One of the big challenges in robotics is to endow agents with autonomous and adaptive capabilities. With this purpose, we embedded a cerebellum-based control system into a humanoid robot that becomes capable of handling dynamical external and internal complexity. The cerebellum is the area of the brain that coordinates and predicts the body movements throughout the body-environment interactions. Different biologically plausible cerebellar models are available in literature and have been employed...
2h
Abstract In this study, polynomial function modeling and rational function modeling were used to create three new models for the estimation of diffuse solar radiation on a tilted surface, which is the most important and necessary parameter for solar energy systems. Solar radiation data used in the study were obtained from the Turkish State Meteorological Service. The new model, created using the rational function modeling for the first time, displayed a better performance than...
2h
El ayuno de día alternativo mejoró los marcadores fisiológicos y moleculares del envejecimiento en humanos sanos y no obesos
2h
Se analizan las evidencias acerca de las intervenciones disponibles
2h
El tratamiento del VIH puede reducir la carga viral a niveles en los que el riesgo de transmisión es muy bajo o inexistente.
18h
Para detener las enfermedades transmitidas por mosquitos, preste atención a cómo se comportan los humanos
20h
Los anestesiólogos advierten que se necesita más investigación, preocupados por el malentendido del público sobre los riesgos y los efectos secundarios.
20h
Las conversaciones automatizadas de mensajes de texto aumentaron la tasa de colonoscopias del 62 al 90 por ciento
20h
The Journal of Alternative and Complementary Medicine, Ahead of Print.
2h
Abstract Background Accidental Accidental awareness during general anesthesia (AAGA) occurs in 1–2% of high-risk practice patients and is a cause of severe psychological trauma, termed post-traumatic stress disorder (PTSD). However, no monitoring techniques can accurately predict or detect AAGA. Since the first reflex for a patient during AAGA is to move, a passive brain-computer interface (BCI) based on the detection of an intention...
2h
Abstract Background Clinical trials management can be studied using project management theory. The CYCLE pilot randomized controlled trial (RCT) was conducted to determine the feasibility of a future rehabilitation trial of early in-bed cycling in the intensive care unit (ICU). In-bed cycling is a novel intervention, not typically available in ICUs. Implementation of this intervention requires personnel with specialized clinical...
2h
Abstract Background A classical approach to produce interscalene brachial plexus block (ISBPB) consistently spares the posterior aspect of the shoulder and ulnar sides of the elbow, forearm, and hand, which are innervated by the lower trunk of the brachial plexus (C8–T1). As an alternative to the classical approach, a caudal approach to ISBPB successfully produces anesthesia of the ulnar sides of the elbow, forearm, and hand. However,...
2h
Abstract Background Clinical Trials Registry - India (CTRI) was established in July 2007 and today hosts thousands of trials, a significant fraction of them registered in the last couple of years. We wished to undertake an up-to-date analysis of specific fields of the registered trials. In doing so we discovered problems with the quality of the data, which we describe in this paper. ...
2h
Abstract Background Carpal tunnel syndrome (CTS) is a common cause of pain, weakness, sensory loss, and activity limitations. Currently, the most common initial treatment is use of a rigid splint immobilizing the wrist, usually during night-time, for several weeks. Evidence regarding the efficacy and effect durability of wrist splinting is weak. The treatment is associated with costs and may cause discomfort and limit daily and work...
15h
Tuberculosis, drug-resistant: Tuberculosis (TB) that does not respond to standard drug treatment. Drug-resistant TB has become a very serious problem in recent years in certain populations. For example, TB resistant to the drug isoniazid (INH) is seen among patients from Southeast Asia. The reason for this INH resistance is not quite clear. However, the presence of INH-like substances in the cough syrups in that part of the world may play a role in causing the INH resistance. An even more serious...
2h
Abstract T cell receptor (TCR) gene-engineered T cells have shown promise in the treatment of melanoma and synovial cell sarcoma, but their application to epithelial cancers has been limited. The identification of novel therapeutic TCRs for the targeting of these tumors is important for the development of new treatments. Here, we describe the preclinical characterization of a TCR directed against Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1, encoded by CT83), a cancer germline...
2h
Abstract Background A sequential combination of radiochemotherapy/endocrinotherapy and cytokine-induced killer cell (CIK) infusion has been shown to be an effective therapy for post-mastectomy breast cancer based on statistical analysis of the patient population. However, whether an individual could obtain an improved prognosis from CIK cell-based treatment remains unknown. In the present study, we focused on immune microenvironment...
16h
Abstract Background Although there are numerous reports focusing on surgical indication for intraductal papillary mucinous neoplasm (IPMN), the recurrence patterns following surgery are less widely reported. To ascertain optimal treatment and postoperative surveillance for IPMN patients, we analyzed patterns and risk factors for recurrence after surgery for IPMN. Methods ...
2h
Abstract Background The EGFR ligand betacellulin (BTC) has been previously shown to protect mice against experimentally induced acute pancreatitis (AP). BTC binds both autonomous ERBB receptors EGFR and ERBB4. In this study, we evaluated the mechanism underlying the protection from AP-associated inflammation in detail. Methods AP was induced with cerulein...
13h
Many people develop bumps on the skin after waxing. In this article, we look at how to prevent and treat bumps after waxing, as well as why they develop.
2h
Doctors do not currently recognize breast implant illness as a medical condition. However, many people report experiencing it. Learn more here.
2h
Abstract Background Due to limited therapeutic options, vancomycin-resistant Enterococcus faecium (VREF) is of great clinical significance. Recently, rising proportions of vancomycin resistance in enterococcal infections have been reported worldwide. This study aims to describe current epidemiological trends of VREF in German hospitals and to identify factors that are associated with an increased likelihood of vancomycin resistance...
2h
Abstract Background To quantify the five year incidence trend of all healthcare-associated infections (HAI) using a real-time HAI electronic surveillance system in a tertiary hospital in Beijing, China. Methods The real-time surveillance system scans the hospital’s electronic databases related to HAI (e.g. microbiological reports and antibiotics...
15h
Abstract In 2012, the Dutch Working Party for Infection Control (WIP) issued the first Guideline for prevention of transmission of highly-resistant micro-organisms (HRMO) in Hospitals. The next step was to focus on long-term care facilities (LTCFs) both for nursing homes as for small-scale living facilities with nursing home care. These facilities providing care for residents with functional disabilities, chronical illnesses and cognitive disorders, such as dementia. The objective...
15h
Abstract Background Escherichia coli is one of the most common strains of extended-spectrum β-lactam (ESBL)-producing bacteria, and the prevention and treatment of ESBL-producing E. coli infections is an ongoing challenge. The clinical characteristics and outcomes of ESBL-producing E. coli bacteremia in non-transplant patients remain to be elucidated. Methods ...
15h
Abstract Introduction Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by interleukin (IL)-1 overproduction. Colchicine is the mainstay drug in the treatment of FMF; however, a minority of patients do not respond despite the highest tolerated doses. We aimed to share our experience with canakinumab, a human monoclonal antibody against IL-1β, in pediatric FMF patients. ...
2h
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
2h
Contributors : Luigi Ombrato ; Ilaria Malanchi ; Probir Chakravarty ; Miriam Llorian-SopenaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe analysed the signature of the non-immune cells from the metastatic niche and the distal lung using the breast tumour 4T1 cell line as a model of lung metastasis from breast cancer
2h
Series Type : Expression profiling by arrayOrganism : Homo sapiensTo comprehensively screen for the changed genes in the MSCs that make up the microenvironment of cancer cells, the characteristics of the risk genes considered in this analysis were compared using microarray analysis.
2h
Contributors : Aurélie Bousard ; Ana Raposo ; Jan J Zylicz ; Christel Picard ; Vanessa Borges Pires ; Yanyan Qi ; Laurène Syx ; Howard Chang ; Edith Heard ; Simão Teixeira da RochaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusXist RNA has been established as the master regulator of X-chromosome inactivation in female eutherian mammals but its mechanism of action remain unclear. By creating novel Xist mutants at the endogenous locus in...
2h
Contributor : Matthew J LozaSeries Type : Expression profiling by arrayOrganism : Homo sapiensCSF-1 is a key regulator of the macrophage lineage. Macrophages are key mediators of inflammation, cancer, and homeostasis and in some cases differentiate from infiltrating blood monocytes. To better understand the the impact of CSF-1 on blood monocytes, transcriptomic changes in ex vivo cultured human whole blood were measured 4 and 24 hrs after addition of CSF-1 and compared to blood cultured without...
2h
Contributors : Anna C Castelo Branco ; Maria Notomi SatoSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensTo evaluate the effect of histamine on LPS induced proinflammatory state of purified monocytes from healthy adults and newborns, we performed a qPCR for 84 genes related to toll-like receptor (TLR) signalling
2h
Contributor : Matthew J LozaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTNF-a is elevated in a variety of inflammatory disease involving epithelial tissues. To better understand the the impact of TNF-a on epithelial biology, 3 epithelial cell lines were cultured with and without TNFa and the transcriptomes compared using were profiled using Affymetrix GeneChip® HG-U133+2 array or HG-U133+PM arrays.
2h
Contributors : Aurélie Bousard ; Ana Raposo ; Jan J Zylicz ; Christel Picard ; Vanessa Borges Pires ; Yanyan Qi ; Laurène Syx ; Howard Chang ; Edith Heard ; Simão Teixeira da RochaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusXist RNA has been established as the master regulator of X-chromosome inactivation in female eutherian mammals but its mechanism of action remain unclear. By creating novel Xist mutants at the endogenous locus in mouse embryonic...
2h
Contributor : Bo ChenSeries Type : Expression profiling by arrayOrganism : Danio rerioWe employed DNA microarray to figure out the possible mechanism of BBR on zebrafish NAFLD model
2h
Contributors : Laura Garcia-Perez ; Frank StaalSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusT cell factor 1 (Tcf1) is the first T cell‒specific protein induced in multipotent progenitors following Notch signaling in the thymus, leading to the activation of two major target genes, Gata3 and Bcl11b. Tcf1 deficiency results in partial arrests in T cell development high apoptosis, and increased development of B cells and myeloid cells. Phenotypically,...
2h
Contributors : Irit Reichenstein ; Eran HornsteinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMotor-neuron specific microRNA-218 (miR-218) was recently put in the spotlight because of its striking roles in mouse development. However, miR-218 relevance to human motor neuron disease was not yet explored. Here, we demonstrate by neuropathology that miR-218 is abundant in healthy human motor neurons. However, in amyotrophic lateral sclerosis (ALS) motor neurons...
2h
Contributors : Joe Sorg ; Marc MonotSeries Type : Expression profiling by high throughput sequencingOrganism : Clostridioides difficileClostridium difficile epidemic strain R20291 was grown in presence of the two main bile acids, Deoxycholate and Cholate.
2h
Contributors : Manonmani Soundararajan ; Tobias A OelschlaegerSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliRapidly growing antibiotic resistance among gastrointestinal pathogens, and the ability of antibiotics to induce the virulence of these pathogens makes it increasingly difficult to rely on antibiotics to treat gastrointestinal infections. The probiotic E. coli strain Nissle 1917 (EcN) is the active component of the pharmaceutical preparation Mutaflor®...
7h
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