IJMS, Vol. 21, Pages 2961: Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21082961 Authors: Ruyi Gao Yongshuai Zhang Yuhui Kang Weiyin Xu Luyao Jiang Tingting Guo Changchao Huan Our previous study showed that glycyrrhizin (GLY) inhibited porcine epidemic diarrhea virus (PEDV) infection, but the mechanisms of GLY anti-PEDV action remain unclear....
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2967: Deeping in the Role of the MAP-Kinases Interacting Kinases (MNKs) in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21082967 Authors: Celia Pinto-Díez Raquel Ferreras-Martín Rebeca Carrión-Marchante Víctor M. González María Elena Martín The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are involved in oncogenic transformation and can promote metastasis and tumor progression. In human cells, there are four...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2973: Attenuation of the Diffuse Noxious Inhibitory Controls in Chronic Joint Inflammatory Pain Is Accompanied by Anxiodepressive-Like Behaviors and Impairment of the Descending Noradrenergic Modulation International Journal of Molecular Sciences doi: 10.3390/ijms21082973 Authors: Raquel Pereira-Silva José Tiago Costa-Pereira Raquel Alonso Paula Serrão Isabel Martins Fani L. Neto The noradrenergic system is paramount for controlling pain and emotions....
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2969: RNA-Binding Proteins as Important Regulators of Long Non-Coding RNAs in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21082969 Authors: Katharina Jonas George A. Calin Martin Pichler The majority of the genome is transcribed into pieces of non-(protein) coding RNA, among which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile molecules that govern basic cellular processes including transcription, splicing,...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2972: Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21082972 Authors: Stefania De Santis Giulio Verna Grazia Serino Raffaele Armentano Elisabetta Cavalcanti Marina Liso Manuela Dicarlo Sergio Coletta Mauro Mastronardi Antonio Lippolis Angela Tafaro Angelo Santino Aldo Pinto Pietro Campiglia Alex Y....
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2966: Differential Expression and Function of Bicellular Tight Junctions in Skin and Oral Wound Healing International Journal of Molecular Sciences doi: 10.3390/ijms21082966 Authors: Trevor R. Leonardo Junhe Shi Dandan Chen Harsh M. Trivedi Lin Chen Bicellular tight junctions are multiprotein complexes that are required for maintenance of barrier function and fence function in epithelial tissues. Wound healing in the oral cavity leads to minimal scar...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1224: Correction: Etelcalcetide in Patients on Hemodialysis with Severe Secondary Hyperparathyroidism. Multicenter Study in “Real Life”. J. Clin. Med. 2019, 8, 1066 Journal of Clinical Medicine doi: 10.3390/jcm9041224 Authors: Domenico Russo Rocco Tripepi Fabio Malberti Biagio Di Iorio Bernadette Scognamiglio Luca Di Lullo Immacolata Gaia Paduano Giovanni Luigi Tripepi Vincenzo Antonio Panuccio The authors wish to make the following corrections...
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JCM, Vol. 9, Pages 1222: Evaluation of the French National Program on Home Return of Patients with Chronic Heart Failure (PRADO-IC): Pilot Study of 91 Patients During Its Deployment in the Bas Rhin Area Journal of Clinical Medicine doi: 10.3390/jcm9041222 Authors: Mylène Radreau Noel Lorenzo-Villalba Samy Talha Jean-Jacques Von Hunolstein Michel Hanssen Anne Koenig Philippe Couppie Bernard Geny Francois Severac Gérald Roul Abrar-Ahmad Zulfiqar Emmanuel Andrès...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1218: Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma Journal of Clinical Medicine doi: 10.3390/jcm9041218 Authors: Hsin-Chih Yeh Ching-Chia Li Sheng-Chen Wen Nirmish Singla Solomon L. Woldu Haley Robyak Chun-Nung Huang Hung-Lung Ke Wei-Ming Li Hsiang-Ying Lee Chia-Yang Li Bi-Wen Yeh Sheau-Fang Yang Hung-Pin Tu Shahrokh F. Shariat Arthur I. Sagalowsky Jay D. Raman Yair...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1219: Diagnostic Criteria for Fibromyalgia: Critical Review and Future Perspectives Journal of Clinical Medicine doi: 10.3390/jcm9041219 Authors: Carmen M. Galvez-Sánchez Gustavo A. Reyes del Paso Fibromyalgia syndrome (FMS) is a chronic illness characterized by widespread pain and other clinical and emotional symptoms. The lack of objective markers of the illness has been a persistent problem in FMS research, clinical management, and social recognition of the disease....
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1216: Common Musculoskeletal Disorders in the Elderly: The Star Triad Journal of Clinical Medicine doi: 10.3390/jcm9041216 Authors: Marco Alessandro Minetto Alessandro Giannini Rebecca McConnell Chiara Busso Guglielmo Torre Giuseppe Massazza Musculoskeletal disorders are debilitating conditions that significantly impair the state of health, especially in elderly subjects. A pathological triad of inter-related disorders that are highly prevalent in the...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1220: Urinary Exosomal MicroRNA Signatures in Nephrotic, Biopsy-Proven Diabetic Nephropathy Journal of Clinical Medicine doi: 10.3390/jcm9041220 Authors: Wen-Chin Lee Lung-Chih Li Hwee-Yeong Ng Pei-Ting Lin Terry Ting-Yu Chiou Wei-Hung Kuo Chien-Te Lee Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD). Elucidating the mechanisms underlying proteinuria in DKD is crucial because it is a common problem in DKD-related...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1215: Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study Journal of Clinical Medicine doi: 10.3390/jcm9041215 Authors: Laura Barrubés Nancy Babio Pablo Hernández-Alonso Estefania Toledo Judith B. Ramírez Sabio Ramón Estruch Emilio Ros Montserrat Fitó Angel M Alonso-Gómez Miquel Fiol Jose Lapetra Lluís Serra-Majem Xavier Pintó Miguel Ruiz-Canela Dolores Corella...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1214: The Effects of Granulocyte Colony-Stimulating Factor in Patients with a Large Anterior Wall Acute Myocardial Infarction to Prevent Left Ventricular Remodeling: A 10-Year Follow-Up of the RIGENERA Study Journal of Clinical Medicine doi: 10.3390/jcm9041214 Authors: Antonio Maria Leone Domenico D’Amario Francesco Cannata Francesca Graziani Josip A. Borovac Giuseppe Leone Valerio De Stefano Eloisa Basile Andrea Siracusano Leonarda Galiuto Gabriella...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1221: Local Serpin Treatment via Chitosan-Collagen Hydrogel after Spinal Cord Injury Reduces Tissue Damage and Improves Neurologic Function Journal of Clinical Medicine doi: 10.3390/jcm9041221 Authors: Jacek M. Kwiecien Liqiang Zhang Jordan R. Yaron Lauren N. Schutz Christian J. Kwiecien-Delaney Enkidia A. Awo Michelle Burgin Wojciech Dabrowski Alexandra R. Lucas Spinal cord injury (SCI) results in massive secondary damage characterized by a...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1212: Novel MAG Variant Causes Cerebellar Ataxia with Oculomotor Apraxia: Molecular Basis and Expanded Clinical Phenotype Journal of Clinical Medicine doi: 10.3390/jcm9041212 Authors: Mariana Santos Joana Damásio Célia Kun-Rodrigues Clara Barbot Jorge Sequeiros José Brás Isabel Alonso Rita Guerreiro Homozygous variants in MAG, encoding myelin-associated glycoprotein (MAG), have been associated with complicated forms of hereditary spastic paraplegia...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1217: Clinical and Histopathological Characteristics of Cutaneous Lymphoid Hyperplasia: A Comparative Study According to Causative Factors Journal of Clinical Medicine doi: 10.3390/jcm9041217 Authors: Choi Lee Lim Won Chang Lee Choi Lee Cutaneous lymphoid hyperplasia (CLH) is a heterogeneous type of reactive lymphocytic infiltration resembling cutaneous lymphoma clinically and histopathologically. Few studies describe the relationship between...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1211: Urinary Incontinence in Women: Modern Methods of Physiotherapy as a Support for Surgical Treatment or Independent Therapy Journal of Clinical Medicine doi: 10.3390/jcm9041211 Authors: Agnieszka Irena Mazur-Bialy Daria Kołomańska-Bogucka Caroline Nowakowski Sabina Tim Urinary incontinence (UI) is a common health problem affecting quality of life of nearly 420 million people, both women and men. Pelvic floor muscle (PFM) training and other physiotherapy...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1213: Decreased Glucose Utilization Contributes to Memory Impairment in Patients with Glufosinate Ammonium Intoxication Journal of Clinical Medicine doi: 10.3390/jcm9041213 Authors: Samel Park Joong Il Kim Nam-jun Cho Se Won Oh Jongkyu Park Ik Dong Yoo Hyo-Wook Gil Sang Mi Lee The symptoms of glufosinate ammonium (GLA) intoxication include gastrointestinal and neurologic symptoms, respiratory failure, and cardiovascular instability. Among these,...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1210: Obesity and Body Composition in Preschool Children with Different Levels of Actigraphy-Derived Physical Activity—A Cross-Sectional Study Journal of Clinical Medicine doi: 10.3390/jcm9041210 Authors: Justyna Wyszyńska Piotr Matłosz Agnieszka Szybisty Paweł Lenik Katarzyna Dereń Artur Mazur Jarosław Herbert Detailed associations between physical activity (PA) and body composition in preschoolers remain unclear. The aim of this study was to assess...
Thu Apr 23, 2020 03:00
JCM, Vol. 9, Pages 1209: Clinical and Radiologic Features Together Better Predict Lung Nodule Malignancy in Patients with Soft-Tissue Sarcoma Journal of Clinical Medicine doi: 10.3390/jcm9041209 Authors: Cecilia Tetta Antonio Giugliano Laura Tonetti Michele Rocca Alessandra Longhi Francesco Londero Gianmarco Parise Orlando Parise Linda Renata Micali Mark La Meir Jos G. Maessen Sandro Gelsomino We test the hypothesis that a model including clinical and...
Thu Apr 23, 2020 03:00
JFMK, Vol. 5, Pages 26: Effects of the Enriched Sports Activities-Program on Executive Functions in Italian Children Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5020026 Authors: Marianna Alesi Giulia Giordano Marcello Giaccone Michele Basile Sebastiano Costa Antonino Bianco Physical activity (PA) during childhood plays an important role in brain development. This role is played in both the structural domain, prefrontal cortex area, and in the functional...
Thu Apr 23, 2020 03:00
J. Imaging, Vol. 6, Pages 26: Analysing Arbitrary Curves from the Line Hough Transform Journal of Imaging doi: 10.3390/jimaging6040026 Authors: Donald Bailey Yuan Chang Steven Le Moan The Hough transform is commonly used for detecting linear features within an image. A line is mapped to a peak within parameter space corresponding to the parameters of the line. By analysing the shape of the peak, or peak locus, within parameter space, it is possible to also use the line Hough transform...
Thu Apr 23, 2020 03:00
JPM, Vol. 10, Pages 29: Pharmacogenomic (PGx) Counseling: Exploring Participant Questions about PGx Test Results Journal of Personalized Medicine doi: 10.3390/jpm10020029 Authors: Tara Schmidlen Amy C. Sturm Laura B. Scheinfeldt As pharmacogenomic (PGx) use in healthcare increases, a better understanding of patient needs will be necessary to guide PGx result delivery. The Coriell Personalized Medicine Collaborative (CPMC) is a prospective study investigating the utility of personalized...
Thu Apr 23, 2020 03:00
Medicina, Vol. 56, Pages 198: Pregnancy and Childbirth in Uterus Didelphys: A Report of Three Cases Medicina doi: 10.3390/medicina56040198 Authors: Slavchev Kostov Yordanov Uterus didelphys is a rare form of congenital anomaly of the Müllerian ducts. The clinical significance of this anomaly of the female reproductive tract is associated with various reproductive issues: increased risk of preterm birth before 37 weeks’ gestation, abnormal fetal presentation,...
Thu Apr 23, 2020 03:00
Medicina, Vol. 56, Pages 199: Missed Down Syndrome Cases after First Trimester False-Negative Screening—Lessons to be Learned Medicina doi: 10.3390/medicina56040199 Authors: Simionescu Stanescu Here, we performed a descriptive analysis of Down syndrome (DS) cases that were misdiagnosed and/or false-negative diagnosed after first trimester traditional screening via risk evaluation using ultrasound, biochemical markers, and different software programs. Our objective was to demonstrate...
Thu Apr 23, 2020 03:00
Medicina, Vol. 56, Pages 196: Systemic Oxidative Stress Markers in Cirrhotic Patients with Hepatic Encephalopathy: Possible Connections with Systemic Ammoniemia Medicina doi: 10.3390/medicina56040196 Authors: Cătălin Sfarti Alin Ciobica Ioana-Miruna Balmus Ovidiu-Dumitru Ilie Anca Trifan Oana Petrea Camelia Cojocariu Irina Gîrleanu Ana Maria Sîngeap Carol Stanciu Background and objectives: Oxidative stress shows evidence of dysregulation in cirrhotic patients...
Thu Apr 23, 2020 03:00
Medicina, Vol. 56, Pages 193: The Effectiveness of Low-dose Dexmedetomidine Infusion in Sedative Flexible Bronchoscopy: A Retrospective Analysis Medicina doi: 10.3390/medicina56040193 Authors: Sheng Hua Wu David Vi Lu Chun Dan Hsu I Cheng Lu Background and objectives: Flexible bronchoscopy has been widely used for diagnosis and intervention, while various drugs are used for sedation during bronchoscopy. We examined two regular standardized sedation options (with or without dexmedetomidine)...
Thu Apr 23, 2020 03:00
Medicina, Vol. 56, Pages 194: Hemicranial Cough-Induced Headache as a First Symptom of a Carotid-Cavernous Fistula-Case Report Medicina doi: 10.3390/medicina56040194 Authors: Svetlana Simić Ljiljana Radmilo José R. Villar Aleksandar Kopitović Dragan Simić Background and objectives: Spontaneous carotid-cavernous fistulas (CCFs) are rare, and they may be caused by an aneurysm rupture. Materials and Methods: A case of a man hospitalized for high-intensity hemicranial headache...
Thu Apr 23, 2020 03:00
Medicina, Vol. 56, Pages 195: Subspecialty Second-Opinion in Multiple Myeloma CT: Emphasis on Clinically Significant Lytic Lesions Medicina doi: 10.3390/medicina56040195 Authors: Alberto Stefano Tagliafico Liliana Belgioia Alessandro Bonsignore Federica Rossi Giulia Succio Bianca Bignotti Alida Dominietto Background and objectives: In order to increase the accuracy of lytic lesion detection in multiple myeloma, a dedicated second-opinion interpretation of medical images...
Thu Apr 23, 2020 03:00
Metabolites, Vol. 10, Pages 167: Metabolic Effects of Bovine Milk Oligosaccharides on Selected Commensals of the Infant Microbiome—Commensalism and Postbiotic Effects Metabolites doi: 10.3390/metabo10040167 Authors: Louise M. A. Jakobsen Maria X. Maldonado-Gómez Ulrik K. Sundekilde Henrik J. Andersen Dennis S. Nielsen Hanne C. Bertram Oligosaccharides from human or bovine milk selectively stimulate growth or metabolism of bacteria associated with the lower gastrointestinal...
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Metabolites, Vol. 10, Pages 164: Metabolomics in Central Sensitivity Syndromes Metabolites doi: 10.3390/metabo10040164 Authors: Joseph S. Miller Luis Rodriguez-Saona Kevin V. Hackshaw Central sensitization syndromes are a collection of frequently painful disorders that contribute to decreased quality of life and increased risk of opiate abuse. Although these disorders cause significant morbidity, they frequently lack reliable diagnostic tests. As such, technologies that can identify...
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Metabolites, Vol. 10, Pages 166: Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux Metabolites doi: 10.3390/metabo10040166 Authors: Ku Chen Lan Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries. Metabolic engineering efforts aim to increase carbon flux towards acetyl-CoA in order to achieve higher productivities of its downstream...
Thu Apr 23, 2020 03:00
Metabolites, Vol. 10, Pages 165: The Urinary Metabolome of Healthy Newborns Metabolites doi: 10.3390/metabo10040165 Authors: Yamilé López-Hernández Juan José Oropeza-Valdez Jorge O. Blanco-Sandate Ana Sofia Herrera-Van Oostdam Jiamin Zheng An Chi Guo Victoria Lima-Rogel Rahmatollah Rajabzadeh Mariana Salgado-Bustamante Jesus Adrian-Lopez C. G. Castillo Emilia Robles Arguelles Joel Monárrez-Espino Rupasri Mandal David S. Wishart The knowledge...
Thu Apr 23, 2020 03:00
Metabolites, Vol. 10, Pages 163: A Review of Lipidomics of Cardiovascular Disease Highlights the Importance of Isolating Lipoproteins Metabolites doi: 10.3390/metabo10040163 Authors: Ming Ding Kathryn M. Rexrode Cutting-edge lipidomic profiling measures hundreds or even thousands of lipids in plasma and is increasingly used to investigate mechanisms of cardiovascular disease (CVD). In this review, we introduce lipidomic techniques, describe distributions of lipids across lipoproteins,...
Thu Apr 23, 2020 03:00
Microorganisms, Vol. 8, Pages 612: Glycosphingolipids Recognized by Acinetobacter baumannii Microorganisms doi: 10.3390/microorganisms8040612 Authors: Madar Johansson Azzouz Häggendal Säljö Malmi Zaviolov Teneberg Acinetobacter baumannii is an opportunistic bacterial pathogen associated with hospital-acquired infections, including pneumonia, meningitis, bacteremia, urinary tract infection, and wound infections. Recognition of host cell surface carbohydrates plays...
Thu Apr 23, 2020 03:00
Microorganisms, Vol. 8, Pages 613: New Approaches for Cryptococcosis Treatment Microorganisms doi: 10.3390/microorganisms8040613 Authors: Spadari Wirth Lopes Ishida Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in patients with HIV infection. The antifungal pharmacological treatment is limited to amphotericin B, fluconazole and 5- flucytosine. In addition to the limited pharmacological options, the high toxicity, increased resistance...
Thu Apr 23, 2020 03:00
Microorganisms, Vol. 8, Pages 611: Engineering Yarrowia lipolytica for the Synthesis of Glutathione from Organic By-Products Microorganisms doi: 10.3390/microorganisms8040611 Authors: Diem T. H. Do Patrick Fickers Tripeptide glutathione, which plays important roles in many cellular mechanisms, is also a biotechnology-oriented molecule with applications in medicine, food and cosmetic. Here, the engineering of the yeast Yarrowia lipolytica for the production of this metabolite at high...
Thu Apr 23, 2020 03:00
Microorganisms, Vol. 8, Pages 610: Taxogenomics of the Genus Cyclobacterium: Cyclobacterium xiamenense and Cyclobacterium halophilum as Synonyms and Description of Cyclobacterium plantarum sp. nov. Microorganisms doi: 10.3390/microorganisms8040610 Authors: Azadeh Shahinpei Mohammad Ali Amoozegar Leila Mirfeizi Mahdi Moshtaghi Nikou Antonio Ventosa Cristina Sánchez-Porro The genus Cyclobacterium belongs to the phylum Bacteroidetes and includes eight species. Our study,...
Thu Apr 23, 2020 03:00
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