There is an increasing clinical interest in the measure and achievement of minimal residual disease (MRD) negativity in the bone marrow of Multiple Myeloma (MM) patients, as defined equally either by Multicolor Flow Cytometry (MFC) or by Next Generation Sequencing (NGS) technologies. At present, modern technologies allow to detect up to one on 104 or on 105 or even on 106 cells, depending on their throughput. MFC approaches, which have been progressively improved up to the so-called Next Generation...
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Within heterogeneous tumors, cancer stem cell (CSC) populations exhibit the greatest tumor initiation potential, promote metastasis, and contribute to therapy resistance. For breast cancer specifically, CSCs are identified by CD44highCD24low cell surface marker expression and increased aldehyde dehydrogenase activity. In general, bulk breast tumor cells possess altered energetics characterized by aerobic glycolysis. In contrast, breast CSCs appear to have adaptive metabolic plasticity that allows...
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Background. Adjuvant chemotherapy after resection of colorectal cancer (CRC) lung metastases may reduce recurrences and improve survival. The choice of best candidates for adjuvant chemotherapy in this setting is controversial, especially when a single lung metastases is resected. The aim of this study is to evaluate the risk of recurrence after radical resection for single lung metastasis from colorectal cancer (CRC). Patients and methods. Demographic, clinical and pathological data were retrospectively...
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Human glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical resection followed by radiation and chemotherapy but it only provides short-term benefits and the prognosis of these brain tumors is still very poor. Glioblastomas contain a population of glioma stem cells (GSCs), with self-renewal ability, which are partly responsible for the tumor resistance to therapy and for the tumor recurrence after treatments. The human adult subventricular...
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Glioblastoma multiforme (GBM) is the grade 4 and the most aggressive form of glioma, with a poor response to current treatments. The expression of microRNAs (miRNAs) is widely dysregulated in various cancers, including GBM. One of the overexpressed miRNAs in GBM is miR-21 which promotes proliferation, invasion and metastatic behaviors of tumor cells. With a size of 30-100 nm, the extracellular vesicles “exosomes” have emerged as a novel and powerful drug delivering systems. Recently, exosomal transfer...
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Objective: Response-shift has been cited as an important measurement consideration when assessing patient reported quality of life (QoL) outcomes over time among patients with severe chronic conditions. Here we report the results of a systematic review of response shift in studies assessing QoL among cancer patients. Methods: A systematic review using MEDLINE, EMBASE, and PsychINFO along with a manual search of the cited references of the articles selected, was conducted. A quality review was...
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Background: Lung adenocarcinoma is a common respiratory malignancy, however urethral metastasis of lung adenocarcinoma has not yet been reported. This study aims to present a rare case of isolated urethral metastasis in a male patient with a history of primary lung adenocarcinoma. Case presentation: A 69-year-old male patient was admitted complaining of dysuria and nocturia for 3 months, with a history of lung adenocarcinoma after surgery. The patient was diagnosed as benign prostatic hyperplasia...
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Background: Glyoxalase-I (Glo-I) is essential for detoxification of methylglyoxal (MGO), a byproduct of glycolysis. Overexpression of Glo-I has been linked to multi-drug resistance in cancer therapy. The aim of this study was to analyze Glo-I in hepatocellular carcinoma (HCC) and the effect of the multi-tyrosine kinase inhibitor sorafenib on Glo-I. Methods: Expression and specific activity of Glo-I was measured in human HCC samples, HCC-cell lines (HepG2, Huh7) and a hepatocyte cell line (AML...
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Objectives: The role of postoperative radiotherapy (PORT) in the treatment of patients with completely resected non-small cell lung cancer (NSCLC) is not clear. Few study explored the trends of the PORT use. In this study, we examine the status of PORT use of completely resected NSCLC in mainland China. Methods: From 2005 to 2014, patients with primary lung cancer from eight hospitals across seven geographic regions of mainland China were selected. Then patients with staged Ⅰ-ⅢA NSCLC receiving...
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Abstract: Chimeric antigen receptor (CAR) T cells are emerging as a novel treatment for patients with refractory/relapsed B-cell non-Hodgkin lymphoma (B-NHL), and combination with PD1 inhibitors may further improve the efficacy of anti-CD19 CAR (CD19 CAR)-T cells in the treatment of lymphomas. In a single-center study, we evaluated the safety and efficacy of a combination therapy with CD19 CAR-T cells and an anti-PD-1 antibody (nivolumab) in patients with relapsed/refractory B-NHL. A total of...
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Background: The chemotherapy response score (CRS) has emerged as a simple and reproducible histopathological grading system for assessing chemotherapy response in patients affected by ovarian high-grade serous carcinoma. Objective: To evaluate the prognostic impact of histological tumor response in ovarian and omental surgical specimens from patients with advanced stage ovarian high-grade serous carcinoma. Study Design: A cohort of 161 women were identified from the database of Department of Gynecology,...
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This study aimed to explore the age-specific effects of P2X7 receptor (P2X7R) knockout on olfactory function in mice. In this study, we analyzed olfactory functions of 2-month-old, 10-month-old and 18-month-old female P2X7R KO mice and age-matched female C57BL/6 wildtype mice (WT mice) by buried food seeking test and olfactory avoidance test. The structure of mitochondria and synapses in olfactory bulb were observed by electron microscopy. The content of interleukin-1 (IL-1β) in olfactory bulb and...
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The hypnotic effect of propofol involves inhibition of GABAergic neurons in the lateral hypothalamus
Propofol is widely used for induction and maintenance of anaesthesia, which causes a rapid loss of consciousness. So far the mechanisms underlying the effect of propofol are still largely unknown. Here, we found that microinjection of propofol in the lateral hypothalamus caused a significant decrease in wakefulness and an increase in the amount of non-rapid eye movement sleep and rapid eye movement sleep. Application of propofol in the lateral hypothalamus affected the electroencephalogram power...
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Cognitive dysfunction accompanied by neurofibromatosis type 1 is one of the significant characteristics of this neurocutaneous disorder and has a serious impact on patients’ quality of life. Although studies on cognitive function in children with neurofibromatosis type 1 have revealed that attentional impairment is a key deficit in these patients, few studies have examined their neuropsychological profile, especially whether the attentional function is also abnormal and specific in adult patients...
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This company has helped fuel the revolution in single-cell sequencing, which has accelerated discoveries in cancer, immunology and neuroscience. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Upadacitinib is for adults with moderately to severely active rheumatoid arthritis who fail to respond adequately or are intolerant to methotrexate.FDA Approvals (Source: Medscape Allergy Headlines)
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Long-term tolerance of islet allografts may be possible without prolonged immunosuppression, according to studies in monkeys.Reuters Health Information (Source: Medscape Allergy Headlines)
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The enzyme telomerase ensures the integrity of linear chromosomes by maintaining telomere length. As a hallmark of cancer, cell immortalization and unlimited proliferation is gained by reactivation of telomerase. However, a significant fraction of cancer cells instead uses alternative telomere lengthening mechanisms to ensure telomere function, collectively known as Alternative Lengthening of Telomeres (ALT). Although the budding yeast Naumovozyma castellii (Saccharomyces castellii) has a proficient...
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In this paper we propose a Bayesian multi-output regressor stacking (BMORS) model that is a generalization of the multi-trait regressor stacking method proposed by Spyromitros-Xioufis et al. (2012; 2016). The proposed BMORS model consists of two stages: in the first stage, a univariate genomic best linear unbiased prediction (GBLUP including genotype x environment interaction GE) model is implemented for each of the traits under study; then the predictions of all traits are included as covariates...
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Compared to angiosperms, gymnosperms lag behind in the availability of assembled and annotated genomes. Most genomic analyses in gymnosperms, especially conifer tree species, rely on the use of de novo assembled transcriptomes. However, the level of allelic redundancy and transcript fragmentation in these assembled transcriptomes, and their effect on downstream applications have not been fully investigated. Here, we assessed three assembly strategies for short-reads data, including the utility of...
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Recent advancements in phenomics coupled with increased output from sequencing technologies can create the platform needed to rapidly increase abiotic stress tolerance of crops, which increasingly face productivity challenges due to climate change. In particular, highthroughput phenotyping (HTP) enables researchers to generate large-scale data with temporal resolution. Recently, a random regression model (RRM) was used to model a longitudinal rice projected shoot area (PSA) dataset in an optimal...
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A persistent headache, or a headache that won’t go away, can have many causes. This article discusses common causes, treatment options, and when to see a doctor.
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Dopamine and serotonin, or the 'happy hormones,' play key roles in mood, depression, and appetite, among other things. Learn about similarities, differences, and what happens when they are out of balance here.
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By studying young monkeys, scientists have identified the first of what they believe to be many brain molecules with a causal role in anxiety.
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Approximately half of all cancer patients receive radiation therapy, which is conventionally delivered in relatively small doses (1.8 to 2 Gy) per daily fraction over 1-2 months. Stereotactic body radiation therapy (SBRT), in which a high daily radiation dose is delivered in 1 to 5 fractions, has improved local control rates for several cancers. However, despite the wide-spread adoption of SBRT in the clinic, controversy surrounds the mechanism by which SBRT enhances local control. Some studies suggest...
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Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia in Remission; Chronic Lymphocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Cytomegalovirus Positive; H ematopoietic Cell Transplant Recipient; Hodgkin Lymphoma; Lymphadenopathy; Lymphoblastic Lymphoma; Myelodysplastic Syndrome; Myelofibrosis; Myeloproliferative Neoplasm; Non-Hodgkin Lymphoma Interventions:...
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Conditions: Interstitial Lung Disease; Lung Cancer Intervention: Sponsor: Portsmouth Hospitals NHS Trust Recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Conditions: Pancreatic Adenocarcinoma; Esophageal Adenocarcinoma; Esophageal Squamous Cell Carcinoma; Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Triple Negative Breast Cancer; Castration-resistant Prostate Cancer; Microsatellite Stable Colorectal C ancer Interventions: Drug: GB1275; Drug: nab-paclitaxel and gemcitabine; Drug: pembrolizumab Sponsor: GB006, Inc., a wholly owned subsidiary of Gossamer Bio, Inc. Recruiting (Source: ClinicalTrials.gov)
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Condition: Breast Cancer Interventions: Drug: Ipatasertib; Drug: Placebo; Drug: Palbociclib; Drug: Fulvestrant Sponsor: Hoffmann-La Roche Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Metastatic Melanoma; Renal Cell Carcinoma; Colon Cancer With MSI-H or dMMR Interventions: Drug: CD24Fc; Drug: Ipilimumab; Drug: Nivolumab Sponsors: OncoImmune, Inc.; Huntsman Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Advanced Hepatobiliary and Malignant Tumors Intervention: Drug: albumin-bound paclitaxel + oxaliplatin Sponsor: Dong Wang Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Metastatic Castration-resistant Prostate Cancer Intervention: Drug: Phase I and Phase II: LAE001/prednisone + afuresertib Sponsor: Laekna Limited Not yet recruiting (Source: ClinicalTrials.gov)
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Real-world Study for the Safety of Albumin-Bound Paclitaxel in Recurrent or Metastatic Breast Cancer
Condition: Breast Cancer Intervention: Other: Observational study Sponsor: CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Condition: Bladder Cancer Intervention: Drug: Paclitaxel-binding albumin Sponsor: Third Military Medical University Recruiting (Source: ClinicalTrials.gov)
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Conditions: Nasopharyngeal Carcinoma; Neoadjuvant Chemotherapy Interventions: Drug: 4 cycles of Neoadjuvant Chemotherapy With Definitive Radiotherapy; Drug: 3 cycles of Neoadjuvant Chemotherapy With concurrent chemoradiotherapy Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting (Source: ClinicalTrials.gov)
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Condition: Carcinoma, Renal Cell Interventions: Other: Laboratory analysis of samples; Other: Application of machine learning Sponsor: CCTU- Cancer Theme Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Conditions: Breast Cancer; Brain Metastases Intervention: Radiation: Fractionated stereotactic radiotherapy(FSRT) Sponsor: Fudan University Recruiting (Source: ClinicalTrials.gov)
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Condition: Prostate Cancer Interventions: Other: Tissue donation; Other: Blood Donation; Other: Urine Donation; Other: Healthcare data linkage Sponsors: University College, London; Medical Research Council; Cancer Research UK; Imperial College London; King's College London Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Allogeneic Hematopoietic Stem Cell Transplant Recipient; Malignant Neoplasm Interventions: Drug: Nozin; Other: Best Practice Sponsors: Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI); Global Life Technologies Corp. Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Cancer Intervention: Radiation: Radical Image-Guided Radiotherapy Sponsors: CCTU- Cancer Theme; University of Cambridge; Microsoft Research Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Cigarette Smoker; Current Every Day Smoker Interventions: Device: Medical Device; Other: Questionnaire Administration; Behavioral: Tobacco Smoking Sponsors: Roswell Park Cancer Institute; National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndromes; Myeloproliferative Neoplasm; Aplastic Anemia Intervention: Sponsor: National Taiwan University Hospital Recruiting (Source: ClinicalTrials.gov)
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Conditions: Tongue Cancer; Floor of Mouth Squamous Cell Carcinoma Intervention: Diagnostic Test: Ultrasound Sponsor: Region Örebro County Recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Conditions: Care Giver; Recurrent Malignant Neoplasm; Refractory Malignant Neoplasm Interventions: Other: Internet-Based Intervention; Other: Best Practice; Other: Quality-of-Life Assessment; Other: Questionnaire Administration Sponsors: Vanderbilt-Ingram Cancer Center; National Institute of Nursing Research (NINR); Palliative Care Research Cooperative Group Active, not recruiting (Source: ClinicalTrials.gov)
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Conditions: Metastatic Pancreatic Adenocarcinoma; Stage IV Pancreatic Cancer AJCC v8 Interventions: Biological: Pegylated Recombinant Human Hyaluronidase PH20; Biological: Pembrolizumab Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Prostate Cancer Intervention: Drug: Goserelin Acetate Sponsors: CMX Research; Peptigroupe Inc Completed (Source: ClinicalTrials.gov)
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Conditions: Nutrition Related Neoplasm/Cancer; Colorectal Cancer; Surgery--Complications; Site Infection; Nutrition Support Intervention: Dietary Supplement: Nutrition supplement Sponsor: Hospital General Universitario Reina Sofía de Murcia Recruiting (Source: ClinicalTrials.gov)
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Condition: Lung Neoplasm Malignant Intervention: Drug: Atezolizumab Injection [Tecentriq] Sponsors: Chonnam National University Hospital; Roche Pharma AG Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Breast Cancer Interventions: Other: InteguPly FD; Other: SimpliDerm Sponsor: Aziyo Biologics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Non-small Cell Lung Cancer Intervention: Drug: donafenib tablets Sponsor: First Affiliated Hospital of Zhejiang University Recruiting (Source: ClinicalTrials.gov)
4h
Conditions: Breast Cancer; Radiodermatitis; Radiotherapy Side Effect; Radiation Dermatitis; Radiation Toxicity; Radiation Injuries; Quality of Life; Breast Neoplasms Intervention: Device: Photobiomodulation Sponsor: AC Camargo Cancer Center Recruiting (Source: ClinicalTrials.gov)
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Condition: Cancer Intervention: Behavioral: Web based decision aid intervention Sponsors: Stanford University; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
4h
Conditions: Cancer; Solid Tumor; Cancer of Skin Intervention: Drug: 2141 V-11 Sponsor: Rockefeller University Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Breast Neoplasms Intervention: Drug: Taxanes or/and anthracycline-based therapy Sponsor: Shengjing Hospital Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Posttraumatic Stress Disorder; Cancer Interventions: Behavioral: Cancer Distress Coach (CaDC) App; Behavioral: CaDC + mCoaching; Behavioral: mCBT Sponsor: Duke University Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Bra; Breast Cancer Surgery; Complication; Compression; Symptoms Intervention: Other: OptiBra study Sponsor: Karolinska University Hospital Recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
4h
Condition: Breast Cancer Metastatic Interventions: Drug: SAR439859; Drug: Endocrine monotherapy as per physician choice Sponsor: Sanofi Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Endothelial Degeneration; Pancreatic Cancer; Pancreatectomy; Postoperative Pancreatic Fistula Interventions: Other: human albumin 5%; Other: gelofusine. Sponsor: University of Malaya Not yet recruiting (Source: ClinicalTrials.gov)
4h
Condition: Biliary Tract Cancer Interventions: Drug: Nivolumab; Drug: DKN-01 Sponsors: Massachusetts General Hospital; Bristol-Myers Squibb; Leap Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Hematologic Malignancy; Old Age; Debility Interventions: Other: Nutritional support; Other: Physical exercise; Drug: Hematologic Drug Sponsors: Maite Antonio, MD, Phd; Institut d'Investigació Biomèdica de Bellvitge; University of Barcelona; Instituto de Salud Carlos III Recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)
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(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)
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