Parasitic weeds represent a major threat to agricultural production across the world. Little is known about which host genetic pathways determine compatibility for any host–parasitic plant interaction. We developed a quantitative assay to characterize the growth of the parasitic weed Phelipanche aegyptiaca on 46 mutant lines of the host plant Arabidopsis thaliana to identify host genes that are essential for susceptibility to the parasite. A. thaliana host plants with mutations in genes involved...
Mon Jun 08, 2020 03:00
Background Differences in the muscular activity between the high-bar back squat (HBBS) and the low-bar back squat (LBBS) on the same representative group of experienced powerlifters are still scarcely investigated. The main purpose of the study was to compare the normalized bioelectrical activity and maximal angles within single homogeneous group between the HBBS and LBBS for 60% one repetition maximum (1RM), 65% 1RM and 70% 1RM. Methods...
Mon Jun 08, 2020 03:00
Background & Aims Oxidative stress (OS) plays an important role in neurodegenerative diseases such as Alzheimer’s disease (AD). Lycopene is a pigment with potent antioxidant and anti-tumor effects. However, its potential role in central nervous system is not well-defined. The aim of this study was to investigate the effect of lycopene on the cell model of AD and determine its underlying mechanisms. Methods M146L...
Mon Jun 08, 2020 03:00
Terrestrial diatoms are an integral component of the soil microbial community. However, their productivity and how it compares to other algal groups remains poorly known. This lack of knowledge hampers their potential use as environmental markers in various applications. As a way forward, we investigated the seasonal and spatial patterns of diatom assemblages and the role of environmental factors on the soil diatom productivity. We collected soil algal samples in 16 sites across the Attert River...
Mon Jun 08, 2020 03:00
The use of ecological models enables determining the current distribution of species, but also their past distribution when matching climatic conditions are available. In specific cases, they can also be used to determine the likelihood of fossils to belong to the same species—under the hypothesis that all individuals of a species have the same ecological requirements. Here, using environmental modeling, we reconstructed the distribution of the Mongolian toad, Strauchbufo raddei, since the Last Glacial...
Fri Jun 05, 2020 03:00
The sweet cherry (Prunus avium) is one of the most economically important fruit species in the world. However, there is a limited amount of genetic information available for this species, which hinders breeding efforts at a molecular level. We were able to describe a high-quality reference genome assembly and annotation of the diploid sweet cherry (2n = 2x = 16) cv. Tieton using linked-read sequencing technology. We generated over 750 million clean reads, representing 112.63 GB of raw sequencing...
Fri Jun 05, 2020 03:00
Background Dexmedetomidine (Dex), a selective a2-adrenergic receptor agonist, has been previously reported to attenuate intrapulmonary shunt during one-lung ventilation (OLV) and to alleviate bronchoconstriction. However, the therapeutic effects of nebulized Dex on pulmonary shunt and lung mechanics during OLV have not been evaluated. Here we determine whether nebulized dexmedetomidine improved pulmonary shunt and lung mechanics in patients undergoing elective thoracic surgery in...
Fri Jun 05, 2020 03:00
Three new chasmosaurines from the Kirtland Formation (~75.0–73.4 Ma), New Mexico, form morphological and stratigraphic intermediates between Pentaceratops (~74.7–75 Ma, Fruitland Formation, New Mexico) and Anchiceratops (~72–71 Ma, Horseshoe Canyon Formation, Alberta). The new specimens exhibit gradual enclosure of the parietal embayment that characterizes Pentaceratops, providing support for the phylogenetic hypothesis that Pentaceratops and Anchiceratops are closely related. This stepwise change...
Fri Jun 05, 2020 03:00
Background So far, several techniques have been recommended for the assessment of craniofacial changes through skeletal tissue superimposition, but the evidence that supports them remains unexplored. The purpose of the present study is to assess the available literature on skeletal-tissue superimpositions of serial craniofacial CT or CBCT images used to detect morphological changes. Materials and Methods Medline (via...
Fri Jun 05, 2020 03:00
Head and neck squamous cell carcinoma (HNSCC) represents a significant world health problem, with approximately 600,000 new cases being diagnosed annually. The prognosis for patients with HNSCC is poor and, therefore, the identification of biomarkers for screening, diagnosis and prognostication would be clinically beneficial. A limited number of studies have used lipidomics to profile lipid species in the plasma of cancer patients. However, the profile and levels of lysophosphatidic acid (LPA) species...
Fri Jun 05, 2020 03:00
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression found in more than 200 diverse organisms. Although it is still not fully established if RNA viruses could generate miRNAs, there are examples of miRNA like sequences from RNA viruses with regulatory functions. In the case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), there are several mechanisms that would make miRNAs impact the virus, like interfering with viral replication, translation and even modulating...
Fri Jun 05, 2020 03:00
Empirical evidence of immune priming in arthropods keeps growing, both at the within- and trans-generational level. The evidence comes mostly from work on insects and it remains unclear for some other arthropods whether exposure to a non-lethal dose of a pathogen provides protection during a second exposure with a lethal dose. A poorly investigated group are arachnids, with regard to the benefits of immune priming measured as improved survival. Here, we investigated immune priming in two arachnids:...
Fri Jun 05, 2020 03:00
Abstract Purpose of Review This review provides clinical characterization and approach to management of neurotoxicities associated with checkpoint inhibitor therapy and chimeric antigen receptor T cell (CAR T cell) therapy. Recent Findings Immuno-oncology has revolutionized cancer treatment. The immunomodulatory effect of these treatments...
Mon Jun 08, 2020 03:00
Abstract Purpose of Review The management of brain and leptomeningeal metastases has changed significantly over the past decade. Recent Findings Historically, radiation therapy had been the mainstay of treatment. Several strategies to limit toxicities with radiation have been developed in the recent years. Increasingly systemic therapy...
Sat Jun 06, 2020 03:00
Abstract Past studies have found poorer performance on vertical heading judgement accuracy compared to horizontal heading judgement accuracy. In everyday life, precise vertical heading judgements are used less often than horizontal heading judgements as we cannot usually control our vertical direction. However, pilots judging a landing approach need to consistently discriminate vertical heading angles to land safely. This study addresses the impact of training on participants’...
Mon Jun 08, 2020 03:00
Abstract We explored how reward and value of effort shapes performance in a sustained vigilance, reaction time (RT) task. It was posited that reward and value would hasten RTs and increase cognitive effort by boosting activation in the sensorimotor cortex and inhibition in the frontal cortex, similar to the horse-race model of motor actions. Participants performed a series of speeded responses while expecting differing monetary rewards (0 pence (p), 1 p, and 10 p) if they responded...
Sun Jun 07, 2020 03:00
In the original publication of the article, Fig. 3 is incorrect.
Fri Jun 05, 2020 03:00
Abstract Background Swallowing after total laryngectomy (TL) is altered and the swallowing related issues are largely underreported. It is important to identify factors that may negatively influence swallowing after TL in order to rehabilitate these patients appropriately. Methods The study included patients who underwent TL from June 2015 to November 2017...
Mon Jun 08, 2020 03:00
Abstract Objective To assess data regarding round window (RW) visibility and surgical approaches in cochlear implant cases, and to describe and analyze surgical steps relevant for the RW approach in cochlear implantation. Study design Prospective clinical study. Methods A questionnaire...
Sat Jun 06, 2020 03:00
Abstract Introduction The novel Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, may need intensive care unit (ICU) admission in up to 12% of all positive cases for massive interstitial pneumonia, with possible long-term endotracheal intubation for mechanical ventilation and subsequent tracheostomy. The most common airway-related complications of such ICU maneuvers are laryngotracheal...
Sat Jun 06, 2020 03:00
Abstract Introduction Herpes zoster laryngitis (HZL) is a recently recognized rare disease, easily mistaken for common viral laryngopharyngitis. There are only a few case reports in the English literature. No study has evaluated the clinical characteristics of HZL. In this study, we analyzed the clinical characteristics of HZL and compared them to those of Ramsay Hunt syndrome (RHS). ...
Sat Jun 06, 2020 03:00
Depressive symptoms affect short- and long-term speech recognition outcome in cochlear implant users
Abstract Purpose To investigate the impact of the amount of depressive symptoms in cochlear implant (CI) recipients on the development of speech recognition after CI-activation up to 2 years. Design Retrospective data analysis of a German short form of the Beck Depression Inventory given at initial activation of the implant in relation to monosyllabic word...
Fri Jun 05, 2020 03:00
Abstract Purpose We here report about the first surgical experience and audiological outcome using a new, perimodiolar malleable cochlear implant electrode array for hearing rehabilitation after subtotal cochleoectomy for intralabyrinthine schwannoma (ILS). Method Based on a cochlear implant with MRI compatibility of the magnet in the receiver coil up to...
Fri Jun 05, 2020 03:00
The Journal of Antibiotics, Published online: 08 June 2020; doi:10.1038/s41429-020-0330-5Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates
Mon Jun 08, 2020 03:00
Mon Jun 08, 2020 03:00
Abstract Background Lower extremity overuse injuries are common in athletes participating in sports with repeated bouts of landing manoeuvres. Biomechanical alterations during landing may be associated with these types of injuries. The objective of this systematic review with meta-analysis was to summarise and determine the relationship between kinematic alterations during a landing task and the development of lower extremity overuse...
Mon Jun 08, 2020 03:00
Abstract Purpose Accurate nodal staging for male urogenital malignancies has important implications for therapy and prognosis. Male pelvic malignancies, including prostatic, penile, testicular, and bladder cancer, typically metastasize to regional lymph nodes first which is reported by the N-stage. Spread beyond these groups to non-regional nodes is regarded as M-stage disease. ...
Mon Jun 08, 2020 08:18
Abstract Purpose To describe the correlation between acute scrotum pain and tension hydrocele, focusing on US and Doppler features. Methods and materials We evaluated retrospectively a series of five patients with a long history of hydrocele who were referred to our institutions for increasing acute scrotal pain. Patients were approached with...
Mon Jun 08, 2020 08:18
Abstract We report on four patients with the nested variant of urothelial carcinoma (NVUC) of the urinary bladder and focus on their magnetic resonance imaging (MRI) findings. MRI showed that all lesions had irregular wall thickening with little protrusion into the bladder lumen. All had extravesical invasion, and two had invaded other organs (uterus and seminal vesicle). On T2-weighted images, all tumors mainly showed relatively strong hypointensity similar to that of the muscularis...
Mon Jun 08, 2020 08:18
Abstract Purpose To assess the efficacy of time-resolved MR angiography (MRA) in evaluating penile vasculature in patients with clinically suspected vascular anomalies contributing to their erectile dysfunction correlating with penile doppler ultrasound (PDUS) findings and clinical outcomes after surgical intervention. Methods Men (n = 26) with...
Mon Jun 08, 2020 08:18
Abstract Nonobstructive azoospermia (NOA) can be caused by various diseases, including congenital disorders, endocrine disorders, infections, tumor or tumor-like diseases, vascular diseases, etc. Diagnosis of the underlying cause of NOA is complicated and challenging. In this study, we introduce an MR examination protocol for the etiological diagnosis of NOA, and demonstrate a series of NOA patients with different causes and imaging findings. Except for lesions of testes, the...
Mon Jun 08, 2020 08:18
Authors: Lusine Paronyan, Lilit Babayan, Arsen Manucharyan, Dezdemonia Manukyan, Haykuhi Vardanyan, Gayane Melik-Andrasyan, Francis Schaffner and Vincent Robert.<br />Parasite Vol. 27 , page 42<br />Published online: 08/06/2020<br /> Keywords: Biodiversity ; Culicidae ; Invasive species ; Vector ; Malaria ; Arbovirus.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/1mtufFGyqZY" height="1" width="1" alt=""/>
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British Journal of Cancer, Published online: 08 June 2020; doi:10.1038/s41416-020-0917-4Intra-arterial hepatic beads loaded with irinotecan (DEBIRI) with mFOLFOX6 in unresectable liver metastases from colorectal cancer: a Phase 2 study
Mon Jun 08, 2020 02:44
British Journal of Cancer, Published online: 08 June 2020; doi:10.1038/s41416-020-0922-7CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma
Mon Jun 08, 2020 02:44
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