Jun 07, 2020 17:03
Publication date: Available online 5 June 2020Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): B. Hersant, G. Werkoff, D. Sawan, M. Sidahmed-Mezi, R. Bosc, S. La Padula, S. Kalsoum, N. Ouidir, J.-P. Meningaud, Y. Belkacemi
Sat Jun 06, 2020 21:08
Related ArticlesEnhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions. Proc Natl Acad Sci U S A. 2020 Jun 05;: Authors: Wang Y, Liu M, Gao J Abstract Molecular dynamics and free energy simulations have been carried out to elucidate the structural origin of differential protein-protein interactions between the common receptor protein angiotensin converting enzyme 2 (ACE2) and the receptor binding domains...
Sun Jun 07, 2020 16:54
Related ArticlesPhosphorylation barcode-dependent signal bias of the dopamine D1 receptor. Proc Natl Acad Sci U S A. 2020 Jun 05;: Authors: Kaya AI, Perry NA, Gurevich VV, Iverson TM Abstract Agonist-activated G protein-coupled receptors (GPCRs) must correctly select from hundreds of potential downstream signaling cascades and effectors. To accomplish this, GPCRs first bind to an intermediary signaling protein, such as G protein or arrestin. These intermediaries...
Sun Jun 07, 2020 16:54
Related ArticlesAboriginal fires modify an ideal free distribution. Proc Natl Acad Sci U S A. 2020 Jun 05;: Authors: O'Connell JF PMID: 32503916 [PubMed - as supplied by publisher]
Sun Jun 07, 2020 16:54
Related ArticlesChecking autoimmune genetic risk to stratify immune checkpoint inhibitor responders. Proc Natl Acad Sci U S A. 2020 Jun 05;: Authors: Sinha AA PMID: 32503915 [PubMed - as supplied by publisher]
Sun Jun 07, 2020 16:54
Related ArticlesCritical period regulation across multiple timescales. Proc Natl Acad Sci U S A. 2020 Jun 05;: Authors: Reh RK, Dias BG, Nelson CA, Kaufer D, Werker JF, Kolb B, Levine JD, Hensch TK Abstract Brain plasticity is dynamically regulated across the life span, peaking during windows of early life. Typically assessed in the physiological range of milliseconds (real time), these trajectories are also influenced on the longer timescales of developmental...
Sun Jun 07, 2020 16:54
Related ArticlesASY1 acts as a dosage-dependent antagonist of telomere-led recombination and mediates crossover interference in Arabidopsis. Proc Natl Acad Sci U S A. 2020 Jun 04;: Authors: Lambing C, Kuo PC, Tock AJ, Topp SD, Henderson IR Abstract During meiosis, interhomolog recombination produces crossovers and noncrossovers to create genetic diversity. Meiotic recombination frequency varies at multiple scales, with high subtelomeric recombination...
Sat Jun 06, 2020 16:34
Related ArticlesNews Feature: How air pollution threatens brain health. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Peeples L PMID: 32493753 [PubMed - as supplied by publisher]
Fri Jun 05, 2020 16:08
Related ArticlesOpinion: Intercepting pandemics through genomics. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Kress WJ, Mazet JAK, Hebert PDN PMID: 32493752 [PubMed - as supplied by publisher]
Fri Jun 05, 2020 16:08
Related ArticlesCarbenium ion-mediated oligomerization of methylglyoxal for secondary organic aerosol formation. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Ji Y, Shi Q, Li Y, An T, Zheng J, Peng J, Gao Y, Chen J, Li G, Wang Y, Zhang F, Zhang AL, Zhao J, Molina MJ, Zhang R Abstract Secondary organic aerosol (SOA) represents a major constituent of tropospheric fine particulate matter, with profound implications for human health and climate. However,...
Fri Jun 05, 2020 16:08
Related ArticlesTestis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ, Mainpal R, Totonchi M, Mohseni Meybodi A, Askari M, Merel-Chali T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Perez Garrido N, Berensztein E, Mekkawy MK,...
Fri Jun 05, 2020 16:08
Related ArticlesRational design of a conformation-specific antibody for the quantification of Aβ oligomers. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Aprile FA, Sormanni P, Podpolny M, Chhangur S, Needham LM, Ruggeri FS, Perni M, Limbocker R, Heller GT, Sneideris T, Scheidt T, Mannini B, Habchi J, Lee SF, Salinas PC, Knowles TPJ, Dobson CM, Vendruscolo M Abstract Protein misfolding and aggregation is the hallmark of numerous human disorders, including...
Fri Jun 05, 2020 16:08
Related ArticlesEmergent linguistic structure in artificial neural networks trained by self-supervision. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Manning CD, Clark K, Hewitt J, Khandelwal U, Levy O Abstract This paper explores the knowledge of linguistic structure learned by large artificial neural networks, trained via self-supervision, whereby the model simply tries to predict a masked word in a given context. Human language communication is...
Fri Jun 05, 2020 16:08
Related ArticlesActive and repressed biosynthetic gene clusters have spatially distinct chromosome states. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Nützmann HW, Doerr D, Ramírez-Colmenero A, Sotelo-Fonseca JE, Wegel E, Di Stefano M, Wingett SW, Fraser P, Hurst L, Fernandez-Valverde SL, Osbourn A Abstract While colocalization within a bacterial operon enables coexpression of the constituent genes, the mechanistic logic of clustering of nonhomologous...
Fri Jun 05, 2020 16:08
Related ArticlesNanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Buss CG, Bhatia SN Abstract The recent advent of immune checkpoint inhibitor (CPI) antibodies has revolutionized many aspects of cancer therapy, but the efficacy of these breakthrough therapeutics remains limited, as many patients fail to respond for reasons that still largely...
Fri Jun 05, 2020 16:08
Related ArticlesSelf-assembled plasmonics for angle-independent structural color displays with actively addressed black states. Proc Natl Acad Sci U S A. 2020 Jun 03;: Authors: Franklin D, He Z, Mastranzo Ortega P, Safaei A, Cencillo-Abad P, Wu ST, Chanda D Abstract Nanostructured plasmonic materials can lead to the extremely compact pixels and color filters needed for next-generation displays by interacting with light at fundamentally small length scales....
Fri Jun 05, 2020 16:08
Alternative splicing (AS) generates various transcripts from a single gene and thus plays a significant role in transcriptomic diversity and proteomic complexity. Alu elements are primate-specific transposable el...
Fri Jun 05, 2020 03:00
The diversification process known as the Lake Tanganyika Radiation has given rise to the most speciose clade of African cichlids. Almost all cichlid species found in the lakes Tanganyika, Malawi and Victoria, ...
Fri Jun 05, 2020 03:00
The latest advancements in DNA sequencing technologies have facilitated the resolution of the phylogeny of insects, yet parts of the tree of Holometabola remain unresolved. The phylogeny of Neuropterida has be...
Wed Jun 03, 2020 03:00
Related ArticlesComparison of 3 γ-probes for simultaneous iodine-125-seed and technetium-99m breast cancer surgery: NEMA standard characterisation with extended processing. EJNMMI Phys. 2020 Jun 05;7(1):37 Authors: Hoog C, Koulibaly PM, Dejean C, Desdoits T, Humbert O, Barranger E, Darcourt J Abstract PURPOSE: Iodine-125 (125I) seeds can be used as landmarks to locate non-palpable breast lesions instead of implanting metal wires. This relatively new...
Sun Jun 07, 2020 16:47
Related ArticlesCompartment syndrome of the leg after thyroid hormone withdrawal; two cases and a systematic review of the literature. BMC Endocr Disord. 2020 Jun 05;20(1):80 Authors: van Veelen NM, Fischli S, Beeres FJP, Eisenhut T, Babst R, Henzen C, Link BC Abstract BACKGROUND: Acute compartment syndrome is a rare complication of severe hypothyroidism. If the symptoms are not recognized promptly and treatment initiated immediately, there is a high...
Sun Jun 07, 2020 16:47
Related ArticlesRadiotheragnostics Paradigm for Radioactive Iodine (Iodide) Management of Differentiated Thyroid Cancer. Curr Pharm Des. 2020 Jun 05;: Authors: Slonimsky E, Tulchinsky M Abstract This review of radioactive iodide treatment (RAIT) extends from historical origins to its modern utilization in differentiated thyroid cancer (DTC). The principles embedded in the radiotheragnostics (RTGs) paradigm are detailed. The diverse approaches in current...
Sun Jun 07, 2020 16:47
Related ArticlesAnatomic evidence shows that lymphatic drainage exists in the pituitary to loop the cerebral lymphatic circulation. Med Hypotheses. 2020 May 30;143:109898 Authors: Elham E, Wumaier R, Wang C, Luo X, Chen T, Zhong N Abstract Respiratory infections can result in intracranial infections and unknown neurological symptoms. The central nervous system lacks classical meningeal lymphatic (circulation) drainage, and the exact underlying mechanisms...
Sun Jun 07, 2020 16:43
Related ArticlesPattern of infections in French and migrant homeless hospitalised at Marseille infectious disease units, France: A retrospective study, 2017-2018. Travel Med Infect Dis. 2020 Jun 03;:101768 Authors: Anh Ly TD, Dao TL, Hoang VT, Braunstein D, Brouqui P, Lagier JC, Parola P, Gautret P Abstract BACKGROUND: No research was conducted on the clinical characteristics and outcomes of Infectious Disease Units (IDU) managed homeless patients (HP)....
Sun Jun 07, 2020 16:43
Related ArticlesComparative genome analysis and characterization of a MDR Klebsiella variicola. Genomics. 2020 Jun 03;: Authors: Srinivasan VB, Rajamohan G Abstract Klebsiella variicola is an emerging pathogen responsible for causing blood-stream infections, urinary and respiratory tract related diseases in humans. In this report, we describe the genome sequence data and phenotypic characterization of K. variicola strain KV093 isolated from India. Comparative...
Sun Jun 07, 2020 16:43
Related ArticlesRisk of viral infection in patients using either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers: A nationwide population-based propensity score matching study. Clin Infect Dis. 2020 Jun 06;: Authors: Lin SY, Ju SW, Lin CL, Lin CC, Hsu WH, Chou CH, Chi CY, Hsu CY, Kao CH Abstract BACKGROUND: We hypothesized that renin-angiotensin system (RAS) blockers have systemic protective effects beyond the respiratory tract...
Sun Jun 07, 2020 16:43
Related ArticlesTigecycline-associated hypofibrinogenemia in a real-world setting. Int J Clin Pharm. 2020 Jun 05;: Authors: Campany-Herrero D, Larrosa-Garcia M, Lalueza-Broto P, Rivera-Sánchez L, Espinosa-Pereiro J, Mestre-Torres J, Pigrau-Serrallach C Abstract Background Tigecycline is a broad-spectrum antibiotic used to treat infections that do not respond to first-line treatments. High-doses and extended treatments are common; therefore, adverse events...
Sun Jun 07, 2020 16:43
Related ArticlesDoes vitamin D deficiency increase the severity of COVID-19? Clin Med (Lond). 2020 Jun 05;: Authors: Weir EK, Thenappan T, Bhargava M, Chen Y Abstract The severity of coronavirus 2019 infection (COVID-19) is determined by the presence of pneumonia, severe acute respiratory distress syndrome (SARS-CoV-2), myocarditis, microvascular thrombosis and/or cytokine storms, all of which involve underlying inflammation. A principal defence against...
Sun Jun 07, 2020 16:43
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