Antibiotics, Vol. 8, Pages 150: Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib Antibiotics doi: 10.3390/antibiotics8030150 Authors: Ramy M. Hanna Maham Khalid Lama Abd El-Nour Umut Selamet Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and...
Mon Sep 16, 2019 03:00
Antibiotics, Vol. 8, Pages 151: Isolation and Antibiotic Resistant Research of Tetragenococcus halophilus from Xuanwei Ham, A China High-Salt-Fermented Meat Products Antibiotics doi: 10.3390/antibiotics8030151 Authors: Yinjiao Li Luying Shan Chen Zhang Zhan Lei Ying Shang We assessed the prevalence of antibiotic resistant and antibiotic resistance genes for 49 Tetragenococcus halophilus (T. halophilus) strains isolated from Xuawei ham in China. The antibiotic resistance phenotype...
Mon Sep 16, 2019 03:00
Antioxidants, Vol. 8, Pages 402: Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells Antioxidants doi: 10.3390/antiox8090402 Authors: Lu Geng Zhang Miao Liu BCR-ABL oncoprotein drives the initiation, promotion, and progression of chronic myelogenous leukemia (CML). Tyrosine kinase inhibitors are the first choice for CML therapy, however, BCR-ABL mediated drug resistance limits its clinical application...
Mon Sep 16, 2019 03:00
Antioxidants, Vol. 8, Pages 403: The Role of Heme Oxygenase-1 in Remote Ischemic and Anesthetic Organ Conditioning Antioxidants doi: 10.3390/antiox8090403 Authors: Bauer Raupach The cytoprotective effects of the heme oxygenase (HO) pathway are widely acknowledged. These effects are mainly mediated by degradation of free, pro-oxidant heme and the generation of carbon monoxide (CO) and biliverdin. The underlying mechanisms of protection include anti-oxidant, anti-apoptotic, anti-inflammatory...
Mon Sep 16, 2019 03:00
Antioxidants, Vol. 8, Pages 401: Regulation of Hydrogen Sulfide Metabolism by Nitric Oxide Inhibitors and the Quality of Peaches during Cold Storage Antioxidants doi: 10.3390/antiox8090401 Authors: Biao Geng Dandan Huang Shuhua Zhu Both nitric oxide (NO) and hydrogen sulfide (H2S) have been shown to have positive effects on the maintenance of fruit quality during storage; however, the mechanisms by which NO regulates the endogenous H2S metabolism remain unknown. In this experiment,...
Mon Sep 16, 2019 03:00
Antioxidants, Vol. 8, Pages 400: Antioxidant and Anticholinesterase Activities of Macrosphyra Longistyla (DC) Hiern Relevant in the Management of Alzheimer’s Disease Antioxidants doi: 10.3390/antiox8090400 Authors: Taiwo O. Elufioye Chidimma G. Chinaka Adebola O. Oyedeji Macrosphyra longistyla has been used in many traditional systems of medicine for its anti-hemorrhagic, antidiabetic, anti-ulcer, and anti-diarrhea properties. The acetylcholinesterase (AChE) and butyrylcholinesterase...
Mon Sep 16, 2019 03:00
Antioxidants, Vol. 8, Pages 399: Induction of Redox-Active Gene Expression by CoCl2 Ameliorates Oxidative Stress-Mediated Injury of Murine Auditory Cells Antioxidants doi: 10.3390/antiox8090399 Authors: Jhang Ho Pak Junyeong Yi Sujin Ryu In Ki Kim Jung-Woong Kim Haeri Baek Jong Woo Chung Free radicals formed in the inner ear in response to high-intensity noise, are regarded as detrimental factors for noise-induced hearing loss (NIHL). We reported previously that intraperitoneal...
Mon Sep 16, 2019 03:00
Arts, Vol. 8, Pages 120: Trends and Anti-Trends in Techno-Art Scholarship: The Legacy of the Arts “Machine” Special Issues Arts doi: 10.3390/arts8030120 Authors: Bessette Fol Leymarie Smith With the goal of casting a spotlight on the posture of the creative community at this crucial moment in human technological history, we present herein a thematic overview of the 23 articles published in the recent Arts Special Issues “The Machine as Art (in the 20th Century)”...
Mon Sep 16, 2019 03:00
Arts, Vol. 8, Pages 119: The Aesthetics of Flow and Cut in the Way of Film: Towards Transnational Transfers of East Asian Concepts to Western Film Theory Arts doi: 10.3390/arts8030119 Authors: Simon Frisch The general concepts in theorising the aesthetics of film are still rooted in occidental traditions. Thus, thinking about film is dominated by Western terms and aesthetic paradigms—such as “pieces of work”, the representation of reality or regarding the...
Mon Sep 16, 2019 03:00
Atmosphere, Vol. 10, Pages 554: Atmospheric Monitoring of Methane in Beijing Using a Mobile Observatory Atmosphere doi: 10.3390/atmos10090554 Authors: Sun Deng Wu Wu Han Miao Yao Cities have multiple fugitive emission sources of methane (CH4) and policies adopted by China on replacing coal with natural gas in recent years can cause fine spatial heterogeneities at the range of kilometers within a city and also contribute to the CH4 inventory. In this study, a...
Mon Sep 16, 2019 03:00
Atmosphere, Vol. 10, Pages 555: Generative Adversarial Networks Capabilities for Super-Resolution Reconstruction of Weather Radar Echo Images Atmosphere doi: 10.3390/atmos10090555 Authors: Chen Zhang Liu Zeng Improving the resolution of degraded radar echo images of weather radar systems can aid severe weather forecasting and disaster prevention. Previous approaches to this problem include classical super-resolution (SR) algorithms such as iterative back-projection (IBP)...
Mon Sep 16, 2019 03:00
Atmosphere, Vol. 10, Pages 553: Anatomy of a Cyclonic Eddy in the Kuroshio Extension Based on High-Resolution Observations Atmosphere doi: 10.3390/atmos10090553 Authors: Yongchui Zhang Xi Chen Changming Dong Mesoscale eddies are common in the ocean and their surface characteristics have been well revealed based on altimetric observations. Comparatively, the knowledge of the three-dimensional (3D) structure of mesoscale eddies is scarce, especially in the open ocean. In the present...
Mon Sep 16, 2019 03:00
Atmosphere, Vol. 10, Pages 552: The Green Infrastructure in Cities as A Tool for Climate Change Adaptation and Mitigation: Slovakian and Polish Experiences Atmosphere doi: 10.3390/atmos10090552 Authors: Ingrid Belčáková Małgorzata Świąder Małgorzata Bartyna-Zielińska Climate change could be seen as a 21st century phenomenon. This topic has been taken up equally by professionals as well as the general public. Adaptation and mitigation actions are needed, especially in cities where...
Mon Sep 16, 2019 03:00
Atmosphere, Vol. 10, Pages 551: North Sea Wave Database (NSWD) and the Need for Reliable Resource Data: A 38 Year Database for Metocean and Wave Energy Assessments Atmosphere doi: 10.3390/atmos10090551 Authors: George Lavidas Henk Polinder The study presents a newly generated hindcast database of metocean conditions for the region of the North Sea by parametrising the newly introduced ST6 physics in a nearshore wave model. Exploring and assessing the intricacies in wave generation...
Mon Sep 16, 2019 03:00
Atmosphere, Vol. 10, Pages 550: Atmospheric Characterization Based on Relative Humidity Control at Optical Turbulence Generator Atmosphere doi: 10.3390/atmos10090550 Authors: Jhonny Villamizar Manuel Herreño Omar Tíjaro Yezid Torres In atmospheric turbulence, relative humidity has been almost a negligible variable due to its limited effect, compared with temperature and air velocity, among others. For studying the horizontal path, a laser beam was propagated in a laboratory...
Mon Sep 16, 2019 03:00
Atmosphere, Vol. 10, Pages 549: Three-Dimensional Wind Measurements with the Fibered Airborne Coherent Doppler Wind Lidar LIVE Atmosphere doi: 10.3390/atmos10090549 Authors: Beatrice Augere Matthieu Valla Anne Durécu Agnès Dolfi-Bouteyre Didier Goular François Gustave Christophe Planchat Didier Fleury Thierry Huet Claudine Besson A three-dimensional (3D) wind profiling Lidar, based on the latest high power 1.5 µm fiber laser development at Onera,...
Mon Sep 16, 2019 03:00
Bioengineering, Vol. 6, Pages 84: Polyhydroxybutyrate Production from Natural Gas in A Bubble Column Bioreactor: Simulation Using COMSOL Bioengineering doi: 10.3390/bioengineering6030084 Authors: Moradi Rashedi Mofradnia Khosravi-Darani Ashouri Yazdian In this study, the simulation of microorganism ability for the production of poly-β-hydroxybutyrate (PHB) from natural gas (as a carbon source) was carried out. Based on the Taguchi algorithm, the optimum...
Mon Sep 16, 2019 03:00
Biomedicines, Vol. 7, Pages 72: Antihyperlipidemic and Antioxidant Effects of Averrhoa Carambola Extract in High-Fat Diet-Fed Rats Biomedicines doi: 10.3390/biomedicines7030072 Authors: Saleem H. Aladaileh Sultan A. M. Saghir Kisantini Murugesu Amirin Sadikun Ashfaq Ahmad Gurjeet Kaur Ayman M. Mahmoud Vikneswaran Murugaiyah The present study explored the antihyperlipidemic potential of a standardized methanolic extract of Averrhoa carambola (A. carambola) leaf (MEACL)...
Mon Sep 16, 2019 03:00
Biomolecules, Vol. 9, Pages 492: Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity Biomolecules doi: 10.3390/biom9090492 Authors: Dimmito Stefanucci Pieretti Minosi Dvorácskó Tömböly Zengin Mollica The endocannabinoid system represents an integrated neuronal network involved in the control of several organisms’ functions, such as feeding behavior. A series of hybrids of 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide...
Mon Sep 16, 2019 03:00
Biomolecules, Vol. 9, Pages 494: Crinamine Induces Apoptosis and Inhibits Proliferation, Migration, and Angiogenesis in Cervical Cancer SiHa Cells Biomolecules doi: 10.3390/biom9090494 Authors: Khumkhrong Piboonprai Chaichompoo Pimtong Khongkow Namdee Jantimaporn Japrung Asawapirom Suksamrarn Iempridee Crinum asiaticum is a perennial herb widely distributed in many warmer regions, including Thailand, and is well-known for its medicinal and ornamental...
Mon Sep 16, 2019 03:00
Biomolecules, Vol. 9, Pages 493: Utilizing the Combination of Binding Kinetics and Micro-Pharmacokinetics Link in Vitro α-Glucosidase Inhibition to in Vivo Target Occupancy Biomolecules doi: 10.3390/biom9090493 Authors: Wang Ji Li Wang Gong Wang Liu Pan Many compounds with good inhibitory activity (i.e., high affinity) within in vitro experiments failed in vivo studies due to a lack of efficacy from limited target occupancy (TO) in the drug discovery process....
Mon Sep 16, 2019 03:00
Biomolecules, Vol. 9, Pages 491: Loosening of Side-Chain Packing Associated with Perturbations in Peripheral Dynamics Induced by the D76N Mutation of β2-Microglobulin Revealed by Pressure-NMR and Molecular Dynamic Simulations Biomolecules doi: 10.3390/biom9090491 Authors: Kazumasa Sakurai Ryosuke Tomiyama Takuma Shiraki Yasushige Yonezawa β2-Microglobulin (β2m) is the causative protein of dialysis-related amyloidosis, and its D76N variant is less stable and...
Mon Sep 16, 2019 03:00
Biomolecules, Vol. 9, Pages 490: Evolutionary Rate Heterogeneity and Functional Divergence of Orthologous Genes in Pyrus Biomolecules doi: 10.3390/biom9090490 Authors: Yunpeng Cao Lan Jiang Lihu Wang Yongping Cai Negatively selected genes (NSGs) and positively selected genes (PSGs) are the two types of most nuclear protein-coding genes in organisms. However, the evolutionary rates and characteristics of different types of genes have been rarely understood. In the present study,...
Mon Sep 16, 2019 03:00
Biosensors, Vol. 9, Pages 108: Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation Biosensors doi: 10.3390/bios9030108 Authors: Arthur Luiz Alves de Araujo Julien Claudel Djilali Kourtiche Mustapha Nadi New technologies, such as biosensors and lab-on-a-chip, are reducing time consumption and costs for the detection and characterization of biological cells. One challenge is to detect and characterize...
Mon Sep 16, 2019 03:00
Cancers, Vol. 11, Pages 1376: Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas Cancers doi: 10.3390/cancers11091376 Authors: Gugel Grimm Liebsch Zipfel Teuber Kluwe Mautner Tatagiba Schuhmann Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively...
Mon Sep 16, 2019 03:00
Cancers, Vol. 11, Pages 1377: MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid Nodules Cancers doi: 10.3390/cancers11091377 Authors: Capitoli Piga Galimberti Leni Pincelli Garancini Clerici Mahajneh Brambilla Smith Magni Pagni The present study applies for the first time as Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging (MSI) on real thyroid Fine...
Mon Sep 16, 2019 03:00
Cancers, Vol. 11, Pages 1375: The Immune Microenvironment of Breast Cancer Progression Cancers doi: 10.3390/cancers11091375 Authors: Tower Ruppert Britt Inflammation is now recognized as a hallmark of cancer. Genetic changes in the cancer cell are accepted as the match that lights the fire, whilst inflammation is seen as the fuel that feeds the fire. Once inside the tumour, the immune cells secrete cytokines that kick-start angiogenesis to ferry in much-needed oxygen and nutrients...
Mon Sep 16, 2019 03:00
Cancers, Vol. 11, Pages 1378: CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis Cancers doi: 10.3390/cancers11091378 Authors: Lin Ko Kao Yang Tsai Chuang Hu Yang Lo Hsu Cytochrome P450 (CYP) 17A1 is an important steroidogenic enzyme harboring 17α-hydroxylase and performing 17,20 lyase activities in multiple steps of steroid hormone synthesis, including dehydroepiandrosterone...
Mon Sep 16, 2019 03:00
Cancers, Vol. 11, Pages 1373: Cytotoxicity and Differentiating Effect of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Myelodysplastic Syndromes Cancers doi: 10.3390/cancers11091373 Authors: Isabella Faraoni Maria Irno Consalvo Francesca Aloisio Emiliano Fabiani Manuela Giansanti Francesca Di Cristino Giulia Falconi Lucio Tentori Ambra Di Veroli Paola Curzi Luca Maurillo Pasquale Niscola Francesco Lo-Coco Grazia Graziani Maria Teresa Voso ...
Mon Sep 16, 2019 03:00
Cancers, Vol. 11, Pages 1374: Targeting Autophagy for Overcoming Resistance to Anti-EGFR Treatments Cancers doi: 10.3390/cancers11091374 Authors: Yoojung Kwon Misun Kim Hyun Suk Jung Youngmi Kim Dooil Jeoung Epidermal growth factor receptor (EGFR) plays critical roles in cell proliferation, tumorigenesis, and anti-cancer drug resistance. Overexpression and somatic mutations of EGFR result in enhanced cancer cell survival. Therefore, EGFR can be a target for the development...
Mon Sep 16, 2019 03:00
Cancers, Vol. 11, Pages 1372: Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer Cancers doi: 10.3390/cancers11091372 Authors: Goran Hamid Mohammad Vessela Vassileva Pilar Acedo Steven W. M. Olde Damink Massimo Malago Dipok Kumar Dhar Stephen P. Pereira Reprogrammed glucose metabolism is one of the hallmarks of cancer, and increased expression of key glycolytic enzymes, such as pyruvate...
Mon Sep 16, 2019 03:00
Cells, Vol. 8, Pages 1094: Maternal Protein Restriction Modulates Angiogenesis and AQP9 Expression Leading to a Delay in Postnatal Epididymal Development in Rat Cells doi: 10.3390/cells8091094 Authors: Talita de Mello Santos Marilia Martins Cavariani Dhrielly Natália Pereira Bruno César Schimming Luiz Gustavo de Almeida Chuffa Raquel Fantin Domeniconi The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during...
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Cells, Vol. 8, Pages 1092: Expression of FGF8, FGF18, and FGFR4 in Gastroesophageal Adenocarcinomas Cells doi: 10.3390/cells8091092 Authors: Jomrich Hudec Harpain Winkler Timelthaler Mohr Marian Schoppmann Even though distinctive advances in the field of esophageal cancer therapy have occurred over the last few years, patients’ survival rates remain poor. FGF8, FGF18, and FGFR4 have been identified as promising biomarkers in a number of cancers;...
Mon Sep 16, 2019 03:00
Cells, Vol. 8, Pages 1093: Single Cell Mass Cytometry of Non-Small Cell Lung Cancer Cells Reveals Complexity of In vivo And Three-Dimensional Models over the Petri-dish Cells doi: 10.3390/cells8091093 Authors: Alföldi Balog Faragó Halmai Kotogány Neuperger Nagy Fehér Szebeni Puskás Single cell genomics and proteomics with the combination of innovative three-dimensional (3D) cell culture techniques can open new avenues toward the understanding of...
Mon Sep 16, 2019 03:00
Cells, Vol. 8, Pages 1091: Expression of FGFR1–4 in Malignant Pleural Mesothelioma Tissue and Corresponding Cell Lines and its Relationship to Patient Survival and FGFR Inhibitor Sensitivity Cells doi: 10.3390/cells8091091 Authors: Gregor Vlacic Mir A. Hoda Thomas Klikovits Katharina Sinn Elisabeth Gschwandtner Katja Mohorcic Karin Schelch Christine Pirker Barbara Peter-Vörösmarty Jelena Brankovic Balazs Dome Viktoria Laszlo Tanja Cufer Ales Rozman Walter...
Mon Sep 16, 2019 03:00
Cells, Vol. 8, Pages 1090: Therapeutic Approaches Targeting Nucleolus in Cancer Cells doi: 10.3390/cells8091090 Authors: Pietro Carotenuto Annalisa Pecoraro Gaetano Palma Giulia Russo Annapina Russo The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in the nucleoplasm, from which...
Mon Sep 16, 2019 03:00
Chemosensors, Vol. 7, Pages 46: Potentiometric Signal Transduction for Selective Determination of 1-(3-Chlorophenyl)piperazine “Legal Ecstasy” Through Biomimetic Interaction Mechanism Chemosensors doi: 10.3390/chemosensors7030046 Authors: Eman H. El-Naby 1-(3-chlorophenyl)piperazine (mCPP) is a wide spread new psychoactive substance producing a stimulant and hallucination similar to those sought from ecstasy. Hence, in the recent years, mCPP has been introduced by the organized crime...
Mon Sep 16, 2019 03:00
Diagnostics, Vol. 9, Pages 121: Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives Diagnostics doi: 10.3390/diagnostics9030121 Authors: Elena-Daniela Grigorescu Cristina-Mihaela Lacatusu Mariana Floria Bogdan-Mircea Mihai Ioana Cretu Laurentiu Sorodoc In-depth understanding of early cardiovascular manifestations in diabetes is high on international research and prevention agendas given that cardiovascular events are the leading cause of...
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Diversity, Vol. 11, Pages 167: Interannual Variation of Benthic Macroinvertebrate Communities at Long-Term Monitoring Sites Impacted by Human Activities: Implications for Bioassessment Diversity doi: 10.3390/d11090167 Authors: Almudena L. Idígoras Chaumel David G. Armanini John A. Schwindt Adam G. Yates Bioassessment assumes that ecological conditions remain stable in the absence of environmental changes. Evidence suggests this assumption may hold for reference streams, but...
Mon Sep 16, 2019 03:00
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