Publication date: Available online 1 September 2019Source: Auris Nasus LarynxAuthor(s): Hyun woo Park, Jungmin Ahn, Min woong Kang, Yang-Sun ChoAbstractObjectiveTo identify the wideband absorbance (WBA) of reconstructed TM comparing with perforated and normal TM, and to investigate the efficacy of WBA to predict postoperative hearing outcome.MethodsNinety-eight adults (128 ears) with normal TM and 40 patients (40 ears) who were diagnosed with chronic suppurative otitis media (CSOM) and underwent...
Sun Sep 01, 2019 16:45
Publication date: Available online 31 August 2019Source: Auris Nasus LarynxAuthor(s): Motofumi Ohki, Yukiyoshi Hyo, Yuji Yoshiyama, Hiroshi Takano, Junko Takahata, Motohiko Suzuki, Sachio Takeno, Toshio Ogoshi, Kenji Suzuki, Kazuhiko Takeuchi, Kensei Naito, Shinichi Haruna, Toshiyuki Fujisawa, Sota Yamaguchi, Muneki Hotomi, Hideyuki Kawauchi, Yuichi Kurono, the working group of the Japan Society for Infection and Aerosol in OtorhinolaryngologyAbstractThe guidance deals with the recommended applications,...
Sat Aug 31, 2019 15:46
AbstractInsect odorant receptors show a limited functional expression in various heterologous expression systems including insect and mammalian cells. This may be in part due to the absence of key components driving the release of these proteins from the endoplasmic reticulum and directing them to the plasma membrane. In order to mitigate this problem we took advantage of small export signals within the human HCN1 and Rhodopsin that have been shown to promote protein release from the endoplasmic...
Sat Aug 31, 2019 03:00
AbstractForkhead box protein J1 (FOXJ1), a member of the forkhead family transcription factors, is a transcriptional regulator of motile ciliogenesis. The nasal respiratory epithelium, but not olfactory epithelium, is lined with FOXJ1-expressing multi-ciliated epithelial cells with motile cilia. In a transgenic mouse where an eGFP transgene is driven by the human FOXJ1 promoter, robust eGFP expression is observed not only in the multi-ciliated cells of the respiratory epithelium, but in a distinctive...
Fri Aug 30, 2019 03:00
Condition: Esophageal CancerIntervention: Sponsor: Sun Yat-sen UniversityRecruiting
Fri Aug 30, 2019 17:36
Conditions: Oncology; Breast Cancer; Prostate Cancer; Gynecologic Cancer; Brain Tumor; Brain Cancer; Gynecologic Tumor; Prostate Tumor; Prostate Neoplasm; Breast Tumor; Radiation Toxicity; Quality of Life; Rectal Cancer; Rectal Tumor; Rectal Neoplasms; Lung Cancer; Lung Tumor; Lung Neoplasm; Esophageal Cancer; Esophagus Cancer; Esophageal Tumor; Esophageal Neoplasm; Esophagus Tumor; Esophagus Neoplasm; Pancreatic Cancer; Pancreatic Tumor; Pancreatic Neoplasms;...
Fri Aug 30, 2019 17:36
Purpose of review The aim if this review is to provide an update on the existing literature of animal bite treatment strategies and provide a systematic approach to animal bites from presentation to reconstruction. Recent findings Dog bites cause 80–90% of animal bites with 26.8–56.5% occurring in the head and neck. Infection rates may be as low as 5.7–9.7%. Primary closure alone is sufficient in 69.8% of dog bites within the first 24 h. Summary Animal bite injuries to the head and neck...
Fri Aug 30, 2019 21:19
Purpose of review Increasing awareness and prevalence of disorders in hearing and balance have placed emphasis on treatment strategies. With the rapid evolution in molecular, gene, and nanotechnology, alternate delivery methods have advanced intracochlear drug delivery. This review aims to raise awareness of recent developments in technologies to augment current clinical practices. Recent findings Intracochlear drug delivery research has expanded with the familiarity and accessibility to...
Fri Aug 30, 2019 21:19
Purpose of review This article describes the physiology of cerebrospinal fluid (CSF). We review current evidence and new concepts relating to CSF physiology with respect to CSF secretion, circulation and resorption and we highlight key pathophysiological associations including the relationship between CSF and intracranial pressure. Recent findings CSF secretion occurs primarily via the choroid plexus. Various transport mechanisms facilitate CSF secretion but the role Aquaporins play in this...
Fri Aug 30, 2019 21:19
Purpose of review To describe the technique and discuss the advantages and outcomes of the trans-mastoid approach (TMA) for temporal bone cerebrospinal fluid (CSF) leak. Recent findings TMA for CSF leak repair is an alternative to middle cranial fossa approach (MCFA) with less morbidity and good outcomes. Summary Persistent CSF leak in the temporal bone whether idiopathic, congenital or acquired, is an indication for surgery. TMA is a valid option for surgery, competing with MCFA in...
Fri Aug 30, 2019 21:19
Purpose of review To review the recent literature on the use of multiple flaps in head and neck reconstruction with attention to form, function, outcomes, and complications. Recent findings Multiple free flap reconstructions are technically feasible with high flap survival rates, tolerable complication rates, and overall adequate functional and aesthetic outcomes, given the large extent of the defects and the high surgical complexity of these cases. Summary Multiple free flap reconstructions...
Fri Aug 30, 2019 21:19
Purpose of review To summarize the current evidence on the diagnostic evaluation of cranial cerebrospinal fluid (CSF) leaks and encephaloceles, including laboratory testing and imaging studies. Recent findings The most sensitive and specific laboratory tests for CSF leak diagnosis are beta-2-transferrin and beta trace protein assays, the former more commonly used because of availability. Imaging studies used for localization of the leak site include high resolution computed tomography (HRCT)...
Fri Aug 30, 2019 21:19
Purpose of review The goal of this article is to review the complex topic of total nasal reconstruction and present a wide range of options for completing this difficult surgical procedure. Recent findings Nasal reconstruction has a long history dating back thousands of years. Some historical techniques still exist today, including the paramedian forehead flap. The introduction of free tissue transfer and other pedicled flaps has provided multiple options for the reconstructive surgeon. The...
Fri Aug 30, 2019 21:19
Purpose of review To review the presenting signs and symptoms of spontaneous cerebrospinal fluid (CSF) leaks of the lateral skull base. Recent findings Research continues to demonstrate that CSF leaks from the lateral skull base are insidious, and present with subtle signs and symptoms. Patients commonly present with symptoms of aural fullness, middle ear effusion, and otorrhea following tympanostomy tube insertion that can be confused for chronic otitis media. More recently headache, pulsatile...
Fri Aug 30, 2019 21:19
Purpose of review The incidence of blast injuries has increased, and the ear is the highest risk organ. Ear injury induced by blast exposure is important in both military and civilian conditions. The permanent hearing loss caused by blast exposure is associated with a decline in the quality of life. In this review, I describe recent therapeutic strategies for each of the ear pathologies caused by blast exposure. Recent findings For tympanic membrane perforation after blast exposure, basic...
Fri Aug 30, 2019 21:19
Purpose of review Spontaneous cerebrospinal fluid (sCSF) leaks often occurs in middle age, obese females. Here we investigate the role of obesity, idiopathic intracranial hypertension (IIH), and obstructive sleep apnea (OSA) in the pathophysiology of sCSF leaks. Recent findings The association of obesity and sCSF leaks has been well established in many studies. It has now been revealed that sCSF leak patients have thinner calvariums along with the skull base. An intracranial process likely...
Fri Aug 30, 2019 21:19
Purpose of review To evaluate the impact of cochlear implantation on hearing outcomes, quality of life, complications, and cognitive function in elderly patients. Recent findings Nine articles published between 2014 and 2019 pertain to cochlear implantation in the elderly population. The findings conclude that cochlear implantation improves autonomy and overall quality of life in the elderly. Summary Design: a pubmed search was employed with title search terms ‘cochlear implant,’ AND...
Fri Aug 30, 2019 21:19
Purpose of review The aim of this article is to describe the middle fossa craniotomy (MFC) approach for the repair of cerebrospinal (CSF) fistula and encephaloceles. Recent findings The MFC approach has a greater than 93% success rate for managing CSF fistula and encephaloceles located along the tegmen tympani and tegmen mastoideum. Posterior fossa defects cannot be managed by an MFC approach. Multilayer repair with the combination of soft tissue and durable substances is preferred. Hydroxyapatite...
Fri Aug 30, 2019 21:19
Purpose of review To describe current standard of care for osteoradionecrosis (ORN) of the mandible and report possible future trends. Recent findings Cutting guides may be used to reduce surgical time and possibly improve outcomes. There has also been recent investigation into the use of pentoxifylline and tocopherol or pentoxifylline, tocopherol and clodronate (a well known conservative medial regime) as a prevention for development of ORN after dental extractions and the first randomized...
Fri Aug 30, 2019 21:19
Purpose of review To explore key management principles and outcomes following surgical intervention for spontaneous CSF leaks of the lateral skull base. Recent findings Outcomes following surgery for spontaneous CSF leaks of the lateral skull base depend on the surgical approach utilized. The approach reported most frequently in the literature is currently the middle fossa approach. Mean leak recurrence rates, regardless of approach, were approximately 6%. The lowest leak recurrence rates...
Fri Aug 30, 2019 21:19
Purpose of review Value has become an increasingly important topic in healthcare delivery as our systems attempt to deliver increased value to patients at lower costs. This review highlights research performed regarding value for head and neck cancer reconstruction in three evolving areas: care pathway development, virtual surgical planning (VSP), and free flap versus locoregional flap reconstruction. Recent findings Improvements in quality-driven patient care in head and neck free tissue...
Fri Aug 30, 2019 21:19
Purpose of review To describe the current state in the diagnosis and management of spontaneous cerebrospinal fluid (sCSF) fistula and encephaloceles. Recent findings The increased incidence of obesity has resulted in more cases of sCSF fistula and encephaloceles. Obesity results in increased intracranial pressure and a greater chance of developing a sCSF fistula or encephalocele. Obstructive sleep apnea can also result in transient increase in intracranial pressure and has been shown to be...
Fri Aug 30, 2019 21:19
Purpose of review Anterior skull base reconstruction has rapidly evolved over the past few years as endoscopic approaches to resect tumors in this region have become more established. The present review evaluates the robust amount of new literature on this topic over the past year with particular attention to minimally invasive methods for reconstruction. Recent findings Although vascularized local flaps remain the mainstay reconstructive choice when available for the anterior skull base,...
Fri Aug 30, 2019 21:19
Abstract Background: The microbiological basis of diaper dermatitis has not been clearly elucidated; however, a better understanding of microbial colonization may be vital for developing appropriate therapies. Methods: Using 16S‐rRNA gene sequencing technology, we characterized and compared the bacterial communities obtained from the buttock‐skin sites of children with diaper dermatitis and from healthy controls. Bacterial diversity in the buttock lesion area and subsequent recovery after emollient...
Sat Aug 31, 2019 19:29
Abstract Background Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long‐term functional swallowing impairment, such as feeding tube dependency. Methods Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT....
Sat Aug 31, 2019 15:19
Abstract Background Three different strategies to manage transient hypocalcemia after total thyroidectomy were compared to evaluate cost‐effectiveness. The reliability of total serum calcium (TSCa), ionized calcium (ICa), and intact parathyroid hormone (iPTH) were investigated to achieve this goal. Methods A multicenter, prospective randomized study was carried out with 169 patients. The strategies were “preventive” (oral calcium + vitamin D supplementation), “reactive” (therapy in hypocalcemia),...
Sat Aug 31, 2019 15:19
Abstract Background Transoral vestibular approach endoscopic thyroidectomy has gained popularity worldwide because it avoids a cutaneous incision. Some surgeons have expressed reservations about operating with only 2 instruments in the endoscopic technique, and some therefore utilize an axillary incision as an adjunct to facilitate dissection. The Intuitive da Vinci single port robotic system offers the potential to overcome this limitation without an axillary incision. Methods In this...
Fri Aug 30, 2019 18:05
Abstract Background Magnifying endoscopy with narrowband imaging (ME‐NBI) is useful in predicting the invasion depth by examining the microvascular status of tumor surfaces. This retrospective study aimed to determine its efficacy in pharyngeal cancer. Methods Between April 2016 and March 2018, 59 lesions from 46 patients who underwent transoral resection were retrospectively analyzed. Using ME‐NBI, microvascular status was classified into B1, B2, or B3, based on the classification of the...
Fri Aug 30, 2019 18:03
Zusammenfassung Es gelingt uns zu zeigen, dass eine simultane Versorgung eines Patienten mit einem neuromodulatorischen System zur tiefen Hirnstimulation (DBS) oder zur Okzipitalnervstimulation (ONS) sowie einem Cochleaimplantat eine mögliche Therapieoption ist und beide Systeme in der Lage sind, ohne gegenseitige Beeinflussung zu arbeiten, sodass in Zukunft eine größere Patientenpopulation, die eine Indikation zur Versorgung mit beiden Systemen aufweist, hiervon profitieren kann.
Fri Aug 30, 2019 03:00
Related ArticlesIncidence of anatomical variations according to the International Frontal Sinus Anatomy Classification (IFAC) and their coincidence with radiological sings of opacification. Eur Arch Otorhinolaryngol. 2019 Aug 30;: Authors: Sommer F, Hoffmann TK, Harter L, Döscher J, Kleiner S, Lindemann J, Leunig A Abstract BACKGROUND: The endonasal access to the frontal recess and sinus may be complicated by a variety of anatomical variations. Previous...
Sun Sep 01, 2019 13:56
Related ArticlesPeripheral blood immunological parameters of children with adenoid hypertrophy with otitis media with effusion: propensity score matching. Eur Arch Otorhinolaryngol. 2019 Aug 30;: Authors: Yang W, Zhao Y, Wang J, Yan XH, Shen T, Qiao Y, Ren J, Cheng D, Chen M Abstract PURPOSE: To evaluate peripheral blood immunological parameters and the possible correlation with age, gender and adenoid size in children with adenoid hypertrophy with OME....
Sun Sep 01, 2019 13:56
Related ArticlesXylitol treats nasal mucosa in rhinitis medicamentosa: an experimental rat model study. Eur Arch Otorhinolaryngol. 2019 Aug 29;: Authors: Cam B, Sari M, Midi A, Gergin O Abstract OBJECTIVE: Rhinitis medicamentosa is drug-induced rhinitis which occurs by prolonged and overdose usage of topical nasal decongestants. There is not much of treatment choice rather than nasal steroids. In this pathological study, we have been aimed to represent...
Sat Aug 31, 2019 13:08
Related ArticlesCochlear implant outcomes in the elderly: a uni- and multivariate analyses of prognostic factors. Eur Arch Otorhinolaryngol. 2019 Aug 28;: Authors: Favaretto N, Marioni G, Brotto D, Sorrentino F, Gheller F, Castiglione A, Montino S, Giacomelli L, Trevisi P, Martini A, Bovo R Abstract PURPOSE: To assess preoperative features that could predict the audiological outcome after cochlear implantation in the elderly, in terms of pure tone audiometry,...
Fri Aug 30, 2019 14:24
To evaluate the possible predictive value and clinicopathological characteristics of Delphian lymph node metastasis in papillary thyroid carcinoma.
Fri Aug 30, 2019 03:00
Conservative management of Warthin tumor (WT) may be a viable alternative to surgery, but there are concerns of missed malignancies on fine needle aspiration biopsy (FNAB). The purpose of this study is to meas...
Thu Aug 29, 2019 03:00
The aim of this study is to evaluate the relation between 25-hydroxyvitamin D levels at diagnosis and pathological characteristics in primary invasive melanoma. A cross-sectional study was designed based on a series of 204 consecutive patients diagnosed of invasive melanomas in the 2013–2017 period at a single institution. 25-hydroxyvitamin D serum levels at diagnosis were assessed, and three groups were defined by vitamin D status: deficiency, insufficiency, and sufficiency. Clinical and pathological...
Wed Aug 28, 2019 03:00
MRI LUMBAR SPINE WITH CONTRASTChanges of lumbar spondylosis. Evidence of laminectomy at L4 - L5, mild disc bulge.Diffuse homogeneously enhancing posterior epidural T2 hypo intense soft tissue at laminectomy site, clumping of nerve roots appears adherent to dura at laminectomy level. Available anteroposterior bony canal diameter is approximately 14 mm. L5 sacralisation.Possibility of posterior epidural fibrosis with an associated arachnoiditis suggested for further clinical evaluation.
Sun Sep 01, 2019 16:25
MRI dorsal region shows an intra dural extramedullary well-defined lentiform shaped arachnoid cyst measuring approximately 22x8mm at D3-4 severely compressing cord from posteriorly with cord flattening.Operated with posterior laminectomy.Histo pathology report : Arachnoid cyst.
Sun Sep 01, 2019 15:54
Description of findings:At D11-12 discal and paradiscal involvement. Diffuse altered marrow signals involving vertebral bodies; diffuse low marrow signals on T1w, intermediate signals on T2w. Diffuse high signal intensity on STIR implies to marrow edema. Posterior elements are uninvolved.Intervening intervertebral disc and end plates are destroyed with endplate erosions, reduced height of vertebral bodies due to sub chondral collapse, exaggerated anterior curvature at this level due to anterior wedging...
Sun Sep 01, 2019 15:03
Objective: To discuss an effect of transmastoid repair of superior semicircular canal dehiscence and its resolution using a mastoid titanium mesh plate. Patients: A 53-year-old woman with a history of superior canal dehiscence syndrome (SCDS) and subsequent transmastoid repair experienced dizziness and a loud, drum-like sound in her repaired ear when touching the ear. Palpating the skin over the mastoid defect reproduced the symptoms and could be observed on binocular microscopy as tympanic...
Wed Aug 28, 2019 03:00
Objective: Metastatic lesions to the internal auditory meatus (IAM) and/or the cerebellopontine angle (CPA) are rare and may appear like a vestibular schwannoma (VS). We herein raise the issue of the diagnosis and treatment of nine malignant cases of the CPA and IAM among three referral centers in France and Japan. The aim of this study was 1) to report malignant lesions of the CPA, their diagnosis and treatment, 2) to review the literature, 3) to propose criteria of suspicion for malignant tumors...
Wed Aug 28, 2019 03:00
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