Abstract Acute total sleep deprivation and partial sleep deprivation have negative impacts on cognitive performance. Studies in subjects who regularly experience sleep loss, however, are rare and often restricted to examination of internal sleeping disorders. To address this issue, we set up a pilot study to explore the effects of a week characterized by sleep disruption on cognitive functioning, using a case–control setting in a maritime pilot group with chronic exposure to intermittent extrinsic,...
Mon Jun 08, 2020 16:13
Abstract Objectives Aim of this cross‐sectional study was to investigate oral health‐related quality of life (OHRQoL) of patients with different rheumatic diseases. Subjects and Methods Patients with rheumatic disease, including rheumatoid arthritis (RA), systemic lupus erythematodes (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), psoriatic arthritis (PsA) and Vasculitis were included. OHRQoL was assessed with the German short form of oral health impact profile (OGIP G14)....
Mon Jun 08, 2020 16:26
Abstract In early December 2019, the acute respiratory illness began in the Wuhan, China, which quickly spread around the world, that today known as COVID‐19. (Sun, Qie, Liu, Ren, & Xi, 2020) Preliminary studies have shown that hospitalized patients have different symptoms, including myalgia, whooping cough, fatigue, and dyspnea and gastrointestinal complains. (Guo et al., 2020; Zhang et al., 2020) In more recent studies, skin manifestations have also been reported in covid‐19 patients.
Mon Jun 08, 2020 16:24
Abstract Martín Carreras‐Presas et al. (2020) reported a case in May in Oral Diseases that they suggested was the first case report describing of a COVID‐19 patient with oral manifestations including oral pain, desquamative gingivitis, ulcers and blisters. Galván Casas et al. (2020) provided a description in April in the British Journal of Dermatology of the cutaneous manifestations of COVID‐19 in an impressive 375 case series, and with that, they had documented for the first time the oral manifestations...
Sun Jun 07, 2020 17:52
Abstract We read with interest the series of cases reported by Martín Carreras‐Presas et al. (2020). We believe that the described oral vesiculobullous manifestations were suggestive of coronavirus disease 2019 (COVID‐19) co‐infections, which at present, are overlooked and poorly understood (Cox et al., 2020). Increased disease severity and mortality amongst individuals with respiratory viral infections are often attributed to subsequent bacterial co‐infections, accounting for approximately 95%...
Sun Jun 07, 2020 17:41
ABSTRACT The Coronavirus disease‐2019 (COVID‐19) pandemic, due to the Severe Acute Respiratory Syndrome Virus 2 (SARS‐CoV‐2) was declared a public health emergency of international concern by the World Health Organization on 30th of January 2020 (World Health Organization, 2020). The first case of COVID‐19 was reported in India on the same day, and at the time of writing, on 20th May 2020, India has reported over 106,000 patients, with over 3,300 related deaths. The country is under a state of lockdown...
Sun Jun 07, 2020 17:40
ABSTRACT We live in extraordinary times, where COVID‐19 pandemic has brought the whole world to a screeching halt. Tensions and contradictions that surround the pandemic ridden world include the availability, and the lack thereof, various facial protection measures to mitigate the viral spread. Here, we comprehensively explore the different type of facial protection measures, including masks, needed both for the pubic and the health care workers (HCW). We discuss the anatomy, the critical issues...
Sun Jun 07, 2020 17:28
ABSTRACT To cope with the emergency from COVID‐19 (2019‐nCoV) and to increase the supply of intensive care beds, all over the world it was necessary to remodel or suspend the deferred and non‐urgent inpatient and outpatient activities, including those provided by the dental clinics.
Sun Jun 07, 2020 17:00
Abstract Oral squamous cell carcinoma (OSCC) is a kind of common malignant tumor worldwide. An increasing number of researches have validated that long non‐coding RNAs (lncRNAs) are closely associated with the occurrence and development of multiple diseases, including cancers. However, the role of lncRNA SNHG12 in OSCC was largely unknown. In present study, qRT‐PCR manifested the up‐regulation of SNHG12 expression in OSCC tissues and cells. Suppression of SNHG12 inhibited cell proliferation, migration,...
Sun Jun 07, 2020 16:47
Abstract Malaria is a worldwide parasitic disease, which affects millions of lives every year. Various medications are recommended by WHO for prevention and treatment of malaria. However, adverse events caused by antimalarials were frequently reported, some of which were severe and fatal. Disorders of many organs related to antimalarials have been well recognized, whereas few studies concentrated on the relationship between antimalarials and oral‐maxillofacial system health. Current review generalized...
Thu Jun 04, 2020 19:21
Standard therapeutic approaches for benign thyroid lesions that warrant intervention are surgery for cold and either surgery or radioiodine for autonomously functioning thyroid nodules (AFTN). Image-guided thermal ablation (TA) procedures are increasingly proposed as therapy options for selected clinical conditions. Due to mounting scientific evidence and widening availability, ETA considered it appropriate to develop guidelines for the use of TA in adult patients. TA procedures are well tolerated,...
Mon Jun 08, 2020 11:52
Advanced papillary thyroid carcinoma (PTC) with cutaneous metastases may cause pain, ulceration, and bleeding. Electrochemotherapy (ECT) is a minimally invasive treatment of tumors located in the skin and subcutaneous tissue. The electric pulses potentiate the toxicity of cytostatic agents entering the tumor cell. It is highly effective especially to relieve pain and improve the quality of life. The adverse events are local and transient. A case of progressive metastatic PTC who developed bleeding...
Fri Jun 05, 2020 10:48
Asthma treatment concepts have profoundly changed over the last 20 years, from standard therapeutic regimens for all patients with asthma towards individually tailored interventions targeting treatable traits (“precision medicine”). A precise and highly effective immune modulation with minimal adverse effects plays a central role in this new concept. Recently, there have been major advances in the treatment of asthma with immune-modulatory compounds. One example is the approval of several highly...
Mon Jun 08, 2020 15:13
Abstract Maintaining good cognitive function at older age is important, but our knowledge of patterns and predictors of cognitive aging is still limited. We used Bayesian model-based clustering to group 5064 participants of the Long Life Family Study (ages 49–110 years) into clusters characterized by distinct trajectories of cognitive change in the domains of episodic memory, attention, processing speed, and verbal fluency. For each domain, we identified 4 or 5 large clusters with...
Mon Jun 08, 2020 03:00
Objectives/Hypothesis To assess the impact of diet on the saliva pepsin concentration of patients with laryngopharyngeal reflux (LPR). Study Design Non‐controlled Prospective Study. Methods Patients with positive LPR regarding hypopharyngeal–esophageal impedance‐pH monitoring (HEMII‐pH) were enrolled from three European Hospitals. Patients collected three saliva samples, respectively, in the morning (fasting), and 1 to 2 hour after lunch and dinner. Patients carefully detailed foods...
Mon Jun 08, 2020 16:08
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00679C, PaperYongxin Song, Tong Zhou, Qinxin Liu, Zhijian Liu, Dongqing LiThis paper presents the detection of nanoparticles and microorganisms using a recently developed side-orifice-based resistive pulse sensor (SO-RPS). By decreasing the channel height of the detection section of the SO-RPS,...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 08, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00291G, PaperYang Zhao, Qiaojing Li, Yong-Sheng Li, Xiu-Feng GaoPeroxidase (POD) and ascorbic acid (AsA) usually coexist in organisms to synergistically protect them from the reactive oxygen damage, and their content undergo dynamic changes in different physiological conditions. What's...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 08, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00854K, PaperChunyuan Song, Yuzhou Sun, Jingjing Zhang, Tao Wang, Yingxin Wang, Ying Liu, Lian-Hui WangZika virus (ZIKV) is a serious threat to human health due to its widespread human arboviral infections, and early diagnosis is one of the keys to preventing infections from spreading,...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 08, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00741B, PaperYoonjeong Lee, Pham Khac Duy, Lawan Sriphong, Nattha Kaewnopparat, Hoeil ChungAxially perpendicular offset (APO) scheme was previously demonstrated as a versatile scheme able to minimize or eliminate the glass background in direct and non-sampling Raman measurement of ethanol sample housed...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 08, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00681E, PaperJian Xu, Kangkai Xu, Yu Han, Di Wang, Xiao Li, Tao Hu, Hong Yi, Zhonghua NiAs a chronic disease, diabetes may result in serious complications that endanger the health and life of patients. Accurate and real-time detection of blood sugar levels is of great significance...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Jun 05, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00563K, PaperReJeana Cary, Sarah Unser, Ilaina Monroe, Joseph Holbrook, Laura SagleA simple, point-of-care plasmonic assay for copper detection in human plasma is developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Jun 05, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00134A, PaperDimple Chavan, Hui Chen, Mary Crum, Binh Vu, Mohammad Safari, Maxwell Smith, Peter Vekilov, Jacinta C. Conrad, Katerina Kourentzi, Richard C. WillsonWe have demonstrated a novel immuno-PCR-based diagnostic platform which uses self-assembled ultra-detectable DNA–avidin nanoparticles stabilized with poly(ethylene glycol) for the ultrasensitive detection of protein analytes.To cite this article before page numbers are assigned, use the DOI...
Fri Jun 05, 2020 02:00
Abstract Universal mismatch repair deficiency (dMMR) testing of colorectal cancer (CRC) is promoted as routine diagnostics to prescreen for Lynch syndrome. We evaluated the yield and experience of age‐related molecular investigation for heritable and nonheritable causes of dMMR in CRC below age 70 to identify Lynch Syndrome. In a prospective cohort of 3602 newly diagnosed CRCs below age 70 from 19 hospitals, dMMR, MLH1 promoter hypermethylation, germline MMR gene and somatic MMR gene testing was...
Mon Jun 08, 2020 15:30
Abstract In the Japanese atomic bomb survivors, risk of lung cancer has been shown to increase with greater acute exposure to ionizing radiation. Although similar findings have been observed in populations exposed to low‐dose, protracted radiation, such studies lack information on cigarette smoking history, a potential confounder. In a cohort of 106 068 U.S. radiologic technologists, we examined the association between estimated cumulative lung absorbed dose from occupational radiation exposure...
Sun Jun 07, 2020 18:09
Abstract Neuroblastoma (NB) is a deadly childhood disease that carries a 50% chance of relapse for anyone in remission and similar level of 5‐year survival. We investigated the value of our proprietary approach ‐ cell surface vimentin (CSV) positive circulating tumor cells (CTC) to monitor treatment response and predict relapse in NB patients under remission in a Phase II long‐term preventative clinical trial. We longitudinally analyzed peripheral blood samples from 93 patients for 27 cycles (~25 months)...
Sun Jun 07, 2020 18:08
Abstract Over the past two decades, several studies have attempted to understand the hypothesis that disrupting the circadian rhythm may promote the development of cancer. Some have suggested that night work and some circadian genes polymorphisms are associated with cancer, including prostate cancer. This study aims to test the hypothesis that prostate cancer risk among night workers may be modulated by genetic polymorphisms in the circadian pathway genes based on data from the EPICAP study, a population‐based...
Sun Jun 07, 2020 18:06
Abstract Previously, the main treatment for multiple myeloma (MM) was cytotoxic chemotherapies, including autologous stem‐cell transplantation (ASCT), but survival benefit in the elderly was limited. More recently, clinical trials and practical experience with novel agents with superior efficacy have shown improved survival, including in the elderly. However, this improvement cannot be simply interpreted as a decline of mortality rate that is an important public health measure of progress against...
Sun Jun 07, 2020 16:20
Abstract Cadmium and lead are persistent environmental toxins that are known or probable carcinogens, based on evidence for causality for non‐hematologic cancers. Associations of these metals with risk of non‐Hodgkin lymphoma (NHL) and multiple myeloma (MM) are unknown but biologically plausible. To examine the associations of circulating levels of lead and cadmium exposure with risk of B‐cell NHL (B‐NHL) and multiple myeloma, we conducted a nested case‐control study among 299 incident B‐cell NHLs...
Sun Jun 07, 2020 16:19
Zusammenfassung Hintergrund Seit dem Auftreten des neuen Coronavirus im Dezember 2019 in China haben viele Länder Schwierigkeiten, die ansteigende Zahl der Infektionen, auch innerhalb des medizinischen Personals, zu kontrollieren. Es hat sich mittlerweile deutlich gezeigt, dass das neue SARS-CoV-2-Virus insbesondere über Aerosole und Tröpfchen der oberen Atemwege übertragen wird und die Infektionsgefahr bei oberen Atemwegsprozeduren deutlich...
Mon Jun 08, 2020 03:00
Zusammenfassung Im vorliegenden Beitrag wird die Technik der Implantation eines neuen aktiven, transkutanen, knochenverankerten Hörimplantats beschrieben. Das Hörimplantat basiert technisch auf einem System, das bereits seit 2012 zuverlässig im Einsatz ist. Die Geometrie des neuen Systems ist an die Erfahrungen mit vorangegangenen Implantaten angepasst. Die Op. ist standardisiert und sicher durchführbar. Aufgrund der optimierten Bauform mit verbesserter Passfähigkeit im Schläfenbein...
Fri Jun 05, 2020 03:00
Zusammenfassung In Deutschland sinken die Operationszahlen der Tonsillektomie seit vielen Jahren, bei Kindern hat die Zahl von Adenotonsillektomien innerhalb eines Jahrzehnts um etwa zwei Drittel abgenommen. Dies steht offensichtlich im Zusammenhang mit der signifikant häufigeren Ausführung der Tonsillotomie, die in erster Linie zur Volumenreduktion hyperplastischer Gaumenmandeln ausgeführt wird. Ziel des vorliegenden Beitrags ist die Darstellung der unterschiedlichen Eingriffsarten,...
Fri Jun 05, 2020 03:00
Abstract Human rhinovirus (HRV) is the most frequent cause of the common cold and acute viral rhinosinusitis. Traditionally, HRV identification was performed using culture‐based, biochemical and serologic methods and limited to HRV‐A and HRV‐B species
Mon Jun 08, 2020 15:53
Abstract Background Childhood asthma is a multifactorial inflammatory condition of the airways, associated with specific changes in respiratory microbiome and circulating metabolome. Methods To explore the functional capacity of asthmatic microbiome and its intricate connection with the host, we performed shotgun sequencing of airway microbiome and untargeted metabolomics profiling of serum samples in a cohort of children with mite‐sensitized asthma and non‐asthmatic controls. Results...
Sun Jun 07, 2020 17:52
Sun Jun 07, 2020 14:43
Abstract The outbreak of the SARS‐CoV‐2‐induced Coronavirus Disease 2019 (COVID‐19) pandemic re‐shaped doctor‐patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related...
Fri Jun 05, 2020 11:44
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