Cells, Vol. 9, Pages 1422: The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient Cells doi: 10.3390/cells9061422 Authors: Chris Happé Kondababu Kurakula Xiao-Qing Sun Denielli da Silva Goncalves Bos Nina Rol Christophe Guignabert Ly Tu Ingrid Schalij Karien C. Wiesmeijer Olga Tura-Ceide Anton Vonk Noordegraaf Frances S. de Man Harm Jan Bogaard Marie-José Goumans Background: Mutations in bone morphogenetic...
Cells, Vol. 9, Pages 1421: The Aquaporin3 Promoter Polymorphism −1431 A/G is Associated with Acute Graft Rejection and Cytomegalovirus Infection in Kidney Recipients Due to Altered Immune Cell Migration Cells doi: 10.3390/cells9061421 Authors: Katharina Rump Tim Rahmel Anna-Maria Rustige Matthias Unterberg Hartmuth Nowak Björn Koos Peter Schenker Richard Viebahn Michael Adamzik Lars Bergmann Major complications after kidney transplantation are graft rejection...
Cells, Vol. 9, Pages 1420: Dementia, Depression, and Associated Brain Inflammatory Mechanisms after Spinal Cord Injury Cells doi: 10.3390/cells9061420 Authors: Yun Li Tuoxin Cao Rodney M. Ritzel Junyun He Alan I. Faden Junfang Wu Evaluation of the chronic effects of spinal cord injury (SCI) has long focused on sensorimotor deficits, neuropathic pain, bladder/bowel dysfunction, loss of sexual function, and emotional distress. Although not well appreciated clinically, SCI...
Cells, Vol. 9, Pages 1419: Exosome-Derived LINC00960 and LINC02470 Promote the Epithelial-Mesenchymal Transition and Aggressiveness of Bladder Cancer Cells Cells doi: 10.3390/cells9061419 Authors: Cheng-Shuo Huang Jar-Yi Ho Jung-Hwa Chiang Cheng-Ping Yu Dah-Shyong Yu Exosomes are essential for several tumor progression-related processes, including the epithelial–mesenchymal transition (EMT). Long non-coding RNAs (lncRNAs) comprise a major group of exosomal components...
Cells, Vol. 9, Pages 1418: The Stemness of Human Ovarian Granulosa Cells and the Role of Resveratrol in the Differentiation of MSCs—A Review Based on Cellular and Molecular Knowledge Cells doi: 10.3390/cells9061418 Authors: Malgorzata Jozkowiak Greg Hutchings Maurycy Jankowski Katarzyna Kulcenty Paul Mozdziak Bartosz Kempisty Robert Z. Spaczynski Hanna Piotrowska-Kempisty Ovarian Granulosa Cells (GCs) are known to proliferate in the developing follicle and undergo...
Cells, Vol. 9, Pages 1417: Phosphoinositide Profile of the Mouse Retina Cells doi: 10.3390/cells9061417 Authors: Stella Finkelstein Sidney M. Gospe Kai Schuhmann Andrej Shevchenko Vadim Y. Arshavsky Ekaterina S. Lobanova Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported to cause visual dysfunction in animal models and human patients, our understanding of the phosphoinositide...
Cells, Vol. 9, Pages 1416: Symmetry Breaking and Epithelial Cell Extrusion Cells doi: 10.3390/cells9061416 Authors: Bageshri Naimish Nanavati Alpha S. Yap Jessica L. Teo Cell extrusion is a striking morphological event found in epithelia and endothelia. It is distinguished by two symmetry-breaking events: a loss of planar symmetry, as cells are extruded in either apical or basal directions; and loss of mechanochemical homogeneity within monolayers, as cells that are fated to be...
Cells, Vol. 9, Pages 1415: Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin–BAF Interaction and BAF Nuclear Localization Cells doi: 10.3390/cells9061415 Authors: Vittoria Cenni Stefano Squarzoni Manuela Loi Elisabetta Mattioli Giovanna Lattanzi Cristina Capanni Reactive Oxygen Species (ROS) are reactive molecules required for the maintenance of physiological functions. Oxidative stress arises when ROS production exceeds the...
Cells, Vol. 9, Pages 1413: Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity Cells doi: 10.3390/cells9061413 Authors: Hu Cano Saez-Torres LeBlanc Saint-Geniez Ng Argüeso D’Amore Endomucin (EMCN) is the type I transmembrane glycoprotein, mucin-like component of the endothelial cell glycocalyx. We have previously shown that EMCN is necessary for vascular endothelial growth factor (VEGF)-induced VEGF receptor 2 (VEGFR2)...
Cells, Vol. 9, Pages 1414: IL-6 trans-Signaling Impairs Sprouting Angiogenesis by Inhibiting Migration, Proliferation and Tube Formation of Human Endothelial Cells Cells doi: 10.3390/cells9061414 Authors: Zegeye Andersson Sirsjö Ljungberg Sprouting angiogenesis is the formation of new capillaries from existing vessels in response to tissue hypoxia due to growth/development, repair/healing, and also chronic inflammation. In this study, we aimed to elucidate the effect of...
Cells, Vol. 9, Pages 1409: microRNA in Extracellular Vesicles Released by Damaged Podocytes Promote Apoptosis of Renal Tubular Epithelial Cells Cells doi: 10.3390/cells9061409 Authors: Jin Seok Jeon Eunbit Kim Yun-Ui Bae Won Mi Yang Haekyung Lee Hyoungnae Kim Hyunjin Noh Dong Cheol Han Seongho Ryu Soon Hyo Kwon Tubular injury and fibrosis are associated with progressive kidney dysfunction in advanced glomerular disease. Glomerulotubular crosstalk is thought...
Cells, Vol. 9, Pages 1411: The Role of Hematopoietic Cell Transplant in the Glycoprotein Diseases Cells doi: 10.3390/cells9061411 Authors: Brianna M. Naumchik Ashish Gupta Heather Flanagan-Steet Richard A. Steet Sara S. Cathey Paul J. Orchard Troy C. Lund The glycoprotein disorders are a group of lysosomal storage diseases (α-mannosidosis, aspartylglucosaminuria, β-mannosidosis, fucosidosis, galactosialidosis, sialidosis, mucolipidosis II, mucolipidosis...
Cells, Vol. 9, Pages 1410: Inhibition of ABCC6 Transporter Modifies Cytoskeleton and Reduces Motility of HepG2 Cells via Purinergic Pathway Cells doi: 10.3390/cells9061410 Authors: Angela Ostuni Monica Carmosino Rocchina Miglionico Vittorio Abruzzese Fabio Martinelli Daniela Russo Ilaria Laurenzana Agata Petillo Faustino Bisaccia ABCC6, belonging to sub-family C of ATP-binding cassette transporter, is an ATP-dependent transporter mainly present in the basolateral...
Cells, Vol. 9, Pages 1408: Closo-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy Cells doi: 10.3390/cells9061408 Authors: Marcos Couto Catalina Alamón María García Mariángeles Kovacs Emiliano Trias Susana Nievas Emiliano Pozzi Paula Curotto Silvia Thorp María Dagrosa Francesc Teixidor Clara Viñas Hugo Cerecetto One of the driving...
Cells, Vol. 9, Pages 1412: Breast Cancer Chemotherapeutic Options: A General Overview on the Preclinical Validation of a Multi-Target Ruthenium(III) Complex Lodged in Nucleolipid Nanosystems Cells doi: 10.3390/cells9061412 Authors: Maria Grazia Ferraro Marialuisa Piccolo Gabriella Misso Francesco Maione Daniela Montesarchio Michele Caraglia Luigi Paduano Rita Santamaria Carlo Irace In this review we have showcased the preclinical development of original amphiphilic...
Cells, Vol. 9, Pages 1406: Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models Cells doi: 10.3390/cells9061406 Authors: James A. Gregory Emily Hoelzli Rawan Abdelaal Catherine Braine Miguel Cuevas Madeline Halpern Natalie Barretto Nadine Schrode Güney Akbalik Kristy Kang Esther Cheng Kathryn Bowles Steven Lotz Susan Goderie Celeste M. Karch Sally Temple Alison Goate Kristen J. Brennand Hemali Phatnani...
Cells, Vol. 9, Pages 1407: Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis Cells doi: 10.3390/cells9061407 Authors: Michael Chvanov Svetlana Voronina Xiaoying Zhang Svetlana Telnova Robert Chard Yulin Ouyang Jane Armstrong Helen Tanton Muhammad Awais Diane Latawiec Robert Sutton David N. Criddle Alexei V. Tepikin ...
Cells, Vol. 9, Pages 1405: Newcastle Disease Virus (NDV) Oncolytic Activity in Human Glioma Tumors Is Dependent on CDKN2A-Type I IFN Gene Cluster Codeletion Cells doi: 10.3390/cells9061405 Authors: Noemi García-Romero Irina Palacín-Aliana Susana Esteban-Rubio Rodrigo Madurga Sergio Rius-Rocabert Josefa Carrión-Navarro Jesús Presa Sara Cuadrado-Castano Pilar Sánchez-Gómez Adolfo García-Sastre Estanislao Nistal-Villan Angel Ayuso-Sacido Glioblastoma (GBM)...
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Challenges, Vol. 11, Pages 10: Intelligent Collaborative Authoring of Place-Based, Cross-Cultural and Media-Rich Experiences Challenges doi: 10.3390/challe11010010 Authors: Konstantinos Kotis Dimitris Spiliotopoulos Andreas Papasalouros In this paper, we present a framework that aims to support the active participation and collaboration of knowledge workers and engineers in the co-authoring of place-based, cross-cultural and media-rich memories, experiences, stories and narration....
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Children, Vol. 7, Pages 59: Neurological Complications and Associated Risk Factors in Children Affected with Chronic Kidney Disease Children doi: 10.3390/children7060059 Authors: Osama Safder Sulafa Sindi Njood Nazer Asmaa Milyani Abdulrahman Makki To investigate the correlation between chronic kidney disease (CKD) and the development of neurological disease among pediatric patients in Saudi Arabia. The present retrospective study recruited patients admitted to King Abdulaziz...
Children, Vol. 7, Pages 58: Allergen Immunotherapy in Pediatric Asthma: A Pragmatic Point of View Children doi: 10.3390/children7060058 Authors: Michele Miraglia Del Giudice Amelia Licari Ilaria Brambilla Maria Angela Tosca Giorgio Ciprandi To date, the only disease-modifying treatment strategy for allergic rhinitis and asthma is allergen immunotherapy (AIT). There is evidence that AIT improves allergic rhinitis and asthma, such as reducing symptom severity and medication...
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Climate, Vol. 8, Pages 73: Building Resilience of Critical Infrastructure: A Case of Impacts of Cyclones on the Power Sector in Odisha Climate doi: 10.3390/cli8060073 Authors: Sujit Kumar Mohanty Ranit Chatterjee Rajib Shaw Odisha is multi-hazard-prone state in the eastern part of India. Among the various disasters, the frequency and severity of cyclones have increased at an alarming rate in the last two decades, which is attributed to climatic change. The state government of Odisha...
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Clocks & Sleep, Vol. 2, Pages 246-257: Sleep and Mental Health among Paramedics from Australia and Saudi Arabia: A Comparison Study Clocks & Sleep doi: 10.3390/clockssleep2020019 Authors: Wahaj Anwar A. Khan Russell Conduit Gerard A. Kennedy Ahmed Abdullah Alslamah Mohammad Ahmad Alsuwayeh Melinda L. Jackson Paramedics face many challenges while on duty, one of which is working different types of shifts. Shift work has been linked to a number of health issues such...
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Cosmetics, Vol. 7, Pages 44: Protective Effects of Salicornia europaea on UVB-Induced Misoriented Cell Divisions in Skin Epithelium Cosmetics doi: 10.3390/cosmetics7020044 Authors: Natsumi Doi Hiro Togari Kenji Minagi Koichi Nakaoji Kazuhiko Hamada Masaaki Tatsuka Correct orientation of cell division is extremely important in the maintenance, regeneration, and repair of continuously proliferating tissues, such as the epidermis. Regulation of the axis of division of epidermal...
Cosmetics, Vol. 7, Pages 43: Investigation Utilizing the HLB Concept for the Development of Moisturizing Cream and Lotion: In-Vitro Characterization and Stability Evaluation Cosmetics doi: 10.3390/cosmetics7020043 Authors: Shoaib Alam Mohammed S. Algahtani Mohammad Zaki Ahmad Javed Ahmad The current study aims to utilize the concept of the hydrophilic–lipophilic balance (HLB) value of ingredients for the development of a stable emulsion-based moisturizing cream and...
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Dentistry Journal, Vol. 8, Pages 57: 2019-nCoV: Measures Adopted at the Departments of Oral Surgery and Radiology during the Period of an Uncontrolled Transmission Increase Dentistry Journal doi: 10.3390/dj8020057 Authors: Lauren Bohner Melanie Maus Johannes Kleinheinz Marcel Hanisch A new mutation of 2019-nCoV emerged and has been spreading worldwide. Dental practices are an important person-to-person transmission route. In this regard, preventive measures are required to avoid...
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Diagnostics, Vol. 10, Pages 383: Shedding Light on Bladder Cancer Diagnosis in Urine Diagnostics doi: 10.3390/diagnostics10060383 Authors: Kit Man Chan Jonathan Gleadle Jordan Li Krasimir Vasilev Melanie MacGregor Blue light cystoscopy (BLC) is the most recent clinical approach in the detection and diagnosis of bladder cancer, a common type of cancer with a high rate of recurrence. Representing a significant advance over previous approaches, this photodynamic diagnostic technique...
Diagnostics, Vol. 10, Pages 384: “Noninfective Endocarditis”: A Case Report of Hereditary Coagulation Disorders in a 28-Year-Old Male Diagnostics doi: 10.3390/diagnostics10060384 Authors: Gregory Reid Luca Koechlin Oliver Reuthebuch Florian Rüter Helmut Hopfer Friedrich Eckstein David Santer We report a case of a young male who presented with acute limb ischemia after sport. With no prior history of disease, a non-infective endocarditis of the native aortic valve was...
Diagnostics, Vol. 10, Pages 382: The Assessment of Myocardial Strain by Cardiac Imaging in Healthy Infants with Acute Bronchiolitis: A Systematic Review and Meta-Analysis Diagnostics doi: 10.3390/diagnostics10060382 Authors: Moises Rodriguez-Gonzalez Alvaro Antonio Perez-Reviriego Ana Castellano-Martinez Helena Maria Cascales-Poyatos This study aims to systematically review the incidence of myocardial strain detected by echocardiography in previously healthy infants with acute...
Diagnostics, Vol. 10, Pages 385: Dural Metastases of Advanced Prostate Cancer Detected by 18F-Fluorocholine Diagnostics doi: 10.3390/diagnostics10060385 Authors: Morassi Bonacina Bnà Zaniboni Savelli Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned with complaints of headache...
Diagnostics, Vol. 10, Pages 381: Platelet-Rich Plasma Ameliorates Cyclophosphamide-Induced Acute Interstitial Cystitis/Painful Bladder Syndrome in a Rat Model Diagnostics doi: 10.3390/diagnostics10060381 Authors: Yung-Hsiang Chen Kee-Ming Man Wen-Chi Chen Po-Len Liu Kao-Sung Tsai Ming-Yen Tsai Yu-Tzu Wu Huey-Yi Chen Background: Interstitial cystitis/painful bladder syndrome (IC/PBS) could be treated to ameliorate urothelial injury. Here, we investigated the efficacy...
Diagnostics, Vol. 10, Pages 380: Renal Tumors in Young Adults: Is Preoperative Computer Tomography Imaging Suggestive for the Nature of the Tumors? Diagnostics doi: 10.3390/diagnostics10060380 Authors: Andreea Zaharie Sorana D. Bolboacă Tudor Moisoiu Dan Burghelea Gheorghita Iacob Liviu Ghervan Florin Ioan Elec Renal cell carcinoma (RCC) accounts for 2–3% of all adult malignant neoplasms and is even rarer in patients under 45 years old. Clear-cell carcinoma...
Diagnostics, Vol. 10, Pages 378: False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice Diagnostics doi: 10.3390/diagnostics10060378 Authors: Krisztián Molnár Endre Kálmán Zsófia Hári Omar Giyab Tamás Gáspár Károly Rucz Péter Bogner Arnold Tóth This study aims to test computer-aided diagnosis (CAD) for thyroid nodules in clinical ultrasonography (US) practice with a focus towards...
Diagnostics, Vol. 10, Pages 379: NS1 Recombinant Proteins Are Efficiently Produced in Pichia pastoris and Have Great Potential for Use in Diagnostic Kits for Dengue Virus Infections Diagnostics doi: 10.3390/diagnostics10060379 Authors: Xisto Prates Dias Dias Silva Paula Dengue is one of the major diseases causing global public health concerns. Despite technological advances in vaccine production against all its serotypes, it is estimated that the dengue virus is...
Diagnostics, Vol. 10, Pages 377: A Fluorescence in Situ Hybridization (FISH) Test for Diagnosing Babesiosis Diagnostics doi: 10.3390/diagnostics10060377 Authors: Shah Mark Caoili Poruri Horowitz Ashbaugh Ramasamy Apicomplexan parasites of the genus Babesia cause babesiosis in humans and animals. The microscopic examination of stained blood smears, detection of serum antibodies by immunoassays, and PCR-based identification of parasite nucleic acid in blood are...
Diagnostics, Vol. 10, Pages 376: Optimized Breath-Hold Compressed-Sensing 3D MR Cholangiopancreatography at 3T: Image Quality Analysis and Clinical Feasibility Assessment Diagnostics doi: 10.3390/diagnostics10060376 Authors: Song Kim Kuehn Paek Magnetic resonance cholangiopancreatography (MRCP) has been widely used in clinical practice, and recently developed compressed-sensing accelerated MRCP (CS-MRCP) has shown great potential in shortening the acquisition time. The purpose...
Diagnostics, Vol. 10, Pages 375: NTD Diagnostics for Disease Elimination: A Review Diagnostics doi: 10.3390/diagnostics10060375 Authors: Taylor Neglected Tropical Diseases (NTDs) marked out for disease elimination provide a lens through which to explore the changing status of diagnosis in global health. This paper reports on the findings of a scoping review, which set out to explore the main debates around diagnosis for the elimination of NTDs, including the multiple roles diagnostic...
Diagnostics, Vol. 10, Pages 374: Arterial Function in Healthy Pregnant Women vs. Non-Pregnant Women—A 10-Year Study Diagnostics doi: 10.3390/diagnostics10060374 Authors: Vladiana Turi Simona Dragan Mircea Iurciuc Lavinia Moleriu Simona Bungau Delia Mirela Tit Daniela-Oana Toader Camelia Cristina Diaconu Tapan Behl Izabella Petre Introduction. Maternal age for the first pregnancy is increasing and so, the prevalence of cardiovascular risk factors in pregnancy...
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Diseases, Vol. 8, Pages 18: Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer’s Diseases Diseases doi: 10.3390/diseases8020018 Authors: Khadijeh Ebrahimi Morteza Jourkesh Saeed Sadigh-Eteghad Stephen R Stannard Conrad P. Earnest Roger Ramsbottom Jose Antonio Khan H. Navin The prevalence of dementia has substantially increased worldwide. Currently, there is no cure for dementia or Alzheimer’s disease (AD), and care for affected patients...
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