This case report describes a woman in her 20s who presented with a right lower neck swelling that appeared intermittently, especially during swallowing and coughing.
This quality improvement cohort study used Lean methodology to identify opportunities to reduce operating room inefficiency and, following a retrospective medical record review, implemented a surgical plan of the day and evaluated its association with reduced operation times.
This cross-sectional study estimates the association of chronic laryngitis with various sinonasal symptoms and endoscopic findings to identify what sinonasal factors are associated with allergic cause of chronic laryngitis.
A man in his 20s presented with a progressive bilateral nasal obstruction accompanied by recurrent nosebleeds. Following removal of the obstruction, histopathologic results showed calcification of the mass. What is your diagnosis?
This article examines otolaryngologist contributions to the opioid epidemic and argues on behalf of limiting opioid prescription and working to make prescribing practices more consistent across disciplines.
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Abstract The submillisecond acuity for detecting rapid spatial and temporal fluctuations in acoustic stimuli observed in humans and laboratory animals depends in part on select groups of auditory neurons that preserve synchrony from the ears to the binaural nuclei in the brainstem. These fibers have specialized synapses and axons that use a low-threshold voltage-activated outward current, IKL, conducted through Kv1 potassium ion channels. These are in turn coupled with HCN channels...
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Abstract Card9 is a signaling adaptor protein in the downstream of many innate pattern recognition receptors(PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis murine model of Rhizopus arrhizus (R. arrhizus) using wild‐type(WT) mice and Card9 knockout (Card9 ‐/‐ ) mice to investigate the antifungal effect of Card9 against R. arrhizus...
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Thyroid, Ahead of Print.
Thyroid, Ahead of Print.
Thyroid, Ahead of Print.
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Objective In patients with head and neck carcinoma of unknown primary (HNCUP;pT0) following TORS‐assisted workup, we have adopted a pharyngeal‐sparing radiation therapy (PSRT) approach targeting only the at‐risk neck and omitting treatment of the pharynx. We report outcomes following PSRT, and compare to institutional historical control subjects who received pharyngeal‐targeted RT (PRT). Methods Between 2009 and 2018, 172 patients underwent TORS‐assisted endoscopy as part of their workup for...
Objectives Determine rate of preoperative biopsy in parotid malignancies, identify factors associated with its use, and its association with surgical margins. Study Design Retrospective cohort. Setting Commission on Cancer–Accredited Institutions. Subjects and Methods We included 5533 patients treated surgically for a parotid malignancy 2004–2014 in the National Cancer Database. Chi‐squared tests, univariable, and multivariable logistic regressions were used to evaluate predictors...
Objective In small (≤2 cm) oral tongue squamous cell carcinoma (OTSCC), we sought to clarify the contribution of pathologic features including perineural invasion (PNI), lymphovascular invasion (LVI), and worst pattern of invasion‐5 (WPOI‐5) to clinical outcomes relative to tumor depth of invasion (DOI) of > or ≤ 4 mm. Methods Cases of ≤2 cm OTSCC treated surgically between 2000 and 2017 at an academic cancer center were reviewed, with retrospective pathologic slide review of DOI, LVI,...
Computed tomography performance in predicting extranodal extension in HPV‐positive oropharynx cancer
Objectives To evaluate the performance characteristics of seven predetermined imaging features on pretreatment computed tomography (CT) in identifying extranodal extension (ENE) in cervical lymph node metastases from human papillomavirus‐positive oropharyngeal carcinoma (HPV‐OPC). Study Design Retrospective study. Methods Seventy‐three patients with HPV‐OPC who underwent primary surgery and cervical lymph node dissection were included. Preoperative contrast‐enhanced CT (cCT) imaging...
Objective To describe comorbidity burden and nonclinical factors associated with all‐cause mortality of sinonasal cancer in the United States. Methods The National Cancer Database (2004–2013) was queried for adult cases of sinonasal cancer (n = 10,518). Outcome of interest was all‐cause mortality. Independent variables included comorbidity score and nonclinical factors such as age, gender, race, facility type, distance to facility, insurance, and income. Survival analysis was conducted via...
Objective Investigate the impact of medical comorbidities on treatment regimen and overall survival (OS) in patients with locally advanced laryngeal cancer. Study Design Retrospective Review of the National Cancer Database (NCDB). Methods The NCDB was queried for patients with T3 and T4 laryngeal cancer. Comorbidity scores were calculated from the Charlson‐Deyo comorbidity index (CDCI). Univariate and multivariate analyses explored the association of CDCI scores on treatment regimen...
Objectives/Hypothesis Obesity is an increasing health concern worldwide. It has been associated with perioperative complications that could affect patient outcomes. Our aim was to compare surgical outcomes in obese and nonobese patients after transoral robotic thyroid (TORT) surgery. Study Design Retrospective cohort study. Methods A total of 304 consecutive patients who underwent TORT between January 2012 to December 2017 were included in the study. Patients were divided into two groups...
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Related ArticlesIs there a relation between sudden sensorineural hearing loss and white matter lesions? Eur Arch Otorhinolaryngol. 2019 Aug 13;: Authors: Fusconi M, Attanasio G, Capitani F, Di Porto E, Diacinto D, Musy I, Ralli M, Ralli G, Greco A, de Vincentiis M, Colonnese C Abstract PURPOSE: Sudden sensorineural hearing loss (SSNHL) has similarities to conditions with vascular etiologies such as myocardial infarction and cerebral stroke. Thus, it...
19h
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Abstract The submillisecond acuity for detecting rapid spatial and temporal fluctuations in acoustic stimuli observed in humans and laboratory animals depends in part on select groups of auditory neurons that preserve synchrony from the ears to the binaural nuclei in the brainstem. These fibers have specialized synapses and axons that use a low-threshold voltage-activated outward current, IKL, conducted through Kv1 potassium ion channels. These are in turn coupled with HCN channels...
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Publication date: Available online 13 August 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): E. Truffert, E. Fournier Charrière, J.-M. Treluyer, C. Blanchet, R. Cohen, B. Gardini, H. Haas, F. Liard, J.-L. Montastruc, R. Nicollas, S. Pondaven, J.-P. Stahl, C. Wood, V. CouloignerAbstractObjectivesTo present the guidelines of the French Society of Otolaryngology-Head and Neck Surgery concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs) in pediatric...
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Purpose of review Value has become an increasingly important topic in healthcare delivery as our systems attempt to deliver increased value to patients at lower costs. This review highlights research performed regarding value for head and neck cancer reconstruction in three evolving areas: care pathway development, virtual surgical planning (VSP), and free flap versus locoregional flap reconstruction. Recent findings Improvements in quality-driven patient care in head and neck free tissue...
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Increased maternal serum placental growth hormone variant in pregnancies complicated by otosclerosis
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AbstractUsing a combined approach of fMRI and non-invasive brain stimulation (tDCS), the present study investigated source memory and its link to mental imagery in the olfactory domain, as well as in the auditory domain. Source memory refers to the knowledge of the origin of mental experiences, differentiating events that have occurred and memories of imagined events. Because of a confusion between internally generated and externally perceived information not only patients that are prone to hallucinations...
AbstractPrevious research has shown that men's mating motivation may increase following exposure to women's body odor during ovulation. In the current study we examined whether exposure to women's fertility odor cues influences social perception among men, while focusing on the role of men's relationship status in moderating this reaction. We collected body odor samples from 43 women during ovulation and during the luteal phase and exposed 85 men to these odor samples while they performed an emotion...
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This case report describes a woman in her 60s who presented with many large scalp cylindroma tumors.
Mission Statement:JAMA Otolaryngology–Head & Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology–Head & Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies,...
To the Editor We read with great interest the article titled “Association Between Red Blood Cell Distribution Width and Outcomes of Open Airway Reconstruction Surgery in Adults” by Xie et al. They concluded that higher pretreatment red blood cell width is associated with lower prosthesis-free breathing after open airway procedures.
In the Original Investigation titled “Sentinel Lymph Node Biopsy Using Preoperative Computed Tomographic Lymphography and Intraoperative Indocyanine Green Fluorescence Imaging in Patients With Localized Tongue Cancer,” published online June 27, 2019, there were errors in the author affiliations section. The Niigata University Graduate School of Medical and Dental Sciences is in Niigata, Japan, not Akita, Japan, as the previous affiliation indicated. Dr Honda’s affiliation has also been corrected...
This cohort study uses data from the US National Cancer Database to report the association of patient survival with treatment facility case volume thresholds among patients with head and neck squamous cell carcinoma.
In the Review article titled “Perioperative Care of Patients With Obstructive Sleep Apnea Undergoing Upper Airway Surgery: A Review and Consensus Recommendations,” published online June 27, 2019, 2 author names were misspelled. “J. Pieter van Maanen, MD, PhD” should have been “J. Peter van Maanen, MD, PhD” and “Sabin Maes, MD” should have been “Sabine Maes, MD.” This article was corrected online.
To the Editor In the January issue, Ohtsuru et al suggest that large-scale mass screening using ultrasonography of the thyroid can identify many detectable cancers from a large pool of nonclinical and subclinical thyroid cancers among young persons in an age-dependent manner, comparing the differences in the age-conditional incidence rate between the Fukushima Health Management Survey (FHMS) for children and young adults within 5 years of the 2011 Fukushima Daiichi nuclear power station accident...
This review uses the Amsterdam Delphi Method to compare patients with obstructive sleep apnea with reference groups undergoing non–upper airway surgery and to assess risk for increased pulmonary complications, oxygen desaturation, difficult intubation, cardiac complications, and atrial fibrillation.
A man with a perforation of the hard palate was admitted following 3 weeks of dysphagia; 1 week of nasal regurgitation, nonproductive cough, and breathy voice; a 25-pound weight loss over the preceding 2 months; and a 1-year history of HIV infection and hepatic tuberculosis. What is your diagnosis?
This cohort study evaluates findings from drug-induced vs natural sleep tests for adults with sleep-disordered breathing, including degrees and types of upper-airway collapse.
This multicenter cohort study evaluates the rate of occult extranodal extension and postoperative nodal upstaging among patients with localized oropharyngeal squamous cell carcinoma treated by transoral robotic surgery with neck dissection.
This cohort study evaluates the identification rate of sentinel lymph nodes using a novel technique of combined preoperative computed tomographic (CT) lymphography and intraoperative indocyanine green fluorescence for localized tongue cancers.
In Reply In our observational study, we comprehensively assessed the characteristics of thyroid cancer screened by ultrasonography among children and young adults with 2 rounds of examination during the first 5 years after the 2011 Fukushima Daiichi nuclear power station accident.
The sentinel lymph node (SLN) concept is based on the premise that lymph flow from the primary tumor travels sequentially to the SLN and then on to the other regional lymph nodes. The histopathologic status of this node should reflect the histopathologic status of the entire nodal basin, and additional treatment of the nodal basin (eg, neck dissection) is routinely performed in case of metastatic involvement of the SLN. Localized (cT1-2N0) oral cancer with negative SLN findings, however, would justify...
To the Editor In the January issue, Ohtsuru et al reported the incidence of thyroid cancer among children in Fukushima, Japan, within 5 years (by second round) after the accident. An Invited Commentary by Bauer and Davies accompanied the article. We have 2 serious concerns.
This Viewpoint provides support for using hyperbaric oxygen therapy within 24 to 48 hours to treat sudden sensorineural hearing loss.
In Reply We thank Dr Lin for the thoughtful review of the utility of the Modified Frailty Index (mFI) to stratify the frailty of surgical patients, as well as for highlighting the correlation between the mFI and red blood cell distribution width (RDW) in patients with coronary artery disease. With that correlation in mind, the proposal that the 2 markers may share a common pathophysiology in adults undergoing airway reconstruction is an interesting one. Accordingly, we reanalyzed the data set. Logistic...
This phase 1 clinical trial assesses the safety, tolerability, and preliminary efficacy of ascending multiple intranasal doses of the investigational phage cocktail AB-SA01 in patients with recalcitrant chronic rhinosinusitis due to Staphylococcus aureus.
This systematic review of 16 English-language studies compares measures of diagnostic accuracy of 18F-fluorocholine positron emission tomography–computed tomography with other imaging modalities in locating parathyroid glands to facilitate minimally invasive surgery.
This cross-sectional study describes national- and state-level diagnostic flexible laryngoscopy and videolaryngostroboscopy utilization and payment trends from 2000 to 2016 in the US Medicare population.
A young woman developed a large, painful mass on her tongue after bite trauma. Histopathologic examination showed ulceration, pseudoepitheliomatous hyperplasia, and acute and chronic inflammation with eosinophils. What is your diagnosis?
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Background: Radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is a rare form of DTC which poses a therapeutic challenge due to the scarcity of effective treatment options. In recent years several tyrosine kinase inhibitors targeting specific molecular pathways involved in its pathogenesis have been investigated, such as sorafenib, lenvatinib, and sunitinib. These appear to be associated with improved progression-free survival (PFS). Objectives: We aim to describe our experience...
Objective: Glucagon-like peptide-1 (GLP-1) analogues are now widely used for the treatment of type 2 diabetes mellitus (DM). Many binding sites for GLP-1 have been demonstrated in the specific tissue compartments of organs including the brain and thyroid. The aim of this study was to investigate the effect of exenatide treatment on thyroid-stimulating hormone (TSH) and thyroid volume in diabetic patients without thyroid disease. Material and Methods: The study included 46 diabetic patients without...
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Publication date: Available online 14 August 2019Source: American Journal of OtolaryngologyAuthor(s): Sanjeev M. Balamohan, Raja Sawhney, Dustin M. Lang, Kartik Cherabuddi, Varun V. Varadarajan, Stewart H. Bernard, Lauren M. Mackinnon, Brian J. Boyce, Patrick J. Antonelli, Philip A. Efron, Peter T. DziegielewskiAbstractObjectiveRecent evidence supports the use of ampicillin-sulbactam as a favored choice for antibiotic prophylaxis following head and neck free flap reconstructive surgery. However,...
Publication date: Available online 13 August 2019Source: American Journal of OtolaryngologyAuthor(s): Osama G. Abdel-Naby AwadAbstractPurposeRecurrent tonsillitis in adults has a significant impact on patients' daily life and healthcare costs. Humoral immunodeficiency increases the susceptibility to recurrent infections. The purpose of this study was to investigate the prevalence and contribution of humoral immunodeficiency in adult patients with recurrent tonsillitis.Material and methodsA prospective...
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Abstract The aim of the present study was to evaluate the association between access to oral health care in the Primary Health Care (PHC) and Oral Health-Related Quality of Life (OHRQoL). The present study was a cross-sectional study, and the sample was composed of 412 users living in the areas covered by the public PHC services who visited a health unit for an oral exam or treatment in the last 24 months. Participants in the study responded to a home-based interview with questions that addressed...
Abstract This cross-sectional study aimed to assess the prevalence of molar incisor hypomineralization (MIH) and its relationship with the number of primary teeth with developmental defects of enamel (DDE). A representative population-based sample of 731 schoolchildren was randomly selected from the public school system in Curitiba, Brazil. Schoolchildren aged 8 years with fully erupted permanent first molars and incisors were eligible for the study. MIH and DDE were classified by four calibrated...
Abstract Cementum is the mineralized tissue covering the tooth root that functions in tooth attachment and post-eruptive adjustment of tooth position. It has been reported to be highly similar to bone in several respects but remains poorly understood in terms of development and regeneration. Here, we investigate whether cementocytes, the residing cells in cellular cementum, have the potential to be protagonist in cementum homeostasis, responding to endocrine signals and directing local cementum metabolism....
Abstract Resinous infiltrants are indicated in the treatment of incipient carious lesions, and further development of these materials may contribute to greater control of these lesions. The aim of this study was to analyze the physical and antibacterial properties of experimental infiltrants containing iodonium salt and chitosan. Nine experimental infiltrants were formulated by varying the concentration of the diphenyliodonium salt (DPI) at 0, 0.5 and 1 mol%; and chitosan at 0, 0.12 and 0.25 g%....
Abstract The aim of this study was to assess the frequency of opioid analgesics prescribed by Brazilian dentists, potential regional differences and their association with socioeconomic and health-related factors. Data for all opioid prescriptions by dentists was obtained from the 2012 database of the National Controlled Substances Management System, regulated by the Brazilian Health Surveillance Agency. The number of defined daily doses (DDD) and DDDs per 1,000 inhabitants per day for each Brazilian...
Abstract The aim of this study was to assess, correlate, and compare users’ perceptions and preference related to maxillary removable retainers. Volunteers were recruited to use four retainer types: conventional wrap-around (CWA), wrap-around with an anterior opening (OWA), “U” wrap-around (UWA), and clear thermoplastic retainer (CT). The main outcomes were the volunteers’ perceptions, evaluated with a 100-mm visual analogue scale, and their preferred retainer. The retainers were used for 21 days...
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Publication date: Available online 14 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Mao-Che Wang, Chia-Huei Chu, Ying-Piao WangAbstractObjectiveIt is generally recognized the most common pediatric otologic surgical procedure is ventilation tube insertion (VTI). Tympanoplasty and mastoidectomy are more frequently performed on adults. In this study we examined the incidence and age distribution of these procedures by use of a population-based birth cohort design,...
Publication date: Available online 14 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Lilun Li, David Strum, Stephen Larson, Diego PreciadoAbstractObjectivesVelopharyngeal insufficiency (VPI) may be due to functional or anatomic causes, and can lead to speech deficits, communication difficulty, and emotional strain on patients and their caregivers. The VPI Effects on Life Outcomes (VELO) instrument quantifies quality of life outcomes in VPI patients both before...
Publication date: Available online 14 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Leila Monshizadeh, Roshanak Vameghi, Mehdi Rahimi, Firoozeh Sajedi, Fariba Yadegari, Seyed Basir HashemiAbstractObjectiveAlthough various studies have depicted the importance of language intervention programs in facilitating language acquisition in cochlear implanted children, to this date rarely has a specific language intervention approach been recommended as better than the...
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Zusammenfassung Einleitung Zungenbewegungsmuster (ZBM) können die Ergebnisse der oberen Atemwegsstimulation (UAS) bei der Behandlung der obstruktiven Schlafapnoe (OSA) beeinflussen. Üblicherweise wird nach der Implantation eine Lagekontrolle mithilfe des konventionellen Röntgens durchgeführt. Wir erstellten ein mehrdimensionales Röntgenbeurteilungssystem und untersuchten, ob sich zwischen diesen Lagebeurteilungen und den ZBM ein Jahr nach...
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Publication date: Available online 13 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Katherine L. Reinshagen, Hugh D. CurtinImaging is useful for the diagnosis, preoperative planning, and postoperative management for a number of vestibular pathologies. Computed tomography (CT) and magnetic resonance imaging (MRI) are the most commonly used modalities to assess the temporal bone. This review will discuss commonly used imaging techniques, review relevant anatomy...
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Publication date: Available online 13 August 2019Source: Acta Otorrinolaringológica EspañolaAuthor(s): Emilio Domínguez-Durán, Pablo Baños-López, Elena Martín-Castillo, Hugo Galera-RuizResumenAntecedentes y objetivoLa migraña vestibular (MV) es una de las causas de síndrome vestibular episódico. Existen muchos fármacos disponibles para su profilaxis y actualmente su elección se realiza mayoritariamente según las comorbilidades del paciente. El objetivo de este artículo es medir la concordancia de...
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Pain and Neck Dysfunction Following Dry Needling With and Without Intramuscular Electrical Stimulus.
Conditions: Neck Pain; Shoulder Pain; Myofascial PainInterventions: Procedure: Dry Needling (DN); Procedure: Dry needling with Intramuscular electrical stimulation (DNES)Sponsor: University of Mary Hardin-BaylorNot yet recruiting
Condition: Head and Neck CancerInterventions: Drug: AMD3100; Drug: PembrolizumabSponsors: Massachusetts General Hospital; Merck Sharp & Dohme Corp.; AperiSys, IncNot yet recruiting
Conditions: Glottis Tumor; Larynx CancerInterventions: Radiation: Single Vocal Cord Irradiation (SVCI); Procedure: Arm A: Transoral CO2-Laser Microsurgical Cordectomy (TLM)Sponsors: Olgun Elicin; University of Bern; The Netherlands Cancer Institute; University of Lausanne Hospitals; University Hospital, Geneva; University of ZurichNot yet recruiting
Condition: CancerInterventions: Behavioral: One-on-one teaching sessions; Behavioral: Telephone booster contactSponsor: Case Comprehensive Cancer CenterNot yet recruiting
Condition: Atopic Dermatitis (AD)Intervention: Drug: KBL697Sponsors: KoBioLabs; Novotech (Australia) Pty LimitedNot yet recruiting
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Abstract The study was performed with 50 patients, 24 patients in Arm A and 26 patients in Arm B. Arm A—Conventional Telecobalt RT 66 Gy/33 fraction in stage T1N0M0 and stage T2N0M0 and Arm B—3D-CRT 66 Gy/33 fraction in T1N0M0 and T2N0M0 used. At the end of RT, 6 weeks, 3 months acute and late toxicities were noted by RTOG/EORTC morbidity scoring criteria for skin reaction, dysphagia and laryngeal toxicity. Fiber optic Laryngoscopy clinical assessment criteria were used to assess...
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Abstract Background Immune checkpoint inhibitors confer significant clinical benefit by bolstering immune‐system activity, however, they also produce a spectrum of immune‐related adverse events (irAEs). Rapid recognition and timely treatment of these patients is essential for improved outcomes. Methods We conducted a systematic review of English‐language articles in MEDLINE, EMBASE, Web of Science, PubMed, and Cochrane CENTRAL databases on patients with head and neck cancer treated with...
Abstract Background To enforce the evidence for causality between high‐risk human papillomavirus (hrHPV) infections and neck squamous cell carcinoma from unknown primary (NSCCUP) and provide biological basis for treatment de‐intensification, we searched for TP53 mutations in association with HPV status. Methods TP53 mutations were searched for by amplification of exons 4 to 10. Results Of the 70 NSCCUP, 27 (39%) harbored HPV infection. TP53 sequencing resulted in the identification...
Abstract Background For patients with head and neck squamous cell carcinoma (SCC) undergoing surgery followed by postoperative radiotherapy (PORT), time from surgery to completion of adjuvant therapy, “package time” impacts locoregional control (LRC). However, the significance of package time in HPV+ oropharyngeal SCC (OPSCC) is unknown. Methods We examined patients undergoing TORS resection with PORT for HPV+ OPSCC from January 2010 to December 2015 with ≥18 months follow‐up (n = 267)....
The cover image is based on the Original Article Parotidectomy by an endoscopic‐assisted postauricular‐groove approach, by Tiancheng Li et al., https://doi.org/10.1002/hed.25720.
The cover image is based on the Original Article Efficacy of posttreatment radioiodine scanning in patients with differentiated thyroid cancer, by Shorook Na'ara et al., https://doi.org/10.1002/hed.25833. Cover Image © Nofar Rada.
The cover image is based on the Original Article Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase‐specific oncolytic Sendai virus, by Yoshihiro Miyagawa et al., https://doi.org/10.1002/hed.25769.
The cover image is based on the Original Article Novel technique for the direct closure of the radial forearm flap donor site defect with a local bilobed flap by Mubarak Ahmed Mashrah et al., https://doi.org/10.1002/hed.25839.
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