Related ArticlesStudents' expectations in an international Master of Science course in radiation biology. Int J Radiat Biol. 2019 02;95(2):233-237 Authors: Combs SE, Kessel C, Berberat PO, Atkinson MJ Abstract PURPOSE: We assessed students' expectations to a full two-year Master of Science course regarding workload, extracurricular activities, learning methods, and career plans. MATERIALS AND METHODS: A questionnaire was handed out to all students...
Related ArticlesPrognostic Role and Clinical Association of Tumor-Infiltrating Lymphocyte, Programmed Death Ligand-1 Expression with Neutrophil-Lymphocyte Ratio in Locally Advanced Triple-Negative Breast Cancer. Cancer Res Treat. 2019 Apr;51(2):649-663 Authors: Lee J, Kim DM, Lee A Abstract PURPOSE: Tumor-infiltrating lymphocyte (TIL), programmed death-ligand 1 (PD-L1) expression and neutrophil-to-lymphocyte ratio (NLR) is associated to immunogenicity...
Current and potential future role of PSMA-PET in patients with castration-resistant prostate cancer.
Related ArticlesCurrent and potential future role of PSMA-PET in patients with castration-resistant prostate cancer. World J Urol. 2019 Mar;37(3):457-467 Authors: Fankhauser CD, Poyet C, Kroeze SGC, Kranzbühler B, Schüler HIG, Guckenberger M, Kaufmann PA, Hermanns T, Burger IA Abstract PURPOSE: To review the current literature and discuss potential future roles of the novel positron emission tomography (PET) tracers targeting the prostate-specific membrane...
Related ArticlesEGFR Mutation Is Associated with Short Progression-Free Survival in Patients with Stage III Non-squamous Cell Lung Cancer Treated with Concurrent Chemoradiotherapy. Cancer Res Treat. 2019 Apr;51(2):493-501 Authors: Park SE, Noh JM, Kim YJ, Lee HS, Cho JH, Lim SW, Ahn YC, Pyo H, Choi YL, Han J, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ Abstract PURPOSE: This study was conducted to evaluate the relationship between epidermal growth factor...
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Decoupling developmental apoptosis and neuroblast proliferation in Drosophila. Dev Biol. 2019 Aug 04;: Authors: Harding K, White K Abstract Cell proliferation and cell death are opposing but fundamental aspects of development that must be tightly controlled to ensure proper tissue organization and organismal health. Developmental apoptosis of abdominal neuroblasts in the Drosophila ventral nerve cord is controlled by multiple upstream spatial and temporal...
MICRORNA-221 IS OVEREXPRESSED IN THE EQUINE ASTHMATIC AIRWAY SMOOTH MUSCLE AND MODULATES SMOOTH MUSCLE CELL PROLIFERATION. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 07;: Authors: Issouf M, Vargas A, Boivin R, Lavoie JP Abstract Airway wall remodeling, including hyperplasia and hypertrophy of smooth muscle cells (ASM) leading to increased smooth muscle mass, is considered central to asthma. However, molecular pathways responsible for ASM remodeling...
Urinary cell cycle arrest biomarker [TIMP-2]·[IGFBP7] in patients with hepatorenal syndrome. Biomarkers. 2019 Aug 07;:1-29 Authors: Zhang CC, Hoffelt DAA, Merle U Abstract Patients with hepatorenal syndrome carry a high short-term mortality. Early diagnosis and treatment are essential for patients` outcome. Nevertheless diagnosis of HRS remains difficult. First-line therapy terlipressin is often associated with severe complications. Biomarkers become...
Related ArticlesPerturbation of tubulin structure by stellate gold nanoparticles retards MDA-MB-231 breast cancer cell viability. J Biol Inorg Chem. 2019 Aug 06;: Authors: Nirmala JG, Beck A, Mehta S, Lopus M Abstract Gold nanoparticles (GNPs) of different sizes and shapes have been investigated extensively for their therapeutic potential against several diseases including cancer. However, the mechanisms with which they affect the cells are yet to be...
Related ArticlesCyclin-dependent kinase inhibitor 2B gene is associated with the sensitivity of hepatoma cells to Sorafenib. Onco Targets Ther. 2019;12:5025-5036 Authors: Weng X, Zeng L, Yan F, He M, Wu X, Zheng D Abstract Purpose: The sensitivity of advanced hepatocellular carcinoma (HCC) to Sorafenib is low. The purpose of this study was to investigate the effects of cyclin-dependent kinase inhibitor 2B (CDKN2B) gene on the prognosis of HCC and the...
Related ArticlesDistinct roles of cohesin acetyltransferases Esco1 and Esco2 in porcine oocyte meiosis I. Cell Cycle. 2019 Aug 06;:1-14 Authors: Lu Y, Chen Y, Cui Z, Xiong B Abstract In mammalian cells, cohesin acetyltransferases Esco1 and Esco2 acetylate cohesin subunit Smc3 to establish chromosome cohesion, ensuring the accurate chromosome segregation. However, we have previously documented that both Esco1 and Esco2 have unique substrates and roles...
Related ArticlesCDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1. Cells. 2019 Aug 05;8(8): Authors: Kim JE, Park H, Choi SH, Kong MJ, Kang TC Abstract 2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester (CDDO-Me) is a triterpenoid analogue of oleanolic acid that exhibits promising anti-cancer, anti-inflammatory, antioxidant and neuroprotective activities....
Related ArticlesAnti-Proliferative and Pro-Apoptotic Effects of Licochalcone A through ROS-Mediated Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells. Int J Mol Sci. 2019 Aug 05;20(15): Authors: Hong SH, Cha HJ, Hwang-Bo H, Kim MY, Kim SY, Ji SY, Cheong J, Park C, Lee H, Kim GY, Moon SK, Yun SJ, Chang YC, Kim WJ, Choi YH Abstract Licochalcone A (LCA) is a chalcone that is predominantly found in the root of Glycyrrhiza species, which is widely...
Related ArticlesPolyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189 Authors: He J, Yu S, Guo C, Tan L, Song X, Wang M, Wu J, Long Y, Gong D, Zhang R, Cao Z, Li Y, Peng C Abstract Paris polyphylla. is a traditional medicinal herb that has long been used to prevent cancer in many Asian countries. Polyphyllin...
Related ArticlesCKLF1 aggravates neointimal hyperplasia by inhibiting apoptosis of vascular smooth muscle cells through PI3K/AKT/NF-κB signaling. Biomed Pharmacother. 2019 Sep;117:108986 Authors: Duan Y, Zhang Y, Qu C, Yu W, Tana, Shen C Abstract Chemokine-like factor 1 (CKLF1) is a cytokine, which has a detrimental effect on the multiple disease progression. Our previous studies reported that arterial injury induced the upregulation of CKLF1 expression...
Related ArticlesRNA-sequencing Profiles of Cell Cycle-Related Genes Upregulated during the G2-Phase in Giardia lamblia. Korean J Parasitol. 2019 Apr;57(2):185-189 Authors: Kim J, Shin MY, Park SJ Abstract To identify the component(s) involved in cell cycle control in the protozoan Giardia lamblia, cells arrested at the G1/S- or G2-phase by treatment with nocodazole and aphidicolin were prepared from the synchronized cell cultures. RNA-sequencing analysis...
Related ArticlesMoringin from Moringa Oleifera Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors. Int J Mol Sci. 2019 Apr 19;20(8): Authors: Cirmi S, Ferlazzo N, Gugliandolo A, Musumeci L, Mazzon E, Bramanti A, Navarra M Abstract In the last decades, glucosinolates (GLs), precursors of isothiocyanates (ITCs), have been studied mostly for...
Related ArticlesVaricella Zoster Virus vasculopathy in a patient treated with immune checkpoint inhibitor for lung cancer. Rev Neurol (Paris). 2019 Jan - Feb;175(1-2):95-97 Authors: Ursu R, Roumi A, Chouahnia K, Altmayer V, Cuzzubbo S, Carpentier AF PMID: 30309661 [PubMed - indexed for MEDLINE]
Related ArticlesNovel ESCRT functions at kinetochores. Aging (Albany NY). 2018 Mar 20;10(3):299-300 Authors: Petsalaki E, Zachos G PMID: 29562220 [PubMed - indexed for MEDLINE]
Related ArticlesTraditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer. Cancer Med. 2018 04;7(4):1546-1559 Authors: Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P Abstract Traditional Chinese medicine (TCM) has a combined therapeutic result in cancer treatment by integrating holistic and local therapeutical effects, by which TCM can enhance...
Related ArticlesYL143, a novel mutant selective irreversible EGFR inhibitor, overcomes EGFRL858R, T790M -mutant resistance in vitro and in vivo. Cancer Med. 2018 04;7(4):1430-1439 Authors: Zhang Z, Zou J, Yu L, Luo J, Li Y, Tu Z, Ren X, Wei H, Song L, Lu X, Ding K Abstract YL143 was identified as a novel wild-type sparing EGFRT790M inhibitor with good pharmacokinetic properties. It potently suppresses EGFRL858R/T790M with an 50% inhibitory concentration...
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Related ArticlesHER2 double-equivocal breast cancer in Chinese patients: a high concordance of HER2 status between different blocks from the same tumor. Breast Cancer Res Treat. 2019 Aug 06;: Authors: Liu Y, Wu S, Shi X, Luo Y, Pang J, Wang C, Mao F, Liang Z, Zeng X Abstract PURPOSE: Human epidermal growth factor receptor 2 (HER2) status is both an independent prognostic factor and a predictive factor for the efficacy of targeted therapy for breast cancer,...
Related ArticlesVasculogenic mimicry is associated with trastuzumab resistance of HER2-positive breast cancer. Breast Cancer Res. 2019 Aug 06;21(1):88 Authors: Hori A, Shimoda M, Naoi Y, Kagara N, Tanei T, Miyake T, Shimazu K, Kim SJ, Noguchi S Abstract BACKGROUND: Trastuzumab is a drug that targets the receptor tyrosine kinase HER2 and is essential for the treatment of HER2-positive breast cancer. Resistance to the drug leads to severe consequences,...
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Related ArticlesGeospatial Analysis of Trauma Burden and Surgical Care Capacity in Teso Sub-region of Eastern Uganda. World J Surg. 2019 Aug 06;: Authors: Lin N, Nwanna-Nzewunwa O, Carvalho M, Wange A, Ajiko MM, Juillard C, Dicker RA Abstract INTRODUCTION: Over 90% of injury-related deaths occur in low- and middle-income countries. Relating spatial distribution of injury burden and trauma care capacity is crucial for effective resource allocation. Our...
Related ArticlesPostoperative Long-Term Outcomes in Elderly Patients with Gastric Cancer and Risk Factors for Death from Other Diseases. World J Surg. 2019 Aug 06;: Authors: Hashimoto T, Kurokawa Y, Mikami J, Takahashi T, Miyazaki Y, Tanaka K, Makino T, Yamasaki M, Motoori M, Kimura Y, Nakajima K, Mori M, Doki Y Abstract BACKGROUND: Elderly patients with gastric cancer are frequently treated surgically in current clinical practice. Although several studies...
Related ArticlesInvited Commentary Re: Early Chemical Thromboprophylaxis does not Increase the Risk of Intracranial Hematoma Progression in Patients with Isolated Severe Traumatic Brain Injury. World J Surg. 2019 Aug 06;: Authors: Benjamin E PMID: 31388705 [PubMed - as supplied by publisher]
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Related ArticlesFatal Right Ventricular Free Wall Rupture During Percutaneous Coronary Intervention for Inferior Acute Myocardial Infarction. Am J Case Rep. 2019 Aug 07;20:1155-1158 Authors: Ueno D, Nomura T, Ono K, Sakaue Y, Hori Y, Yoshioka K, Kikai M, Keira N, Tatsumi T Abstract BACKGROUND Ventricular rupture is a complication of acute myocardial infarction (AMI) that results in hemopericardium and cardiac tamponade and has a high mortality rate....
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Related Articles[Discovery of a new division system in brain and the regionalized drainage route of brain interstitial fluid]. Beijing Da Xue Xue Bao Yi Xue Ban. 2019 Jun 18;51(3):397-401 Authors: Han HB Abstract Brain extracellular space (ECS) is a narrow, irregular space, which provides immediate living environment for neural cells and accounts for approximately 15%-20% of the total volume of living brain. Twenty-five years ago, as an interventional...
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Related ArticlesPreclinical discovery and development of fingolimod for the treatment of multiple sclerosis. Expert Opin Drug Discov. 2019 Aug 07;:1-14 Authors: Volpi C, Orabona C, Macchiarulo A, Bianchi R, Puccetti P, Grohmann U Abstract Introduction: Fingolimod, the first oral disease-modifying treatment (DMT) in multiple sclerosis (MS), is a sphingosine 1-phosphate receptor (S1PR) ligand. Approved in 2010, fingolimod has been extensively studied and...
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Related ArticlesDifferential Diagnosis of Epithelioid Malignant Mesothelioma With Lung and Breast Pleural Metastasis: A Systematic Review Compared With a Standardized Panel of Antibodies-A New Proposal That May Influence Pathologic Practice. Arch Pathol Lab Med. 2019 Aug 07;: Authors: Le Stang N, Burke L, Blaizot G, Gibbs AR, Lebailly P, Clin B, Girard N, Galateau-Sallé F, MESOPATH and EURACAN networks Abstract CONTEXT.—: Pleural mesothelioma is a rare...
Related ArticlesEmergency response to radiological and nuclear accidents and incidents. Br J Haematol. 2019 Aug 06;: Authors: Gale RP, Armitage JO, Hashmi SK Abstract Bone marrow damage is an important consequence of exposure to acute high-dose whole-body radiation. As such, haematologists can play an important role in managing this complication. However, these accident and incident scenarios are complex and often involve injuries to other organs and...
Related ArticlesMalignant solitary fibrous tumour of the kidney with an extensive thrombus: A case report and review of the literature. Urol Case Rep. 2019 Sep;26:100974 Authors: Couture F, Legault B, Ekindi N, Noel-Lamy M, Pavic M, Richard PO Abstract Solitary fibrous tumours (SFTs) are neoplasms originating from mesenchymal cells, usually found in lung pleura. Extrapleuritic lesions are extremely rare, with about 60 cases of SFTs of the kidney available...
Large cell neuroendocrine carcinoma of the submandibular gland: a case report and literature review.
Related ArticlesLarge cell neuroendocrine carcinoma of the submandibular gland: a case report and literature review. Pathologica. 2019 Jun;111(2):70-75 Authors: Mascitti M, Luconi E, Togni L, Rubini C Abstract Neuroendocrine tumors (NET) are a heterogeneous group of malignancies with a broad spectrum of histomorphologies, tissue origins, and clinical outcomes, which arise from neural crest cells with neuroendocrine differentiation. Salivary gland tumors...
Related ArticlesLong-Term Survival and Complete Response to Anastrozole in Breast Cancer Patient With Cutaneous Metastases Only. Anticancer Res. 2019 Aug;39(8):4393-4398 Authors: Sedloev T, Vlahova A, Usheva S, Vasileva-Slaveva M, Spiridonova T, Spirdonov J Abstract BACKGROUND/AIM: Metastatic breast cancer (MBC) represents a wide spectrum of heterogeneous conditions with different secondary spread sites, time to relapse and biology. MBC is still considered...
Related ArticlesChronic Myeloid Leukemia as Secondary Malignancy Following the Treatment of Hodgkin Lymphoma: A Case Series. Anticancer Res. 2019 Aug;39(8):4333-4335 Authors: Millett R, Aggarwal A, Tabbara I, Nassereddine S Abstract Secondary malignancies are relatively common and clinically important phenomena following both chemotherapy and radiotherapy. The majority of these cases are acute leukemias, the occurrence of which have been thoroughly...
Related ArticlesCirculating Protein Biomarkers to Differentiate Uterine Sarcomas from Leiomyomas. Anticancer Res. 2019 Aug;39(8):3981-3989 Authors: Glorie N, Baert T, VAN DEN Bosch T, Coosemans AN Abstract Uterine sarcomas are rare but very aggressive. Uterine myomas, on the other hand, are the most common benign tumors of the uterus. Currently there is no diagnostic technique available to distinguish them with certainty. This study aimed to summarize...
Related ArticlesRapidly Progressive Malignant Fibrous Histiocytoma of Right Atrium: a Rare Case Report. Braz J Cardiovasc Surg. 2019 06 01;34(3):372-376 Authors: Aksu T, Gode S, Oz K, Ersoy B, Ustunısık CT, Guner Y, Atay OF, Erentug V Abstract We are going to present a case of malignant fibrous histiocytoma in the right atrium, which is a very rare entity. The patient had a right atrial mass, which prolapsed through the tricuspid valve into the right...
Related ArticlesTumour-induced Osteomalacia Secondary to Intracranial Tumours - Report of 2 Cases. J Assoc Physicians India. 2019 Apr;67(4):85-86 Authors: Gunawat PV, Shaikh ST, Deopujari CE Abstract Tumor induced osteomalacia (TIO) is a paraneoplastic syndrome which is mostly caused by a phosphaturic mesenchymal tumour mixed connective tissue variant (PMTMCT). These tumours do not have any specific site predilection but their presence in cranial compartment...
Related ArticlesBilateral mantle cell lymphoma of the ciliary body that responded to a combined local radiotherapy and chemotherapy regimen: a case report. BMC Cancer. 2019 Apr 15;19(1):355 Authors: Pei M, Zhao C, Gao F, Zhang M Abstract BACKGROUND: Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) that often affects men over the age of 60. Systemic metastasis of MCL to eyes is rare and intraocular involvement is even...
Related ArticlesAdult neuroblastoma: a rare diagnosis of an adrenal mass. BMJ Case Rep. 2019 Apr 11;12(4): Authors: Ramsingh J, Casey H, Watson C Abstract A 22-year-old woman presented to her local district hospital with left-sided abdominal pain. She denied any urinary or gastrointestinal symptoms. She had a CT scan of her abdomen which showed a probable 8Ã5Ã8âcm left-sided adrenal mass. Functional tests for hormone excess were negative. She was referred...
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