Related ArticlesRobustness study of noisy annotation in deep learning based medical image segmentation. Phys Med Biol. 2020 Jun 05;: Authors: Yu S, Chen M, Zhang E, Wu J, Yu H, Yang Z, Ma L, Gu X, Lu W Abstract Partly due to the use of exhaustive-annotated data, deep networks have achieved impressive performance on medical image segmentation. Medical imaging data paired with noisy annotation are, however, ubiquitous, but little is known about the effect...
Sat Jun 06, 2020 15:54
Related ArticlesTargeting acute myeloid leukemia stem cells: Current therapies in development and potential strategies with new dimensions. Crit Rev Oncol Hematol. 2020 May 24;152:102993 Authors: Tan Y, Wu Q, Zhou F Abstract High relapse rate of acute myeloid leukemia (AML) is still a crucial problem despite considerable advances in anti-cancer therapies. One crucial cause of relapse is the existence of leukemia stem cells (LSCs) with self-renewal ability,...
Sat Jun 06, 2020 15:54
Related ArticlesCortisol and Dehydroepiandrosterone Response to ACTH and Frailty in Older Women. J Gerontol A Biol Sci Med Sci. 2020 Jun 05;: Authors: Le NP, Varadhan R, Fried LP, Cappola AR Abstract BACKGROUND: The response to adrenocorticotropic hormone (ACTH) is poorly characterized in old-old adults and may provide insight into the physiologic response to stress. METHODS: We performed a standard 250 mcg ACTH stimulation test in a home-based...
Sat Jun 06, 2020 15:54
Related ArticlesIntegrated Biophysical Modeling and Image Analysis: Application to Neuro-Oncology. Annu Rev Biomed Eng. 2020 Jun 04;22:309-341 Authors: Mang A, Bakas S, Subramanian S, Davatzikos C, Biros G Abstract Central nervous system (CNS) tumors come with vastly heterogeneous histologic, molecular, and radiographic landscapes, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics have...
Sat Jun 06, 2020 15:54
Related ArticlesUltrasound validation of predictive model for central cervical lymph node metastasis in papillary thyroid cancer on BRAF. Future Oncol. 2020 Jun 05;: Authors: Chen J, Li XL, Zhang YF, Wang D, Wang Q, Zhao CK, Li MX, Wei Q, Ji G, Xu HX Abstract Aim: To compare the value of predictive power of the models for central cervical lymph node metastasis (CLNM) in papillary thyroid carcinomas (PTCs). Patients & methods: 220 PTCs were prospectively...
Sat Jun 06, 2020 15:54
Related ArticlesImmunotherapy combinations for the treatment of patients with solid tumors. Future Oncol. 2020 Jun 05;: Authors: Bluthgen MV, Basté N, Recondo G Abstract Immune checkpoint inhibitors directed against CTLA-4, PD-1 and PD-L1 have transformed the treatment of patients with cancer. Immunotherapy regimens have evolved from a single agent approach to the combination of immune checkpoint inhibitors like anti CTLA-4 and PD-1, immune checkpoint...
Sat Jun 06, 2020 15:54
Related ArticlesComprehensive analysis of microenvironment-related genes in lung adenocarcinoma. Future Oncol. 2020 Jun 05;: Authors: Tao Y, Li Y, Liang B Abstract Aim: Understanding the cell types and cell compositions in tumor environment (TME) and the gene changes in lung adenocarcinoma (LUAD) may provide insights on immune profiles and treatment targets for LUAD patients. Materials & methods: The RNA-Seq data from The Cancer Genome Atlas database...
Sat Jun 06, 2020 15:54
Related ArticlesNanoparticle albumin-bound paclitaxel/liposomal-encapsulated doxorubicin in HER2-negative metastatic breast cancer patients. Future Oncol. 2020 Jun 05;: Authors: Fabi A, Ferretti G, Malaguti P, Gasparro S, Nisticò C, Arpino G, Papaldo P, Russillo M, Catania G, Schettini F, Giannarelli D, Cognetti F Abstract Aim: To investigate the toxicity of nab-paclitaxel (wNP)/nonpegylated liposome-encapsulated doxorubicin (wNPLD) combination in HER2-negative...
Sat Jun 06, 2020 15:54
Related ArticlesHealth orientation and individual tendencies of a sample of Italian genetic testing consumers. Mol Genet Genomic Med. 2020 Jun 05;:e1291 Authors: Oliveri S, Durosini I, Cutica I, Cincidda C, Spinella F, Baldi M, Gorini A, Pravettoni G Abstract BACKGROUND: Over the last decade, genetic testing (GT) had markedly spread in European countries and struggled the debate concerning the psychological effects on the population. The aim of this...
Sat Jun 06, 2020 15:54
Related ArticlesFertility-sparing treatment for early-stage epithelial ovarian cancer: Contemporary oncologic, reproductive and endocrinologic perspectives. J Obstet Gynaecol Res. 2020 Jun 04;: Authors: Mandelbaum RS, Klar M, Takiuchi T, Bainvoll L, Matsuzaki S, Paulson RJ, Matsuo K Abstract AIM: Epithelial ovarian cancer (EOC) can be a devastating diagnosis in women of reproductive age who desire future fertility. However, in early-stage disease, fertility-sparing...
Sat Jun 06, 2020 14:20
Related ArticlesIntegrative analysis of key candidate genes and signaling pathways in autoimmune thyroid dysfunction related to anti-CTLA-4 therapy by bioinformatics. Invest New Drugs. 2020 Jun 04;: Authors: Zhang Y, Garofano F, Wu X, Schmid M, Krawitz P, Essler M, Schmidt-Wolf IGH Abstract Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), the first immune checkpoint to be targeted clinically, has provided an effective treatment option for various...
Sat Jun 06, 2020 14:20
Related ArticlesThe Evolution of Targeted Therapies in Chronic Lymphocytic Leukaemia. Curr Hematol Malig Rep. 2020 Jun 04;: Authors: Gianfelici V, Levato L, Molica S Abstract PURPOSE OF REVIEW: The treatment landscape for chronic lymphocytic leukaemia (CLL) is rapidly evolving, with several targeted agents recently approved. These compounds have dramatically changed the natural history of the disease. RECENT FINDINGS: However, with the array...
Sat Jun 06, 2020 14:20
Related ArticlesHormonal prostate cancer therapies and cardiovascular disease: a systematic review. Heart Fail Rev. 2020 Jun 04;: Authors: Cereda V, Falbo PT, Manna G, Iannace A, Menghi A, Corona M, Semenova D, Calò L, Carnevale R, Frati G, Lanzetta G Abstract Therapeutic intervention for prostate cancer mostly relies on eliminating circulating androgen or antagonizing its effect at the cellular level. As the use of endocrine therapies grows, an under-reported...
Sat Jun 06, 2020 14:20
Related ArticlesValidation of an online tool for early prediction of the failure-risk in gestational trophoblastic neoplasia patients treated with methotrexate. Cancer Chemother Pharmacol. 2020 Jun 04;: Authors: Dekeister K, Bolze PA, Tod M, Tod R, Massardier J, Lotz JP, Hajri T, Colomban O, Seckl MJ, Osborne R, Freyer G, Golfier F, You B Abstract PURPOSE: In a low-risk gestational trophoblastic neoplasia (GTN) treated with methotrexate (MTX), the modeled...
Sat Jun 06, 2020 14:20
Related ArticlesClinical Outcomes and Multidisciplinary Patterns of Failure for Olfactory Neuroblastoma: The Ohio State Experience. J Neurol Surg B Skull Base. 2020 Jun;81(3):287-294 Authors: Wolfe AR, Blakaj D, London N, Blakaj A, Klamer B, Pan J, Wakely P, Prevedello L, Bonomi M, Bhatt A, Raval R, Palmer J, Prevedello D, Gamez M, Carrau R Abstract Purpose Olfactory neuroblastoma (ONB) is a rare head and neck cancer believed to be originated from neural...
Sat Jun 06, 2020 14:20
Related ArticlesAnti-aging and anti-tumor effect of FPP® supplementation. Eur J Transl Myol. 2020 Apr 07;30(1):8905 Authors: Logozzi M, Di Raimo R, Mizzoni D, Fais S Abstract The beneficial effect of FPP® as antioxidant is known. Here we summarize recent data supporting future implementation of FPP® in tumor treatment and in controlling aging at the molecular level. We first showed that oral FPP® is able to control tumor growth and with inducing a potent...
Sat Jun 06, 2020 14:20
Related ArticlesThe Addition of EGFR Inhibitors in Neoadjuvant Therapy for KRAS-Wild Type Locally Advanced Rectal Cancer Patients: A Systematic Review and Meta-Analysis. Front Pharmacol. 2020;11:706 Authors: Zhong X, Zhou Y, Cui W, Su X, Guo Z, Hidasa I, Li Q, Wang Z, Song Y Abstract Background: Patients with locally advanced rectal cancer (LARC) are at higher risk of local and distant recurrence and are thus more vulnerable to metastatic diseases. Neoadjuvant...
Sat Jun 06, 2020 14:20
Related ArticlesDeciphering human macrophage development at single-cell resolution. Nature. 2020 May 20;: Authors: Bian Z, Gong Y, Huang T, Lee CZW, Bian L, Bai Z, Shi H, Zeng Y, Liu C, He J, Zhou J, Li X, Li Z, Ni Y, Ma C, Cui L, Zhang R, Chan JKY, Ng LG, Lan Y, Ginhoux F, Liu B Abstract Macrophages are the first cells of the nascent immune system to emerge during embryonic development. In mice, embryonic macrophages infiltrate developing organs, where...
Sat Jun 06, 2020 14:20
Related ArticlesBreast cancer nursing interventions and clinical effectiveness: a systematic review. BMJ Support Palliat Care. 2020 Jun 04;: Authors: Chan RJ, Teleni L, McDonald S, Kelly J, Mahony J, Ernst K, Patford K, Townsend J, Singh M, Yates P Abstract OBJECTIVES: To examine the effects of nurse-led interventions on the health-related quality of life, symptom burden and self-management/behavioural outcomes in women with breast cancer. METHODS:...
Sat Jun 06, 2020 14:20
Related ArticlesNRG1/ERBB3 pathway activation induces acquired resistance to XPO1 inhibitors. Mol Cancer Ther. 2020 Jun 04;: Authors: Miyake TM, Pradeep S, Bayraktar E, Stur E, Handley KF, Wu SY, Rodriguez-Aguayo C, Lee JS, Lopez-Berestein G, Coleman RL, Sood AK Abstract XPO1 inhibitors have shown promise in cancer treatment, but mechanisms of resistance to these drugs are not well understood. In this study, we established selective inhibitors of nuclear...
Sat Jun 06, 2020 14:20
Related ArticlesDivergent Impact of Breast Cancer Laterality on Clinicopathological, Angiogenic, and Hemostatic Profiles: A Potential Role of Tumor Localization in Future Outcomes. J Clin Med. 2020 Jun 02;9(6): Authors: Barbara RC, Piotr R, Kornel B, Elżbieta Z, Danuta R, Eduardo N Abstract To date, lateral differences of invasive breast cancer (IBrC) with respect to the angiogenic and hemostatic profiles were never studied. Here, we aimed to determine...
Sat Jun 06, 2020 14:20
Related ArticlesCurrent Strategies and Novel Therapeutic Approaches for Metastatic Urothelial Carcinoma. Cancers (Basel). 2020 Jun 02;12(6): Authors: Mollica V, Rizzo A, Montironi R, Cheng L, Giunchi F, Schiavina R, Santoni M, Fiorentino M, Lopez-Beltran A, Brunocilla E, Brandi G, Massari F Abstract Urothelial carcinoma (UC) is a frequent cause of cancer-related deaths worldwide. Metastatic UC has been historically associated with poor prognosis, with...
Sat Jun 06, 2020 14:20
Related ArticlesUrban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis. Cells. 2020 Jun 02;9(6): Authors: Tsai MH, Chi MC, Hsu JF, Lee IT, Lin KM, Fang ML, Lee MH, Lee CW, Liu JF Abstract BACKGROUND: Rheumatoid arthritis (RA) has been associated with air pollution, possibly due to the augmentation of inflammatory effects. In this study, we aimed to determine the roles of...
Sat Jun 06, 2020 14:20
Related ArticlesSmall extracellular vesicle loading systems in cancer therapy: Current status and the way forward. Cytotherapy. 2019 11;21(11):1122-1136 Authors: Zhang YF, Shi JB, Li C Abstract Systemic chemotherapy is a conventional and important strategy for inhibition of cancer progression, but it is usually accompanied by various adverse effects. Targeting drug delivery systems, effective tools to avoid the adverse effects of chemotherapy, have...
Sat Jun 06, 2020 14:20
Related ArticlesRadiomics in cervical cancer: Current applications and future potential. Crit Rev Oncol Hematol. 2020 May 24;152:102985 Authors: Ai Y, Zhu H, Xie C, Jin X Abstract Cervical cancer is the most commonly diagnosed cancer among women. Early diagnosis and prediction will greatly improve the treatment outcome. Many clinical parameters have been used as diagnostic and prognostic factors for cervical cancer patients, including tumor stage, histological...
Fri Jun 05, 2020 15:01
Related ArticlesNanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer. J Control Release. 2020 Jun 01;: Authors: Liao ZX, Huang KY, Kempson IM, Li HJ, Tseng SA, Yang PC Abstract Lung cancer is the primary cause of cancer-related death worldwide. 85%-90% of cases are non-small cell lung cancer (NSCLC) which characteristically exhibits altered epidermal growth factor receptor (EGFR) signaling is a...
Fri Jun 05, 2020 15:01
Related ArticlesThe SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells. Toxicol Appl Pharmacol. 2020 Jun 01;:115080 Authors: Chang YC, Kondapuram SK, Yang TH, Syed SB, Cheng SM, Lin TY, Lin YC, Coumar MS, Chang JY, Leung E, Cheung CHA Abstract Upregulation of ABCB1/MDR1 (P-gp) and BIRC5/Survivin promotes multidrug resistance in a variety of human cancers. LCL161 is an anti-cancer...
Fri Jun 05, 2020 15:01
Related ArticlesDe-Escalation After DE-ESCALATE and RTOG 1016: A Head and Neck Cancer InterGroup Framework for Future De-Escalation Studies. J Clin Oncol. 2020 Jun 04;:JCO2000056 Authors: Mehanna H, Rischin D, Wong SJ, Gregoire V, Ferris R, Waldron J, Le QT, Forster M, Gillison M, Laskar S, Tahara M, Psyrri A, Vermorken J, Porceddu S Abstract Human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) is increasing rapidly. The younger age, significantly...
Fri Jun 05, 2020 15:01
Related ArticlesHIV Lymphoma and Burkitts Lymphoma. Cancer J. 2020 May/Jun;26(3):260-268 Authors: Noy A Abstract Despite widely available antiretroviral therapy, lymphoma remains the leading cause of death for human immunodeficiency virus (HIV)-infected persons in economically developed countries. Even a few months of drug interruptions can lead to drops in the CD4 cell count, HIV viremia, and an increased risk of lymphoma. Currently, good HIV control...
Fri Jun 05, 2020 13:27
Related ArticlesIncidence Rates of Gynecologic Cancers in the U.S. Active Duty Military Population. Mil Med. 2020 Jun 04;: Authors: Owens S, Blando T, Tesema YB, Butts E, Newton J, Bristow R, Randall LM Abstract INTRODUCTION: Despite an increasing number of female service members, incidence rates of gynecologic cancers (other than cervical cancer) have not been previously documented in the U.S. active duty military population. This study sought to determine...
Fri Jun 05, 2020 13:27
Related ArticlesReal-world disease burden and outcomes of brain metastases in EGFR mutation-positive non-small-cell lung cancer. Future Oncol. 2020 Jun 04;: Authors: Nadler E, Espirito JL, Pavilack M, Baidoo B, Fernandes A Abstract Aim: To evaluate the real-world impact of brain metastases (BM) among patients with EGFR mutation-positive (EGFRm) metastatic non-small-cell lung cancer (NSCLC). Materials & methods: This retrospective, observational matched...
Fri Jun 05, 2020 13:27
Related ArticlesSelf-perceived burden and its associations with health-related quality of life among urologic cancer patients. Eur J Cancer Care (Engl). 2020 Jun 03;:e13248 Authors: Ting CY, Teh GC, Yu KL, Alias H, Tan HM, Wong LP Abstract OBJECTIVE: This study examined the prevalence of self-perceived burden (SPB) and its association with health-related quality of life (HRQoL) among urologic cancer patients. METHODS: This was a prospective,...
Fri Jun 05, 2020 13:27
Related ArticlesComparison of Drug Inhibitory Effects ([Formula: see text]) in Monolayer and Spheroid Cultures. Bull Math Biol. 2020 Jun 03;82(6):68 Authors: Berrouet C, Dorilas N, Rejniak KA, Tuncer N Abstract Traditionally, the monolayer (two-dimensional) cell cultures are used for initial evaluation of the effectiveness of anticancer drugs. In particular, these experiments provide the [Formula: see text] curves that determine drug concentration that...
Fri Jun 05, 2020 13:27
Related ArticlesRadiomic biomarkers for head and neck squamous cell carcinoma. Strahlenther Onkol. 2020 Jun 03;: Authors: Tanadini-Lang S, Balermpas P, Guckenberger M, Pavic M, Riesterer O, Vuong D, Bogowicz M Abstract Tumor heterogeneity is a well-known prognostic factor in head and neck squamous cell carcinoma (HNSCC). A major limitation of tissue- and blood-derived tumor markers is the lack of spatial resolution to image tumor heterogeneity. Tissue...
Fri Jun 05, 2020 13:27
Related ArticlesFirst-Line Management of Advanced High-Grade Serous Ovarian Cancer. Curr Oncol Rep. 2020 Jun 04;22(6):64 Authors: Mahmood RD, Morgan RD, Edmondson RJ, Clamp AR, Jayson GC Abstract PURPOSE OF REVIEW: Epithelial ovarian cancer is a disease that encompasses a number of histologically and molecularly distinct entities; the most prevalent subtype being high-grade serous (HGS) carcinoma. Standard first-line treatment of advanced HGS carcinoma...
Fri Jun 05, 2020 13:27
Related ArticlesIdentification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer. Cancer Manag Res. 2020;12:3389-3399 Authors: Han F, Liu S, Jing J, Li H, Yuan Y, Sun LP Abstract Background: Ring finger protein 180 (RNF180) is a tumor suppressor gene regulated by promoter methylation. We previously demonstrated that the RNF180 promoter methylation could be a risk...
Fri Jun 05, 2020 13:27
Related ArticlesResistance training and total and site-specific cancer risk: a prospective cohort study of 33,787 US men. Br J Cancer. 2020 Jun 04;: Authors: Rezende LFM, Lee DH, Keum N, Wu K, Eluf-Neto J, Tabung FK, Giovannucci EL Abstract BACKGROUND: Muscle-strengthening activities have been recommended for health benefits. However, it is unclear whether resistance training is associated with cancer risk, independent of total physical activity. ...
Fri Jun 05, 2020 13:27
Related Articles[The Nationwide Survey on Avoidance of Targeted Radionuclide Therapy in Patients with Limited Activities of Daily Living and Those Undergoing Hemodialysis]. Kaku Igaku. 2020;57(1):39-46 Authors: Mori H, Inaki A, Kayano D, Wakabayashi H, Hosono M, Higashi T, Oriuchi N, Abe K, Uchiyama M, Kinuya S Abstract Targeted radionuclide therapy with high-dose radioisotopes should be performed in isolation rooms. Patients can be released only after...
Fri Jun 05, 2020 13:27
Related ArticlesThe impact of immunotherapy on the survival of pancreatic adenocarcinoma patients who received definitive surgery of the pancreatic tumor: a retrospective analysis of the National Cancer Database. Radiat Oncol. 2020 Jun 03;15(1):139 Authors: Amin S, Baine M, Meza J, Alam M, Lin C Abstract BACKGROUND: Immunotherapy has paved the way for new therapeutic opportunities in cancer but has failed to show any efficacy in Pancreatic Adenocarcinoma...
Fri Jun 05, 2020 13:27
Related ArticlesClinical association of progesterone receptor isoform A with breast cancer metastasis consistent with its unique mechanistic role in preclinical models. BMC Cancer. 2020 Jun 03;20(1):512 Authors: Rosati R, Oppat K, Huang Y, Kim S, Ratnam M Abstract BACKGROUND: Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness....
Fri Jun 05, 2020 13:27
Related ArticlesGenerating Oncology Patient Trust in the Nurse: An Integrative Review. West J Nurs Res. 2020 Jun 04;:193945920930337 Authors: Rajcan L, Lockhart JS, Goodfellow LM Abstract An integrative review was conducted to evaluate the extent and quality of literature regarding adult oncology patients' trust in nurses. Nineteen studies met the inclusion criteria. Three themes were identified, which are as follows: nurse trust facilitating behaviors,...
Fri Jun 05, 2020 13:27
Related ArticlesWell Differentiated Grade 3 Neuroendocrine Tumors of the Digestive Tract: A Narrative Review. J Clin Med. 2020 Jun 01;9(6): Authors: Pellat A, Coriat R Abstract The 2017 World Health Organization (WHO) classification of neuroendocrine neoplasms (NEN) of the digestive tract introduced a new category of tumors named well-differentiated grade 3 neuroendocrine tumors (NET G-3). These lesions show a number of mitosis, or a Ki-67 index higher...
Fri Jun 05, 2020 13:27
Related ArticlesIn Vivo Validation of the BIANCA Biophysical Model: Benchmarking against Rat Spinal Cord RBE Data. Int J Mol Sci. 2020 Jun 01;21(11): Authors: Carante MP, Aricò G, Ferrari A, Karger CP, Kozlowska W, Mairani A, Sala P, Ballarini F Abstract (1) Background: Cancer ion therapy is constantly growing thanks to its increased precision and, for heavy ions, its increased biological effectiveness (RBE) with respect to conventional photon therapy....
Fri Jun 05, 2020 13:27
Related ArticlesMetabolic Profiling of Early and Late Recurrent Pancreatic Ductal Adenocarcinoma Using Patient-Derived Organoid Cultures. Cancers (Basel). 2020 Jun 01;12(6): Authors: Braun LM, Lagies S, Klar RFU, Hussung S, Fritsch RM, Kammerer B, Wittel UA Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and will become the second most common cause of cancer-associated mortality by 2030. The poor prognosis arises from...
Fri Jun 05, 2020 13:27
Related ArticlesDepressive symptoms affect short- and long-term speech recognition outcome in cochlear implant users. Eur Arch Otorhinolaryngol. 2020 Jun 05;: Authors: Heinze-Köhler K, Lehmann EK, Hoppe U Abstract PURPOSE: To investigate the impact of the amount of depressive symptoms in cochlear implant (CI) recipients on the development of speech recognition after CI-activation up to 2 years. DESIGN: Retrospective data analysis of a German...
Sun Jun 07, 2020 13:01
Related ArticlesHearing rehabilitation after subtotal cochleoectomy using a new, perimodiolar malleable cochlear implant electrode array: a preliminary report. Eur Arch Otorhinolaryngol. 2020 Jun 05;: Authors: Plontke SK, Fröhlich L, Cozma S, Koitschev A, Reimann K, Weiß R, Götze G, Seiwerth I, Kösling S, Rahne T Abstract PURPOSE: We here report about the first surgical experience and audiological outcome using a new, perimodiolar malleable cochlear...
Sun Jun 07, 2020 13:01
Related ArticlesEndoscopic nasopharyngoscopy and ENT specialist safety in the COVID 19 era: the back endoscopy approach to the patient. Eur Arch Otorhinolaryngol. 2020 Jun 04;: Authors: Di Maio P, Traverso D, Iocca O, De Virgilio A, Spriano G, Giudice M Abstract PURPOSE: To propose a way to safely perform endoscopic nasopharyngoscopy in ENT outpatient clinic during the COVID-19 pandemic. METHODS: This manuscript highlights the importance of...
Sat Jun 06, 2020 13:03
Related ArticlesOlfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life. Eur Arch Otorhinolaryngol. 2020 Jun 04;: Authors: Meini S, Suardi LR, Busoni M, Roberts AT, Fortini A Abstract PURPOSE: COVID-19 displays a variety of clinical manifestations; in pauci-symptomatic patients olfactory (OD) and gustatory dysfunctions (GD) may represent the first or only symptom. This topic is currently...
Sat Jun 06, 2020 13:03
Related ArticlesAcute mastoiditis in infants younger than 6 months: is an alternative treatment protocol needed? Eur Arch Otorhinolaryngol. 2020 Jun 04;: Authors: Sokolov M, Tzelnick S, Stern S, Hilly O, Scheuerman O, Raveh E, Ulanovski D Abstract OBJECTIVES: Several studies have reported that younger children suffer from increased incidence and more severe episodes of acute mastoiditis (AM) than older children, whereas other researchers have found the...
Sat Jun 06, 2020 13:03
Related ArticlesIsolated enhancement of the superior semi-circular canal on inner ear MRI: acute vestibular syndrome or superior semi-circular canal dehiscence? Eur Arch Otorhinolaryngol. 2020 Jun 04;: Authors: Eliezer M, Toupet M, Guichard JP, Houdart E, Hautefort C Abstract PURPOSE: Recently, it has been reported that patients with acute vestibular syndrome (AVS) could present a marked enhancement of the semi-circular canals, involving mostly the superior...
Sat Jun 06, 2020 13:03
Related ArticlesA model to predict postoperative complications for otorhinolaryngology and maxillofacial surgery procedures in elderly patients. Eur Arch Otorhinolaryngol. 2020 Jun 03;: Authors: Locatello LG, Comini LV, Bettiol A, Vannacci A, Spinelli G, Mannelli G Abstract PURPOSE: All kinds of ear, nose, and throat and maxillofacial surgery (ENT/MFS) procedures are being increasingly performed in the elderly although old age is a major risk factor...
Fri Jun 05, 2020 13:07
Related ArticlesPatient-Reported Outcome Questionnaires for the evaluation of olfactory and gustatory dysfunctions in COVID-19. Eur Arch Otorhinolaryngol. 2020 Jun 03;: Authors: Lechien JR, Hsieh J, Barillari MR, Cammaroto G, Hans S, Chiesa-Estomba CM, Saussez S PMID: 32494948 [PubMed - as supplied by publisher]
Fri Jun 05, 2020 13:07
Publication date: Available online 6 June 2020Source: Allergology InternationalAuthor(s): Hirohisa Saito
Sun Jun 07, 2020 12:51
Publication date: Available online 4 June 2020Source: Allergology InternationalAuthor(s): Isao Suzaki, Akihiko Tanaka, Kojiro Hirano, Sawa Arai, Hitome Kobayashi
Fri Jun 05, 2020 18:22
Abstract Background Lymph node enlargement is commonly used to indicate abnormality. Objective To evaluate the normal size and prevalence of abdominal lymph nodes in children at CT. Materials and methods In this retrospective study, we included a total of 152 children...
Sun Jun 07, 2020 03:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Jun 05, 2020 10:00
Thyroid, Ahead of Print.
Fri Jun 05, 2020 10:00
Thyroid, Ahead of Print.
Fri Jun 05, 2020 10:00
Thyroid, Ahead of Print.
Fri Jun 05, 2020 10:00
Thyroid, Ahead of Print.
Thu Jun 04, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Fri Jun 05, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Fri Jun 05, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Jun 05, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Thu Jun 04, 2020 10:00
Abstract The gingival smile is considered unpleasant and can be treated in different ways according to its etiological factor. When caused by maxillary vertical growth excess, orthognathic surgery may be indicated to correct the vertical excess. The aim of this integrative review was to evaluate the impact of orthognathic surgery on the treatment of gingival smile. An electronic search was performed of the PubMed/Medline, Cochrane Library, Scopus, and Google Scholar databases....
Sun Jun 07, 2020 03:00
Abstract Rationale Νeurosteroids, like dehydroepiandrosterone (DHEA), play an important role in neurodegeneration and neural protection, but they are metabolized in androgens, estrogens, or other active metabolites. A newly developed synthetic DHEA analog, BNN27 ((20R)-3β,21-dihydroxy-17R,20-epoxy-5-pregnene), exerts neurotrophic and neuroprotective actions without estrogenic or androgenic effects. ...
Sun Jun 07, 2020 03:00
Abstract Rational The ability of conditioned stimuli to affect instrumental responding is a robust finding from animal as well as human research and is assumed as a key factor regarding the development and maintenance of addictive behaviour. Objectives While it is well known that stress is an important factor for relapse after treatment, little is known about...
Sat Jun 06, 2020 03:00
Background. Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory and demyelinating disorder of the central nervous system, with a distinct tendency to a perivenous localization of pathological changes. Children are the most affected population and frequently presented after exanthematous viral infections or vaccination. Due to the rarity of this disease, the annual incidence rate in the population is not precisely known. Case Presentation. Here, we present a 28-year-old male HIV-1 positive...
Sat Jun 06, 2020 15:05
Abstract Introduction We performed a systematic review and meta-analysis of clinical outcomes for patients with acromegaly treated with stereotactic radiosurgery (SRS). Methods Primary outcomes were 5- and 10-year endocrine remission (ER) and endocrine control (EC). Secondary outcomes were 10-year radiographic local control (LC), visual toxicity, and...
Sat Jun 06, 2020 03:00
Abstract Introduction There are no effective treatments for gliomas after progression on radiation, temozolomide, and bevacizumab. Microglia activation may be involved in radiation resistance and can be inhibited by the brain penetrating antibiotic minocycline. In this phase 1 trial, we examined the safety and effect on survival, symptom burden, and neurocognitive function of reirradiation, minocycline, and bevacizumab. ...
Sat Jun 06, 2020 03:00
Abstract Introduction Low-grade glioma (LGG) represent the most common pediatric central nervous system tumor. When total surgical resection is not feasible, chemotherapy is first-line therapy in children. Multiple pediatric LGG chemotherapy regimens have been investigated with variable 2-year event free survival (EFS) rates of 39–69%. To date, treatment of pediatric LGG with a carboplatin and vinblastine (C/VBL) chemotherapy regimen...
Sat Jun 06, 2020 03:00
Abstract Purpose The CellSearch® system has been used to identify circulating tumor cells (CTCs) in cerebrospinal fluid (CSF) to diagnose leptomeningeal metastasis (LM) in patients with epithelial cancers. Using this system, we prospectively explored sequential CSF CTC enumeration in patients with LM from HER2+ cancers receiving intrathecal (IT) trastuzumab to capture dynamic changes in CSF CTC enumeration. ...
Sat Jun 06, 2020 03:00
Abstract Introduction A novel neurosurgical enhanced recovery after surgery (ERAS) program shortens postoperative hospital stay and accelerates functional recovery in elective craniotomy patients. There is a need to evaluate the impact of ERAS program on patients’ health-related quality of life (HRQOL). Methods In a single-center randomized controlled...
Sat Jun 06, 2020 03:00
Abstract Purpose The purpose of this review is to assess the recent evidence regarding the management of squamous cell carcinoma of the skull-base and to discuss the implications of these findings on clinical practice. Method Free text Medline and MeSH term search of publications relating to Squamous Cell Carcinoma & Skull-base and Skull base,...
Fri Jun 05, 2020 03:00
Abstract Introduction Supratentorial pediatric high-grade gliomas (pHGGs) are aggressive malignancies that lack effective treatment options. Deep genomic sequencing by multiple groups has revealed that the primary alterations unique to pHGGs occur in epigenetic and kinase genes. These mutations, fusions, and deletions present a therapeutic opportunity by use of small molecules targeting epigenetic modifiers and kinases that contribute...
Fri Jun 05, 2020 03:00
Abstract The microenvironment of oral cancer is highly dynamic and has been proved to affect tumor progression. Pericytes are blood vessels surrounding cells that have recently gained attention for their roles in vascular and cancer biology. The objective of the present study was to survey the scientific literature for conclusive evidence about whether pericytes are part of blood vessels in oral squamous cell carcinoma (OSCC) and their roles in the tumor microenvironment and clinical...
Sat Jun 06, 2020 03:00
Abstract Salivary gland neoplasms of the buccal mucosa are relatively rare and often present with an unusual histopathologic profile when compared with other intraoral locations. We present a series of minor salivary gland neoplasms of the buccal mucosa and discuss demographics, clinical presentation, and histologic findings. An IRB approved retrospective search of University of Florida Oral Pathology Biopsy Service archive from 1994 to 2018 for all salivary gland neoplasms...
Sat Jun 06, 2020 03:00
Abstract Odontogenic myxoma (OM) is an uncommon benign odontogenic tumor arising in the jaw. Though it has slight histologic overlap with other entities, definitive diagnosis is imperative considering the tumor’s aggressive nature, high recurrence rate, and necessity of radical surgical intervention in large-sized lesions. With IRB approval, a retrospective search of the University of Florida College of Dentistry Oral Pathology Biopsy Service archives from 1994 to...
Sat Jun 06, 2020 03:00
Abstract We describe the histological, histochemical, and immunohistochemical features of an unusual neoplasm of the parathyroid gland showing the histologic criteria of a mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN). To the best of our knowledge, this is the first report of such a tumor. A 43-year old male presented with acute and severe abdominal pain due to acute pancreatitis. On physical examination a painless lump in the right neck was detected and laboratory analyses...
Sat Jun 06, 2020 03:00
Abstract An example of a mandibular rhabdomyosarcoma in a 15-year-old male is described featuring EWSR1-TFCP2 fusion with homolateral lymph node metastasis and apparent metastasis to the thoracic vertebra T7. This type of rhabdomyosarcoma has preference for the craniofacial skeleton. Histologically, the tumor was composed of spindle and epithelioid cells characterized by nuclear pleomorphism, cytologic atypia and brisk mitotic activity. Immunohistochemically, it featured diffuse...
Fri Jun 05, 2020 03:00
Abstract Rosai–Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion...
Fri Jun 05, 2020 03:00
Abstract Porocarcinoma (synonym: malignant eccrine poroma) is a rare aggressive carcinoma type with terminal sweat gland duct differentiation. The squamous variant of porocarcinoma is even less frequent and might be indistinguishable from conventional squamous cell carcinoma (SCC). We herein describe the first case of a carcinoma presenting as a primary parotid gland malignancy in a 24-year-old male without any other primary tumor. Total parotidectomy and neck dissection were performed...
Fri Jun 05, 2020 03:00
Publication date: Available online 5 June 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Vít Bába, Lubomír Kopp, Jiří Cihlář, Adéla Samešová, David Kachlík
Sat Jun 06, 2020 22:31
Publication date: Available online 5 June 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Susanne Rein, Thomas Kremer, Khosrow Siamak Houschyar, Frank Siemers, Hubertus Philipps
Sat Jun 06, 2020 22:31
Publication date: July 2020Source: Annals of Anatomy - Anatomischer Anzeiger, Volume 230Author(s):
Fri Jun 05, 2020 14:29
Publication date: July 2020Source: Annals of Anatomy - Anatomischer Anzeiger, Volume 230Author(s):
Fri Jun 05, 2020 14:29
Publication date: Available online 5 June 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Lorenzo Alibardi
Fri Jun 05, 2020 14:29
Publication date: Available online 5 June 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Tobias Fritz, Pascal Ducommun, Tim Pohlemann, Maurizio Calcagni, Thomas Tschernig, Michael D. Menger, Wolfgang Metzger, Florian S. Frueh
Fri Jun 05, 2020 14:29
Publication date: Available online 5 June 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): A. Kanewska, M. Ito, Y. Karasawa, M. Inada, F. Garreis, F. Paulsen, M. Takeuchi
Fri Jun 05, 2020 14:29
Publication date: Available online 5 June 2020Source: Revue des Maladies RespiratoiresAuthor(s): L. Plantier, F. Costes, pour les groupes de travail «Fonction» et «Alvéole» de la Société de Pneumologie de Langue Française
Sat Jun 06, 2020 19:36
Introduction. It is acknowledged that patients undergoing neurosurgery with neurological illness are at higher risk of lower extremity deep vein thrombosis (DVT). As an underlying life-threatening complication, the incidence and risk factors for high-risk patients with lower extremity deep vein thrombosis are still controversial in relative high-risk patients after neurosurgery. Materials and Methods. A total of 204 patients who underwent neurosurgery and were considered as a high-risk group of DVT...
Sat Jun 06, 2020 11:05
Objectives. To confirm that patients affected by colorectal cancer have the V2 region of Septin 9 (SEPT9) gene hypermethylated in the circulating free DNA from a peripheral blood sample before surgery and to determine if this hypermethylated DNA disappears from the patients after complete resection of the tumour. Methods. Plasma from 10 patients with colorectal cancer was collected preoperative and three months after surgery. The analysis of the methylation status of the promoter region of the SEPT9...
Fri Jun 05, 2020 21:20
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