Πέμπτη 2 Απριλίου 2020


[Department of Error] Department of Error
Mease PJ, Rahman P, Gottlieb AB, et al. Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial. Lancet 2020; 395: 1126–36—In this Article, the following sentence from the Participants section has been corrected as follows: “Patients were permitted, but not required, to continue stable use of selected standard treatments, including NSAIDs or other analgesics up to the regional marketed dose approved; oral corticosteroids...
The Lancet
6h
[Correspondence] COVID-19 in Europe: the Italian lesson
Severe acute respiratory syndrome coronavirus 2 is rapidly spreading worldwide,1 and WHO declared the coronavirus disease 2019 (COVID-19) outbreak a pandemic on March 11, 2020.2
The Lancet
6h
[Correspondence] Immunosuppression for hyperinflammation in COVID-19: a double-edged sword?
Mehta and colleagues1 postulate that hyperinflammation in coronavirus disease 2019 (COVID-19) could be a driver of severity that is amenable to therapeutic targeting since retro-spective data have shown that systemic inflammation is associated with adverse outcome. However, correlation does not equal causation, and it is equally plausible that increased virus burden (secondary to failure of the immune response to control infection) drives inflammation and consequent severity (as shown for other viruses2)...
The Lancet
6h
[Department of Error] Department of Error
Deodhar A, Helliwell PS, Boehncke W-H, et al. Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFa inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial. Lancet 2020; published online March 13. https://doi.org/10.1016/S0140-6736(20)30265-8—In this Article in table 2, the p value row for the short form-36 mental component summary is now correctly labelled as “Unadjusted p value”. This correction has...
The Lancet
6h
[Comment] Mass gathering events and reducing further global spread of COVID-19: a political and public health dilemma
The coronavirus disease 2019 (COVID-19) pandemic1 presents countries with major political, scientific, and public health challenges. Pandemic preparedness and reducing risk of global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are key concerns. Mass gathering (MG) events2 pose considerable public health challenges to health authorities and governments. Historically, sporting, religious, music, and other MGs have been the source of infectious diseases that have spread globally.
The Lancet
6h
[Correspondence] The global community needs to swiftly ramp up the response to contain COVID-19
“Much of the global community is not yet ready for COVID-19 [coronavirus disease 2019]”.1 This is arguably one of the most resonating phrases in the Report of the WHO-China Joint Mission on Coronavirus Disease 2019,1 released publicly on Feb 28, 2020. Major transmission hotspots were brought under control in China, but subsequently others sprouted across the globe. Since late February, 2020, the daily number of new cases has been higher in other parts of the world. New major epicentres have established...
The Lancet
6h
[Comment] Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic
The coronavirus disease 2019 (COVID-19) pandemic that first emerged in Wuhan in China's Hubei province1 has quickly spread to the rest of China and many other countries. Within 3 months, more than 125 000 people have been infected and the death toll had reached over 4600 worldwide on March 12, 2020.2 In an attempt to contain the virus, the Chinese Government has made unprecedented efforts and invested enormous resources and these containment efforts have stemmed the spread of the disease.3 As of...
The Lancet
6h
[Comment] Targeting p19 in psoriatic arthritis: more than just another therapeutic approach?
Pharmacological management of chronic immune-mediated inflammatory conditions has experienced many advances in the past decade. Psoriatic arthritis has for a long time almost exclusively had therapeutic strategies that were originally developed for rheumatoid arthritis, on which most arthritis research has focused. The complexity of psoriatic arthritis, with its different disease manifestations besides the arthritis (enthesitis, dactylitis, involvement of the axial skeleton, and skin and nail disease),...
The Lancet
6h
[Articles] Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFα inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial
Guselkumab demonstrated a favourable benefit–risk profile and might be an effective treatment option for patients with active psoriatic arthritis.
The Lancet
6h
[Articles] Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial
Guselkumab, a human monoclonal antibody that specifically inhibits IL-23 by binding the cytokine's p19 subunit, was efficacious and demonstrated an acceptable benefit–risk profile in patients with active psoriatic arthritis who were naive to treatment with biologics. These data support the use of selective inhibition of IL-23 to treat psoriatic arthritis.
The Lancet
6h
[Articles] First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA
Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while Patient 1 was symptomatic. Despite active symptom monitoring and testing of symptomatic and some asymptomatic contacts, no further transmission was detected.
The Lancet
6h
COVID‐19 in a Designated Infectious Diseases Hospital Outside Hubei Province, China
Abstract Background The clinical characteristics of novel coronavirus disease (COVID‐2019) patients outside the epicenter of Hubei province are less understood. Methods We analyzed the epidemiological and clinical features of all COVID‐2019 cases in the only referral hospital in Shenzhen city, China from January 11, 2020 to February 6, 2020 and followed until March 6, 2020. Results Among the 298 confirmed cases, 233 (81.5%) had been to Hubei while 42 (14%) did not have...
Allergy
6h
Simple Approaches for the Synthesis of AgNPs in Solution and Solid Phase Using Modified Methoxypolyethylene Glycol and Evaluation of Their Antimicrobial Activity
International Journal of Nanomedicine
6h
The Response of Human Osteoblasts, Epithelial Cells, Fibroblasts, Macrophages and Oral Bacteria to Nanostructured Titanium Surfaces: A Systematic Study [Corrigendum]
International Journal of Nanomedicine
6h
Engineering of Aerogel-Based Biomaterials for Biomedical Applications
International Journal of Nanomedicine
6h
Issue Information
The Journal of Dermatology
6h
Issue Information
The Journal of Dermatology
6h
Real life experience of apremilast in psoriasis and arthritis psoriatic patients: Preliminary results on metabolic biomarkers
Abstract Psoriasis is a common inflammatory skin condition, affecting 2–4% of the worldwide population. Psoriasis remains an important public health challenge because there are many clinical forms of psoriasis in particular sites, probably related to the dysregulation of different cytokines. Therefore, there is a continuous need to improve treatment options with mechanisms of action different from those of the currently known therapies. Advances in knowledge of the molecular bases of pathogenesis...
The Journal of Dermatology
23h
3D Primary Cell Culture: A Novel Preclinical Model For Pancreatic Neuroendocrine Tumors (PanNETs)
Molecular mechanisms underlying the development and progression of PanNET are still insufficiently understood. Efficacy of currently approved PanNET therapies is limited. While novel treatment options are being developed, patient stratification permitting more personalized treatment selection in PanNET is yet not feasible since no predictive markers are established. The lack of representative in vitro and in vivo models as well as the rarity and heterogeneity of PanNET are prevailing reasons for...
NEN : Last 20 articles
7h
Genetic Factors Contribute to Subsequent Neoplasms in Survivors of Childhood Cancer
CA: A Cancer Journal for Clinicians
7h
New Study Links Hair Chemicals to Breast Cancer
CA: A Cancer Journal for Clinicians
7h
Effect of Combination Therapy of Canagliflozin Added to Teneligliptin Monotherapy in Japanese Subjects with Type 2 Diabetes Mellitus: A Retrospective Study
Recently, dipeptidyl peptidase-4 (DPP-4) inhibitors and sodium-glucose cotransporter 2 (SGLT2) inhibitors have been very often used in subjects with type 2 diabetes mellitus (T2DM). In addition, combination drugs of both inhibitors have attracted much attention in aspects of its cost-effectiveness and improvement of patients’ adherence. However, it is still poorly understood which factors are related to the efficacy of SGLT2 inhibitors as add-on therapy to DPP-4 inhibitors. Therefore, we aimed to...
Hindawi Publishing Corporation
7h
A Strength-Based Intervention to Increase Participation in Leisure Activities in Children with Neuropsychiatric Disabilities: A Pilot Study
The aim is to evaluate the feasibility of an intervention model with a client-centered goal-directed approach with the aim to enhance the child’s participation in leisure activities, self-efficacy, and activity performance. A pilot intervention using a client-centered goal-directed approach and a single-subject design was performed. Two Swedish boys with neuropsychiatric diagnosis aged 12 and 14 years old were included, and 3 leisure activity goals were identified. The intervention was carried out...
Hindawi Publishing Corporation
7h
Inflammatory Factors Induce Thrombosis through the miR-146b-3p/p38MAPK/COX-2 Pathway
Objective. Inflammatory responses play important roles in the pathogenesis of atherosclerosis. The purpose of this study was to investigate the relationship between microRNA-146b-3p (miR-146b-3p) and inflammatory factors in thrombosis. Method. THP-1 cells were cultured in vitro, Western blot was used to determine the protein levels of COX-2 and p38MAPK in the cells, and real-time PCR was used to detect the mRNA expression of miRNA-146b-3p and COX-2. A lentiviral expression vector of miRNA-146b-3p...
Hindawi Publishing Corporation
7h
Efficacy and Safety of Integrated Traditional Chinese Medicine and Western Medicine on the Treatment of Rheumatoid Arthritis: A Meta-Analysis
Objective. Integrated therapy of traditional Chinese medicine (TCM) and Western medicine (WM) has gradually been applied to the treatment of rheumatoid arthritis (RA). Recently published studies have provided a wealth of data and information about the effectiveness of combination treatments, but high-quality evidence-based meta-analysis on this issue is not available yet. This study was conducted to compare and evaluate the efficacy and safety of the integrated therapy for RA. Methods. PubMed, EMBASE,...
Hindawi Publishing Corporation
7h
Pkh1p-Ypk1p and Pkh1p-Sch9p Pathways Are Activated by Acetic Acid to Induce a Mitochondrial-Dependent Regulated Cell Death
The yeast Saccharomyces cerevisiae undergoes a mitochondrial-dependent regulated cell death (RCD) exhibiting typical markers of mammalian apoptosis. We have previously shown that ceramide production contributes to RCD induced by acetic acid and is involved in mitochondrial outer membrane permeabilization and cytochrome c release, especially through hydrolysis of complex sphingolipids catalyzed by Isc1p. Recently, we also showed that Sch9p regulates the translocation of Isc1p from the endoplasmic...
Hindawi Publishing Corporation
7h
Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods 2019
Hindawi Publishing Corporation
7h
Noncoding RNAs as Biomarkers for Acute Coronary Syndrome
Acute coronary syndrome (ACS), consisting of acute myocardial infarction and unstable angina, is the most dangerous and fatal form of coronary heart disease. Acute coronary syndrome has sudden onset and rapid development, which may lead to malignant life-threatening conditions at any time. Therefore, early detection and diagnosis are critical for patients with ACS. Recent studies have found that noncoding RNA is of great significance in the diagnosis and treatment of cardiovascular diseases. In this...
Hindawi Publishing Corporation
7h
Separable Nonlinear Least-Squares Parameter Estimation for Complex Dynamic Systems
Nonlinear dynamic models are widely used for characterizing processes that govern complex biological pathway systems. Over the past decade, validation and further development of these models became possible due to data collected via high-throughput experiments using methods from molecular biology. While these data are very beneficial, they are typically incomplete and noisy, which renders the inference of parameter values for complex dynamic models challenging. Fortunately, many biological systems...
Hindawi Publishing Corporation
7h
Facile Method for Obtaining Gold-Coated Polyester Surfaces with Antimicrobial Properties
The antimicrobial and antifungal activity of polymers used in medical devices has been extensively studied due to the growing impact of hospital-related infections in patients. The ideal biocidal polymeric materials should be very effective in the microorganism’s inhibition, not toxic to the human body, and environmentally friendly. In this context, this work is aimed at obtaining antimicrobial and antifungal properties at the polyester film surfaces without introducing toxic effects. Poly (ethylene...
Hindawi Publishing Corporation
7h
Tea Polysaccharide (TPS) Reduces Astrocytes Apoptosis Induced by Oxygen-Glucose Deprivation/Reoxygenation by Regulating the miR-375/SRXN1 Axis
Objective. To investigate the effect of tea polysaccharides (TPS) mediated by miR-375/SRXN1 axis on mice with cerebral ischemia-reperfusion injury and proliferation and apoptosis of astrocytes (AS) conducted with oxygen-glucose deprivation/reoxygenation (OGD/R). Methods. Mouse model of middle cerebral artery occlusion (MCAO) and OGD/R-induced AS injury model were established; brain obstruction volume was measured by TTC staining; dry/wet weight ratio was used for measuring brain water content; hydrogen...
Hindawi Publishing Corporation
7h
Comment on “CPEO and Mitochondrial Myopathy in a Patient with DGUOK Compound Heterozygous Pathogenetic Variant and mtDNA Multiple Deletions”
Hindawi Publishing Corporation
7h
Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients
Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients’ reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency...
Hindawi Publishing Corporation
7h
Curcumin Inhibits Proliferation and Epithelial-Mesenchymal Transition in Lens Epithelial Cells through Multiple Pathways
Background. Posterior capsule opacification (PCO), a complication of extracapsular lens extraction surgery that causes visual impairment, is characterized by aberrant proliferation and epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs). Curcumin, exerting inhibitive effects on cell proliferation and EMT in cancer, serves as a possible antidote towards PCO. Methods. Cellular proliferation of LECs after treatment of curcumin was measured with MTT assay and flow cytometry. The transcriptional...
Hindawi Publishing Corporation
7h
Analysis of Occupational Stress and Its Relationship with Secretory Immunoglobulin A in the Xinjiang Plateau Young Military Recruits
Background. With the continuous improvement of the modernization of the Chinese military and the major adjustments made by the state to the recruitment policy, the newly recruited military undergone multiple pressures such as targeted high-intensity military training and environmental changes. The mental health of military has become a crucial factor of improving the fighting capacity effectiveness of the troops. Objectives. To explore occupational stress of young recruits in the Xinjiang plateau...
Hindawi Publishing Corporation
7h
Development and Validation of a Bordetella pertussis Whole-Genome Screening Strategy
The immune response elicited by the protective whole-cell pertussis (wP) versus the less-protective acellular pertussis (aP) vaccine has been well characterized; however, important clinical problems remain unsolved, as the inability of the currently administered aP vaccine is resulting in the reemergence of clinical disease (i.e., whooping cough). Strong evidence has shown that original, childhood aP and wP priming vaccines provide a long-lasting imprint on the CD4+ T cells that impacts protective...
Hindawi Publishing Corporation
7h
Characterization of a Complex Mixture of Immunomodulator Peptides Obtained from Autologous Urine
A complex mixture of peptides plays a key role in the regulation of the immune system; different sources as raw materials mainly from animals and vegetables have been reported to provide these extracts. The batch-to-batch product consistency depends on in-process controls established. However, when an immunomodulator is a customized product obtained from the same volunteer who will receive the product to personalize the treatment, the criteria to establish the consistency between volunteers are different....
Hindawi Publishing Corporation
7h
The Role of MicroRNAs in Regulatory T Cells
MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. Here, we review the recent progress in understanding the roles of microRNAs...
Hindawi Publishing Corporation
7h
Analysis of Similarities and Differences between Acoustic Emission and Charge Signal Based on Fractal Characteristics of Coal Fracture
Rock burst is a catastrophic dynamic disaster caused by sudden failure and instability of coal, which brings threats to deep coal mining; the AE-charge signals and the fragment distribution are related to both mechanical properties of coal and disaster early warning directly. Hence, the variation of AE and charge induction during coal failure, fractal feature of coal fragments, and their relationship should be studied in depth. In this paper, uniaxial loading test was carried out for coal with bursting...
Hindawi Publishing Corporation
7h

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