Τρίτη 6 Αυγούστου 2019

Medicine by Alexandros G. Sfakianakis


Response to Michalaki et al. re: “Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach”
Thyroid, Ahead of Print.
liebertpub1
1h
Chirurgie der Trachea
Laryngo-Rhino-Otol 2019; 98: 545-554DOI: 10.1055/a-0834-4299Die Chirurgie der Trachea ist ein Spezialgebiet, in dem aufgrund der Vielzahl von Indikationen und der erweiterten Topografie viele Disziplinen gemeinsam tätig sind. Nicht nur wegen der besonderen funktionellen Bedeutung, sondern auch wegen seiner komplexen Morphologie, Anatomie und Physiologie stellt dieses Organ eine besondere therapeutische Herausforderung...
Laryngo-Rhino-Otologie
7h
Bamboo nodes
Laryngo-Rhino-Otol 2019; 98: 534-535DOI: 10.1055/a-0861-5252© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text
Laryngo-Rhino-Otologie
7h
Adenotonsillektomie: Umfrage zu Methoden und Befindlichkeiten der Operateure
Laryngo-Rhino-Otol 2019; 98: 530-531DOI: 10.1055/a-0898-8626Kilavuz AE et al. Surgeons’ preferences and anxiety levels in paediatric adenotonsillectomy: European perspective. J Laryngol Otol 2019; 133: 333–338 Zur gleichzeitigen Entfernung von Gaumen- und Rachenmandeln gibt es verschiedene chirurgische Verfahren. Türkische HNO-Ärzte untersuchten, welche Verfahren Chirurgen für die Adenotonsillektomie präferieren...
Laryngo-Rhino-Otologie
7h
Prävalenz und Schwere eines Tinnitus bei Otosklerose
Laryngo-Rhino-Otol 2019; 98: 532-533DOI: 10.1055/a-0898-8662Dziendziel B et al. Prevalence and severity of tinnitus in Polish otosclerosis patients qualified for stapes surgery. Eur Arch Otorhinolaryngol 2019; doi: 10.1007/s00405–019–05317–8 Polnische Wissenschaftler beurteilten Prävalenz und Schwere eines Tinnitus bei einer Gruppe von für eine Stapesoperation geeigneten Patienten mit Otosklerose....
Laryngo-Rhino-Otologie
7h
Inzidenz des Glottiskarzinoms bei jungen Patienten
Laryngo-Rhino-Otol 2019; 98: 531-532DOI: 10.1055/a-0898-8551Bayan S et al. Glottic Carcinoma in Young Patients. Ann Otol Rhinol Laryngol 2019; 128: 25S–32S In jüngster Zeit mehren sich die Hinweise, dass Stimmbandkarzinome ähnlich wie Oropharynxkarzinome öfter bei nicht rauchenden Patienten mit HPV-Infektionen auftreten. Darüber hinaus gibt es Beobachtungen, die zeigen, dass Glottiskarzinom-Patienten...
Laryngo-Rhino-Otologie
7h
Keloidbehandlung mit intraläsionaler Kryochirurgie
Laryngo-Rhino-Otol 2019; 98: 536-544DOI: 10.1055/a-0960-6100Die Überproduktion veränderter Kollagenfasern und die Überexpression von Tumor-Growth-Factor-β muss gehemmt werden, um den Wachstumsprozess innerhalb einer Keloidnarbe zu unterbrechen. Dies kann mit den klassischen Therapieverfahren kaum gelingen. Die Behandlungsergebnisse der Keloidtherapie sind nur schwer vorherzusagen und die Rezidivrate liegt meist über...
Laryngo-Rhino-Otologie
7h
Trotz Aufklärung – Unwirksame Einwilligung mangels Bedenkzeit
Laryngo-Rhino-Otol 2019; 98: 575-576DOI: 10.1055/a-0861-5274© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text
Laryngo-Rhino-Otologie
7h
Fragen für die Facharztprüfung
Laryngo-Rhino-Otol 2019; 98: 588-589DOI: 10.1055/a-0861-5285© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text
Laryngo-Rhino-Otologie
7h
Rezidivierende respiratorische Papillomatose: Aktuelles zu Diagnose und Therapie
Laryngo-Rhino-Otol 2019; 98: 577-587DOI: 10.1055/a-0896-9729Die rezidivierende respiratorische Papillomatose (RRP) – ausgelöst durch das humane Papillomavirus (HPV) – ist durch warzenartige Veränderungen der Atemwege gekennzeichnet. Der klinische Verlauf ist variabel, die Diagnosestellung erfolgt nicht selten wesentlich später als der Symptombeginn, insbesondere bei Kindern. Die Behandlung wird individuell festgelegt...
Laryngo-Rhino-Otologie
7h
Plastisch-rekonstruktive Gesichtschirurgie
Laryngo-Rhino-Otol 2019; 98: 590-594DOI: 10.1055/a-0861-5329© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text
Laryngo-Rhino-Otologie
7h
Kommentar der Schriftleitung
Laryngo-Rhino-Otol 2019; 98: 527-528DOI: 10.1055/a-0861-5219© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text
Laryngo-Rhino-Otologie
7h
Radiation Dose Intensification With Accelerated Hypofractionated Intensity Modulated Radiation Therapy and Concurrent FOLFOX for Inoperable Esophageal Cancer
Conditions:   Esophagus Cancer;   Esophageal Cancer;   Cancer of the EsophagusInterventions:   Radiation: Intensity Modulated Radiation Therapy;   Drug: FOLFOX regimen;   Other: MD Anderson Symptom Inventory (MDASI)-Plus module;   Other: EuroQol (EQ-5D);   Other: SF-12;   Other: MOS Social Support Measure;   Other: CES-D;   Procedure: Blood for ctDNA;   Procedure: Urine for ctDNA;   Procedure: Blood for SCCASponsor:   Washington University School of MedicineNot yet recruiting
ClinicalTrials
17h
Phase 2a Study to Evaluate Suppression of Methotrexate-induced Mucositis by TK112690
Condition:   MucositisInterventions:   Drug: TK-112690;   Drug: Placebo TK-112690Sponsors:   Tosk, Inc.;   Crystal Life SciencesRecruiting
ClinicalTrials
17h
Regional Strategy for Transfer for Mechanical Thrombectomy
Conditions:   Stroke;   Ischemic;   Large Vessel OcclusionIntervention:   Other: Mechanical thrombectomySponsor:   University Hospital, MontpellierNot yet recruiting
ClinicalTrials
17h
Complete Decongestive Therapy on Head and Neck Lymphedema
Conditions:   Lymphedema of Face;   Secondary LymphedemaInterventions:   Procedure: Complete Decongestive Therapy;   Other: ObservationSponsor:   Our Lady of the Lake HospitalNot yet recruiting
ClinicalTrials
17h
Microwave vs. Radiofrequency Ablation for Benign Thyroid Nodules: A Multicenter Randomized Controlled Trial Study
Conditions:   Benign Thyroid Nodules;   AblationInterventions:   Device: Ultrasound-guided Percutaneous Microwave Ablation;   Device: Ultrasound-guided Percutaneous Radiofrequency AblationSponsor:   Chinese PLA General HospitalNot yet recruiting
ClinicalTrials
17h
Impedance Spectroscopy in Esophageal Cancer
Condition:   Cancer of EsophagusIntervention:   Device: impedanceSponsors:   Sana Klinikum Offenbach;   Biomedical Microsystems Fraunhofer-Institute,St. Ingebert Germany;   Stockert Gmbh Freiburg im BreisgauNot yet recruiting
ClinicalTrials
17h
Novel treatment for mild and moderate VPI using implantable AlloDerm for posterior pharyngeal wall augmentation: Case series and review of surgical techniques
Publication date: Available online 5 August 2019Source: American Journal of OtolaryngologyAuthor(s): Kunal R. Shetty, Libby M. Ward, Jessica R. Levi, Gregory GrilloneAbstractPurposeMild and moderate velopharyngeal insufficiency is a relatively common structural defect of the velopharyngeal sphincter that occurs congenitally or secondarily to various medical conditions resulting in speech inadequacy. Currently, multiple surgical methods exist to treat mild and moderate velopharyngeal insufficiency;...
American Journal of Otolaryngology
19h
In vitro inhibitory activity of N-acetylcysteine on tympanostomy tube biofilms from methicillin-resistant <em>Staphylococcus aureus</em> and quinolone-resistant <em>Pseudomonas aeruginosa</em>
Publication date: Available online 6 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Yonghyun Jun, Cha Kyung Youn, Eu-Ri Jo, Sung Il ChoAbstractObjectivesBiofilm formation in tympanostomy tubes causes persistent and refractory otorrhea. In the present study, we investigated the in vitro antibiofilm activity of N-acetylcysteine (NAC) against biofilm formation by methicillin-resistant Staphylococcus aureus (MRSA) and quinolone-resistant Pseudomonas aeruginosa (QRPA).MethodsWe...
Pediatric Otorhinolaryngology
19h
Very painful acute frontal sinusitis revealing granulomatosis with polyangiitis
Publication date: Available online 5 August 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): M. Montero, T. Mom, P. Smets, L. GilainAbstractIntroductionGranulomatosis with polyangiitis (GPA) is a necrotizing vasculitis of small and medium-sized vessels comprising inflammation of the vessel wall and perivascular and extravascular granulomas, frequently presenting in the form of chronic sinusitis.ObservationWe report the case of a 27-year-old man who presented with...
Otorhinolaryngology
20h
Transmastoid labyrinthectomy
Publication date: Available online 5 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Danielle R. Trakimas, Steven D. Rauch, Aaron K. RemenschneiderTransmastoid labyrinthectomy is a highly effective procedure for controlling vertigo attacks in patients with refractory Meniere's disease and ipsilateral nonserviceable hearing. Performed under general anesthesia, the procedure involves a cortical mastoidectomy with subsequent opening and removal of the vestibular...
Otolaryngology-Head and Neck Surgery
20h
IgG4-Related Disease of the Thyroid Gland Requiring Emergent Total Thyroidectomy: A Case Report
Abstract IgG4-related disease of the thyroid gland is a recently recognized subtype of thyroiditis, often with rapid progression requiring surgical treatment. It is considered as a spectrum of disease varying from early IgG4-related Hashimoto’s thyroiditis (HT) pattern to late fibrosing HT or Riedel’s thyroiditis patterns. Here, we report a 47-year-old Malay woman presenting with progressively painless neck swelling over 3 years and subclinical hypothyroidism. Computed tomography...
Head and Neck Pathology
21h
Papillary Carcinoma of Stensen’s Duct with Intestinal Differentiation
Abstract Stensen’s duct carcinoma (StDC) is an extremely rare neoplasm, with fewer than 40 cases reported in the literature. We report a unique case of primary StDC with papillary features and intestinal differentiation of a 74-year-old male. We discuss the radiologic and pathologic correlation along with the differential diagnosis of this rare entity.
Head and Neck Pathology
21h
P53 Gene Mutation Identified by Next Generation Sequencing in Poorly Differentiated Neuroendocrine Carcinoma of the Nasal Cavity
Abstract Neuroendocrine carcinomas (NECs) are epithelial neoplasms showing morphologic, immunophenotypic or ultrastructural evidence of neuroendocrine differentiation. The 2017 WHO Classification of Head and Neck Tumours classifies NECs into well, moderately and poorly differentiated NECs according to light microscopic features, mitotic rate and presence of tumour necrosis. In this study, we performed next generation sequencing (NGS) using a targeted 161 cancer gene panel on...
Head and Neck Pathology
21h
The health utility of mild and severe dysphonia
Objectives/Hypothesis The impact of disease states can be measured using health state utilities, which are values that reflect economic preferences for health outcomes. Utilities for dysphonia have not been studied using direct methods. The objective of this project was to establish the baseline health utilities of mild and severe dysphonia from a societal perspective. Study Design Direct utility elicitation survey. Methods Four health states (monocular blindness, binocular blindness,...
The Laryngoscope
21h
The utility of intraoperative navigation of the temporal bone for otolaryngology resident training
Objectives To determine whether image guidance improves dissection quality among residents in the temporal bone lab and to gauge their reactions to its use. Methods Prospective cohort study of nine otolaryngology residents who dissected cadaveric temporal bones with and without image guidance in the temporal bone laboratory. Quality of dissection was measured with the Welling scale. A survey was administered assessing their interactions with the navigation system. Results There was no...
The Laryngoscope
21h
Use of multiple free flaps in head and neck reconstruction
Purpose of review To review the recent literature on the use of multiple flaps in head and neck reconstruction with attention to form, function, outcomes, and complications. Recent findings Multiple free flap reconstructions are technically feasible with high flap survival rates, tolerable complication rates, and overall adequate functional and aesthetic outcomes, given the large extent of the defects and the high surgical complexity of these cases. Summary Multiple free flap reconstructions...
Otolaryngology
22h
Reconstruction of the mandible for osteoradionecrosis
Purpose of review To describe current standard of care for osteoradionecrosis (ORN) of the mandible and report possible future trends. Recent findings Cutting guides may be used to reduce surgical time and possibly improve outcomes. There has also been recent investigation into the use of pentoxifylline and tocopherol or pentoxifylline, tocopherol and clodronate (a well known conservative medial regime) as a prevention for development of ORN after dental extractions and the first randomized...
Otolaryngology
22h
Predicting radiation dosimetric distribution in different regions of the jaw in patients receiving radiotherapy for squamous cell carcinoma of the tonsil
Abstract Background Radiotherapy (RT), the main treatment for patients with head and neck cancer, can lead to dental complications. Methods We identified 244 patients with squamous cell carcinoma of the tonsil treated with RT from 2004 to 2013. For each patient, we contoured the 10 tooth‐bearing regions and calculated the radiation dose (gray, Gy) to each region. From this data set, we built two predictive models to determine the expected maximum radiation dose, one for the non‐molar regions...
Head & Neck
23h
Could the infiltration of the thyroarytenoid muscle define the pT2 glottic carcinoma?
Abstract Background The involvement of the thyroarytenoid (TA) muscle by glottic cancer may be related to an impaired vocal cord mobility, which is classified as cT2 disease. The primary endpoint was to evaluate the prognostic significance of TA muscle involvement in early glottic cancer treated with transoral laser microsurgery (TLM). Methods A review was conducted on a cohort of 209 patients consecutively treated with TLM for early glottic carcinoma. Univariate analysis was used to examine...
Head & Neck
23h
Postoperative infection predicts poor survival in locoregionally advanced oral cancer
Abstract Background We ascertain the association of postoperative infection on survival in patients with locoregionally advanced oral cavity squamous cell carcinoma (OCSCC). Methods A retrospective study of patients with stage III/IVA OCSCC undergoing curative‐intent surgery was performed. Postoperative infection was considered within 30 days after surgery. Kaplan‐Meier survival curves were used to compare overall survival (OS) in patients with postoperative infection. Cox regression and...
Head & Neck
23h
In response: Tailored approach for recurrent laryngeal nerve dissection according to different endoscopic endocrine surgery
Head & Neck
23h
Tailored approach for recurrent laryngeal nerve dissection according to different endoscopic endocrine surgery
Head & Neck
23h
Surgical consensus guidelines on sentinel node biopsy in patients with oral cancer
Head & Neck
23h
Letter to the editor‐in‐chief of Head and Neck
Head & Neck
23h

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