Background: Non-adherence to direct oral anticoagulants (DOACs) remains a matter of concern, especially for patients with a recent stroke. However, data on electronically monitored adherence and adherence-improving interventions are scarce. Aims: We aim to use electronic monitoring in DOAC-treated stroke patients to (i) evaluate the effect of an educational, reminder-based adherence-improving intervention, (ii) investigate predictors of non-adherence, (iii) identify reliable self-report measures...
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To provide guidance on how systematic review authors, guideline developers, and health technology assessment practitioners should approach the use of the risk of bias in nonrandomized studies of interventions (ROBINS-I) tool as a part of GRADE's certainty rating process.; The study design and setting comprised iterative discussions, testing in systematic reviews, and presentation at GRADE working group meetings with feedback from the GRADE working group.; We describe where to start the initial assessment...
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BACKGROUND: Atraumatic needles have been proposed to lower complication rates after lumbar puncture. However, several surveys indicate that clinical adoption of these needles remains poor. We did a systematic review and meta-analysis to compare patient outcomes after lumbar puncture with atraumatic needles and conventional needles. METHODS: In this systematic review and meta-analysis, we independently searched 13 databases with no language restrictions from inception to Aug 15, 2017, for randomised...
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Importance: Harms and benefits of opioids for chronic noncancer pain remain unclear. Objective: To systematically review randomized clinical trials (RCTs) of opioids for chronic noncancer pain. Data Sources and Study Selection: The databases of CENTRAL, CINAHL, EMBASE, MEDLINE, AMED, and PsycINFO were searched from inception to April 2018 for RCTs of opioids for chronic noncancer pain vs any nonopioid control. Data Extraction and Synthesis: Paired reviewers independently extracted data. The analyses...
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Chronically infecting pathogens avoid clearance by the innate immune system by promoting premature transition from an initial pro-inflammatory response toward an anti-inflammatory tissue-repair response. STAT3, a central regulator of inflammation, controls this transition and thus is targeted by numerous chronic pathogens. Here, we show that BepD, an effector of the chronic bacterial pathogen Bartonella henselae targeted to infected host cells, establishes an exceptional pathway for canonical STAT3...
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Abstract Purpose Three cases of acetabular labral tear (ALT) diagnosed with sonography (US) are reported. We aim to show utility for US with the addition of manual hip traction as an adjunctive modality to the current diagnostic imaging of choice, magnetic resonance arthrography (MRA), for diagnosing ALT. Methods Three cases of young athletic patients with...
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Abstract Various computing subdisciplines, such as computer science and software engineering, each have their own curricular guidelines. They can be very difficult to understand and compare for people such as prospective students, industry personnel, and even faculty members. This is compounded by a lack of information surrounding undergraduate computing curricular topics via visual methods. This paper describes two experimental activities where the objective is to explore the...
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Abstract This study aims to investigate the effect of mixed reality applications on students' motivation to learn science. The study further aims to identify students' attitudes toward augmented reality applications and also intends to explore the students' views on mixed reality applications. A total of 42 primary school students participated in the study for a duration of 8 weeks. The results of the study indicate that mixed reality applications are effective in students' motivation...
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In the original publication of this article [1], the author pointed out the legends of Figs. 1 and 2 are not entire. The correct legends are:
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This letter is in response to a recent paper by Millstone and Dawson (2019) in which the authors criticise the re-evaluation of the high intensity sweetener aspartame in 2013 by the former EFSA’s Panel on Food...
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Nucleic Acid Therapeutics, Ahead of Print.
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ObjectivesOccupational exposure to soft paper dust is associated with impaired lung function. Whether there is an increased risk for asthma or chronic obstructive pulmonary disease (COPD) is unclear.MethodsWe studied 7870 workers from three Swedish soft paper mills, and defined high-exposed workers, as having been exposed to soft paper dust exceeding 5 mg/m3 for at least 5 years. The remaining workers were classified as ‘low exposed’. Person-years at risk were calculated and stratified according...
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Publication date: Available online 2 April 2020Source: Clinical BiochemistryAuthor(s): Rui Zhen Tan, Corey Markus, Tze Ping Loh
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A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinsons disease
A growing number of genetic susceptibility factors have been identified for Parkinson’s disease (PD). The combination of inherited risk variants is likely to affect not only risk of developing PD but also its clinical course. Variants in the GBA gene are particularly common, being found in approximately 5% to 10% of patients, and they lead to more rapid disease progression.1 However, the effect of concomitant genetic risk factors on disease course in GBA-PD is not known.The aggregation of α-synuclein,...
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IntroductionDisorder of consciousness (DOC) is common in patients with acute brain injury (ABI) and it weighs heavily in goals of care discussion.1 Dopaminergic agents to support recovery have shown encouraging results in chronic DOC following traumatic brain injury (TBI) and are currently the most promising candidates to also support recovery during the acute post injury phase.2 Amantadine is a neurohormonal modulator that increases the concentration of dopamine at the synaptic cleft. Behavioural...
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Corticosteroids remain an important tool for inducing remission in inflammatory bowel disease (IBD) but they have no role in maintenance of remission. The significant adverse side effect profile of these drugs means their use should be avoided where possible or measures taken to reduce their risk. Despite an expanding array of alternative therapies, corticosteroid dependency and excess remain common. Appropriate steroid use is now regarded a key performance indicator in the management of IBD. This...
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Biosensors, Vol. 10, Pages 33: Electrochemical Sensing of Serotonin by a Modified MnO2-Graphene Electrode Biosensors doi: 10.3390/bios10040033 Authors: Nehru Chinnathambi Fazio Neri Leonardi Bonavita Neri The development of MnO2-graphene (MnO2-GR) composite by microwave irradiation method and its application as an electrode material for the selective determination of serotonin (SE), popularly known as “happy chemical”, is reported....
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Biosensors, Vol. 10, Pages 32: Electrochemical (Bio)Sensors for Pesticides Detection Using Screen-Printed Electrodes Biosensors doi: 10.3390/bios10040032 Authors: Beatriz Pérez-Fernández Agustín Costa-García Alfredo de la Escosura- Muñiz Pesticides are among the most important contaminants in food, leading to important global health problems. While conventional techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) have traditionally...
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Publication date: Available online 2 April 2020Source: Journal of BiomechanicsAuthor(s): Kevin G. Aubol, Clare E. Milner
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Abstract Objective Perforate the expanded polytetrafluoroethylene membrane of the GORE® CARDIOFORM Septal Occluder (GSO) and GORE® CARDIOFORM ASD Occluder (GCA) after implantation. Background Percutaneous transseptal access to the left atrium is necessary for many structural and electrophysiological procedures. The potential need to access the left atrium may influence decision‐making for patent foramen ovale or atrial septal defect closure. Methods Sixteen canines underwent...
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We read the editorial by Singer and colleagues with great interest.1 It is encouraging to see the medical community mobilising in this way in response to the threat of medical misinformation. This announcement is timely; as the coronavirus disease (COVID-19) pandemic escalates, we see more and more medical misinformation being circulated online, from conspiracy theories regarding the origins of the virus to non-evidence based home remedies.2 This needs to be addressed by key stakeholders, including...
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A 65-year-old woman presented with 2 days of acute onset fever, with left pinna pain, swelling and erythema (figures 1 and 2). She had no significant medical history. Physical examination revealed a body temperature of 38.0°C, facial rash sparing the nasolabial fold and Milian’s ear sign. Laboratory data showed neutrophilic leucocytosis. Erysipelas was diagnosed and treated with oral amoxicillin (1500 mg/day). Within 10 days, the patient’s symptoms improved.Erysipelas is a common infection involving...
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The ongoing effort to fight COVID-19 wins broad support, even across partisan divides -- Read more on ScientificAmerican.com
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In an era of big research, having confidence in scientists, individually or collectively, involves trade-offs -- Read more on ScientificAmerican.com
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Publication date: Available online 2 April 2020Source: Journal of Controlled ReleaseAuthor(s): Sodam Kim, Sang-Gu Yim, Ajeesh Chandrasekharan, Keum-Yong Seong, Tae Wook Lee, Byeongyeon Kim, Keunyoung Kim, Sungyoung Choi, Seung Yun Yang
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Publication date: Available online 2 April 2020Source: Journal of Controlled ReleaseAuthor(s): Rui Pedro Moura, Catarina Pacheco, Ana Paula Pêgo, Anne des Rieux, Bruno Sarmento
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Publication date: Available online 1 April 2020Source: Journal of Controlled ReleaseAuthor(s): Inés Beekers, Merel Vegter, Kirby R. Lattwein, Frits Mastik, Robert Beurskens, Antonius F.W. van der Steen, Nico de Jong, Martin D. Verweij, Klazina Kooiman
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Publication date: Available online 1 April 2020Source: Journal of Controlled ReleaseAuthor(s): Yu Zhang, Huiping Hu, Wenqi Tang, Qian Zhang, Ming Li, Honglin Jin, Zi Huang, Zheng Cui, Jingya Xu, Kaiping Wang, Chen Shi
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Abstract Prognosis aims at estimating the future course of a given disease in probabilistic terms. As in diagnosis, where clinicians are interested in knowing the accuracy of a new test to identify patients affected by a given disease, in prognosis they wish to accurately identify patients at risk of a future event conditional to one or more prognostic factors. Thus, accurate risk predictions play a primary role in all fields of clinical medicine and in geriatrics as well because...
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Abstract The aim of this work is to determine the effect of chronic immobilization stress on kinetics and dosimetry of 67Ga in a mouse model. A control group (CG) and a stress group (SG), each with 15 mice, were included in the study, and the latter group was subjected to a chronic immobilization stress model 2 h daily for 14 consecutive days. At day 13, 67Ga-citrate was administered intraperitoneally (11.24 ± 0.44 MBq) to each mouse. Then, sets of three mice were obtained sequentially...
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Abstract Monte Carlo codes have been used for approximately 80 years to solve various problems in medical physics. In this paper, the importance of the MCNPX code in treatment planning is highlighted. As illustrative examples of the role of MCNPX in this field, some dosimetric parameters, isodose distribution curves, and figures of merit (FOMs) were considered for photon beams of various energies. To the best of the authors’ knowledge, such a systematic study has not been done...
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Abstract This work analyzes the relationship between short-term exposure to fine particulate matter and its incidence of respiratory and cardiorespiratory diseases. It involved the socioeconomic status of the population distributed in representative areas of Santiago de Chile, the capital city of Chile. The data used were collected from monitoring stations of fine particulate matter concentrations, classification of cardio-respiratory diseases, and the annual age distribution of...
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Governmental Public Health Powers in the COVID-19 Pandemic—Stay-at-home Orders and Business Closures
This Viewpoint provides historical and legal context for governmental directives to close schools and businesses, ban public gatherings, impose curfews, issue stay-at-home orders, require quarantines for travelers, and impose travel restrictions during the COVID-19 pandemic, urging transparent evidence-based processes to ensure equity and social justice.
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JFB, Vol. 11, Pages 22: Cytotoxic Effects of Plant Sap-Derived Extracellular Vesicles on Various Tumor Cell Types Journal of Functional Biomaterials doi: 10.3390/jfb11020022 Authors: Kim Yoo Jung Lee Hyun Park Na Yeon Edible plants have been widely used in traditional therapeutics because of the biological activities of their natural ingredients, including anticancer, antioxidant, and anti-inflammatory properties. Plant sap contains such medicinal...
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Intraductal papillary mucinous neoplasm (IPMN) is an intraepithelial precancerous lesion of pancreatic ductal adenocarcinoma (PDAC) that progresses from adenoma to carcinoma, and long noncoding RNAs (lncRNA) might be involved in the tumorigenesis. In this study, we obtained the expression profiles of more than 4000 lncRNAs by probe reannotation of a microarray dataset. As a correlation network‐based systems biology method, weighted gene coexpression network analysis (WGCNA) was used to find clusters...
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LIMD1 was downregulated in NSCLC, inhibited proliferation, and facilitated apoptosis of NSCLC cells. LIMD1‐AS1 was downregulated in NSCLC and positively regulated LIMD1 expression. LIMD1‐AS1 stabilized LIMD1 mRNA through interacting with hnRNP U. Abstract Background Non‐small cell lung cancer (NSCLC) occupies the majority of lung cancer cases and is notorious for the awful prognosis. LIM domains‐containing 1 (LIMD1) is suggested as a tumor suppressor in lung cancer, but its mechanism in NSCLC...
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