Antidiabetic and Antioxidant Activities of Bioactive Compounds from Endophytes
Authors
Authors and affiliations
Rosa Martha Perez Gutierrez1
Email author
Adriana Neira González2
1.Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industrias ExtractivasInstituto Politecnico Nacional (IPN) Unidad Profesional Adolfo Lopez Mateos S/N Av, Instituto Politécnico Nacional Ciudad de MexicoMexico CityMexico
2.Laboratorio de Productos NaturalesInstituto de Química, Universidad Nacional Autónoma de México, Ciudad UniversitariaMexico CityMexico
Reference work entry
First Online: 12 June 2019
Part of the Reference Series in Phytochemistry book series (RSP)
Abstract
The aim of the present chapter is to appraise the phytochemical and pharmacological potential of the endophytes. This chapter will further highlight the future research prospects of the study of endophytes with antioxidant and antidiabetic activities. Informations on endophytes were obtained from related publications using electronic scientific databases. Based on previous reports, it could be said that the endophytes have emerged as excellent source of compounds which could be used for the treatment of skin diseases and microbial infections and as anticancer and anti-inflammatory agents. The studies provide new knowledge on the isolation and characterization of novel bioactives especially in the discovery of novel therapeutic drugs with antioxidant and antidiabetic properties. however, current research on the pharmacological properties of all the endophyte species including bioassay-guided isolation of phytoconstituents and their mechanism of action, pharmacokinetics, bioavailability, efficacy, and safety should be carried out in the future to add more value to this study.

Keywords
Endophytes Medicinal plants Marine plants Antioxidants Antidiabetic
Abbreviations
ABTS
2,2-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid)

AGEs
Advanced glycation end products

AgNPs
Silver nanoparticles

ALP
Alkaline phosphatase

ALT
Alanine aminotransferase

AMPK
AMP-activated protein kinase

AST
Aspartate aminotransferase

CAT
Catalase

CE6
Not identified

CE9
Not identified

CEC12
Cochliobolus sp.

CED3
Diaporthe sp.

CED4
Diaporthe sp.

CED7
Diaporthe sp.

CEDp11
Diaporthe phaseolorum

CEDp2
Diaporthe phaseolorum

CEP1
Phomopsis sp.

CEP10
Phomopsis sp.

CEP4
Phomopsis sp.

CES13
Sordariomycetes sp.

CES8
Sordariomycetes sp.

CVD
Cardiovascular diseases

DAPG
2,4-Diacetylphloroglucinol

DPPH
1,1-Diphenyl-2-picrylhydrazyl

EtOAc
Ethyl acetate

FRAP
Ferric reducing ability of plasma

FTIR
Fourier-transform infrared spectroscopy

GC-MS
Gas chromatography mass spectrometry

GPx
Glutathione peroxidase

ITS
Internal transcribed spacer

MDA
Malondialdehyde

NCB
Gene sequencing

PMS-NADH
Phenazine methosulfate-nicotinamide adenine dinucleotide

ROS
Reactive oxygen species

SOD
Superoxide dismutase

T2D
Type 2 diabetes mellitus

TEM
Transmission electron microscopy

UV-Vis
Ultraviolet-visible spectroscopy

VOLF4
Aspergillus sp.

VOLF5
Peniophora sp.

VOR5
Fusarium nematophilum

XRD
X-ray diffraction

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