Main Points Astrocytes respond to neuron‐generated thrombin with activation and a protective phenotype. Neurons secrete thrombin in response to ischemia, which activates astrocytes mediated by protease activated receptors. Abstract Astrocytes protect neurons during cerebral injury through several postulated mechanisms. Recent therapeutic attention has focused on enhancing or augmenting the neuroprotective actions of astrocytes but in some instances astrocytes can assume a neurotoxic phenotype....
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Schwann cell (SC)‐specific monocarboxylate transporter 1 (MCT1) deficiency causes hypomyelination of sensory, but not motor, axons during aging. Selective ablation of MCT1 within SCs impairs glycolytic and mitochondrial functions. SC‐specific MCT1 deficiency impairs proteins that regulate myelin and lipid metabolism in peripheral nerves. Abstract Schwann cell (SC)‐specific monocarboxylate transporter 1 (MCT1) knockout mice were generated by mating MCT1f/f mice with myelin protein...
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iNOS−/− microglia exhibited reduced phagocytic capacity, without significant changes in TRPV2 or phagocytic receptor mRNA expression. iNOS−/− microglia displayed reduced plasma membrane expression and activity of TRPV2, which was restored by NO‐donors. Blocking PKG and/or PI3K activity in mouse microglia significantly reduced the plasma membrane expression and activity of TRPV2. Abstract Microglia phagocytosis is critical for central nervous system development, and dysregulation of phagocytosis...
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Contributors : Zhengyi Zhang ; Jingnan Pi ; Dongling Zou ; Xiaoshuang Wang ; Jiayue Xu ; Yanni Ma ; Dong Wang ; Jia YuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTwo miRNA arms from the same precursor, miR-574-5p and miR-574-3p, were reversely expressed and played exact opposite role in gastric cancer progression. miR-574-5p/-3p ratio was also strongly correlated with higher TNM stages and shorter survival of patients. The increase of miR-574-5p/-3p...
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Author: Vasilev, Martin R.; Liversedge, Simon P.; Rowan, Daniel; Kirkby, Julie A.; Angele, Bernhard DOI: 10.1037/xhp0000680 Publication Date: August 22, 2019
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Author: Makwana, Mukesh; Srinivasan, Narayanan DOI: 10.1037/xhp0000687 Publication Date: August 22, 2019
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Author: Husta, Cecilia; Dalmaijer, Edwin; Belopolsky, Artem; Mathot, Sebastiaan DOI: 10.1037/xhp0000689 Publication Date: August 22, 2019
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Author: Mittelstadt, Victor; Miller, Jeff; Kiesel, Andrea DOI: 10.1037/xhp0000690 Publication Date: August 22, 2019
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Author: Constable, Merryn D.; Elekes, Fruzsina; Sebanz, Natalie; Knoblich, Gunther DOI: 10.1037/xhp0000691 Publication Date: August 22, 2019
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Author: Kinoshita, Sachiko; Verdonschot, Rinus G. DOI: 10.1037/xhp0000692 Publication Date: August 22, 2019
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Author: Kattner, Florian; Ellermeier, Wolfgang DOI: 10.1037/xhp0000695 Publication Date: August 22, 2019
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Author: Cho, Jieun; Chong, Sang Chul DOI: 10.1037/xhp0000686 Publication Date: August 22, 2019
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Publication date: Available online 26 August 2019Source: Toxicology LettersAuthor(s): C.L. Ursini, E. Omodeo Salè, A.M. Fresegna, A. Ciervo, C. Jemos, R. Maiello, G. Buresti, C. Colosio, F.M. Rubino, Stefan Mandić-Rajčević, P. Chiarella, D. Carbonari, P. Delrio, P. Maiolino, P. Marchetti, R. Boccia, S. Iavicoli, D. CavalloAbstractHealth-care personnel handling antineoplastic drugs could be at risk for adverse health effects. We aimed to evaluate genotoxic and cytotoxic effects of antineoplastic drug...
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Abstract Increasing evidence indicates that developmental exposure to nonylphenol (NP) causes damage to the central nervous system (CNS). As the most unique and primary component of neuron, axon is an essential structure for the CNS function. Here, we investigated whether developmental exposure to NP affected rat axonal development in vivo and in vitro. Our results showed that developmental exposure to NP 10, 50, and 100 mg/(kg day) caused an obvious decrease in axonal length and...
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Publication date: Available online 26 August 2019Source: Journal of Controlled ReleaseAuthor(s): Seyyed Pouya Hadipour Moghaddam, Raziye Mohammadpour, Hamidreza GhandehariAbstractSilica nanoparticles (SiO2 NPs) have potential utility in controlled release. Despite significant research in this area, there is a gap in the understanding of the correlation between SiO2 NP physicochemical properties on the one hand and their degradation in solutions, in cells, and in vivo on the other. Here, we fabricated...
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Publication date: Available online 26 August 2019Source: Journal of Controlled ReleaseAuthor(s): Xiang Yi Chen, Adeel Masood Butt, Mohd Cairul Iqbal Mohd AminAbstractThe current conventional injectable vaccines face several drawbacks such as inconvenience and ineffectiveness in mucosal immunization. Therefore, the current development of effective oral vaccines is vital to enable the generation of dual systemic and mucosal immunity. In the present study, we examine the potential of pH-responsive bacterial...
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Publication date: Available online 26 August 2019Source: Journal of Controlled ReleaseAuthor(s): Run Han, Hui Xiong, Zhuyifan Ye, Yilong Yang, Tianhe Huang, Qiufang Jing, Jiahong Lu, Hao Pan, Fuzheng Ren, Defang OuyangAbstractAmorphous solid dispersion (SD) is an effective solubilization technique for water-insoluble drugs. However, physical stability issue of solid dispersions still heavily hindered the development of this technique. Traditional stability experiments need to be tested at least three...
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Publication date: Available online 26 August 2019Source: Clinical TherapeuticsAuthor(s): Jill L. Maron
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Using a tracer-based approach with near-infrared fluorescence and magnetic resonance imaging in mice, the authors establish the concept of a cranial-to-caudal circulation of cerebrospinal fluid within the spinal column, with clearance to lymphatic vessels at the sacral terminus.
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Vol. 216, No. 3, March 4, 2019. 10.1084/jem.20180765.The authors regret that in their original paper, the Masson’s image of the control group in Fig. 7 J was incorrect as a result of an error during figure...
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Atmosphere, Vol. 10, Pages 503: Different Representation of Mesoscale Convective Systems in Convection-Permitting and Convection-Parameterizing NWP Models and Its Implications for Large-Scale Forecast Evolution Atmosphere doi: 10.3390/atmos10090503 Authors: Karsten Peters Cathy Hohenegger Daniel Klocke Representing mesoscale convective systems (MCSs) and their multi-scale interaction with the large-scale atmospheric dynamics is still a major challenge in state-of-the-art global...
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Atmosphere, Vol. 10, Pages 502: Tropical Atlantic Variability: Observations and Modeling Atmosphere doi: 10.3390/atmos10090502 Authors: William Cabos Alba de la Vara Shunya Koseki We review the state-of-the-art knowledge of Tropical Atlantic Variability (TAV). A well-developed observing system and sustained effort of the climate modeling community have improved our understanding of TAV. It is dominated by the seasonal cycle, for which some mechanisms have been identified. The interannual...
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Atmosphere, Vol. 10, Pages 501: Characteristics of Ozone Pollution, Regional Distribution and Causes during 2014–2018 in Shandong Province, East China Atmosphere doi: 10.3390/atmos10090501 Authors: Ji Zhang Chao Wang Kai Qu Jiewei Ding Yiqun Shang Houfeng Liu Min Wei The summer ozone pollution of Shandong province has become a severe problem in the period 2014–2018. Affected by the monsoon climate, the monthly average ozone concentrations in most areas were...
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Atmosphere, Vol. 10, Pages 498: Flash Drought Characteristics Based on U.S. Drought Monitor Atmosphere doi: 10.3390/atmos10090498 Authors: L. Gwen Chen Jon Gottschalck Adam Hartman David Miskus Rich Tinker Anthony Artusa Understanding the characteristics of flash drought events and further predicting the onset of such events on subseasonal timescales is of critical importance for impact assessment, disaster mitigation, and loss prevention. In this study, we employ a rate-of-change...
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Atmosphere, Vol. 10, Pages 499: Temporal Variations of the Turbulence Profiles at the Sayan Solar Observatory Site Atmosphere doi: 10.3390/atmos10090499 Authors: Artem Shikhovtsev Pavel Kovadlo Vladimir Lukin The paper focuses on the development of the method to estimate the mean characteristics of the atmospheric turbulence. Using an approach based on the shape of the energy spectrum of atmospheric turbulence over a wide range of spatial and temporal scales, the vertical profiles...
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Atmosphere, Vol. 10, Pages 500: Possible Impacts of Snow Darkening Effects on the Hydrological Cycle over Western Eurasia and East Asia Atmosphere doi: 10.3390/atmos10090500 Authors: Jeong Sang Maeng-Ki Kim William K. M. Lau Kyu-Myong Kim In this paper, we investigated the possible impact of snow darkening effect (SDE) by light-absorbing aerosols on the regional changes of the hydrological cycle over Eurasia using the NASA GEOS-5 Model with aerosol tracers and a state-of-the-art...
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Atmosphere, Vol. 10, Pages 497: Projected Changes to Mean and Extreme Surface Wind Speeds for North America Based on Regional Climate Model Simulations Atmosphere doi: 10.3390/atmos10090497 Authors: Dae Il Jeong Laxmi Sushama This study evaluates projected changes to surface wind characteristics for the 2071–2100 period over North America (NA), using four Global Environmental Multiscale regional climate model simulations, driven by two global climate models (GCMs) for two...
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Atmosphere, Vol. 10, Pages 496: Characteristics of Fine Particulate Matter (PM2.5) over Urban, Suburban, and Rural Areas of Hong Kong Atmosphere doi: 10.3390/atmos10090496 Authors: Muhammad Bilal Janet E. Nichol Majid Nazeer Yuan Shi Lunche Wang K. Raghavendra Kumar Hung Chak Ho Usman Mazhar Max P. Bleiweiss Zhongfeng Qiu Khaled Mohamed Khedher Simone Lolli In urban areas, fine particulate matter (PM2.5) associated with local vehicle emissions can cause...
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Abstract Partial nephrectomy is the mainstay of treatment for localized kidney cancer. A proportion of patients are upstaged post-operatively to locally advanced disease (pT3a). We aimed to identify the incidence of upstaging to pT3a during partial nephrectomy and its relationship to a robotic approach. The National Cancer Database was queried for patients diagnosed with cT1M0 disease between 2010 and 2015 who underwent an open or robotic partial nephrectomy with final stage pT1–3a....
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Abstract All people are unique and so are their diseases. Our genomes, disease histories, behavior, and lifestyles are all different; therefore it is not too surprising that people often respond differently when administered the same drugs. Cancer, in particular, is a complex and heterogeneous disease, originating in patients with different genomes, in cells with the different epigenomes, formed and evolving on the basis of random processes, with the response to therapy not only...
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Publication date: Available online 26 August 2019Source: Addictive BehaviorsAuthor(s): Maria A. Parker, Stacey C. Sigmon, Andrea C. VillantiAbstractIntroductionIndividuals with drug use disorders or affective disorders have higher cigarette smoking prevalence and smoking intensity and are less likely to quit than the general population. We sought to estimate the prevalence of cigarette smoking by drug use and psychiatric diagnoses and to explore to what extent a co-occurring diagnosis was associated...
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Publication date: Available online 26 August 2019Source: Addictive BehaviorsAuthor(s): Christine M. Miller, Robert B. Whitley, Kray A. Scully, Michael B. MadsonAbstractThe investigation of drinking refusal self-efficacy and alcohol protective behavioral strategies (PBSA) has revealed inconsistent results. Sex may be one factor that plays a role in these results given the demonstrable differences between the alcohol use behaviors of men and women. The current study examined the moderating effects...
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Publication date: Available online 26 August 2019Source: Addictive BehaviorsAuthor(s): Jessica M. Cronce, Lindsey Zimmerman, Isaac C. Rhew, Jennifer M. Cadigan, David C. Atkins, Christine M. LeeAbstractBoth social and drinking behavior have the potential to modify mood. However, if social drinking enhances positive mood and reduces negative mood, as compared to non-drinking social behavior, then interventions to reinforce non-drinking via sober social activity are undermined. Using multilevel modeling...
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