Related ArticlesAnti-hepatoma effect of taccalonolide A through suppression of sonic hedgehog pathway. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):939-947 Authors: Tian H, He Z Abstract Taccalonolide A has been reported to have anti-tumour efficiency. However, the underlying mechanism for taccalonolides A therapy of hepatocellular carcinoma (HCC) is still obscure. Cell viability was evaluated by cell counting kit-8 (CCK-8) assay. Apoptosis was...
Fri Jun 05, 2020 14:23
Related ArticlesDiallyl disulphide-loaded spherical gold nanoparticles and acorn-like silver nanoparticles synthesised using onion extract: catalytic activity and cytotoxicity. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):948-960 Authors: Lee YJ, Cha SH, Kim H, Choi SE, Cho S, Park Y Abstract Onion (Allium cepa) extract was used for the green synthesis of gold and silver nanoparticles. Each colloidal solution exhibited surface plasmon resonance,...
Fri Jun 05, 2020 14:23
Related ArticlesWhether miR-4293 rs12220909 variant affects cancer susceptibility: evidence from 11255 subjects. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):933-938 Authors: Ji D, An M, Fang Q Abstract Background: miR-4293 rs12220909 polymorphism was reported associated with tumorigenesis, but the results are controversial. Thus, we planned to verify and obtain precise results.Methods: Databases were searched and reviewed up to November, 2019....
Fri Jun 05, 2020 14:23
Related ArticlesConceptual Design and Preliminary Results of A VR-Based Radiation Safety Training System for Interventional Radiologists. Radiat Prot Dosimetry. 2020 Jun 05;: Authors: Guo Y, Mao L, Zhang G, Chen Z, Pei X, Xu XG Abstract To help minimise occupational radiation exposure in interventional radiology, we conceptualised a virtual reality-based radiation safety training system to help operators understand complex radiation fields and to...
Sat Jun 06, 2020 17:30
Related ArticlesResponse of Current Photon Personal Dosemeters to New Operational Quantities. Radiat Prot Dosimetry. 2020 Jun 04;: Authors: Ekendahl D, Čemusová Z, Kurková D, Kapuciánová M Abstract The ICRU proposed new operational quantities, which are defined in close relation to effective dose and absorbed dose. Most of the current personal dosemeters were designed to measure personal dose equivalents. Because of differences between the new and...
Fri Jun 05, 2020 14:05
Related ArticlesThe Frequencies of X-Ray Examinations and CT Scans: Findings from a Sample Investigation in Jiangsu, China. Radiat Prot Dosimetry. 2020 Jun 04;: Authors: Du X, Wang J, Zhu B Abstract OBJECTIVE: The present study was performed to evaluate the frequencies of two kinds of examinations using a proportional sample of 262 medical institutions and to observe the factors affecting the amount of examination-related exposure. The other aim...
Fri Jun 05, 2020 14:05
Related ArticlesTranscranial direct current stimulation facilitates response inhibition through dynamic modulation of the fronto-basal ganglia network. Brain Stimul. 2020 Jan - Feb;13(1):96-104 Authors: Sandrini M, Xu B, Volochayev R, Awosika O, Wang WT, Butman JA, Cohen LG Abstract BACKGROUND: Response inhibition refers to the ability to stop an on-going action quickly when it is no longer appropriate. Previous studies showed that transcranial direct...
Sat Jun 06, 2020 13:32
Related ArticlesScoping review of chronic rhinosinusitis proteomics. Rhinology. 2020 Jun 03;: Authors: Kao SS, Bassiouni A, Ramezanpour M, Chegeni N, Colella AD, Chataway TK, Wormald PJ, Vreugde S, Psaltis AJ Abstract BACKGROUND: Progressive advances in proteomic technology has improved our understanding of the chronic rhinosinusitis (CRS) pathogenesis and endotypes. This scoping review aims to present a comprehensive and descriptive analysis of nasal...
Sat Jun 06, 2020 15:28
Related ArticlesTrigeminal endonasal perception - an outcome predictor for septoplasty. Rhinology. 2020 Jun 03;: Authors: Bischoff S, Poletti SC, Kunz S, Kiessling SY, Hinder D, Dreher A, Akdis CA, Soyka MB Abstract BACKGROUND: No adequate test exists to predict outcome after septoplasty. Despite adequate surgery, patients still might experience nasal breathing impairment. The aim of this study was to determine if pre-operative trigeminal sensitivity...
Sat Jun 06, 2020 15:28
Related ArticlesChronic rhinosinusitis disease control as a metric for guiding treatment. Rhinology. 2020 Jun 01;58(3):193 Authors: Sedaghat A, Hopkins C Abstract The assessment of Chronic Rhinosinusitis, like any other disease, may involve multiple possible disease manifestations, including subjective patient-reported outcomes, objective disease (e.g. endoscopy or radiographic), and physician-driven (e.g. need for systemic medications). Disease control...
Sat Jun 06, 2020 15:28
Related ArticlesAnalysis of COVID-19 transmission: Low risk of presymptomatic spread? Arch Pathol Lab Med. 2020 Jun 05;: Authors: Slifka MK, Messer WB, Amanna IJ PMID: 32501120 [PubMed - as supplied by publisher]
Sat Jun 06, 2020 17:23
Related ArticlesPathology Laboratory Policies and Procedures for Releasing Diagnostic Tissue for Cancer Research. Arch Pathol Lab Med. 2020 Jun 04;: Authors: Yuan Y, Van Dyke AL, Petkov VI, Hussey S, Moravec R, Altekruse SF, Sandoval M, Cress RD, Mueller LM, Mogi A, Hernandez BY, Selk FR, Lynch CF, Tucker TC, Lynch MA, Lefante C, Wu XC, Sweeney C, Doherty JA, Penberthy LS Abstract CONTEXT.—: The Surveillance, Epidemiology, and End Results (SEER) cancer...
Fri Jun 05, 2020 17:53
Abstract Purpose of Review Our day-to-day life is saturated with health data that was previously out of reach. Over the last decade, new devices and fitness technology companies are attempting to tap into this data, uncovering a treasure trove of useful information that, when applied correctly, has the potential to revolutionize the way we approach healthcare and chronic conditions like asthma, especially in the wake of the COVID-19...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review The recent increase in childhood food allergy prevalence strongly suggests that environmental exposures are contributing to food allergy development. This review summarizes current knowledge about the role of the external exposome in food allergy. Recent Findings There is growing evidence that environmental...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review Food allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and interactions between families, school personnel, and clinicians are important to ensure the health and...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review This paper explores how the Environmental Exposure Unit (EEU) experimental model can be used to further our understanding of pharmacotherapies and immunotherapies for the treatment of allergic rhinitis (AR). Recent Findings EEUs are used increasingly for the study of combination therapies, immunotherapies, and...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review Occupational allergic diseases (OAD) such as occupational contact dermatitis (OCD), occupational asthma (OA), and occupational rhinitis (OR) are the most prevalent occupational diseases in industrialized countries. The purpose of this review is to provide an update about the main occupational metal and solvent exposures related to allergy and airway diseases and to discuss newly defined causative agents...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review Atopic dermatitis (AD), chronic spontaneous urticaria (CSU), and allergic contact dermatitis (ACD) represent three important allergic dermatoses with many unmet therapeutic needs. The development of biologic agents has opened the door to both new treatment options and improved understanding of the underlying pathophysiology, both shared and unique for these entities. With several FDA-approved medications...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review Otitis media (OM) is a disease with very high prevalence in infancy, substantial burden on healthcare resources, and relevant impact on the quality of life of families. The link between OM and allergy is controversial and still debated. However, a fundamental premise has to be placed before introducing this topic: there is the need to use clear and unambiguous terms. Literature abounds with misleading...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review Pediatric and adult chronic rhinosinusitis (CRS) have some similarities but a number of differences. This article reviews the similarities and differences between pediatric and adult CRS. Recent Findings Rhinosinusitis is an inflammatory disease of the nose and the paranasal sinuses. In adults, inflammation...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review Both adults and children are frequently affected by symptoms of itchy urticarial lesions that cause considerable distress and impact nearly all their daily activities. A comprehensive history is critical to identify the etiology in patients who have chronic spontaneous urticaria (CSU) (those with symptoms for > 6 weeks) and is more important than extensive laboratory serum tests. Unfortunately, most...
Sat Jun 06, 2020 03:00
Abstract Purpose of Review Recent research efforts have spurred great progress in the diagnosis and management of eosinophilic esophagitis (EoE). Nonetheless, challenges remain in addressing disease burden and impairment in the growing EoE population. We highlight work from the Cincinnati Center for Eosinophilic Disorders, the Consortium of Eosinophilic Gastrointestinal Disease Researchers, and others that address these ongoing...
Sat Jun 06, 2020 03:00
Related ArticlesRecurrent metastatic clear cell renal carcinoma with sarcomatoid dedifferentiation treated with surgery and Cabozantinib. Oncotarget. 2020 May 19;11(20):1922-1928 Authors: Boustany J, Abdessater M, Hachem CE, Khoury ZE, Khoury WE, Khoury RE Abstract Renal cell carcinoma with sarcomatoid dedifferentiation is an entity of RCC that has undergone an anaplastic transformation with both a carcinomatous and a sarcomatous component. The standard...
Sat Jun 06, 2020 13:17
Related ArticlesMuscle mass, not radiodensity, predicts physical function in cancer patients with or without cachexia. Oncotarget. 2020 May 19;11(20):1911-1921 Authors: Anderson LJ, Chong N, Migula D, Sauer A, Garrison M, Wu P, Dash A, Garcia JM Abstract BACKGROUND: There is a need to better understand the relationship between functional impairment and muscle mass in cancer cachexia. This study aimed to establish the relationship between computed...
Sat Jun 06, 2020 13:17
Related ArticlesImmunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II. Oncotarget. 2020 May 19;11(20):1894-1910 Authors: Mazumder S, Swank V, Komar AA, Johnson JM, Tuohy VK Abstract Epithelial ovarian carcinoma (EOC) is the most prevalent and lethal form of ovarian cancer. The low five-year overall survival after EOC diagnosis indicates an urgent need for more effective...
Sat Jun 06, 2020 13:17
Related ArticlesAberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma. Oncotarget. 2020 May 19;11(20):1876-1893 Authors: Saeed H, Sinha S, Mella C, Kuerbitz JS, Cales ML, Steele MA, Stanke J, Damron D, Safadi F, Kuerbitz SJ Abstract The paternally imprinted neuronatin (NNAT) gene has been identified as a target of aberrant epigenetic silencing in diverse cancers, but no association with pediatric bone cancers has been...
Sat Jun 06, 2020 13:17
Related ArticlesPLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation. Oncotarget. 2020 May 19;11(20):1862-1875 Authors: Roldán DB, Grimmler M, Hartmann C, Hubich-Rau S, Beißert T, Paret C, Cagna G, Rohde C, Wöll S, Koslowski M, Türeci Ö, Sahin U Abstract PLAC1 (placenta enriched 1) is a mammalian trophoblast-specific protein. Aberrant expression of PLAC1 is observed in various human cancers, where it is involved in...
Sat Jun 06, 2020 13:17
Related ArticlesKnock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells. Oncotarget. 2020 May 19;11(20):1846-1861 Authors: Chakraborty A, Aziz F, Roh E, Le LTM, Dey R, Zhang T, Rathore MG, Biswas AS, Bode AM, Dong Z Abstract The Timeless (TIM) and it's interacting partner TIPIN protein complex is well known for its role in replication checkpoints and normal DNA replication processes. Recent studies revealed the involvement of TIM...
Sat Jun 06, 2020 13:17
Related ArticlesExosome-mediated delivery of miR-30a sensitize cisplatin-resistant variant of oral squamous carcinoma cells via modulating Beclin1 and Bcl2. Oncotarget. 2020 May 19;11(20):1832-1845 Authors: Kulkarni B, Gondaliya P, Kirave P, Rawal R, Jain A, Garg R, Kalia K Abstract Exosomes facilitate cross-talk amongst tumor cells, and thus also possess the potential to influence tumor-microenvironment and chemo-resistance. miRNAs, the important...
Sat Jun 06, 2020 13:17
Related ArticlesPineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats. Oncotarget. 2020 May 19;11(20):1816-1831 Authors: Kayahara GM, Valente VB, Pereira RB, Lopes FYK, Crivelini MM, Miyahara GI, Biasoli ÉR, Oliveira SHP, Bernabé DG Abstract Clinical investigations suggest that melatonin suppression and circadian dysfunction may be related to cancer development in shift workers. Studies also show...
Sat Jun 06, 2020 13:17
Related ArticlesEntinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway. Oncotarget. 2020 May 19;11(20):1799-1815 Authors: Idso JM, Lao S, Schloemer NJ, Knipstein J, Burns R, Thakar MS, Malarkannan S Abstract Histone deacetylase inhibitors (HDACi) are an emerging cancer therapy; however, their effect on natural killer (NK) cell-mediated anti-tumor responses remain unknown. Here, we evaluated the impact of a...
Sat Jun 06, 2020 13:17
After the publication of the original manuscript we found that the calculation of the supplemental data regarding the capacity of PTT-based blood pressure (BP) recordings to detect changes in systolic and diastolic BP in different cohorts of patients was incorrect. These errors occured when data were transformed from MS Excel to Sigma-Plot tables. In this correction, the affected data and the respective figures were now revised.
Sat Jun 06, 2020 03:00
Abstract Purpose It is unclear if there is a consistent signature in breath patterns prior to an impending obstructive apneic event in patients with sleep-disordered breathing (SDB). Objective To use continuous recordings of ambient sound in sleep using a smartphone to track auditory signatures of breaths and measure their regularity preceding apneic...
Sat Jun 06, 2020 03:00
Related ArticlesCorrection: "Changes in the medical burden of pyogenic and tuberculous spondylitis between 2007 and 2016: A nationwide cohort study". J Clin Neurosci. 2020 Jun 01;: Authors: Kim YS, Kim JG, Yi J, Choi JM, Chung CK, Choi UY, Han IB, Sohn S Abstract BACKGROUND: This nationwide study aimed to compare the medical burdens of pyogenic spondylitis (PS) and tuberculous spondylitis (TS) between 2007 and 2016 in Korea. METHODS: We used...
Sat Jun 06, 2020 13:08
Related ArticlesSurgical Treatment for Cerebrospinal Fluid Leaks in Patients With Inner Ear Malformations. Otol Neurotol. 2020 Jun 04;: Authors: Bois E, Demondion S, Elmaleh M, François M, Teissier N, Van Den Abbeele T Abstract OBJECTIVE: The aim of this study is to present our technique of surgical closure in a series of patients suffering from cerebrospinal fluid (CSF) leak due to inner ear malformations. STUDY DESIGN AND SETTING: We conducted...
Sat Jun 06, 2020 17:04
Related ArticlesEvaluation of Risk Factors for Cerebrospinal Leakage in Pediatric Patients With Cerebral Palsy Treated With Intrathecal Baclofen. J Pediatr Orthop. 2020 Jul;40(6):e522-e526 Authors: Imerci A, Rogers KJ, Miller F, Sees JP Abstract BACKGROUND: Insertion of an intrathecal baclofen (ITB) pump can provide significant benefits in patients with cerebral palsy (CP). However, there are little data describing the risk of complications. Specifically,...
Sat Jun 06, 2020 17:04
Related ArticlesMiddle Cranial Fossa Encephalocele and Cerebrospinal Fluid Leakage: Etiology, Approach, Outcomes. J Neurol Surg B Skull Base. 2020 Jun;81(3):268-274 Authors: McNulty B, Schutt CA, Bojrab D, Babu S Abstract Objective To compare outcome data for surgical approaches in the management of a middle cranial fossa encephalocele or cerebrospinal fluid (CSF) leak and, secondarily, to evaluate the role of obesity and the etiology of the defect....
Sat Jun 06, 2020 13:06
Related ArticlesResumption of Positive-Pressure Ventilation Devices for Obstructive Sleep Apnea following Transsphenoidal Surgery: An Institutional Experience of a Surgical Cohort. J Neurol Surg B Skull Base. 2020 Jun;81(3):237-243 Authors: Gravbrot N, Jahnke H, White WL, Little AS Abstract Objectives Transsphenoidal surgery creates a skull base defect that may cause postoperative cerebrospinal fluid (CSF) leakage or pneumocephalus. This study reviewed...
Sat Jun 06, 2020 13:06
Related ArticlesTraumatic non-missile penetrating transnasal anterior skull-base fracture and brain injury with cerebrospinal fluid leak: intraoperative leak detection and an effective reconstruction procedure for a localized skull base defect especially after COVID-19 outbreak. World Neurosurg. 2020 Jun 01;: Authors: Yoneoka Y, Aizawa N, Nonomura Y, Ogi M, Seki Y, Akiyama K Abstract BACKGROUND: Cerebrospinal fluid leakage in penetrating skull base injury...
Fri Jun 05, 2020 17:18
Related ArticlesCerebrospinal fluid leakage due to nasoseptal flap partial necrosis: A pitfall for skull base reconstruction of endoscopic endonasal surgery. Surg Neurol Int. 2020;11:121 Authors: Yamada H, Toda M, Fukumura M, Imai R, Ozawa H, Ogawa K, Yoshida K Abstract Background: Vascularized nasoseptal flaps allow for the reconstruction of large dural defects and have remarkably reduced the incidence of postoperative complications during endoscopic...
Fri Jun 05, 2020 13:22
Related ArticlesSellar trough technique for endoscopic endonasal transclival repair. Surg Neurol Int. 2020;11:99 Authors: Wong AK, Raviv J, Wong RH Abstract Background: Endoscopic endonasal transclival approaches provide direct access to the ventral skull base allowing the treating of clival and paraclival pathology without the manipulation of the brain or neurovascular structures. Postoperative spinal fluid leak, however, remains a challenge and various...
Fri Jun 05, 2020 13:22
Publication date: Available online 5 June 2020Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-facialeAuthor(s): S Pondaven-Letourmy, F Alvin, Y Boumghit, F Simon
Sat Jun 06, 2020 13:03
Publication date: Available online 5 June 2020Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-facialeAuthor(s): Ludovic de Gabory, Ahmed Alharbi, Mélodie Kérimian, Marie-Edith Lafon
Sat Jun 06, 2020 13:03
There is broad consensus that widespread SARS-CoV-2 testing is essential to safely reopening the United States. A big concern has been test availability, but test accuracy may prove a larger long-term problem. While debate has focused on the accuracy of antibody tests, which identify prior…
Fri Jun 05, 2020 03:00
Governments around the world and throughout the United States are beginning to "reopen their economies" in stages. Some have been considering the use of serologic antibody testing to screen for possible immunity and to identify people who could return to the workplace with less severe mitigation…
Fri Jun 05, 2020 03:00
To address the unprecedented challenge posed by the Covid-19 pandemic, much of the world — including an estimated 90% of Americans — was locked down and socially distanced. Large gatherings were prohibited, most schools and nonessential businesses were closed, and people were asked to stay at home…
Fri Jun 05, 2020 03:00
The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
Thu Jun 04, 2020 03:00
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the global, rapidly emerging virus causing coronavirus disease 2019 (Covid-19). The current public health strategies to mitigate transmission are rapid identification of cases, isolation, contact tracing, and self-quarantine of those…
Wed Jun 03, 2020 03:00
Publication date: July 2020Source: Hearing Research, Volume 392Author(s):
Sat Jun 06, 2020 12:50
This study evaluated the effect of extending the duration of exposure to curing light on the depth of cure of two conventional (RBC1‐conventional and RBC2‐conventional) and two bulk‐fill (RBC1‐bulk and RBC2‐bulk) resin composites. Polywave and single‐peak photocuring units were used. Cylinder‐shaped specimens were exposed to curing light either for the time period recommended by the manufacturer or twice the length of that time, and depth of cure was estimated using manual scraping (similar to the...
Fri Jun 05, 2020 22:00
Abstract Objective The COVID‐19 pandemic seems to be developing into a planetary‐scale mental health experiment, undermining the foundations of our being human, obliging us to keep physically apart from one another, and inducing us to see other people as a potential threat. Methods In the world of pediatric oncology, we have found ourselves up against new challenges. In this article, we discuss the difficulties found in conducting psychological support sessions while complying with physical...
Fri Jun 05, 2020 15:44
Abstract Objective Genetic testing for hereditary breast and ovarian cancer (HBOC) due to pathogenic variants in BRCA1 or BRCA2 is why most women present to familial cancer centers. Despite being assessed as low risk for HBOC, many women proceed with genetic testing. This study explored the genetic testing experiences of unaffected women at low risk of HBOC to clarify what motivates these women to have testing, and what are the implications of the results. Methods A qualitative approach...
Thu Jun 04, 2020 19:30
Thu Jun 04, 2020 19:29
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivePostpancreatectomy hemorrhage is a life-threatening complication. Hemorrhage occurring >24 hours after the index operation is defined as late hemorrhage. This study was performed to analyze the therapeutic management and prognostic factors of late hemorrhage after pancreatectomy.MethodsWe identified 87 patients with late hemorrhage among 2031 patients who underwent pancreatic surgery from January 2013 to December...
Fri Jun 05, 2020 13:50
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Primitive neuroectodermal tumours (PNETs) are rare malignant small round cell tumours. Notably, despite widespread reports of PNET in multiple parts of the body, it is extremely rare in the pelvis. Here, a rare case of giant PNET of the pelvis, that was treated with surgical intervention comprising hemipelvectomy and amputation, is reported. A 42-year-old female patient presented with an enlarged mass on the left hip and severe...
Fri Jun 05, 2020 13:48
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Pituitary metastases are rare, and metastatic pituitary lesions originating from endometrial adenocarcinoma are extremely rare. These lesions can be mistaken for pituitary adenomas and their diagnosis can be very difficult. Pituitary metastases mostly affect the posterior lobe and patients may develop diabetes insipidus. Patients with endometrial cancer complicated with diabetes, including poor glycemic control, may also suffer...
Fri Jun 05, 2020 13:46
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Osteomyelitis from a retained foreign body should be included in the differential diagnosis of any osteolytic lesion of the foot. We report here a case of a 59-year-old man who presented with swelling over the dorsolateral aspect of the right foot. Plain x-ray showed an osteolytic lesion that mimicked a pseudotumor. Magnetic resonance imaging (MRI) showed multilocular fluid collection over the right cuboid with a hypointense...
Fri Jun 05, 2020 13:40
Journal of International Medical Research, Volume 48, Issue 6, June 2020. BackgroundWe assessed the clinical presentations, biomarkers, and Gd-EOB-DTPA-enhanced MRI features that were associated with oxaliplatin-induced sinusoidal obstruction syndrome (SOS) to detect chemotherapy-associated SOS in a timely manner.MethodsFifty-seven patients who underwent oxaliplatin-based chemotherapy and Gd-EOB-DTPA-enhanced MRI were included. Post-oxaliplatin heterogeneity in liver parenchyma was scored on a grading...
Fri Jun 05, 2020 13:38
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Capsular contracture is one of the most distressing complications of breast implant use in both aesthetic and reconstructive plastic surgery procedures. This systematic review was performed to assess the effectiveness of all nonsurgical treatments for established capsular contracture.
Thu Jun 04, 2020 15:42
Journal of International Medical Research, Volume 48, Issue 6, June 2020. BackgroundTo determine the diagnostic accuracy of preoperative T/N stage using MRI in lower and middle rectal cancer patients and the impacts on clinical decision-making.Patients and methodsThere were 354 patients recruited from May 2017 to February 2019. MRI was performed within 2 weeks before surgery. Histopathologic results were evaluated for the postoperative T/N stage and MRI diagnostic accuracy was assessed based on the...
Thu Jun 04, 2020 14:24
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveIn this case–control study, we retrospectively analyzed the intestinal flora compositions of patients with early-stage chronic kidney disease (CKD).MethodsForty-seven patients with early CKD who were treated at the Traditional Chinese Medicine Hospital between March and October 2018 were enrolled, and 150 healthy volunteers were enrolled in the healthy control group. Fresh stool samples were collected. The V3–V4 region...
Thu Jun 04, 2020 14:22
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo examine the effects of position management, manual rotation of the fetal position, and using a U-shaped birth stool in primiparous women with a fetus in a persistent occiput posterior position.MethodsThis was a prospective pilot study of women who delivered at Gansu Provincial Maternity and Child-care Hospital between January and June 2018. The women were divided into the position management ([PM] position management,...
Thu Jun 04, 2020 14:20
Journal of International Medical Research, Volume 48, Issue 6, June 2020. An 84-year-old woman complaining of acute-onset chest distress for 2 hours was referred to the Department of Cardiology, Guangzhou Red Cross Hospital, China. A physical examination showed signs of acute pulmonary edema with considerably elevated blood pressure of 186/120 mmHg. An electrocardiogram showed ST segment depression in leads I, II, and III, and from V4 to V6. A laboratory test showed markedly elevated creatine, high-sensitivity...
Thu Jun 04, 2020 13:04
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo evaluate the efficacy and safety of multiple- versus single-dose gonadotropin-releasing hormone agonist (GnRH-a) addition to luteal phase support (LPS), in patients with a first in vitro fertilization (IVF) failure associated with luteal phase deficiency (LPD).MethodsEighty patients with a first IVF failure associated with LPD were randomly assigned into single-dose and multiple-dose GnRH-a groups. In the second...
Thu Jun 04, 2020 12:53
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Whether an unplanned pregnancy should be terminated during follow-up of a hydatidiform mole is controversial. We report a patient who had an unplanned pregnancy with a hydatidiform mole at 2 months after uterine curettage when the human chorionic gonadotropin level had decreased to a negative value. Hydatidiform mole was confirmed by histopathology. Uterine curettage was performed twice and regular follow-ups were performed...
Thu Jun 04, 2020 12:52
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the relationship between 5-hydroxytryptamine transporter gene promoter region (5-HTTLPR) gene polymorphism and post-stroke depression (PSD).MethodsWe searched the CNKI, China Science and Technology Journal, China WanFang, PubMed, Embase, and Web of Science databases for studies of the relationship between 5-HTTLPR polymorphism and PSD. Data were evaluated using Stata software.ResultsThe L allele was...
Thu Jun 04, 2020 12:50
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the impact of enhanced recovery after surgery (ERAS) on the postoperative neutrophil–lymphocyte ratio (NLR) in patients with colorectal cancer.MethodsA total of 200 patients with colorectal cancer who underwent surgery between January 2015 and November 2018 were enrolled in the study. They were divided into a traditional treatment group (n=100) and an ERAS group (n=100). The traditional treatment group...
Thu Jun 04, 2020 12:43
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesTo compare body mass index (BMI); serum parameters; and urine parameters between patients with and without urolithiasis.MethodsData from 1164 patients admitted to our Department of Urology from January 2011 to July 2013 were retrospectively reviewed; 714 patients (age, 5–87 years; male:female ratio, 1.8:1) exhibited urolithiasis, and 450 patients (age, 12–94 years; male:female ratio, 3.8:1) did not. Blood and urine...
Thu Jun 04, 2020 12:40
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo clarify the efficacy of functional magnetic stimulation (FMS) in improving hemiplegic upper extremity function in patients with sub-acute stroke.MethodsIn this randomized controlled trial, 40 sub-acute stroke patients with hemiplegia were recruited from inpatient wards in the Department of Rehabilitation and randomly assigned to two groups. In the FMS group, magnetic stimulation was applied to extensor muscle groups...
Thu Jun 04, 2020 12:38
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Airway management under anesthesia is given special attention in patients who have large goiters. Nasogastric tube insertion may be difficult in intubated patients with large goiters. Several methods have been proposed to facilitate the insertion of nasogastric tubes in patients with endotracheal intubation; however, a standard insertion method has not been established. A 33-year-old man was admitted to our otolaryngology department...
Thu Jun 04, 2020 12:14
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Lipomas are rare benign tumors in the larynx. We encountered a 70-year-old man with a large lipoma in the subglottic area. His chief symptom was a 3-month history of progressive dyspnea. Transnasal flexible endoscopy showed a large mass on the posterior wall of the subglottic region. A computed tomography scan revealed a lesion occupying 75% to 80% of the subglottic airway. In this article, we discuss the imaging changes, clinical...
Thu Jun 04, 2020 12:08
Journal of International Medical Research, Volume 48, Issue 6, June 2020. BackgroundWe aimed to analyze the epidemiological and drug-resistance trends among bacterial cultures from perioperative infections in patients with primary ovarian cancer.MethodsMedical and bacteriological records for patients with ovarian cancer patients who developed perioperative infections after primary cytoreductive surgery from 1999 to 2018 were reviewed retrospectively.ResultsThe incidence of perioperative infections...
Thu Jun 04, 2020 12:05
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThe aim of this study was to determine the frequency and type of drug therapy problems (DTPs) in older institutionalized adults.MethodWe conducted a cross-sectional observational study from February to June 2016 at a 150-bed public nursing home in Croatia, where comprehensive medication management (CMM) services were provided. A rational decision-making process, referred to as the Pharmacotherapy Workup method, was...
Thu Jun 04, 2020 11:18
Journal of International Medical Research, Volume 48, Issue 6, June 2020. The discovery of epidermal growth factor receptor (EGFR) somatic mutations and the availability of tyrosine kinase inhibitors (TKIs) as targeted therapies have altered the therapeutic prospects of advanced non-small-cell lung cancer (NSCLC). G719X and S768I are uncommon mutations, and they often exist as compound mutations. A few reports have described the efficacy of first- and second-generation EGFR-TKIs. However, the efficacy...
Thu Jun 04, 2020 11:09
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveIn this survey, we assessed the current clinical management of postoperative delirium (POD) among Chinese anesthesiologists, after publishing the European POD guideline.MethodsWe administered an electronic survey, designed according to the European POD guideline. The survey was completed using mobile devices.ResultsIn total, 1,514 respondents from China participated in the survey. Overall, 74.4% of participants reported...
Thu Jun 04, 2020 11:04
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesA relationship exists between sirtuin-1 expression and growth and survival of malignant tumors. This study aimed to investigate the prognostic value of sirtuin-1 and vascular endothelial growth factor (VEGF) expression in patients with liposarcoma by examining associations between their expression levels and clinical outcomes.MethodsClinical and histopathological characteristics and follow-up and survival information...
Thu Jun 04, 2020 10:57
The XRCC4 rs1805377 polymorphism is not associated with the risk of cancer: An updated meta-analysis
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesA growing number of studies have reported that genes involved in the repair of DNA double-strand breaks might be cancer-susceptibility genes. The x-ray cross-complementing group 4 gene (XRCC4) encodes a protein that functions in the repair of DNA double-strand breaks, and this meta-analysis aimed to investigate the relationship between the XRCC4 rs1805377 polymorphism and cancer occurrence.MethodsWe retrieved case–control...
Thu Jun 04, 2020 10:52
Journal of International Medical Research, Volume 48, Issue 6, June 2020. This study was performed to investigate the feasibility of using a three-dimensional (3D) finite element model for laryngomalacia severity assessment. We analyzed laryngeal computed tomography images of seven children with laryngomalacia using Mimics software. The gray threshold of different tissues was distinguishable, and a 3D visualization model and finite element model were constructed. The laryngeal structure parameters...
Thu Jun 04, 2020 09:27
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivePericardial adipose tissue volume (PATV) is related to the mechanism of coronary artery disease (CAD), but its association with CAD risk factors is not clear. This study aimed to investigate the relationships between PATV and its associated factors.MethodsA total of 682 inpatients were consecutively enrolled in this study. Patients were divided into the high PATV group (PATV ≥174.5 cm3; n = 506) and low PATV group...
Thu Jun 04, 2020 09:24
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesWe investigated performance of antenatal pelvic floor muscle training (PFMT) among Chinese pregnant women, to explore its effects on postpartum stress urinary incontinence (SUI).MethodsWe conducted a prospective cohort study in Shenzhen, China among 815 singleton pregnant women age ≥18 years, who were continent before pregnancy. Telephone follow-up was conducted at 6 weeks postpartum. Logistic univariable and multivariable...
Thu Jun 04, 2020 04:14
Background Postoperative extrahepatic metastases (EHM) contribute to a grim outcome in patients with hepatocellular carcinoma (HCC) who are undergoing curative surgical resection. The current study investigated the clinical value of circulating tumor cells (CTCs) in predicting EHM after curative surgery. Methods A total of 197 patients with HCC who were undergoing curative surgical resection were assigned to a retrospective training cohort (144 patients) or a prospective validation cohort...
Fri Jun 05, 2020 18:37
Abstract Increasing evidence points to the presence of low-level de novo T790M mutations in patients with non-small cell lung carcinoma (NSCLC) harboring activating EGFR mutations. We utilized digital PCR (dPCR), a highly sensitive gene mutation detection method, to detect pre-treatment T790M mutations in NSCLC tumor samples and correlated the T790M status with clinical features and patient outcomes. DNA extracted from pre-treatment NSCLC tumor tissue with known activating EGFR...
Sat Jun 06, 2020 03:00
Abstract High-grade neuroendocrine tumors (HGNET) have distinctive tumor biology/behaviour. Newer modalities of treatment (immunotherapy) for them have been included in recent NCCN guidelines. Detection of programmed death receptor-ligand 1 (PD-L1) expression by immunohistochemistry have made easy identification of patients eligible for immunotherapy. We aimed to ascertain expression of PD-L1 on small cell and large cell neuroendocrine carcinomas of lung and review existing literature....
Sat Jun 06, 2020 03:00
Abstract The MRI targeted biopsy (MRI-TBx) may increase the detection rate of clinically significant cancer (csPCa) in candidates for re-biopsy. However, there will be several patients in whom MRI is contraindicated. In this retrospective study we assessed the ability of combination of PDS guided biopsies (PDS-TBx) and modified SBx to substitute MRI-TBx. 154 men with persistently elevated PSA were referred for re-biopsy. Our protocol included a combination of MRI-TBx, DPS-TBx...
Fri Jun 05, 2020 03:00
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. In this article, we present a case of a young female patient with previously diagnosed lupus pneumonitis, now with a flare and new superimposed COVID-19 infection that was treated with intravenous steroids. On computed tomography scans, she had extensive interstitial lung fibrosis in addition to a positive COVID-19 polymerase chain reaction test requiring 6 L of oxygen via nasal cannula on admission....
Fri Jun 05, 2020 13:56
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. On December 31, 2019, the World Health Organization was informed of a cluster of cases of pneumonia of unknown cause detected in Wuhan City, Hubei Province, China. The pneumonia was caused by a virus called SARS-Cov-2 (severe acute respiratory syndrome coronavirus 2), which was later named coronavirus infectious disease 2019 (COVID-19). The symptoms most commonly reported by patients affected by COVID-19...
Thu Jun 04, 2020 10:22
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Septic cerebral emboli can be a challenging diagnosis to give, especially if atypical bacterial infections are the cause of it. Correct diagnosis of this condition can change the management route of the patient and result in a nonsurgical treatment. To our best knowledge, this is the first case of septic cerebral embolus caused by Corynebacterium mucifaciens reported. In this study, a 65-year-old...
Thu Jun 04, 2020 10:21
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. We sincerely thank Dr Andrew Whyte, who keenly reviewed our case report and came up with critical reasoning to justify his thoughts and critique with regard to our published article, “An Unusual Case of Acquired Angioedema and Monoclonal Gammopathy of Renal Significance in a Middle-Aged Caucasian Female.” We agree with the author that hypocomplementemic urticarial vasculitis can be a reasonable contender...
Thu Jun 04, 2020 10:20
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. In the middle of a pandemic, patients with cough and fever are thought to have SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It should be remembered that in the desert southwest of the United States, we have an ongoing epidemic of coccidioidomycosis (CM). There are additionally many other respiratory illnesses that could be confused with CoV-2 or overlooked. This is a case report of...
Thu Jun 04, 2020 10:20
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundPlaque psoriasis (PsO) is a chronic inflammatory disease that often presents at peak reproductive age in women of child-bearing potential (WOCBP). With the emergence of biologic therapies to treat PsO, guidance on disease management in WOCBP is needed to inform treatment decisions before, during, and after pregnancy.ObjectivesTo develop a practical, up-to-date consensus document, based on available evidence and expert opinion where...
Fri Jun 05, 2020 13:52
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri Jun 05, 2020 10:16
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri Jun 05, 2020 06:04
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri Jun 05, 2020 06:03
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Thu Jun 04, 2020 05:47
Future Oncology, Ahead of Print.
Fri Jun 05, 2020 08:13
Future Oncology, Ahead of Print.
Fri Jun 05, 2020 07:32
Future Oncology, Ahead of Print.
Fri Jun 05, 2020 07:16
Future Oncology, Ahead of Print.
Fri Jun 05, 2020 06:51
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