Abstract Ecological interactions between different species of yeasts have been observed and described extensively, but the mechanisms of interaction remain poorly understood. A hindrance to the characterization of multispecies yeast ecosystems is the lack of accurate methods for rapid real-time analysis of population dynamics in synthetic multispecies consortia. Here, we sought to accelerate and improve the sensitivity of ecological modelling and characterization of a synthetic...
Mon Jun 01, 2020 03:00
Abstract Baicalin is reported as an effective drug for ulcerative colitis (UC). However, its effect on gut microbiota and short-chain fatty acids (SCFAs) remains unknown. In this study, we investigated the role of baicalin on Th17/Treg balance, gut microbiota community, and SCFAs levels in trinitrobenzene sulphonic acid (TNBS)-induced UC rat model. We found the DAI scores were significantly increased in the TNBS-treated rats, while reduced in the baicalin-treated group in a...
Mon Jun 01, 2020 03:00
Abstract Amino groups derived from naturally abundant amino acids or (di)amines can be used as “shuttles” in nature for oxygen transfer to provide intermediates or products comprising N-O functional groups such as N-hydroxy, oxazine, isoxazolidine, nitro, nitrone, oxime, C-, S-, or N-nitroso, and azoxy units. To this end, molecular oxygen is activated by flavin, heme, or metal cofactor-containing enzymes and transferred to initially obtain N-hydroxy compounds, which can be further...
Fri Jun 05, 2020 03:00
Abstract Background The present study aims to comprehensively analyze expression of Activin signaling components in oral cancer, to determine the predominant Activin expressed and its influence on prognosis. As our preliminary studies indicated regulation of Activin gene by p63, we also propose to assess its correlation with p63/p53 in oral tumors and its impact on outcome. Methods Expression of Activin subunits, receptors and regulators was assessed by qRT‐PCR and western blotting. Correlation...
Mon Jun 08, 2020 12:45
Abstract Background Sarcomatoid variant of oral squamous cell carcinoma (OSCC) are aggressive tumors that frequently recur and metastasize. Our aim was to determine the survival outcomes and factors that predict its incidence in recurrent and second primary tumors (SPT). Methods We retrospectively analyzed the records of SPT and recurrent OSCC cases with sarcomatoid differentiation. The overall survival (OS) and disease free survival (DFS) was determined by the Kaplan‐Meier method. Logistic...
Sun Jun 07, 2020 17:47
Playstation 4 controller alternatives. (Ales Nesetril via Unsplash/)Like an athlete with a preferred pair of sneakers or a favorite bat, a heart-and-soul gamer has the one controller they wouldn’t think of going into battle without. Whether it’s due to responsive buttons, comfortable grip, or just an inspiring design, these are the controllers we reach for when it’s game on.If you’re looking for your next controller for gaming, you can start here. We found some of the best and more versatile PlayStation...
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Make it less of a pain to entertain. (Amazon/)Limited kitchen counter space next to the sink is a common problem, but if you wash at least some of your dishes by hand, drying them thoroughly with a towel and putting them away each time you have a meal isn’t always possible. A dish rack that maximizes the space you have will give you an incentive to keep your home neat and tidy, and could even provide room for that espresso maker you’ve been coveting. These four excellent choices are a big improvement...
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Park equipment closed down in New Zealand to help stop the spread of COVID-19. (Unsplash/)States around the country—and countries around the world—are working on reopening social and economic activity while still grappling with the COVID-19 pandemic. But that doesn’t mean we’re ready to revert back to life as usual. Epidemiologists are still unsure of when the world will return to normal. Here are some key pieces of COVID-19 news you may have missed this week. New Zealand has no active cases of the...
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A cluster of spawning sockeye salmon running in the Bristol Bay ecosystem. (Courtesy of the U.S. Environmental Protection Agency/)This story originally featured on Field & Stream.The battle over Pebble Mine—and the fate of the world’s largest salmon run—is expected to hit a major turning point this month. The U.S. Army Corps of Engineers’ final Environmental Impact Statement, a key document in permitting the controversial mine, may arrive as early as June 15. That document will ultimately present...
Mon Jun 08, 2020 23:00
Slice and dice easier. (amoon ra via Unsplash/)You can always eat more fruit. This is something that can’t be said about everything in your fridge or pantry, but it’s true of nature’s candy. Sure, some varietals make you work for it a little, but that shouldn’t be an excuse.With these innovative and convenient fruit-specific slicers and de-corers, you will no longer have any reason to avoid adding more fruit to your daily diet.Lord of the rings. (Amazon/)Hacking into a pineapple can be an arduous...
Mon Jun 08, 2020 22:02
Make the cool choice. (SHOP SLO via Unsplash/)When high heat and humidity come on strong, a simple open window with a fan in front of it just doesn’t cut it. Sometimes, it can even make things worse. Instead of trapping hot air in your home and moving it from point A to point B, put an air conditioner in the nearest window and bask in the unique comfort and relief that only air conditioning can bring when the mercury rises. You’ll sweat less, think more clearly, and you’ll find that it’s so easy...
Mon Jun 08, 2020 21:52
Splash-tastic, as they say. (Christine Larsen via Unsplash/)When the weather heats up, people—especially kids—will find any way possible to cool down. Water balloons, a neighbor’s sprinkler, even just a no-frills blast from a garden hose will do. But the strive to refresh can also be fun, thanks to the right inflatable pool.From simple pools to elaborate activity centers, here are some of the best ways to easily turn your backyard into an epic play space.Almost a beach. (Amazon/)Pools of any size...
Mon Jun 08, 2020 21:47
Protesters in Washington, D.C. faced off with canisters of tear gas at the end of May. (Koshu Kunii/Unsplash/)Grey clouds waft over scattering crowds in the footage from Seattle this past Sunday. The yells and screams of police and protesters alike are punctuated by shots of flare guns. Eventually, the street empties out, but the haze of tear gas continues to swirl under the lights.As more and more dissidents take to the streets in solidarity with Black Lives Matter, US police have unleashed some...
Mon Jun 08, 2020 21:35
You're already paying for your subscriptions, so you better get everything you can from them. (Daniel Korpai / Unsplash/)The number of Apple subscriptions you can sign up for has grown sharply. Today, monthly fees get you access to music, movies, TV shows, news, and exclusive games directly from Apple.While the prices for these subscriptions are competitive enough, you'll still want to get your money's worth—and that means making sure you're aware of all the features and tricks available to you.Apple...
Mon Jun 08, 2020 19:00
The light is strong enough for reading, but changes brightness and color depending on what you're doing. (Hatch /)Quality of sleep has endured some collateral damage during the COVID-19 pandemic. Even when people stick to their normal schedules, roughly a third of us suffer from bouts of acute, short-term insomnia. And since social distancing has thrown off our routines—and is causing even normal sleepers to experience unpleasant or chaotic dreams—the problem has only gotten worse. These troubles...
Mon Jun 08, 2020 17:00
Take home the best. (Mae Mu via Unsplash/)Only the unimaginative think waffles are just for breakfast. True connoisseurs know that they make a perfect meal any time of the day, topped with maple syrup, fruit, ice-cream, fried chicken, whatever. It’s tough to find a bad way to eat a waffle. The kind you keep in the freezer are convenient, but if you want waffles that are super fluffy and have delicately crispy edges like the ones at a restaurant (not to mention way cheaper to freeze on your own),...
Mon Jun 08, 2020 16:10
The Agulhas II, the ship used to image the ridges (Courtesy Julian Dowdeswell/)In the past couple of decades, we’ve had satellites trained on Earth’s ice sheets, documenting climate change-induced losses. But those years are a small sample when it comes to understanding the range of behavior these frozen areas can exhibit over the eons of geologic time.That’s why glacial geologists are now looking underwater to learn more about ice sheets. Just like glaciers have carved the land, leaving behind features...
Mon Jun 08, 2020 15:00
There's more than one solution to these head-scratchers. (PopSci/)We know you are bored at home right now—we are too. Here are some puzzles and brainteasers to challenge your family and friends with, either in person or over video chat. Few tasks send shivers up more spines than a math problem. Expunge your fears by cracking these puzzles dubbed “Sums” by their creator, engineer Gordon Burgin.A small set of rules: The numbers in each sector of the above circle, square, and star equal the sum of the...
Sun Jun 07, 2020 16:00
A close up view of the giant larvacean, the blue tad-pole-like swoosh in the center, and its snot palace. (MBARI/)Every animal has its own idea of the perfect home. For the giant larvacean, that home is pretty darn weird—and new research shows that their slimy homes are even wackier than we thought. With their bulbous heads and flat tails, these gelatinous invertebrates look like big, ghostly tadpoles. Though they grow to reach the size of a breakfast muffin, they are usually surrounded by self-constructed...
Sat Jun 06, 2020 22:00
Behold: the power of the sun. (Vivint Solar/Unsplash/)If you live in an area with abundant sunlight—hello, fellow southern Californians—you’ve probably thought about installing solar panels on your roof to save on your electric bill. But with so much information, it can be hard to know where to start.Look no further—start hereBetween the different types of panels, financing, inverters, and other jargon, researching solar energy can feel overwhelming at first. That’s why I recommend starting at a...
Sat Jun 06, 2020 16:30
It looks serene, but your phone hates it. (Twitter /)Changing your phone’s background image is fun. Who doesn’t want to see your cat stuck inside of a Trader Joe’s bag every time you pick up your device? But, some Android users have found that setting a particular image as their phone’s background is enough to send their smartphones into an inescapable loop that renders it mostly useless. The picture itself is a very appealing, but relatively generic, image of a serene landscape behind a small island...
Sat Jun 06, 2020 12:00
Mangrove trees and shrubs grow along tropical and subtropical coastlines, thriving in conditions that would kill most other plants. Mangroves also absorb a lot of excess carbon dioxide from the atmosphere (Kerrylee Rogers /)If we don’t curb fossil fuel emissions, mangroves around the world will be drowned by rapidly rising seas, researchers reported June 4 in the journal Science. The scientists used sediment cores to examine how the ancestors of today’s mangroves responded to sea level rise thousands...
Sat Jun 06, 2020 01:00
Most birding institutions and clubs discount Black participants, either through their whiteness or inaccessibility. (National Park Service /)Jacqueline L. Scott is a PhD student in Social Justice Education at the University of Toronto. This story originally featured on The Conversation.Birdwatching is open to all. Unless you are Black.This is the message Christian Cooper received as he was birding in New York City’s Central Park last week. When Cooper asked a white woman to obey the posted signs...
Fri Jun 05, 2020 23:00
This is a crowd from a concert, but the same techniques apply. (Pixabay/)It’s essential to document the world, especially in the midst of profound events such as the current protests and rallies happening around the country. But as any photojournalist or news shooter will tell you, putting images into the world comes with great responsibility. There’s a ton of information in every photo and video you share, some of which you might not even be aware of.Blurring faces in a flashLaws regarding facial...
Mon Jun 08, 2020 18:04
Gloves, masks, and signs—protest essentials. (Clay Banks / Unsplash/)Protesting has always been risky business. The current situation in the US, with people in all 50 states standing up to racism and police brutality, is no exception. But since we’re still in the middle of a pandemic, these demonstrations have an extra layer of risk.If you want to support the cause from home, you can help by donating to organizations and raising awareness of the issues that ignited the protests in the first place....
Fri Jun 05, 2020 17:00
Stay hydrated and prepared for anything, even in the most peaceful of protests. (Julian Wan on Unsplash/)Even if you’re planning on attending a peaceful protest, you should never assume you won’t encounter dangerous situations while exercising your first amendment rights.We chatted with nurses and healthcare providers across the country to see what you absolutely need to keep on you and keep in mind as you head out to protest. Here are a few tips for keeping your cool in a potentially fiery environment.Prepping...
Sun Jun 07, 2020 18:42
New instruments can generate maps of neutron stars in unprecedented detail, but physicists are still trying to figure out what lies beneath the surface. (NASA, NICER, GSFC's CI Lab/)The Earth is a balmy oasis in cosmos of raging extremes, and few bodies are more extreme than neutron stars. These objects form when stars of a certain mass die, and their cores collapse and cram a couple of suns worth of mass into an orb the size of a city. Inside, atoms as we know them—dense beads of protons and neutrons...
Fri Jun 05, 2020 18:40
Abstract ImmunoCAP ISAC (ISAC, Phadia, Uppsala, Sweden) helps to reveal the IgE sensitization profile of multisensitized patients and the potential risk for severe reactions.1 It is also useful for identifying cross‐reactive IgE patterns and might direct the treatment of allergic disease.1 This multiplex allergen test enables the measurement of IgE antibodies to a fixed panel of 112 components from 51 allergen sources in a single step, including two major venom components, honeybee rApi m1 and yellow...
Mon Jun 08, 2020 11:53
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