Κυριακή, 1 Σεπτεμβρίου 2019


Quality of surgery and surgical reporting for patients with primary gastrointestinal stromal tumours participating in the EORTC STBSG 62024 adjuvant imatinib study
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Peter Hohenberger, Sylvie Bonvalot, Frits van Coevorden, Pjotr Rutkowski, Eberhard Stoeckle, Christine Olungu, Saskia Litiere, Eva Wardelmann, Alessandro Gronchi, Paolo CasaliAbstractBackgroundEORTC (European Organisation of Research and Treatment of Cancer) 62024 is a phase III randomised trial evaluating adjuvant imatinib in patients with gastrointestinal stromal tumours (GISTs) and no evidence of residual disease...
European Journal of Cancer
Sun Sep 01, 2019 16:23
Clinical efficacy of the optimal biological dose in early-phase trials of anti-cancer targeted therapies
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Pauline Corbaux, Mévidette El-Madani, Michel Tod, Julien Péron, Denis Maillet, Jonathan Lopez, Gilles Freyer, Benoit YouAbstractBackgroundDetermining the optimal biological dose (OBD) has been described as an alternative strategy to the maximum tolerated doses (MTDs) for identifying the recommended phase II trial doses (RP2Ds) of phase I anti-cancer therapies. However, the clinical relevance is still unknown. An...
European Journal of Cancer
Sun Sep 01, 2019 16:23
Therapeutic relevance of targeted sequencing in management of patients with advanced biliary tract cancer: DNA damage repair gene mutations as a predictive biomarker
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Heejung Chae, Deokhoon Kim, Changhoon Yoo, Kyu-pyo Kim, Jae Ho Jeong, Heung-Moon Chang, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Shin Hwang, Ki-Hun Kim, Gi-Won Song, Chul Soo Ahn, Jae Hoon Lee, Dae Wook Hwang, Song Cheol Kim, Se Jin Jang, Seung-Mo Hong, Tae Won Kim, Baek-Yeol RyooAbstractPurposeIn biliary tract cancer (BTC), standard chemotherapy has limited benefit and no molecular targeted agents have been approved....
European Journal of Cancer
Sat Aug 31, 2019 12:54
Impact of primary tumor location on outcome of liposarcoma patients, a retrospective cohort study
Publication date: Available online 31 August 2019Source: European Journal of Surgical OncologyAuthor(s): M. Vos, W.C. Boeve, T.M. van Ginhoven, S. Sleijfer, C. Verhoef, D.J. GrünhagenAbstractBackgroundTumor location as prognostic factor for patients with liposarcoma (LPS) has been studied modestly with varying outcomes. The aim was to establish the impact of tumor location on recurrence and survival of LPS patients.MethodsA retrospective database of patients treated for LPS until December 2017 was...
European Journal of Surgical Oncology (EJSO)
Sat Aug 31, 2019 14:39
Prognostic value of mismatch repair deficiency in patients with advanced gastric cancer, treated by surgery and adjuvant 5-fluorouracil and leucovorin chemoradiotherapy
Publication date: Available online 31 August 2019Source: European Journal of Surgical OncologyAuthor(s): Su Mi Kim, Ji Yeong An, Sun-ju Byeon, Jeeyun Lee, Kyoung-Mee Kim, Min-Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung KimAbstractObjectiveThe predictive value of mismatch repair protein deficiency (MMRD) for chemoradiotherapeutic outcome has rarely been reported in gastric cancer. This study investigated the clinical significance of MMRD as a prognostic factor for tumor recurrence, and...
European Journal of Surgical Oncology (EJSO)
Sat Aug 31, 2019 14:39
Reply to: Characteristics in patients with symptomatic colorectal carcinomas and those detected by screening’
Publication date: Available online 30 August 2019Source: European Journal of Surgical OncologyAuthor(s): Maximino Redondo, Teresa Téllez
European Journal of Surgical Oncology (EJSO)
Sat Aug 31, 2019 14:39
Pressurized IntraPeritoneal Aerosol Chemotherapy with one minute of electrostatic precipitation (ePIPAC) is feasible, but the histological tumor response in peritoneal metastasis is insufficient
Publication date: Available online 29 August 2019Source: European Journal of Surgical OncologyAuthor(s): Martin Graversen, Sönke Detlefsen, Signe Bremholm Ellebaek, Claus Fristrup, Per Pfeiffer, Michael B. MortensenAbstractIntroductionElectrostatic precipitation Pressurized IntraPeritoneal Aerosol Chemotherapy (ePIPAC) has shown superior penetration depth and tissue uptake compared to standard PIPAC. We investigated the feasibility and objective tumor response to ePIPAC with 1 min of precipitation...
European Journal of Surgical Oncology (EJSO)
Fri Aug 30, 2019 14:28
Treatment sequencing in oncology: balancing clinical trial and real-world evidence
Future Oncology, Volume 15, Issue 25, Page 2887-2889, September 2019.
Future Oncology
Fri Aug 30, 2019 12:16
Treatment sequencing in oncology: balancing clinical trial and real-world evidence.
Related ArticlesTreatment sequencing in oncology: balancing clinical trial and real-world evidence. Future Oncol. 2019 Sep;15(25):2887-2889 Authors: Caffo O PMID: 31469005 [PubMed - in process]
Future Oncology.
Sat Aug 31, 2019 14:21
Abemaciclib, a potent cyclin-dependent kinase 4 and 6 inhibitor, for treatment of ER-positive metastatic breast cancer.
Related ArticlesAbemaciclib, a potent cyclin-dependent kinase 4 and 6 inhibitor, for treatment of ER-positive metastatic breast cancer. Future Oncol. 2019 Aug 29;: Authors: Lee KA, Shepherd ST, Johnston SR Abstract CDK 4/6 inhibitors have given patients with estrogen receptor (ER)-positive/HER2-negative (ER+/HER2ࢤ) advanced metastatic breast cancer important new therapeutic options. Abemaciclib is different to the other two licensed and approved CDK...
Future Oncology.
Fri Aug 30, 2019 15:29
The cell of origin and the leukemia stem cell in acute myeloid leukemia
Abstract There is experimental and observational evidence that the cells of the leukemic clone in acute myeloid leukemia (AML) have different phenotypes even though they share the same somatic mutations. The organization of the malignant clone in AML has many similarities to normal hematopoiesis, with leukemia stem cells (LSCs) that sustain leukemia and give rise to more differentiated cells. LSCs, similar to normal hematopoietic stem cells (HSCs), are those cells that are able to give rise to a...
Genes, Chromosomes and Cancer
Sat Aug 31, 2019 11:03
Detection of CSF1 rearrangements deleting the 3'UTR in tenosynovial giant cell tumors
ABSTRACT Tenosynovial giant cell tumors (TGCTs) are characterized by rearrangements of CSF1, thought to drive overexpression of macrophage colony‐stimulating factor (CSF1), thereby promoting tumor growth and recruitment of non‐neoplastic mononuclear and multinucleated inflammatory cells. While fusions to collagen promoters have been described, the mechanism of CSF1 overexpression has been unclear in a majority of cases. Two cohorts of TGCT were investigated for CSF1 rearrangements using fluorescence...
Genes, Chromosomes and Cancer
Fri Aug 30, 2019 18:33
From presentation to paper: gender disparities in oncological research
Gender disparities in scientific publications have been identified in oncological research. Oral research presentations at major conferences enhance visibility of presenters. The share of women presenting at such podia is unknown. We aim to identify gender‐based differences in contributions to presentations at two major oncological conferences. Abstracts presented at plenary sessions of the American Society of Clinical Oncology (ASCO) Annual Meetings and European Society for Medical Oncology (ESMO)...
International Journal of Cancer
Sat Aug 31, 2019 17:32
Associations between calcium and magnesium intake and the risk of incident gastric cancer, a prospective cohort analysis of the NIH‐AARP Diet and Health Study
Gastric cancer remains a leading cause of cancer‐related mortality. Identifying dietary and other modifiable disease determinants has important implications for risk attenuation in susceptible individuals. Our primary aim was to estimate the association between dietary and supplemental intakes of calcium and magnesium and the risk of incident gastric cancer. We conducted a prospective cohort analysis of the NIH‐AARP Diet and Health Study. We used Cox proportional hazard modeling to estimate the association...
International Journal of Cancer
Sat Aug 31, 2019 17:29
A Chirality‐Dependent Action of Vitamin C in Suppressing KRAS Mutant Tumor Growth by the Oxidative Combination: Rationale for Cancer Therapeutics
Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their resistance to established therapies and high mortality rates. Here, we developed a novel and extremely effective combinational therapeutic approach to target KRAS mutant tumors through the generation of a cytotoxic oxidative stress. At high concentrations, Vitamin C (VC) is known to provoke oxidative stress and selectively kill KRAS mutant cancer cells, although its effects...
International Journal of Cancer
Sat Aug 31, 2019 17:28
Plasma clearance of RAS mutation under therapeutic pressure is a rare event in metastatic colorectal cancer
In metastatic colorectal cancer (mCRC), circulating tumor DNA (ctDNA) monitoring can be used to genotype tumors and track clonal evolution. We investigated the clearance of RAS mutated clones under chemotherapy pressure by ctDNA analysis in patients with a RAS mutated mCRC. Patients with a RAS mutated tumor included in the prospective PLACOL study, were monitored for ctDNA. Analyzes were based on optimized targeted next generation sequencing and/or droplet‐based digital PCR (ddPCR). For plasma samples...
International Journal of Cancer
Sat Aug 31, 2019 17:22
Systematic comparison of plasma EBV DNA, anti‐EBV antibodies and miRNA levels for early detection and prognosis of Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is originated from the epithelial cells of nasopharynx, Epstein–Barr virus (EBV)‐associated and has the highest incidence and mortality rates mostly in Southeast Asia. Late presentation is a common issue and early detection could be the key to reduce the disease burden. Sensitivity of plasma EBV DNA, an established NPC biomarker, for stage I NPC is controversial. Most newly reported NPC biomarkers have neither been externally validated nor compared to the established...
International Journal of Cancer
Fri Aug 30, 2019 18:43
BRCA1 promoter methylation in peripheral blood is associated with the risk of triple‐negative breast cancer
Methylation of the promoter of the BRCA1 gene in DNA derived from peripheral blood cells is a possible risk factor for breast cancer. It is not clear if this association is restricted to certain types of breast cancer or is a general phenomenon. We evaluated BRCA1 methylation status in peripheral blood cells from 942 breast cancer patients and from 500 controls. We also assessed methylation status in 262 paraffin‐embedded breast cancer tissues. Methylation status was assessed using methylation‐sensitive...
International Journal of Cancer
Fri Aug 30, 2019 18:39
Long Intergenic Non‐coding RNA Profiles of Pheochromocytoma and Paraganglioma: A Novel Prognostic Biomarker
Many long intergenic noncoding RNAs (lincRNAs) serve as cancer biomarkers for diagnosis or prognostication. To understand the role of lincRNAs in the rare neuroendocrine tumors pheochromocytoma and paraganglioma (PCPG), we performed first time in‐depth characterization of lincRNA expression profiles and correlated findings to clinical outcomes of the disease. RNA‐Seq data from patients with PCPGs and 17 other tumor types from The Cancer Genome Atlas and other published sources were obtained. Differential...
International Journal of Cancer
Fri Aug 30, 2019 18:30
Identification of novel epithelial ovarian cancer loci in Women of African Ancestry
Women of African Ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European Ancestry. We conducted a genome‐wide association study (GWAS) in African ancestry women with 755 EOC cases, including 537 high‐grade serous ovarian carcinomas (HGSOC), and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (P < 1x10−6), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604...
International Journal of Cancer
Fri Aug 30, 2019 18:29
Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer
Triple negative breast cancer (TNBC) is an incurable disease where novel therapeutic strategies are needed. Proteolysis targeting chimeric (PROTAC) are novel compounds that promote protein degradation by bindi...
Journal of Experimental & Clinical Cancer Research - Latest Articles
Fri Aug 30, 2019 03:00
Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway
Ovarian carcinomas are the deadliest gynecological malignancies owing to their high rate of recurrence and high resistance to platinum-based chemotherapy. Recent studies have shown platinum-dependent enrichmen...
Journal of Experimental & Clinical Cancer Research - Latest Articles
Fri Aug 30, 2019 03:00
Small nucleolar RNA host gene 1 promotes development and progression of colorectal cancer through negative regulation of miR‐137
Abstract Small nucleolar RNA host gene 1 (SNHG1) is critical in the progression of cancers. However, the mechanism by which SNHG1 regulates the progression of colorectal cancer (CRC) remains unclear. Expressions of SNHG1 and miR‐137 in CRC tissues and cell lines were evaluated by quantitative real‐time polymerase chain reaction. A luciferase reporter gene assay was conducted to investigate miR‐137 target. Additionally, RNA pull‐down assay was performed to explore the physical association between...
Molecular Carcinogenesis
Fri Aug 30, 2019 12:45
Anchored Transponder Guided Lung Radiation Therapy
Publication date: Available online 31 August 2019Source: Practical Radiation OncologyAuthor(s): Michael C. Dobelbower, Richard A. Popple, Douglas J. Minnich, Daniel A. Nader, Frank Zimmerman, Gerald E. Paris, Felix J.F. Herth, Daniela R. Gompelmann, Falk F. Roeder, Parag J. Parikh, Andrew M. McDonald
Practical Radiation Oncology
Sun Sep 01, 2019 17:53
What dose specification should be used for NRG radiation therapy trials, dose-to-medium or dose-to-water?
Publication date: Available online 31 August 2019Source: Practical Radiation OncologyAuthor(s): Maria Lavin Cabanas, Chenyu Yan, Ronald J. Lalonde, Dwight E. Heron, M. Saiful HuqAbstractPurposeTo compare the doses calculated by AAA, Acuros dose-to-medium and Acuros dose-to-water for the lung patients treated at our institution and show that further investigation and clarification are needed about what dose specification should be used for NRG clinical trials.Methods and MaterialsTwenty-one lung patients...
Practical Radiation Oncology
Sat Aug 31, 2019 18:00
Feasibility study of an intervention to improve emotional well‐being and cognitive functioning in brain tumour survivors
Psycho-Oncology
Fri Aug 30, 2019 21:24
Transforming growth factor beta 1 levels predict echocardiographic changes at three years after adjuvant radiotherapy for breast cancer
Transforming growth factor beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) are cytokines involved in fibrotic processes causing radiotherapy (RT)-induced cardiovascular changes. We aimed to investiga...
Radiation Oncology - Latest Articles
Fri Aug 30, 2019 03:00
Assessment of setup uncertainty in hypofractionated liver radiation therapy with a breath-hold technique using automatic image registration–based image guidance
Target localization in radiation therapy is affected by numerous sources of uncertainty. Despite measures to minimize the breathing motion, the treatment of hypofractionated liver radiation therapy is further ...
Radiation Oncology - Latest Articles
Fri Aug 30, 2019 03:00
Repeat stereotactic body radiation therapy (SBRT) for salvage of isolated local recurrence after definitive lung SBRT
Stereotactic body radiotherapy (SBRT) is an established treatment option in the management of patients with early-stage non-small cell lung cancer (NSCLC). Prospective studies have demonstrated that SBRT achieves high rates of local tumor control [1–3]. Compared to conventionally-fractionated radiotherapy (CFRT) for early stage NSCLC, SBRT is associated with equivalent tumor control, shortened treatment times, and decreased toxicity, with larger retrospective studies even suggesting a survival benefit...
Radiotherapy and Oncology
Sat Aug 31, 2019 03:00
Sensitivity of radiomic features to inter-observer variability and image pre-processing in Apparent Diffusion Coefficient (ADC) maps of cervix cancer patients
Cervical cancer is the fourth most frequent cancer in women, with an estimated 570,000 new cases in 2018, representing 6.6% of all female cancers worldwide. Cervical cancer still represents a significant burden for middle- and low-income countries [1]. Standard treatment for locally advanced (stage IB2-IVA) cervical cancer is concurrent chemoradiation.
Radiotherapy and Oncology
Fri Aug 30, 2019 03:00

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