Mon Apr 20, 2020 18:26
Abstract SARS‐CoV‐2 is a new corona virus responsible for the pandemic named Coronavirus Disease 2019 (COVID‐19). The disease causes severe acute respiratory syndromes with a significant morbidity and mortality. We provide a review with a focus on COVID‐19 in dermatology. We discuss triage of suspected infectious patients, protection of medical doctors and nurses. We discuss the available data on cutaneous symptoms, although disease‐specific symptoms have yet not been observed. COVID‐19 is a challenge...
Mon Apr 20, 2020 18:25
ABSTRACT Background Climatotherapy (CT) is a treatment with immediate high clearance rate for chronic psoriasis, but evidence of long‐term effects is scarce. Objective Assessment of the impact of a single CT treatment on disease activity and quality of life at 4‐6 months follow‐up. Methods A prospective study of patients with psoriasis undergoing 4 weeks of CT in Israel describes long‐term outcomes of CT. Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI)...
Mon Apr 20, 2020 18:24
Abstract The new coronavirus pandemic poses question and challenges for dermatologists. One of question is if psoriasis patients treated with immunomodulating and immunosuppressive drugs have to discontinue their treatment in the midts of fears for the infection and its consequences. One of the challenges is how can we support our patients in this critical time. Previous coronaviruses outbreaks reports, current published evidences on pathogenesis and on clinical reports of COVID infection in immunosuppressed...
Mon Apr 20, 2020 18:23
Related ArticlesThree Reasons Why Artificial Intelligence Might Be the Radiologist's Best Friend. Radiology. 2020 Apr 21;:200855 Authors: van Rijn RR, De Luca A PMID: 32319861 [PubMed - as supplied by publisher]
Thu Apr 23, 2020 15:17
Related ArticlesVariation of PI-RADS Interpretations between Experts: A Significant Limitation. Radiology. 2020 Apr 21;:192650 Authors: Milot L PMID: 32319860 [PubMed - as supplied by publisher]
Thu Apr 23, 2020 15:17
Related ArticlesUsing Deep Learning for MRI to Identify Responders to Chemoradiotherapy in Rectal Cancer. Radiology. 2020 Apr 21;:200417 Authors: Koh DM PMID: 32319859 [PubMed - as supplied by publisher]
Thu Apr 23, 2020 15:17
Related ArticlesSolid Hypoechoic Adnexal Lesions with Acoustic Shadowing Warrant an MRI Recommendation in the O-RADS Risk Stratification and Management System. Radiology. 2020 Apr 21;:200437 Authors: Wilson MP, Katlariwala P, Low G PMID: 32315270 [PubMed - as supplied by publisher]
Wed Apr 22, 2020 14:25
Related ArticlesAnterior Mitral Leaflet Aneurysm. Radiology. 2020 Apr 21;:200004 Authors: Rajagopal R, Jagia P PMID: 32315269 [PubMed - as supplied by publisher]
Wed Apr 22, 2020 14:25
Related ArticlesAxillary Nodal Evaluation in Breast Cancer: State of the Art. Radiology. 2020 Apr 21;:192534 Authors: Chang JM, Leung JWT, Moy L, Ha SM, Moon WK Abstract Axillary lymph node (LN) metastasis is the most important predictor of overall recurrence and survival in patients with breast cancer, and accurate assessment of axillary LN involvement is an essential component in staging breast cancer. Axillary management in patients with breast...
Wed Apr 22, 2020 14:25
Related ArticlesDeep Learning Measurement of Leg Length Discrepancy in Children Based on Radiographs. Radiology. 2020 Apr 21;:192003 Authors: Zheng Q, Shellikeri S, Huang H, Hwang M, Sze RW Abstract Background Radiographic measurement of leg length discrepancy (LLD) is time consuming yet cognitively simple for pediatric radiologists. Purpose To compare deep learning (DL) measurements of LLD in pediatric patients to measurements performed by radiologists....
Wed Apr 22, 2020 14:25
Related ArticlesWorld Health Organization Grade II/III Glioma Molecular Status: Prediction by MRI Morphologic Features and Apparent Diffusion Coefficient. Radiology. 2020 Apr 21;:191832 Authors: Maynard J, Okuchi S, Wastling S, Busaidi AA, Almossawi O, Mbatha W, Brandner S, Jaunmuktane Z, Koc AM, Mancini L, Jäger R, Thust S Abstract Background A readily implemented MRI biomarker for glioma genotyping is currently lacking. Purpose To evaluate clinically...
Wed Apr 22, 2020 14:25
Related ArticlesVariability of the Positive Predictive Value of PI-RADS for Prostate MRI across 26 Centers: Experience of the Society of Abdominal Radiology Prostate Cancer Disease-focused Panel. Radiology. 2020 Apr 21;:190646 Authors: Westphalen AC, McCulloch CE, Anaokar JM, Arora S, Barashi NS, Barentsz JO, Bathala TK, Bittencourt LK, Booker MT, Braxton VG, Carroll PR, Casalino DD, Chang SD, Coakley FV, Dhatt R, Eberhardt SC, Foster BR, Froemming AT, Fütterer JJ,...
Wed Apr 22, 2020 14:25
Related ArticlesPredicting Rectal Cancer Response to Neoadjuvant Chemoradiotherapy Using Deep Learning of Diffusion Kurtosis MRI. Radiology. 2020 Apr 21;:190936 Authors: Zhang XY, Wang L, Zhu HT, Li ZW, Ye M, Li XT, Shi YJ, Zhu HC, Sun YS Abstract Background Preoperative response evaluation with neoadjuvant chemoradiotherapy remains a challenge in the setting of locally advanced rectal cancer. Recently, deep learning (DL) has been widely used in...
Wed Apr 22, 2020 14:25
Abstract Kinship among interacting individuals is often associated with sociality and also with sex ratio effects. Parasitoids in the bethylid genus Goniozus are sub‐social, with single foundress females exhibiting post‐ovipositional maternal care via short‐term aggressive host and brood defence against conspecific females. Due to local mate competition (LMC) and broods normally being produced by a single foundress, sex ratios are female biased. Contests between adult females are, however, not...
Wed Apr 22, 2020 21:33
Abstract The impact of sexual selection on the adaptive process remains unclear. On the one hand, sexual selection might hinder adaptation by favouring costly traits and preferences that reduce nonsexual fitness. On the other hand, condition dependence of success in sexual selection may accelerate adaptation. Here, we used replicate populations of Drosophila melanogaster to artificially select on male desiccation resistance while manipulating the opportunity for precopulatory sexual selection in...
Tue Apr 21, 2020 22:42
Abstract The concept of fitness is central to evolutionary biology, yet it is difficult to define and to measure. In plant biology, fitness is often measured as seed count. However, under an array of circumstances, seed count may be a biased proxy of fitness; for example, when individuals vary in allocation to sexual vs. asexual reproduction. A more subtle example, but also likely to be important in natural populations, is when interindividual variation in conditions during development results...
Mon Apr 20, 2020 11:28
Silanol defects determine adsorption and catalysis in zeolites by their hydrophilic properties, but they can also contribute to catalytic reactions through their weak acidities or cooperative effects with other active sites. Well‐defined silanol defect clusters (see structure: cyan H, red O, black Si) with distinct size in topologically related zeolites, SSZ‐70 and ITQ‐1 are identified by NMR spectroscopy. Abstract Nests of three silanol groups are located on the internal pore surface of calcined...
Thu Apr 23, 2020 11:35
A dual function asymmetric catalysis by a chiral phosphoric acid catalyst that controls both enantioselective addition of an achiral α‐vinyl allylboronate to aldehydes and pseudo‐axial orientation of the α‐vinyl group in the transition state is developed. Abstract We report a dual function asymmetric catalysis by a chiral phosphoric acid catalyst that controls both enantioselective addition of an achiral α‐vinyl allylboronate to aldehydes and pseudo‐axial orientation of the α‐vinyl group in...
Wed Apr 22, 2020 22:00
Ring strain: 2,2‐Disubstituted oxetanes, easily prepared by a double Corey–Chaykovsky reaction, readily isomerize into homoallylic alcohols using B(C6F5)3 as a catalyst. DFT calculations show a key intramolecular proton migration. The synthetic potential was proven by the synthesis of several chiral disubstituted alcohols, with high enantiomeric excesses, by asymmetric hydrogenation of the homoallylic alcohols. Abstract The selective isomerization of strained heterocyclic compounds is an important...
Wed Apr 22, 2020 15:19
P‐P‐Pick up a proton: Inhibitor protonation inside human acid β‐glucosidase or glucocerebrosidase (GCase), the enzyme involved in Gauchers disease, was directly observed using fluorescence. The results show that that derivatives of the inhibitors 1‐deoxynojirimycin and isofagomine are protonated by GCase when bound, even if they are completely unprotonated outside the enzyme. Abstract Gaucher disease is caused by mutations in human acid β‐glucosidase or glucocerebrosidase (GCase), the enzyme...
Wed Apr 22, 2020 13:26
Constructing supramolecular materials with tunable properties and functions is a great challenge due to the complex competition between multiple assembly pathways. Herein, we report dipeptide can self‐assemble into aerogels with entirely different surface wettability through precisely controlling assembly pathways. Charged groups or aromatic residues are selected to expose on the surface of their nanoscale building blocks which result in either superhydrophilic or highly hydrophobic surface. With...
Tue Apr 21, 2020 22:53
<p class="Abstract" style="margin: 0cm 0cm 30pt; text‐align: justify; line‐height: 12.2667px; font‐size: 8pt; font‐family: Arial, sans‐serif; color: rgb(0, 0, 0);"><span lang="EN‐US">The Classical Nucleation Theory (CNT) is the most common theoretical framework used to explain particle formation. However, nucleation is a complex process with reaction pathways which are often not covered by the CNT. Here, we study the formation mechanism of Cu nanospheres using in‐situ‐X‐Ray absorption...
Tue Apr 21, 2020 22:17
An aniline‐infiltrated polymer‐of‐intrinsic‐microporosity (PIM) membrane is reported for direct valorization of CO2 from its mixture with O2. The acid–base interaction between CO2 and aniline enhances CO2/O2 separation, enabling catalytic electrodes capable of producing CO from a feed gas with an O2/CO2 ratio as high as 9:1 and of reducing CO2 selectively to formate in the presence of O2. Abstract Hybrid electrodes with improved O2 tolerance and capability of CO2 conversion into liquid products...
Tue Apr 21, 2020 22:00
Double Rotors with Fluxional Axles: Domino Rotation and Azide‐Alkyne Huisgen Cycloaddition Catalysis
The simple preparation of the multicomponent devices [Cu 4 ( A ) 2 ] 4+ and [Cu 2 ( A )( B )] 2+ , both rotors with fluxional axles undergoing domino rotation, highlights the potential of self‐sorting. The concept of domino rotation requires the interconversion of axle and rotator allowing the spatiotemporal decoupling of two degenerate exchange processes in [Cu 4 ( A ) 2 ] 4+ occurring at 142 kHz. Addition of two equiv. of B to rotor [Cu 4 ( A ) 2 ] 4+ afforded...
Tue Apr 21, 2020 20:45
As there is a great demand of 2D metal networks, especially out of gold for a plethora of applications we show a universal synthetic method via phase boundary gelation which allows the fabrication of networks displaying areas of up to 2 cm 2 . They are transferred to many different substrates, like glass, glassy carbon, silicon, or polymers like PDMS. In addition to the standardly used web thickness, the networks are parametrized by their fractal dimension. By variation of experimental conditions,...
Tue Apr 21, 2020 19:23
We report the one step synthesis and characterization of a new and robust titanium‐based Metal Organic Framework, ACM‐1 . In this new structure, based on infinite Ti‐O chains and 4,4′,4″,4″′‐(pyrene‐1,3,6,8‐tetrayl) tetrabenzoic acid as a photosensitizer ligand, the combination of highly mobile photogenerated electrons and a strong hole localization at the organic linker results in large charge separation lifetimes. The suitable energies for band gap and CBM offer great potential for a wide range...
Tue Apr 21, 2020 19:21
Galvanic replacement reactions have been studied as a versatile route to synthesize nanostructured alloys. However, the galvanic replacement chemistry of alkali metals has rarely been explored. A protective interphase layer will be formed outside templates when the redox potential exceeds the potential windows of nonaqueous solutions, and the complex interfacial chemistry remains elusive. Here, we demonstrate the formation of room‐temperature liquid metal alloys of Na and K via galvanic replacement...
Tue Apr 21, 2020 19:19
The thermal decomposition of graphene oxide (GO) is a complex process at the atomic level and not fully understood. Here, a subclass of GO , oxo‐functionalized graphene (oxo‐G) was used to study its thermal disproportionation. We present the impact of annealing on the electronic properties of a monolayer oxo‐G flake and correlated the chemical composition and topography corrugation by two‐probe transport measurements, XPS, TEM , FTIR and STM. Surprisingly, we found that oxo‐G, processed at...
Tue Apr 21, 2020 17:49
A single Sondheimer–Wong diyne was synthesized from 6,13‐dibromopentaleno[1,2‐b:4,5‐b′]dinaphthalene by local probe chemistry on a ultra‐thin film of NaCl formed on a Cu(111) surface at 4.3 K in an endergonic reaction. Compounds were directly identified by scanning tunneling microscopy with a CO functionalized tip. Abstract Recent advances in scanning probe microscopy on surface enable not only direct observation of molecular structures but also local probe reactions, in which unstable short‐lived...
Tue Apr 21, 2020 17:25
Sustainable energy supply and sufficient chemical production are highly dependent on many essential catalytic processes for our sustainable society. On pursuing next‐generation catalysts, single‐atom catalysts (SACs) with high‐active sites atomically dispersed on substrates exhibit unique advantages regarding the maximum atomic efficiency, abundant chemical structures, and extraordinary catalytic performances for multiple vital reactions. In particular, M–N–C SACs (where M is a transition metal atom)...
Tue Apr 21, 2020 17:07
The Cinchona alkaloid scaffold was synthetically merged with the indole ring system, and the bioactivities of the products in phenotypic assays revealed a novel class of autophagy inhibitors, azaquindoles. Subsequent characterization of potent azaquindole‐1 in the morphological cell painting assay guided target identification efforts. In contrast to the parent Cinchona alkaloids, azaquindoles selectively inhibit starvation‐ and rapamycin‐induced autophagy by targeting the lipid kinase VPS34. ...
Tue Apr 21, 2020 16:37
The electrochemical phase evolution of metal‐based pre‐catalysts (Co4N) to polycrystalline CoSx that are rich in active sites in working Li‐S batteries is revealed. This transformation propels all‐phase polysulfide‐involving reactions and enables stable operation of high‐rate and electrolyte‐starved Li‐S batteries. Abstract In situ evolution of electrocatalysts is of paramount importance in defining catalytic reactions. Catalysts for aprotic electrochemistry such as lithium–sulfur (Li‐S)...
Tue Apr 21, 2020 16:35
Resistance is futile: By site‐specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized. The most potent compounds exhibited an approximately 1000‐fold increased antimicrobial activity and were able to overcome the most important types of vancomycin resistance. Abstract Multidrug‐resistant bacteria represent one of the biggest challenges facing modern medicine. The increasing...
Tue Apr 21, 2020 16:34
Tuning the boom: Volatile copper(II) azide is stabilized by the addition of both tetrazole ligands and phlegmatizing agents. The resulting complexes can be tuned in terms of their sensitivity and serve to replace lead azide as well as lead styphnate, thus reducing the release of toxic lead to the environment. Abstract A concept for stabilizing highly sensitive and explosive copper(II) azide with 1‐N‐substituted tetrazoles is described. It was possible to stabilize the system by the use of highly...
Tue Apr 21, 2020 16:33
Flexible cyanides: Bulky cations and fast crystallization allowed the isolation and structurally characterization of examples of HCN‐cyanide aggregates [CN(HCN)2)]− and [CN(HCN)3]− in the solid state. X‐ray structure elucidation revealed hydrogen‐bridged linear [CN(HCN)2]− and Y‐shaped [CN(HCN)3]− molecular ions in the crystal. Abstract Although pure hydrogen cyanide can spontaneously polymerize or even explode, when initiated by small amounts of bases (e.g. CN−), the reaction of liquid HCN...
Tue Apr 21, 2020 16:33
The DNAzyme is in control: An RNA‐cleaving DNAzyme (EC1) is used to control three DNA assembly reactions, resulting in an all‐DNA system with the capability of ligand recognition, signal amplification, and signal reporting. Abstract We report on a programmable all‐DNA biosensing system that centers on the use of a 4‐way junction (4WJ) to transduce a DNAzyme reaction into an amplified signal output. A target acts as a primary input to activate an RNA‐cleaving DNAzyme, which then cleaves an RNA‐containing...
Tue Apr 21, 2020 16:31
Impure as the driven glow: A trace impurity resulting from an unexpected solvent–chromophore reaction leads to highly efficient room‐temperature phosphorescence. Abstract Organic luminogens with persistent room‐temperature phosphorescence (RTP) have found a wide range of applications. However, many RTP luminogens are prone to severe quenching in the crystalline state. Herein, we report a strategy to construct a donor‐sp3‐acceptor type luminogen that exhibits aggregation‐induced emission (AIE)...
Tue Apr 21, 2020 16:29
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