Abstract Purpose To investigate the synergistic effect of resveratrol on the bystander effect of TK/GCV suicide gene system in melanoma cells. Methods The effect of resveratrol on the growth of B16 cells and the synergistic effect of resveratrol with or without GCV were detected by MTT assay and high content screening assay. The effect of resveratrol on GJIC...
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Hepatocellular carcinoma is a primary liver malignancy in which the risk of development is always multifunctional. Interleukin-6 is a proinflammatory and multifunctional cytokine, which plays an important role...
10h
Main Points Genetic deletion of astrocytic connexins aggravates chronic seizure burden in experimental epilepsy. Astrocyte disconnection attenuates the severity of hippocampal sclerosis. Seizure‐induced adult hippocampal neurogenesis is independent of astrocytic connexins. Abstract The astroglial gap junctional network formed by connexin (Cx) channels plays a central role in regulating neuronal activity and network synchronization. However, its involvement in the development and...
10h
Abstract Cyber security adversaries and engagements are ubiquitous and ceaseless. We delineate Adversarial Genetic Programming for Cyber Security, a research topic that, by means of genetic programming (GP), replicates and studies the behavior of cyber adversaries and the dynamics of their engagements. Adversarial Genetic Programming for Cyber Security encompasses extant and immediate research efforts in a vital problem domain, arguably occupying a position at the frontier where...
10h
Doctors could be forced to withdraw lifesaving treatment from stable or improving patients to prioritise those deemed likely to have a better prognosis if the demand on the heath service during the...
10h
The visas of doctors, nurses, and paramedics that will expire before 1 October will automatically be extended for one year, free of charge, the government has announced.The extension will also apply...
10h
A leading obstetrician and gynaecologist has been suspended from the UK medical register for 12 months after a tribunal found that he had made inappropriate sexual advances to female...
10h
The Department of Health and Social Care for England has relaxed the rules on sharing patients’ confidential data and is requiring healthcare bodies to provide patient information to each other to...
10h
New evidence has emerged from China indicating that the large majority of coronavirus infections do not result in symptoms.Chinese authorities began publishing daily figures on 1 April on the number...
10h
Doctors could be forced to withdraw lifesaving treatment from stable or improving patients to prioritise those deemed likely to have a better prognosis if the demand on the heath service during the...
12h
The visas of doctors, nurses, and paramedics that will expire before 1 October will automatically be extended for one year, free of charge, the government has announced.The extension will also apply...
12h
A leading obstetrician and gynaecologist has been suspended from the UK medical register for 12 months after a tribunal found that he had made inappropriate sexual advances to female...
13h
The Department of Health and Social Care for England has relaxed the rules on sharing patients’ confidential data and is requiring healthcare bodies to provide patient information to each other to...
13h
New evidence has emerged from China indicating that the large majority of coronavirus infections do not result in symptoms.Chinese authorities began publishing daily figures on 1 April on the number...
14h
Head to Head, 7 MarchSerial title in print: Drug industry debateMazzucato and Li, and Darzi provide compelling arguments for and against the nationalisation of the pharmaceutical industry.1 Mazzucato...
14h
For healthcare staff at the front line of the covid-19 pandemic, work has suddenly become a frightening place. Impossible decisions threaten long term psychological damage from moral injury, say Neil...
15h
On 11 March, Rishi Sunak, the chancellor of the exchequer, presented his first budget and promised an extra £5bn (€5.7bn; $6.2bn) for public services to help them deal with covid-19.1What is the £5bn...
16h
The BMA has warned that doctors are at risk of serious illness or even death because of a lack of proper personal protective equipment (PPE). To determine the vulnerability of healthcare workers on...
16h
Covid-19, which is caused by the single stranded RNA coronavirus SARS-CoV-2, poses therapeutic dilemmas. Some suggestions for drug treatment seem problematic.1 They include various antiviral drugs,...
16h
AbstractObjectivesTo outline which infectious diseases in the pre-covid-19 era persist in children and adolescents in China and to describe recent trends and variations by age, sex, season, and...
16h
Poor prison healthcare has been reported by Armstrong.1 Improving prison health services is critical for fighting epidemics such as covid-19.On 20 February 2020, over 500 new covid-19 cases in five...
17h
The BMJ contacted the Ministry of Justice for comment on this story and received the comment too late to include in the original copy.1The statement read: “Prisoners are able to access a range of...
19h
This Week, 7 MarchI read this news story1 with great sadness. A systemic failure has led to the suicide of a doctor fearing the loss of his livelihood, public disgrace, and humiliation based on an...
20h
Head to Head, 7 MarchSerial title in print: Drug industry debateMazzucato and Li, and Darzi provide compelling arguments for and against the nationalisation of the pharmaceutical industry.1 Mazzucato...
20h
China’s ban on eating and trading wildlife due to the coronavirus crisis could become law within the next three months, according to conservationists
10h
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
10h
Being stressed changes the way we make decisions. An experiment that sees people hunt for George Clooney's face while experiencing electric shocks could help explain why
11h
Following a healthy diet or exercising could impact how your brain ages, but the effects on cognitive skills later in life depend on specific gene variants that not everyone has
11h
Many great ape species are already in a precarious situation because of their dwindling numbers. Now they may also be at risk from the coronavirus pandemic
13h
Going out into the natural world is good for your health and mind, and you can still get some of the same benefits even when stuck inside, says Graham Lawton
13h
Crucial climate talks due to be held this November have been postponed, but a short delay could give countries time to get better organised - and see Donald Trump replaced with someone who supports a climate deal
15h
To fight the new coronavirus, researchers are investigating more than 60 drugs, including remdesivir and hydroxychloroquine and brand new ones. Here’s a breakdown of progress so far
15h
When Earth and Venus formed, they both had global magma oceans deep underground. Earth’s has turned solid by now, but Venus’s may still remain hidden
23h
by Amy J. Sterling, William J. Snelling, Patrick J. Naughton, Nigel G. Ternan, James S. G. Dooley Enterococci are robust gram-positive bacteria that are found in a variety of surroundings and that cause a significant number of healthcare-associated infections. The genus possesses a high-efficiency pheromone-responsive plasmid (PRP) transfer system for genetic exchange that allows antimicrobial-resistance determinants to spread within bacterial populations. The pCF10 plasmid system is the best...
11h
by Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V. Ferreira, Laszlo A. Groh, Mirian Domenech, Fernando González-Camacho, Niels P. Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G. Netea Among infectious diseases, tuberculosis is the leading cause of death worldwide, and represents a serious threat, especially in developing countries. The protective effects of Bacillus Calmette-Guerin (BCG), the current vaccine against tuberculosis, have been related not only to specific...
11h
by Matthew Esparza, Amir Mor, Hanspeter Niederstrasser, Kris White, Alexander White, Ke Zhang, Shengyan Gao, Juan Wang, Jue Liang, Sei Sho, Ramanavelan Sakthivel, Adwait A. Sathe, Chao Xing, Raquel Muñoz-Moreno, Jerry W. Shay, Adolfo García-Sastre, Joseph Ready, Bruce Posner, Beatriz M. A. Fontoura Influenza A viruses are human pathogens with limited therapeutic options. Therefore, it is crucial to devise strategies for the identification of new classes of antiviral medications. The influenza...
11h
by Jessica R. Galloway-Peña, Dimitrios P. Kontoyiannis
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by Justin T. Hsieh, Ashley L. St. John
11h
Abstract Background The poor prognosis of esophagus cancer (EC) is mainly due to its high invasiveness and metastasis, so it is urgent to search effectively prognostic markers and explore their roles in the mechanism of metastasis. Materials and methods Based on the TCGA database, we downloaded the RNA-Seq for analyzing the expression of ATP6V0D2. QRT-PCR...
11h
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