Molecules, Vol. 25, Pages 1948: Design, Synthesis, and Biological Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Dual Degradation of IGF-1R and Src Molecules doi: 10.3390/molecules25081948 Authors: Sudhakar Manda Na Keum Lee Dong-Chan Oh Jeeyeon Lee A focused PROTAC library was developed to degrade both IGF-1R and Src proteins, which are associated with various cancers. PROTACs with IGF-1R and Src degradation potentials were synthesized by tethering different...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1959: HOCl Responsive Lanthanide Complexes Using Hydroquinone Caging Units
Molecules, Vol. 25, Pages 1959: HOCl Responsive Lanthanide Complexes Using Hydroquinone Caging Units Molecules doi: 10.3390/molecules25081959 Authors: Elena Del Giorgio Thomas Just Sørensen Redox biology is still looking for tools to monitor redox potential in cellular biology and, despite a large and sustained effort, reliable molecular probes have yet to emerge. In contrast, molecular probes for reactive oxygen and nitrogen have been widely explored. In this manuscript, three kinetically...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1960: Apigenin Inhibits Histamine-Induced Cervical Cancer Tumor Growth by Regulating Estrogen Receptor Expression Molecules doi: 10.3390/molecules25081960 Authors: Erkang Zhang Yani Zhang Zhuoyan Fan Lei Cheng Shiwen Han Huilian Che Apigenin is a natural flavone with anti-inflammatory and antioxidant properties and antitumor abilities against several types of cancers. Previous studies have found that the antitumor effects of apigenin may be due...
Thu Apr 23, 2020 03:00
Molecules, Vol. 25, Pages 1956: Precise Measurement of Tellurium Isotope Ratios in Terrestrial Standards Using a Multiple Collector Inductively Coupled Plasma Mass Spectrometry Molecules doi: 10.3390/molecules25081956 Authors: Rajamanickam Murugan Tatsuo Aono Sarata Kumar Sahoo Precise tellurium (Te) isotope ratio measurement using mass spectrometry is a challenging task for many decades. In this paper, Te isotope ratio measurements using multi-collector inductively coupled plasma...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 813: Synergy Effect of Au and SiO2 Modification on SnO2 Sensor Properties in VOCs Detection in Humid Air Nanomaterials doi: 10.3390/nano10040813 Authors: Gulevich Rumyantseva Gerasimov Khmelevsky Tsvetkova Gaskov Nanocomposites based on Au- and SiO2-modified SnO2 were studied as sensitive materials for ethanol and benzene detection in dry (RH = 1%) and humid (RH = 20%) air. Modification of SnO2 by amorphous SiO2 (13 mol.%) was effectuated...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 812: Generating Silicon Nanofiber Clusters from Grinding Sludge by Millisecond Pulsed Laser Irradiation Nanomaterials doi: 10.3390/nano10040812 Authors: Momoki Takahashi Kobinata Kobayashi Kawai Yan Silicon nanofiber clusters were successfully generated by the irradiation of millisecond pulsed laser light on silicon sludge disposed from wafer back-grinding processes. It was found that the size, intensity, and growing speed of the laser-induced...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 808: 3-Dimensional Porous Carbon with High Nitrogen Content Obtained from Longan Shell and Its Excellent Performance for Aqueous and All-Solid-State Supercapacitors Nanomaterials doi: 10.3390/nano10040808 Authors: Yuhao Liu Xiaoxiao Qu Guangxu Huang Baolin Xing Fengmei Zhang Binbin Li Chuanxiang Zhang Yijun Cao Three-dimensional porous carbon is considered as an ideal electrode material for supercapacitors (SCs) applications owing to...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 811: Multi-Frequency Resonance Behaviour of a Si Fractal NEMS Resonator Nanomaterials doi: 10.3390/nano10040811 Authors: Tzanov Llobet Torres Perez Barniol Novel Si-based nanosize mechanical resonator has been top-down fabricated. The shapeof the resonating body has been numerically derived and consists of seven star-polygons that forma fractal structure. The actual resonator is defined by focused ion-beam implantation on a SOIwafer where...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 810: Biological Safety and Biodistribution of Chitosan Nanoparticles Nanomaterials doi: 10.3390/nano10040810 Authors: Sonin Pochkaeva Zhuravskii Postnov Korolev Vasina Kostina Mukhametdinova Zelinskaya Skorik Naumysheva Malashicheva Somov Istomina Rubanova Aleksandrov Vasyutina Galagudza : The effect of unmodified chitosan nanoparticles with a size of ~100 nm and a weakly positive charge...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 809: Investigation on Mn3O4 Coated Ru Nanoparticles for Partial Hydrogenation of Benzene towards Cyclohexene Production using ZnSO4, MnSO4 and FeSO4 as Reaction Additives Nanomaterials doi: 10.3390/nano10040809 Authors: Liu Chen Sun Chen Peng Liu Mn3O4 coated Ru nanoparticles (Ru@Mn3O4) were synthesized via a precipitation-reduction-gel method. The prepared catalysts were evaluated for partial hydrogenation of benzene towards cyclohexene...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 806: Facile Synthesis of Solution-Processed Silica and Polyvinyl Phenol Hybrid Dielectric for Flexible Organic Transistors Nanomaterials doi: 10.3390/nano10040806 Authors: Chen Zhang Guan Zhang A high-quality dielectric layer is essential for organic thin-film transistors (OTFTs) operated at a low-power consumption level. In this study, a facile improved technique for the synthesis of solution-processed silica is proposed. By optimizing the...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 807: The Effect of Different Oxygen Surface Functionalization of Carbon Nanotubes on the Electrical Resistivity and Strain Sensing Function of Cement Pastes Nanomaterials doi: 10.3390/nano10040807 Authors: B. Del Moral I. Martín Gullón R. Navarro O. Galao F.J. Baeza E. Zornoza B. Calderón I. Rodríguez N. Arnaiz M.D. Romero Sánchez P. Garcés Different studies in the literature indicate the effectiveness of CNTs as reinforcing...
Thu Apr 23, 2020 03:00
Nanomaterials, Vol. 10, Pages 805: Noble Metal-Free TiO2-Coated Carbon Nitride Layers for Enhanced Visible Light-Driven Photocatalysis Nanomaterials doi: 10.3390/nano10040805 Authors: Bo Zhang Xiangfeng Peng Zhao Wang Composites of g-C3N4/TiO2 were one-step prepared using electron impact with dielectric barrier discharge (DBD) plasma as the electron source. Due to the low operation temperature, TiO2 by the plasma method shows higher specific surface area and smaller particle size...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1192: Bus Stops Near Schools Advertising Junk Food and Sugary Drinks Nutrients doi: 10.3390/nu12041192 Authors: Donna Huang Amanda Brien Lima Omari Angela Culpin Melody Smith Victoria Egli Children rarely understand the full extent of the persuasive purpose of advertising on their eating behaviours. Addressing the obesogenic environments in which children live, through a quantification of outdoor advertising, is essential in informing policy changes...
03:00
Nutrients, Vol. 12, Pages 1191: Effect of Increased Daily Water Intake and Hydration on Health in Japanese Adults Nutrients doi: 10.3390/nu12041191 Authors: Nakamura Watanabe Tanaka Yasui Nishihira Murayama Increased hydration is recommended as healthy habit with several merits. However, supportive data are sparse. To assess the efficacy of increased daily water intake, we tested the effect of water supplementation on biomarkers in blood, urine, and saliva. Twenty-four...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1190: Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression Nutrients doi: 10.3390/nu12041190 Authors: Hiroaki Eguchi Toshiyuki Matsunaga Satoshi Endo Kenji Ichihara Akira Ikari Claudins (CLDNs) play crucial roles in the formation of tight junctions. We have reported that abnormal expression of CLDN2 confers chemoresistance in the spheroids of human...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1188: Plasma Metabolome Alterations Associated with Extrauterine Growth Restriction Nutrients doi: 10.3390/nu12041188 Authors: Danuta Dudzik Isabel Iglesias Platas Montserrat Izquierdo Renau Carla Balcells Esponera Beatriz del Rey Hurtado de Mendoza Carles Lerin Marta Ramón-Krauel Coral Barbas Very preterm infants (VPI, born at or before 32 weeks of gestation) are at risk of adverse health outcomes, from which they might be partially protected...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1189: A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma Nutrients doi: 10.3390/nu12041189 Authors: Cammalleri Dal Monte Amato Bagnoli Rusciano There is indication that nutritional supplements protect retinal cells from degeneration. In a previous study, we demonstrated that dietary supplementation with an association of forskolin, homotaurine,...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1186: Association of Basal Metabolic Rate and Nutrients Oxidation with Cardiometabolic Risk Factors and Insulin Sensitivity in Sedentary Middle-Aged Adults Nutrients doi: 10.3390/nu12041186 Authors: Amaro-Gahete Jurado-Fasoli Ruiz Castillo This cross-sectional study aimed to examine the association of basal metabolic rate (BMR) and basal fat and carbohydrate oxidation (BFox and BCHox, respectively) with cardiometabolic risk factors and insulin sensitivity...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1185: Intestinal Permeability, Inflammation and the Role of Nutrients Nutrients doi: 10.3390/nu12041185 Authors: Ricard Farré Marcello Fiorani Saeed Abdu Rahiman Gianluca Matteoli The interaction between host and external environment mainly occurs in the gastrointestinal tract, where the mucosal barrier has a critical role in many physiologic functions ranging from digestion, absorption, and metabolism. This barrier allows the passage and absorption...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1181: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections Nutrients doi: 10.3390/nu12041181 Authors: Philip C. Calder Anitra C. Carr Adrian F. Gombart Manfred Eggersdorfer Public health practices including handwashing and vaccinations help reduce the spread and impact of infections. Nevertheless, the global burden of infection is high, and additional measures are necessary. Acute...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1180: Effect of a 12-Week Almond-Enriched Diet on Biomarkers of Cognitive Performance, Mood, and Cardiometabolic Health in Older Overweight Adults Nutrients doi: 10.3390/nu12041180 Authors: Alison Mary Coates Samantha Morgillo Catherine Yandell Andrew Scholey Jonathan David Buckley Kathryn Ann Dyer Alison Marie Hill Long term nut consumption is associated with reduced risk of coronary heart disease and better cognitive function. This study...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1184: Reply to “Limitations of the Digestible Indispensable Amino Acid Score (DIAAS) and Choice of Statistical Reporting. Comment on “A Comparison of Dietary Protein Digestibility, Based on DIAAS Scoring, in Vegetarian and Non-Vegetarian Athletes.” Nutrients 2019, 11, 3106” Nutrients doi: 10.3390/nu12041184 Authors: Carol S. Johnston Heidi Lynch Christopher Wharton We appreciate the critique of our paper (Ciuris et al [...]
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1182: Consumption of Cooked Black Beans Stimulates a Cluster of Some Clostridia Class Bacteria Decreasing Inflammatory Response and Improving Insulin Sensitivity Nutrients doi: 10.3390/nu12041182 Authors: Mónica Sánchez-Tapia Irma Hernández-Velázquez Edgar Pichardo-Ontiveros Omar Granados-Portillo Amanda Gálvez Armando R Tovar Nimbe Torres There is limited information on the effect of black beans (BB) as a source of protein and resistant starch...
Thu Apr 23, 2020 03:00
Nutrients, Vol. 12, Pages 1183: Limitations of the Digestible Indispensable Amino Acid Score (DIAAS) and Choice of Statistical Reporting. Comment on “A Comparison of Dietary Protein Digestibility, Based on DIAAS Scoring, in Vegetarian and Non-Vegetarian Athletes. Nutrients 2019, 11, 3106” Nutrients doi: 10.3390/nu12041183 Authors: Angela Genoni Joel C Craddock Emma F Strutt Dear Editor, [...]
Thu Apr 23, 2020 03:00
Pathogens, Vol. 9, Pages 312: Phenylpropanoid Pathway Engineering: An Emerging Approach towards Plant Defense Pathogens doi: 10.3390/pathogens9040312 Authors: Yadav Wang Wei Amo Ahmed Yang Zhang Pathogens hitting the plant cell wall is the first impetus that triggers the phenylpropanoid pathway for plant defense. The phenylpropanoid pathway bifurcates into the production of an enormous array of compounds based on the few intermediates of the shikimate pathway...
Thu Apr 23, 2020 03:00
Pathogens, Vol. 9, Pages 311: Long-Term Incubation PrPCWD with Soils Affects Prion Recovery but Not Infectivity Pathogens doi: 10.3390/pathogens9040311 Authors: Alsu Kuznetsova Debbie McKenzie Catherine Cullingham Judd M. Aiken Chronic wasting disease (CWD) is a contagious prion disease of cervids. The infectious agent is shed from animals at the preclinical and clinical stages of disease where it persists in the environment as a reservoir of CWD infectivity. In this study,...
Thu Apr 23, 2020 03:00
Pathogens, Vol. 9, Pages 310: Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically Pathogens doi: 10.3390/pathogens9040310 Authors: Handi Dahmana Oleg Mediannikov Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most important...
Thu Apr 23, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 77: Drug Conjugates for Targeting Eph Receptors in Glioblastoma Pharmaceuticals doi: 10.3390/ph13040077 Authors: Puja Sharma Callie Roberts Denise Herpai Izabela D. Fokt Waldemar Priebe Waldemar Debinski Glioblastoma (GBM) is a complex and heterogeneous tumor that warrants a comprehensive therapeutic approach for treatment. Tumor-associated antigens offer an opportunity to selectively target various components of the GBM microenvironment...
Thu Apr 23, 2020 03:00
Pharmaceuticals, Vol. 13, Pages 76: Atomic Nanogenerators in Targeted Alpha Therapies: Curie’s Legacy in Modern Cancer Management Pharmaceuticals doi: 10.3390/ph13040076 Authors: Mareike Roscher Gábor Bakos Martina Benešová Atomic in vivo nanogenerators such as actinium-225, thorium-227, and radium-223 are of increasing interest and importance in the treatment of patients with metastatic cancer diseases. This is due to their peculiar physical, chemical, and biological characteristics,...
Thu Apr 23, 2020 03:00
Pharmaceutics, Vol. 12, Pages 387: Control of the Lung Residence Time of Highly Permeable Molecules after Nebulization: Example of the Fluoroquinolones Pharmaceutics doi: 10.3390/pharmaceutics12040387 Authors: Julien Brillault Frédéric Tewes Pulmonary drug delivery is a promising strategy to treat lung infectious disease as it allows for a high local drug concentration and low systemic side effects. This is particularly true for low-permeability drugs, such as tobramycin or colistin,...
Thu Apr 23, 2020 03:00
Pharmaceutics, Vol. 12, Pages 385: Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers Pharmaceutics doi: 10.3390/pharmaceutics12040385 Authors: Andrea Kovács Adrienn Kazsoki Balázs Démuth Bernadett Szirányi János Madarász Károly Süvegh Romána Zelkó Electrospun nanofibers were prepared from furosemide-containing hydroxypropyl cellulose and poly(vinylpyrrolidone) aqueous solutions using...
Thu Apr 23, 2020 03:00
Pharmacy, Vol. 8, Pages 72: Pharmacist-Driven Culture and Sexually Transmitted Infection Testing Follow-Up Program in the Emergency Department Pharmacy doi: 10.3390/pharmacy8020072 Authors: Stephanie C. Shealy Christine Alexander Tina Grof Hardison Joseph Magagnoli Julie Ann Justo Caroline Derrick Joseph Kohn Hana Rac Winders Troy Privette Majdi N. Al-Hasan P. Brandon Bookstaver Expanding pharmacist-driven antimicrobial stewardship efforts in the emergency...
Thu Apr 23, 2020 03:00
Plants, Vol. 9, Pages 547: OsbHLH073 Negatively Regulates Internode Elongation and Plant Height by Modulating GA Homeostasis in Rice Plants doi: 10.3390/plants9040547 Authors: Jinwon Lee Sunok Moon Seonghoe Jang Sichul Lee Gynheung An Ki-Hong Jung Soon Ki Park Internode elongation is one of the key agronomic traits determining a plant’s height and biomass. However, our understanding of the molecular mechanisms controlling internode elongation is still limited...
Thu Apr 23, 2020 03:00
Plants, Vol. 9, Pages 548: Developing a Sufficient Protocol for the Enhancement of α-Glucosidase Inhibitory Activity by Urena lobata L. Aeroponic Hairy Roots Using Exogenous Factors, a Precursor, and an Elicitor Plants doi: 10.3390/plants9040548 Authors: Cao Vu Hoang Bui Quach Aeroponics is considered as a potential method for the culture of herbal plants due to the high growth rate, quantity and quality enhancement of secondary metabolites, and substantial environmental...
Thu Apr 23, 2020 03:00
Plants, Vol. 9, Pages 546: Frequency, Spectrum, and Stability of Leaf Mutants Induced by Diverse γ-Ray Treatments in Two Cymbidium Hybrids Plants doi: 10.3390/plants9040546 Authors: Sang Hoon Kim Se Won Kim Joon-Woo Ahn Jaihyunk Ryu Soon-Jae Kwon Byoung-Cheorl Kang Jin-Baek Kim Ionizing radiation combined with in vitro tissue culture has been used for development of new cultivars in diverse crops. The effects of ionizing radiation on mutation induction have been analyzed...
Thu Apr 23, 2020 03:00
Plants, Vol. 9, Pages 549: Unraveling the Phylogenomic Relationships of the Most Diverse African Palm Genus Raphia (Calamoideae, Arecaceae) Plants doi: 10.3390/plants9040549 Authors: Andrew J. Helmstetter Suzanne Mogue Kamga Kevin Bethune Thea Lautenschläger Alexander Zizka Christine D. Bacon Jan J. Wieringa Fred Stauffer Alexandre Antonelli Bonaventure Sonké Thomas L. P. Couvreur Palms are conspicuous floristic elements across the tropics. In continental...
Thu Apr 23, 2020 03:00
Religions, Vol. 11, Pages 214: Rejecting “Controversial” Issues in Education: A Case Study of Ultra-Orthodox Jewish Schools in Belgium Religions doi: 10.3390/rel11040214 Authors: Leni Franken François Levrau In liberal democracies, fundamental rights and freedoms can conflict, and if they do, it is not always clear which right the state should prioritize. Should the right of parents to choose education in line with their own convictions prevail, or should the right of children to...
Thu Apr 23, 2020 03:00
Religions, Vol. 11, Pages 213: Free to Die: A Lutheran-Relational Approach to Medical Assistance in Dying Religions doi: 10.3390/rel11040213 Authors: Kayko Driedger Hesslein In 2016, Canada legalized Bill C-14, which removed from the Criminal Code medical assistance in dying (MAID) under certain circumstances. In essence, the Bill legalized what is commonly described as euthanasia, under the provisions that the patient has a terminal medical diagnosis, anticipates extreme suffering,...
Thu Apr 23, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου