Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11803-8Metal film-based electronics usually fail via uncontrolled cracking at small strains. Here, the authors design a micro-/nano-structured surface with bundled flexible nanowires onto which a metal film can stretch more than a regular flat surface, retard penetrating cracks and remain sensitive.
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Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11912-4The sensing of polychlorinated dibenzo-p-dioxins (PCDDs) is important for the environment and public health but challenging to achieve. Here the authors report a stable zirconium-based metal-organic framework for the selective sensing of two representative PCCDs based on the fluorescence quenching method.
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Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11806-5Due to the low ring strain and facile dimerization, ring-opening metathesis polymerization of cyclopentadiene, readily obtainable from petroleum feedstock, has not been realized. Here the authors show an ultrarapidly initiating trifluoromethanesulfonamide-based ruthenium catalyst enables it at low temperatures.
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Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11740-6NocTE is a nonribosomal peptide synthetase thioesterase that completes the biosynthesis of pro-nocardicin G, the precursor for nocardicin β-lactam antibiotics. Here the authors provide mechanistic insights into NocTE by determining its crystal structures in the ligand-free form and covalently linked to a fluorophosphonate substrate mimic.
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Researchers from Northwestern University have developed a novel way to track how nanoparticles interact with cancer cells and whether they reach their tagets. The team’s work shows that if a nanoparticle targets cancer cells, it undergoes more rotational and translational movement compared to nanoparticles that cannot target cancer cells effectively. This exciting development can be used to screen different nanoparticle formulations based on size, charge, shape, and targeting molecule to...
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Researchers from the Polytechnic University of Milan and the University Hospital of Basel have developed a microfluidic chip containing cartilage, which can be subjected to mechanical stress. The procedure mimics the conditions of osteoarthritis and could help in developing new treatments. Osteoarthritis is relatively common among people over 60, with 20% of women and 10% of men suffering its effects at this age. However, perhaps surprisingly, there are no drugs available that can...
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Researchers at the University of Arizona have developed a simple and inexpensive method that can be used to detect tiny traces of norovirus in water samples. The technique involves a smartphone camera and a paper microfluidics device, and could help to identify sources of norovirus before it can cause illness. In the US, norovirus causes approximately 20 million cases of food poisoning annually. However, the virus isn’t just responsible for temporary illness; it can sometimes lead to...
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Researchers from Carnegie Mellon University and Nanyang Technological University in Singapore have developed a new microfabricated sensor array that performs 3D electrophysiology of cellular organoids. Their work demonstrates that the device can be designed to wrap around small organoids and measure voltage changes across the surface of the organoids without leading to significant loss of viability of the cells. This is an exciting development that can permit more advanced scientific discovery using...
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CVRx, a Minneapolis, Minnesota company, won FDA approval for the first neuromodulation device designed to address heart failure. Intended as a treatment option for patients with an ejection fraction ≤35% and New York Heart Failure Classification of III or II (with recent history of Class III), the device stimulates the carotid artery and in turn the baroreceptors that control cardiovascular activity. The system monitors and adjusts the signals it delivers to achieve optimal beat-to-beat...
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Nature Neuroscience, Published online: 27 August 2019; doi:10.1038/s41593-019-0463-7Breen et al. map RNA editing profiles in cortical samples from individuals with schizophrenia and controls, and find links between altered RNA editing in glutamatergic and postsynaptic density genes and schizophrenia genetic risk architecture.
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Nature Neuroscience, Published online: 27 August 2019; doi:10.1038/s41593-019-0485-1A new study sheds light on how sensitivity to communication sounds is established in the brain. Juvenile finches raised with tutors of either the same or different species always learned the tutors’ songs. Cortical neurons developed selectivity for the learned song by tuning for its secondary acoustic features.
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Nature Neuroscience, Published online: 27 August 2019; doi:10.1038/s41593-019-0469-1Gehrlach et al. show how the posterior insular cortex processes and modulates diverse internally and externally generated aversive states, and they dissect the functional contribution of segregated projections mediating inhibition of ongoing behaviors.
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Nature Neuroscience, Published online: 27 August 2019; doi:10.1038/s41593-019-0499-8Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus to the lateral habenula via the central amygdala is now uncovered as a key neural circuit governing comorbid depressive symptoms in chronic pain.
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Abstract The current research reports an efficient methodology of new sorbent (SSBC) synthesis based on neglected sepia shells for the sequestration of cationic dye (Methylene blue, MB) and an anionic dye (Reactive black 5, RB5) from aqueous solutions. The as-synthesized SSBC was produced by reaction of sepia shell powder with urea in the presence of formaldehyde. In the first part of the work, the sorbent was scrutinized by using scanning electron microscopy, energy-dispersive...
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Publication date: Available online 27 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Peng You, Ryan Instrum, Sumit K. Agrawal, Lorne S. ParnesBenign paroxysmal positional vertigo is the most common etiology of peripheral vertigo and is caused by the hydrodynamic influence from free-floating canaliths. Any of the 3 semicircular canals can be involved, but posterior canal BPPV is the predominant subtype. The condition is diagnosed clinically, and the preponderance...
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Publication date: Available online 26 August 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Y. Ni, Z. Yang, H. Xu, P. Lu, W. Wang, F. LiuAbstractThe aims of this study were to compare preoperative and postoperative quality of life (QoL) in 24 patients with fibrous dysplasia of the mandible, and evaluate the effects of two surgical techniques on their postoperative QoL. Their QoL was assessed using the University of Washington Quality of Life (UW-QoL) questionnaire. The patients...
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Publication date: Available online 26 August 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): B. Passmore-Webb, B. Gurney, H.M. Yuen, J. Sloane, J. Lee, M. Proctor, F. Sundram, C. Newlands, S. SharmaAbstractSentinel lymph node biopsy (SLNB) is an accurate staging procedure for malignant melanoma but its use in patients with melanoma of the head and neck has been questioned in the past because of a perceived record of poor safety and accuracy. Technical improvements have sought...
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(Source: Oral and Maxillofacial Surgery)
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ConclusionsCoronectomy is a relatively safe technique for preservation of the IAN. However, prospective large scale research is needed to more accurately report on the prevalence of short- and long-term complications. (Source: Oral and Maxillofacial Surgery)
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This study described voice use and lifestyle information about student actors and assessed whether different information is reported at study intake compared to data extracted from a 3-week voice Log. (Source: Journal of Voice)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Sentinel lymph node biopsy (SLNB) is an accurate staging procedure for malignant melanoma but its use in patients with melanoma of the head and neck has been questioned in the past because of a perceived record of poor safety and accuracy. Technical improvements have sought to redress this.Vital structures and variable lymphatic pathways can make its use in the head and neck challenging. In our study we have examined the data and the experiences of clinicians from University Hospital Southampton...
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The aims of this study were to compare preoperative and postoperative quality of life (QoL) in 24 patients with fibrous dysplasia of the mandible, and evaluate the effects of two surgical techniques on their postoperative QoL. Their QoL was assessed using the University of Washington Quality of Life (UW-QoL) questionnaire. The patients was divided into two groups according to the two different surgical techniques used. The first group (n=11) were managed with focal bone modification, and their results...
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An assessment of the quality of oral and maxillofacial surgery clinical practice guidelines is lacking. The aim of this investigation was to assess the quality of guidelines using the RIGHT (Reporting Items for practice Guidelines in HealThcare) checklist. The primary outcome was to assess the score (quality) of guidelines based on the RIGHT checklist and to identify predictors (region, type, single or multi-centre, and speciality/non-speciality) influencing the quality score. In this review, following...
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CONCLUSIONS: Multidisciplinary providers play an important role in supporting positive adjustment in patients affected by craniofacial conditions and their families. PMID: 31446785 [PubMed - as supplied by publisher] (Source: The Cleft Palate-Craniofacial Journal)
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CONCLUSION: The TVP muscle is substantially reduced in volume, length, and thickness in children with 22q11DS. These findings serve as preliminary support for the association of patient hearing and otologic severity and TVP dysmorphology. PMID: 31446782 [PubMed - as supplied by publisher] (Source: The Cleft Palate-Craniofacial Journal)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any...
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Ghrelin plays a central role in controlling major biological processes. As for other G protein-coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to its receptor remain obscure. Using a combination of solution-state NMR and molecular modeling, we demonstrate that binding to the growth hormone secretagogue receptor...
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Folates are critical for central nervous system function. Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRα/Folr1), known to be regulated by ligand-activated nuclear receptors. Cerebral folate delivery primarily occurs at the choroid plexus through FRα and PCFT;...
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