Microorganisms, Vol. 8, Pages 609: Incidental Prophylactic Appendectomy Is Associated with a Profound Microbial Dysbiosis in the Long-Term Microorganisms doi: 10.3390/microorganisms8040609 Authors: Lidia Sánchez-Alcoholado José Carlos Fernández-García Carolina Gutiérrez-Repiso M Rosa Bernal-López Luis Ocaña-Wilhelmi Eduardo García-Fuentes Isabel Moreno-Indias Francisco J. Tinahones Incidental prophylactic surgeries are performed in certain situations. Incidental...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1995: Fluorescent Biaryl Uracils with C5-Dihydro- and Quinazolinone Heterocyclic Appendages in PNA Molecules doi: 10.3390/molecules25081995 Authors: Ali Heidari Arash Ghorbani-Choghamarani Maryam Hajjami Robert H. E. Hudson There has been much effort to exploit fluorescence techniques in the detection of nucleic acids. Canonical nucleic acids are essentially nonfluorescent; however, the modification of the nucleobase has proved to be a fruitful way...
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Molecules, Vol. 25, Pages 1994: Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy Molecules doi: 10.3390/molecules25081994 Authors: Daniel P. Feldmann Joshua Heyza Christoph M. Zimmermann Steve M. Patrick Olivia M. Merkel Platinum-based chemotherapy remains a mainstay treatment for the management of advanced non-small cell lung cancer. A key cellular factor that contributes to sensitivity to platinums is the 5′-3′...
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Molecules, Vol. 25, Pages 1993: The Cytotoxic and Apoptotic Effects of the Brown Algae Colpomenia sinuosa are Mediated by the Generation of Reactive Oxygen Species Molecules doi: 10.3390/molecules25081993 Authors: Reem Al Monla Zeina Dassouki Achraf Kouzayha Yahya Salma Hala Gali-Muhtasib Hiba Mawlawi Brown algae are a novel resource of biogenic molecules, however few studies have been conducted in the Mediterranean to assess the cytotoxic mechanisms of algal-derived compounds....
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Molecules, Vol. 25, Pages 1992: Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin) Molecules doi: 10.3390/molecules25081992 Authors: Catherine A. Tindall Sebastian Dommel Veronika Riedl David Ulbricht Stefanie Hanke Norbert Sträter John T. Heiker Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin...
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Molecules, Vol. 25, Pages 1991: Effects of Graphene Oxide Nanofilm and Chicken Embryo Muscle Extract on Muscle Progenitor Cell Differentiation and Contraction Molecules doi: 10.3390/molecules25081991 Authors: Bałaban Wierzbicki Zielińska Szczepaniak Sosnowska Daniluk Cysewski Koczoń Chwalibog Sawosz Finding an effective muscle regeneration technique is a priority for regenerative medicine. It is known that the key factors determining tissue formation...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1990: Protective Effects of Vitamin K Compounds on the Proteomic Profile of Osteoblasts under Oxidative Stress Conditions Molecules doi: 10.3390/molecules25081990 Authors: Muszyńska Ambrożewicz Gęgotek Grynkiewicz Skrzydlewska Oxidative stress, which accompanies the pathogenesis of many bone diseases, contributes to the reduction of osteoblast activity, resulting in the inhibition of differentiation. This study aimed to assess the effect of...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1989: MnO2/rGO/CNTs Framework as a Sulfur Host for High-Performance Li-S Batteries Molecules doi: 10.3390/molecules25081989 Authors: Dong Meng Hong Liu Shen Xia Yang Lithium-sulfur batteries are very promising next-generation energy storage batteries due to their high theoretical specific capacity. However, the shuttle effect of lithium-sulfur batteries is one of the important bottlenecks that limits its rapid development. Herein, physical...
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Molecules, Vol. 25, Pages 1988: Mechanical and Thermal Properties of Polyether Polytriazole Elastomers Formed by Click-Chemical Reaction Curing Glycidyl Azide Polymer Molecules doi: 10.3390/molecules25081988 Authors: Liming He Jun Zhou Yutao Wang Zhongliang Ma Chunlin Chen Energetic binders are a research hot-spot, and much emphasis has been placed on their mechanical properties. In this study, propargyl-terminated ethylene oxide-tetrahydrofuran copolymer (PTPET) was synthesized....
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1987: Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs Molecules doi: 10.3390/molecules25081987 Authors: Angelica Artasensi Alessandro Pedretti Giulio Vistoli Laura Fumagalli Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of population and according to the World Health Organization (WHO) the number of adults living with diabetes is expected to increase. Since type 2 diabetes mellitus (T2DM) is...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1986: Interactions of Tea-Derived Catechin Gallates with Bacterial Pathogens Molecules doi: 10.3390/molecules25081986 Authors: Taylor Green tea-derived galloylated catechins have weak direct antibacterial activity against both Gram-positive and Gram-negative bacterial pathogens and are able to phenotypically transform, at moderate concentrations, methicillin-resistant Staphylococcus aureus (MRSA) clonal pathogens from full β-lactam resistance (minimum...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1985: N-Acetylation of Amines in Continuous-Flow with Acetonitrile—No Need for Hazardous and Toxic Carboxylic Acid Derivatives Molecules doi: 10.3390/molecules25081985 Authors: Orsy Fülöp Mándity A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes milder reagent than those used conventionally. The reaction was tested on various...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1980: In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei Molecules doi: 10.3390/molecules25081980 Authors: Phan Baek Lee Byun Shum No Kinetoplastid parasites, including Leishmania and Trypanosoma spp., are life threatening pathogens with a worldwide distribution. Next-generation therapeutics for treatment are needed as current treatments have limitations, such as toxicity and...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1984: Hematite Nanoparticles from Unexpected Reaction of Ferrihydrite with Concentrated Acids for Biomedical Applications Molecules doi: 10.3390/molecules25081984 Authors: Lunin Lizunova Mochalova Yakovtseva Cherkasov Nikitin Kolychev The development of synthetic ways to fabricate nanosized materials with a well-defined shape, narrow-sized distribution, and high stability is of great importance to a rapidly developing area of nanotechnology....
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1974: Cytotoxic Activities and Molecular Mechanisms of the Beauvericin and Beauvericin G1 Microbial Products against Melanoma Cells Molecules doi: 10.3390/molecules25081974 Authors: Haet Nim Lim Jun-Pil Jang Hee Jeong Shin Jae-Hyuk Jang Jong Seog Ahn Hye Jin Jung Melanoma is the most serious type of skin cancer and remains highly drug-resistant. Therefore, the discovery of novel effective agents against melanoma is in high demand. Herein, we investigated...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1983: Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation Molecules doi: 10.3390/molecules25081983 Authors: Kunal Kumar Peng Wang Ethan A. Swartz Susmita Khamrui Cody Secor Michael B. Lazarus Roberto Sanchez Andrew F. Stewart Robert J. DeVita Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1979: The Rheolaser Master™ and Kinexus Rotational Rheometer® to Evaluate the Influence of Topical Drug Delivery Systems on Rheological Features of Topical Poloxamer Gel Molecules doi: 10.3390/molecules25081979 Authors: Cristiano Froiio Mancuso De Gaetano Ventura Fresta Paolino Poloxamer 407 copolymer is a versatile and widely used thermo-reversible material. Its use has many advantages, such as bio-adhesion, enhanced solubilization...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1966: Large-Scale Evaluation of Major Soluble Macromolecular Components of Fish Muscle from a Conventional 1H-NMR Spectral Database Molecules doi: 10.3390/molecules25081966 Authors: Feifei Wei Minoru Fukuchi Kengo Ito Kenji Sakata Taiga Asakura Yasuhiro Date Jun Kikuchi Conventional proton nuclear magnetic resonance (1H-NMR) has been widely used for identification and quantification of small molecular components in food. However, identification...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1977: Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions Molecules doi: 10.3390/molecules25081977 Authors: Giovanni Turchetti Stefania Garzoli Valentina Laghezza Masci Carla Sabia Ramona Iseppi Pierluigi Giacomello Antonio Tiezzi Elisa Ovidi Schinus molle (L.) is a dioecious plant of the Anacardiaceae family, originating in South America and currently widespread...
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Molecules, Vol. 25, Pages 1981: Volatilome of Chill-Stored European Seabass (Dicentrarchus labrax) Fillets and Atlantic Salmon (Salmo salar) Slices under Modified Atmosphere Packaging Molecules doi: 10.3390/molecules25081981 Authors: Athanasios Kritikos Ioanna Aska Sotirios Ekonomou Athanasios Mallouchos Foteini F. Parlapani Serkos A. Haroutounian Ioannis S. Boziaris Fish spoilage occurs due to production of metabolites during storage, from bacterial action and chemical...
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Molecules, Vol. 25, Pages 1975: Kinetic Studies on Radical Scavenging Activity of Kaempferol Decreased by Sn(II) Binding Molecules doi: 10.3390/molecules25081975 Authors: Zhi-Yin Yang Ling-Ling Qian Yi Xu Meng-Ting Song Chao Liu Rui-Min Han Jian-Ping Zhang Leif H. Skibsted Sn(II) binds to kaempferol (HKaem, 3,4′,5,7-tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) at the 3,4-site forming [Sn(II)(Kaem)2] complex in ethanol. DPPH• scavenging...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1978: In the Mists of a Fungal Metabolite: An Unexpected Reaction of 2,4,5-Trimethoxyphenylglyoxylic Acid Molecules doi: 10.3390/molecules25081978 Authors: Immo Serbian Anne Loesche Sven Sommerwerk Phil Liebing Dieter Ströhl René Csuk The reactions of phenylglyoxylic acids during the synthesis and biological evaluation of fungal metabolites led to the discovery of hitherto unknown compounds with a p-quinone methide (p-QM) structure. The formation...
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Molecules, Vol. 25, Pages 1976: Tailoring the Properties of Thermo-Compressed Polylactide Films for Food Packaging Applications by Individual and Combined Additions of Lactic Acid Oligomer and Halloysite Nanotubes Molecules doi: 10.3390/molecules25081976 Authors: Sandra Rojas-Lema Luis Quiles-Carrillo Daniel Garcia-Garcia Beatriz Melendez-Rodriguez Rafael Balart Sergio Torres-Giner In this work, films of polylactide (PLA) prepared by extrusion and thermo-compression were...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1982: Technetium-Radiolabeled Mannose-Functionalized Gold Nanoparticles as Nanoprobes for Sentinel Lymph Node Detection Molecules doi: 10.3390/molecules25081982 Authors: Oscar J. Estudiante-Mariquez Andrés Rodríguez-Galván David Ramírez-Hernández Flavio F. Contreras-Torres Luis A. Medina Gold nanoparticles (AuNPs) are considered valuable nanomaterials for the design of radiolabeled nanoprobes for single-photon emission computed tomography (SPECT)...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1964: 5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl)alkancarboxylic Acids as Antimicrobial Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies Molecules doi: 10.3390/molecules25081964 Authors: Volodymyr Horishny Victor Kartsev Athina Geronikaki Vasyl Matiychuk Anthi Petrou Jasmina Glamoclija Ana Ciric Marina Sokovic Background: Infectious diseases symbolize a global consequential strain on public health security...
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Molecules, Vol. 25, Pages 1970: Concise Synthesis of Catechin Metabolites 5-(3′,4′-Dihydroxyphenyl)-γ-valerolactones (DHPV) in Optically Pure Form and Their Stereochemical Effects on Skin Wrinkle-Reducing Activities Molecules doi: 10.3390/molecules25081970 Authors: Joonseong Hur A-Ram Kim Hyun Su Kim Changjin Lim Taewoo Kim Tae-Aug Kim Jaehoon Sim Young-Ger Suh A concise and scalable synthetic route for optically pure (4S) and (4R)-5-(3′,4′-dihydroxyphenyl)-γ-valerolactones...
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Molecules, Vol. 25, Pages 1971: Application of MM-PBSA Methods in Virtual Screening Molecules doi: 10.3390/molecules25081971 Authors: Poli Granchi Rizzolio Tuccinardi Computer-aided drug design techniques are today largely applied in medicinal chemistry. In particular, receptor-based virtual screening (VS) studies, in which molecular docking represents the gold standard in silico approach, constitute a powerful strategy for identifying novel hit compounds active against...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1967: A Systems Biological Approach to Understanding the Mechanisms Underlying the Therapeutic Potential of Red Ginseng Supplements Against Metabolic Diseases Molecules doi: 10.3390/molecules25081967 Authors: Jeong Lim Kim Ki Lee Suh So Kwon Kim Red ginseng has been widely used in health-promoting supplements in Asia and is becoming increasingly popular in Western countries. However, its therapeutic mechanisms against most diseases...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1962: Dielectric Spectroscopy of Water Dynamics in Functionalized UiO-66 Metal-Organic Frameworks Molecules doi: 10.3390/molecules25081962 Authors: Sergejus Balčiūnas Diana Pavlovaitė Martynas Kinka Jyun-Yi Yeh Po-Chun Han Fa-Kuen Shieh Kevin C.-W. Wu Mantas Šimėnas Robertas Grigalaitis Jūras Banys We present a dielectric spectroscopy study of dipolar dynamics in the hydrated UiO-66(Zr) type metal-organic frameworks (MOFs) functionalized...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1973: Qualitative Phytochemical Fingerprint and Network Pharmacology Investigation of Achyranthes aspera Linn. Extracts Molecules doi: 10.3390/molecules25081973 Authors: Kouadio Ibrahime Sinan Gokhan Zengin Dimitrina Zheleva-Dimitrova Ouattara Katinan Etienne Mohamad Fawzi Mahomoodally Abdelhakim Bouyahya Devina Lobine Annalisa Chiavaroli Claudio Ferrante Luigi Menghini Lucia Recinella Luigi Brunetti Sheila Leone Giustino Orlando...
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Molecules, Vol. 25, Pages 1969: Biophenolic Compounds Influence the In-Mouth Perceived Intensity of Virgin Olive Oil Flavours and Off-Flavours Molecules doi: 10.3390/molecules25081969 Authors: Alessandro Genovese Ferdinando Mondola Antonello Paduano Raffaele Sacchi In this study, the influence of phenolic compounds on the sensory scores attributed to extra virgin olive oil (EVOO) by panel test was investigated. Two model olive oils (MOOs) with identical concentrations of volatile...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1968: Analysis of Antioxidant Activity and Flavonoids Metabolites in Peel and Flesh of Red-Fleshed Apple Varieties Molecules doi: 10.3390/molecules25081968 Authors: Zhang Xu Xu Sun Zhu Zhang In this research, we compared the phenotypical characters, total anthocyanins content, total phenols content, and antioxidant activity of red-fleshed apple cultivars ‘XJ4′, ‘QN-5′, ‘DH’ and...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1963: Three-Component Access to Functionalized Spiropyrrolidine Heterocyclic Scaffolds and Their Cholinesterase Inhibitory Activity Molecules doi: 10.3390/molecules25081963 Authors: Sarra Boudriga Saoussen Haddad Vikneswaran Murugaiyah Moheddine Askri Michael Knorr Carsten Strohmann Christopher Golz A novel one-pot [3+2]-cycloaddition reaction of (E)-3-arylidene-1-phenyl-succinimides, cyclic 1,2-diketones (isatin, 5-chloro-isatin and acenaphtenequinone),...
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Molecules, Vol. 25, Pages 1965: Understanding Surface Modulation to Improve the Photo/Electrocatalysts for Water Oxidation/Reduction Molecules doi: 10.3390/molecules25081965 Authors: Yunhee Cho Thi Anh Le Hyoyoung Lee Water oxidation and reduction reactions play vital roles in highly efficient hydrogen production conducted by an electrolyzer, in which the enhanced efficiency of the system is apparently accompanied by the development of active electrocatalysts. Solar energy, a sustainable...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1972: Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia Molecules doi: 10.3390/molecules25081972 Authors: Thu Myo Aung Clericuzio Armijos Vidari Mushrooms have a long history of uses for their medicinal and nutritional properties. They have been consumed by people for thousands of years. Edible mushrooms are collected in the wild or cultivated worldwide. Recently, mushroom extracts and their secondary metabolites...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1957: Development and In Vitro and In Vivo Evaluation of Microspheres Containing Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate for the Oral Delivery of Berberine Hydrochloride Molecules doi: 10.3390/molecules25081957 Authors: Ying Li Chunyan Zhu Microspheres containing absorption enhancer (sodium N-[8-(2-hydroxybenzoyl)amino]caprylate, SNAC) were developed to enhance the oral bioavailability of berberine hydrochloride (BER) with poor intestinal membrane permeability....
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1955: Early Steps in the Biosynthetic Pathway of Rishirilide B Molecules doi: 10.3390/molecules25081955 Authors: Philipp Schwarzer Olga Tsypik Chijian Zuo Ahmad Alali Julia Wunsch-Palasis Tanja Heitzler Jana Derochfort Mirjam Bernhardt Xiaohui Yan Thomas Paululat Andreas Bechthold The biological active compound rishirilide B is produced by Streptomyces bottropensis. The cosmid cos4 contains the complete rishirilide B biosynthesis...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1958: A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies Molecules doi: 10.3390/molecules25081958 Authors: Lucia Ferron Raffaella Colombo Barbara Mannucci Adele Papetti The reuse of byproducts from agricultural and food industries represents the key factor in a circular economy, whose interest has grown in the last two decades. Thus, the extraction...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1961: Oxidative Dehydrogenation of Propane over Vanadium-Containing Faujasite Zeolite Molecules doi: 10.3390/molecules25081961 Authors: Małgorzata Smoliło Katarzyna Samson Ting Zhou Dorota Duraczyńska Małgorzata Ruggiero-Mikołajczyk Agnieszka Drzewiecka-Matuszek Dorota Rutkowska-Zbik Oxidative dehydrogenation (ODH) of light alkanes to olefins—in particular, using vanadium-based catalysts—is a promising alternative to the...
Thu Apr 23, 2020 03:00
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