Πέμπτη 15 Αυγούστου 2019


Concurrent Internal Jugular Vein Phlebectasia and Omohyoid Sling Syndrome
This case report describes a woman in her 20s who presented with a right lower neck swelling that appeared intermittently, especially during swallowing and coughing.
JAMA Otolaryngology–Head & Neck Surgery Online First
11h
Association of a Lean Surgical Plan of the Day With Reduced Operating Room Time for Head and Neck Free Flap Reconstruction
This quality improvement cohort study used Lean methodology to identify opportunities to reduce operating room inefficiency and, following a retrospective medical record review, implemented a surgical plan of the day and evaluated its association with reduced operation times.
JAMA Otolaryngology–Head & Neck Surgery Online First
11h
Association of Sinonasal Factors With Chronic Laryngitis in Korean Adults
This cross-sectional study estimates the association of chronic laryngitis with various sinonasal symptoms and endoscopic findings to identify what sinonasal factors are associated with allergic cause of chronic laryngitis.
JAMA Otolaryngology–Head & Neck Surgery Online First
11h
Progressive Bilateral Nasal Obstruction Due to Nasopharyngeal Mass
A man in his 20s presented with a progressive bilateral nasal obstruction accompanied by recurrent nosebleeds. Following removal of the obstruction, histopathologic results showed calcification of the mass. What is your diagnosis?
JAMA Otolaryngology–Head & Neck Surgery Online First
11h
Reflections on the Otolaryngologist’s Role in Opioid Stewardship
This article examines otolaryngologist contributions to the opioid epidemic and argues on behalf of limiting opioid prescription and working to make prescribing practices more consistent across disciplines.
JAMA Otolaryngology–Head & Neck Surgery Online First
11h
Sound Localization in Preweanling Mice Was More Severely Affected by Deleting the Kcna1 Gene Compared to Deleting Kcna2 , and a Curious Inverted-U Course of Development That Appeared to Exceed Adult Performance Was Observed in All Groups
Abstract The submillisecond acuity for detecting rapid spatial and temporal fluctuations in acoustic stimuli observed in humans and laboratory animals depends in part on select groups of auditory neurons that preserve synchrony from the ears to the binaural nuclei in the brainstem. These fibers have specialized synapses and axons that use a low-threshold voltage-activated outward current, IKL, conducted through Kv1 potassium ion channels. These are in turn coupled with HCN channels...
Latest Results for Journal of the Association for Research in Otolaryngology
19h
Impairment of Th cell response in Card9 knockout mice with cutaneous mucormycosis caused by Rhizopus arrhizus
Abstract Card9 is a signaling adaptor protein in the downstream of many innate pattern recognition receptors(PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis murine model of Rhizopus arrhizus (R. arrhizus) using wild‐type(WT) mice and Card9 knockout (Card9 ‐/‐ ) mice to investigate the antifungal effect of Card9 against R. arrhizus...
Experimental Dermatology
1d
DNA Methylation-Based Method to Differentiate Malignant from Benign Thyroid Lesions
Thyroid, Ahead of Print.
liebertpub1
1h
Mouse Model of Thyroid Cancer Progression and Dedifferentiation Driven by STRN-ALK Expression and Loss of p53: Evidence for the Existence of Two Types of Poorly Differentiated Carcinoma
Thyroid, Ahead of Print.
liebertpub1
1h
Downregulation of Type 3 Deiodinase in the Hypothalamus During Inflammation
Thyroid, Ahead of Print.
liebertpub1
1d
Pharyngeal‐sparing radiation for head and neck carcinoma of unknown primary following TORS assisted work‐up
Objective In patients with head and neck carcinoma of unknown primary (HNCUP;pT0) following TORS‐assisted workup, we have adopted a pharyngeal‐sparing radiation therapy (PSRT) approach targeting only the at‐risk neck and omitting treatment of the pharynx. We report outcomes following PSRT, and compare to institutional historical control subjects who received pharyngeal‐targeted RT (PRT). Methods Between 2009 and 2018, 172 patients underwent TORS‐assisted endoscopy as part of their workup for...
The Laryngoscope
20h
Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins
Objectives Determine rate of preoperative biopsy in parotid malignancies, identify factors associated with its use, and its association with surgical margins. Study Design Retrospective cohort. Setting Commission on Cancer–Accredited Institutions. Subjects and Methods We included 5533 patients treated surgically for a parotid malignancy 2004–2014 in the National Cancer Database. Chi‐squared tests, univariable, and multivariable logistic regressions were used to evaluate predictors...
The Laryngoscope
20h
Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma
Objective In small (≤2 cm) oral tongue squamous cell carcinoma (OTSCC), we sought to clarify the contribution of pathologic features including perineural invasion (PNI), lymphovascular invasion (LVI), and worst pattern of invasion‐5 (WPOI‐5) to clinical outcomes relative to tumor depth of invasion (DOI) of > or ≤ 4 mm. Methods Cases of ≤2 cm OTSCC treated surgically between 2000 and 2017 at an academic cancer center were reviewed, with retrospective pathologic slide review of DOI, LVI,...
The Laryngoscope
20h
Computed tomography performance in predicting extranodal extension in HPV‐positive oropharynx cancer
Objectives To evaluate the performance characteristics of seven predetermined imaging features on pretreatment computed tomography (CT) in identifying extranodal extension (ENE) in cervical lymph node metastases from human papillomavirus‐positive oropharyngeal carcinoma (HPV‐OPC). Study Design Retrospective study. Methods Seventy‐three patients with HPV‐OPC who underwent primary surgery and cervical lymph node dissection were included. Preoperative contrast‐enhanced CT (cCT) imaging...
The Laryngoscope
20h
Comorbidity burden and nonclinical factors associated with sinonasal cancer all‐cause mortality
Objective To describe comorbidity burden and nonclinical factors associated with all‐cause mortality of sinonasal cancer in the United States. Methods The National Cancer Database (2004–2013) was queried for adult cases of sinonasal cancer (n = 10,518). Outcome of interest was all‐cause mortality. Independent variables included comorbidity score and nonclinical factors such as age, gender, race, facility type, distance to facility, insurance, and income. Survival analysis was conducted via...
The Laryngoscope
20h
Effect of medical comorbidities on treatment regimen and survival in T3/T4 laryngeal cancer
Objective Investigate the impact of medical comorbidities on treatment regimen and overall survival (OS) in patients with locally advanced laryngeal cancer. Study Design Retrospective Review of the National Cancer Database (NCDB). Methods The NCDB was queried for patients with T3 and T4 laryngeal cancer. Comorbidity scores were calculated from the Charlson‐Deyo comorbidity index (CDCI). Univariate and multivariate analyses explored the association of CDCI scores on treatment regimen...
The Laryngoscope
1d
Obesity May Not Affect Outcomes of Transoral Robotic Thyroidectomy: Subset Analysis of 304 Patients
Objectives/Hypothesis Obesity is an increasing health concern worldwide. It has been associated with perioperative complications that could affect patient outcomes. Our aim was to compare surgical outcomes in obese and nonobese patients after transoral robotic thyroid (TORT) surgery. Study Design Retrospective cohort study. Methods A total of 304 consecutive patients who underwent TORT between January 2012 to December 2017 were included in the study. Patients were divided into two groups...
The Laryngoscope
1d
Is there a relation between sudden sensorineural hearing loss and white matter lesions?
Related ArticlesIs there a relation between sudden sensorineural hearing loss and white matter lesions? Eur Arch Otorhinolaryngol. 2019 Aug 13;: Authors: Fusconi M, Attanasio G, Capitani F, Di Porto E, Diacinto D, Musy I, Ralli M, Ralli G, Greco A, de Vincentiis M, Colonnese C Abstract PURPOSE: Sudden sensorineural hearing loss (SSNHL) has similarities to conditions with vascular etiologies such as myocardial infarction and cerebral stroke. Thus, it...
http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino
19h
Sound Localization in Preweanling Mice Was More Severely Affected by Deleting the Kcna1 Gene Compared to Deleting Kcna2 , and a Curious Inverted-U Course of Development That Appeared to Exceed Adult Performance Was Observed in All Groups
Abstract The submillisecond acuity for detecting rapid spatial and temporal fluctuations in acoustic stimuli observed in humans and laboratory animals depends in part on select groups of auditory neurons that preserve synchrony from the ears to the binaural nuclei in the brainstem. These fibers have specialized synapses and axons that use a low-threshold voltage-activated outward current, IKL, conducted through Kv1 potassium ion channels. These are in turn coupled with HCN channels...
Journal of the Association for Research in Otolaryngology
19h
Guidelines of the French Society of Otorhinolaryngology (SFORL): Nonsteroidal anti-inflammatory drugs (NSAIDs) and pediatric ENT infections. Short version
Publication date: Available online 13 August 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): E. Truffert, E. Fournier Charrière, J.-M. Treluyer, C. Blanchet, R. Cohen, B. Gardini, H. Haas, F. Liard, J.-L. Montastruc, R. Nicollas, S. Pondaven, J.-P. Stahl, C. Wood, V. CouloignerAbstractObjectivesTo present the guidelines of the French Society of Otolaryngology-Head and Neck Surgery concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs) in pediatric...
Otorhinolaryngology
1d
Optimizing value in head and neck cancer free flap surgery
Purpose of review Value has become an increasingly important topic in healthcare delivery as our systems attempt to deliver increased value to patients at lower costs. This review highlights research performed regarding value for head and neck cancer reconstruction in three evolving areas: care pathway development, virtual surgical planning (VSP), and free flap versus locoregional flap reconstruction. Recent findings Improvements in quality-driven patient care in head and neck free tissue...
Otolaryngology
10h
Validation of the olfactory disorders questionnaire for English‐speaking patients with olfactory disorders
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Clinical utility and effectiveness of a training programme in the application of a new classification of narrow‐band imaging for vocal cord leukoplakia: A multicentre study
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Does access to saltwater swimming pools reduce ear pathology and hearing loss in school children of remote arid zone aboriginal communities? A prospective 3‐year cohort study
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Long‐term quality of life and sensory impact of great auricular nerve preservation in parotid surgery as measured with the Parotidectomy Outcome Inventory‐8
Latest Issue of Clinical Otolaryngology RSS Feed
1d
E‐cigarettes and head and neck cancers: A systematic review of the current literature
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Increased maternal serum placental growth hormone variant in pregnancies complicated by otosclerosis
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Role of diffusion‐weighted imaging in the discrimination of purulent intrasinusal content: A retrospective study
Latest Issue of Clinical Otolaryngology RSS Feed
1d
The use of freeze‐dried retronasal stimuli to assess olfactory function
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Responsiveness of acoustic rhinometry to septorhinoplasty by comparison with rhinomanometry and subjective instruments
Latest Issue of Clinical Otolaryngology RSS Feed
1d
The management of suspected or confirmed laryngopharyngeal reflux patients with recalcitrant symptoms: A contemporary review
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Functional relevance of computational fluid dynamics in the field of nasal obstruction: A literature review
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Post‐laryngectomy adjuvant radiotherapy in patients with pharyngocutaneous fistulae: Treatment regimens, outcomes and complications in 67 patients
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Usefulness of ENT clinical examinations in hospitalised patients chronically addicted to alcohol and tobacco to detect head and neck squamous cell carcinomas. A retrospective study of 159 patients
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Effects of a wireless frequency modulation system on learning ability and emotional and behaviour problem improvement in 11 children with cochlear implant
Latest Issue of Clinical Otolaryngology RSS Feed
1d
The genetics of cholesteatoma study. Loss‐of‐function variants in an affected family
Latest Issue of Clinical Otolaryngology RSS Feed
1d
The intra‐operative use of biological products: A multi‐centre regional patient perspective of a potential consenting conundrum
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Evolving management strategies in head and neck paragangliomas: A single‐centre experience with 147 patients over a 60‐year period
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Does cartilage thickness affect hearing results in real life? Long‐term results of cartilage and fascia graft in type 1 tympanoplasty
Latest Issue of Clinical Otolaryngology RSS Feed
1d

The use of ARTISS™ in performing parotidectomies as day case surgery: A single‐centre review of 31 cases
Latest Issue of Clinical Otolaryngology RSS Feed
1d
A population‐based time trend study in the incidence of malignant otitis externa
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Polydioxanone sheet as a rigid framework in skull‐base repair: Our experience in thirteen patients
Latest Issue of Clinical Otolaryngology RSS Feed
1d
CT and clinical prognostic factors in Bell's palsy: A study of 56 cases
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Large parapharyngeal tumours: Operative technique and case series of 17 patients
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Transoral laser microsurgery using high‐flow nasal cannula oxygenation: Our experience of 21 cases
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Preoperative electrophysiological analysis predicts preservation of hearing and facial nerve function following vestibular schwannoma surgery with continuous intraoperative neural monitoring: Clinical outcomes of 22 cases
Latest Issue of Clinical Otolaryngology RSS Feed
1d
“How clean are your injections?”
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Giving epistaxis two fingers
Latest Issue of Clinical Otolaryngology RSS Feed
1d
CO2 laser “Ablation Suction” technique for treatment of laryngeal recurrent respiratory papillomatosis
Latest Issue of Clinical Otolaryngology RSS Feed
1d
Issue Information
Clinical Otolaryngology
1d
Externalization errors of olfactory source monitoring in healthy controls - an fMRI study
AbstractUsing a combined approach of fMRI and non-invasive brain stimulation (tDCS), the present study investigated source memory and its link to mental imagery in the olfactory domain, as well as in the auditory domain. Source memory refers to the knowledge of the origin of mental experiences, differentiating events that have occurred and memories of imagined events. Because of a confusion between internally generated and externally perceived information not only patients that are prone to hallucinations...
Chemical Senses
23h
Women's body odor during ovulation improves social perception in single men
AbstractPrevious research has shown that men's mating motivation may increase following exposure to women's body odor during ovulation. In the current study we examined whether exposure to women's fertility odor cues influences social perception among men, while focusing on the role of men's relationship status in moderating this reaction. We collected body odor samples from 43 women during ovulation and during the luteal phase and exposed 85 men to these odor samples while they performed an emotion...
Chemical Senses
1d
Massive Scalp Cylindromas Treated With Staged Resection and Split-Thickness Skin Grafting
This case report describes a woman in her 60s who presented with many large scalp cylindroma tumors.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
JAMA Otolaryngology–Head & Neck Surgery
Mission Statement:JAMA Otolaryngology–Head & Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology–Head & Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies,...
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
August Issue Highlights
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Association Between Red Blood Cell Width and Modified Frailty Index
To the Editor We read with great interest the article titled “Association Between Red Blood Cell Distribution Width and Outcomes of Open Airway Reconstruction Surgery in Adults” by Xie et al. They concluded that higher pretreatment red blood cell width is associated with lower prosthesis-free breathing after open airway procedures.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Errors in Author Affiliations
In the Original Investigation titled “Sentinel Lymph Node Biopsy Using Preoperative Computed Tomographic Lymphography and Intraoperative Indocyanine Green Fluorescence Imaging in Patients With Localized Tongue Cancer,” published online June 27, 2019, there were errors in the author affiliations section. The Niigata University Graduate School of Medical and Dental Sciences is in Niigata, Japan, not Akita, Japan, as the previous affiliation indicated. Dr Honda’s affiliation has also been corrected...
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Prognostic Case Volume Thresholds in Patients With Head and Neck Squamous Cell Carcinoma
This cohort study uses data from the US National Cancer Database to report the association of patient survival with treatment facility case volume thresholds among patients with head and neck squamous cell carcinoma.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Misspelled Author Names in Byline
In the Review article titled “Perioperative Care of Patients With Obstructive Sleep Apnea Undergoing Upper Airway Surgery: A Review and Consensus Recommendations,” published online June 27, 2019, 2 author names were misspelled. “J. Pieter van Maanen, MD, PhD” should have been “J. Peter van Maanen, MD, PhD” and “Sabin Maes, MD” should have been “Sabine Maes, MD.” This article was corrected online.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h

Incidence of Thyroid Cancer Among Children and Young Adults in Fukushima, Japan
To the Editor In the January issue, Ohtsuru et al suggest that large-scale mass screening using ultrasonography of the thyroid can identify many detectable cancers from a large pool of nonclinical and subclinical thyroid cancers among young persons in an age-dependent manner, comparing the differences in the age-conditional incidence rate between the Fukushima Health Management Survey (FHMS) for children and young adults within 5 years of the 2011 Fukushima Daiichi nuclear power station accident...
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Perioperative Care of Patients With Obstructive Sleep Apnea Undergoing Upper Airway Surgery
This review uses the Amsterdam Delphi Method to compare patients with obstructive sleep apnea with reference groups undergoing non–upper airway surgery and to assess risk for increased pulmonary complications, oxygen desaturation, difficult intubation, cardiac complications, and atrial fibrillation.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Perforation of the Hard Palate
A man with a perforation of the hard palate was admitted following 3 weeks of dysphagia; 1 week of nasal regurgitation, nonproductive cough, and breathy voice; a 25-pound weight loss over the preceding 2 months; and a 1-year history of HIV infection and hepatic tuberculosis. What is your diagnosis?
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Obstruction Patterns During Drug-Induced vs Natural Sleep Endoscopy in Sleep Apnea
This cohort study evaluates findings from drug-induced vs natural sleep tests for adults with sleep-disordered breathing, including degrees and types of upper-airway collapse.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Occult Nodal Disease and Occult Extranodal Extension in Patients With Oropharyngeal Squamous Cell Carcinoma
This multicenter cohort study evaluates the rate of occult extranodal extension and postoperative nodal upstaging among patients with localized oropharyngeal squamous cell carcinoma treated by transoral robotic surgery with neck dissection.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Use of CT Lymphography and Indocyanine Green Fluorescence Imaging in Localized Tongue Cancer
This cohort study evaluates the identification rate of sentinel lymph nodes using a novel technique of combined preoperative computed tomographic (CT) lymphography and intraoperative indocyanine green fluorescence for localized tongue cancers.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Incidence of Thyroid Cancer Among Children and Young Adults in Fukushima, Japan—Reply
In Reply In our observational study, we comprehensively assessed the characteristics of thyroid cancer screened by ultrasonography among children and young adults with 2 rounds of examination during the first 5 years after the 2011 Fukushima Daiichi nuclear power station accident.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
New Developments in Sentinel Lymph Node Biopsy Procedure in Localized Oral Cancer
The sentinel lymph node (SLN) concept is based on the premise that lymph flow from the primary tumor travels sequentially to the SLN and then on to the other regional lymph nodes. The histopathologic status of this node should reflect the histopathologic status of the entire nodal basin, and additional treatment of the nodal basin (eg, neck dissection) is routinely performed in case of metastatic involvement of the SLN. Localized (cT1-2N0) oral cancer with negative SLN findings, however, would justify...
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Incidence of Thyroid Cancer Among Children and Young Adults in Fukushima, Japan
To the Editor In the January issue, Ohtsuru et al reported the incidence of thyroid cancer among children in Fukushima, Japan, within 5 years (by second round) after the accident. An Invited Commentary by Bauer and Davies accompanied the article. We have 2 serious concerns.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Hyperbaric Oxygen Therapy vs Medical Therapy for Sudden Sensorineural Hearing Loss
This Viewpoint provides support for using hyperbaric oxygen therapy within 24 to 48 hours to treat sudden sensorineural hearing loss.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Association Between Red Blood Cell Width and Modified Frailty Index—Reply
In Reply We thank Dr Lin for the thoughtful review of the utility of the Modified Frailty Index (mFI) to stratify the frailty of surgical patients, as well as for highlighting the correlation between the mFI and red blood cell distribution width (RDW) in patients with coronary artery disease. With that correlation in mind, the proposal that the 2 markers may share a common pathophysiology in adults undergoing airway reconstruction is an interesting one. Accordingly, we reanalyzed the data set. Logistic...
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Safety and Tolerability of Bacteriophage Therapy for Staphylococcus aureus Chronic Rhinosinusitis
This phase 1 clinical trial assesses the safety, tolerability, and preliminary efficacy of ascending multiple intranasal doses of the investigational phage cocktail AB-SA01 in patients with recalcitrant chronic rhinosinusitis due to Staphylococcus aureus.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
18 F-Fluorocholine Positron Emission Tomography–Computed Tomography and Hyperparathyroidism
This systematic review of 16 English-language studies compares measures of diagnostic accuracy of 18F-fluorocholine positron emission tomography–computed tomography with other imaging modalities in locating parathyroid glands to facilitate minimally invasive surgery.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Trends in Diagnostic Flexible Laryngoscopy and Videolaryngostroboscopy Utilization
This cross-sectional study describes national- and state-level diagnostic flexible laryngoscopy and videolaryngostroboscopy utilization and payment trends from 2000 to 2016 in the US Medicare population.
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
An Exophytic Dorsolateral Tongue Mass in a Young Patient
A young woman developed a large, painful mass on her tongue after bite trauma. Histopathologic examination showed ulceration, pseudoepitheliomatous hyperplasia, and acute and chronic inflammation with eosinophils. What is your diagnosis?
JAMA Otolaryngology–Head & Neck Surgery Current Issue
11h
Sorafenib and Sunitinib for the Treatment of Metastatic Thyroid Cancer of Follicular Origin: A 7-Year Single-Centre Experience
Background: Radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is a rare form of DTC which poses a therapeutic challenge due to the scarcity of effective treatment options. In recent years several tyrosine kinase inhibitors targeting specific molecular pathways involved in its pathogenesis have been investigated, such as sorafenib, lenvatinib, and sunitinib. These appear to be associated with improved progression-free survival (PFS). Objectives: We aim to describe our experience...
Thyroid
15h
The Effect of Exenatide on Thyroid-Stimulating Hormone and Thyroid Volume
Objective: Glucagon-like peptide-1 (GLP-1) analogues are now widely used for the treatment of type 2 diabetes mellitus (DM). Many binding sites for GLP-1 have been demonstrated in the specific tissue compartments of organs in­cluding the brain and thyroid. The aim of this study was to investigate the effect of exenatide treatment on thyroid-stimulating hormone (TSH) and thyroid volume in diabetic patients without thyroid disease. Material and Methods: The study included 46 diabetic patients without...
Thyroid
15h
Prophylactic antibiotics in head and neck free flap surgery: A novel protocol put to the test
Publication date: Available online 14 August 2019Source: American Journal of OtolaryngologyAuthor(s): Sanjeev M. Balamohan, Raja Sawhney, Dustin M. Lang, Kartik Cherabuddi, Varun V. Varadarajan, Stewart H. Bernard, Lauren M. Mackinnon, Brian J. Boyce, Patrick J. Antonelli, Philip A. Efron, Peter T. DziegielewskiAbstractObjectiveRecent evidence supports the use of ampicillin-sulbactam as a favored choice for antibiotic prophylaxis following head and neck free flap reconstructive surgery. However,...
American Journal of Otolaryngology
14h
Prevalence of humoral immunodeficiency in adult patients with recurrent tonsillitis
Publication date: Available online 13 August 2019Source: American Journal of OtolaryngologyAuthor(s): Osama G. Abdel-Naby AwadAbstractPurposeRecurrent tonsillitis in adults has a significant impact on patients' daily life and healthcare costs. Humoral immunodeficiency increases the susceptibility to recurrent infections. The purpose of this study was to investigate the prevalence and contribution of humoral immunodeficiency in adult patients with recurrent tonsillitis.Material and methodsA prospective...
American Journal of Otolaryngology
1d
Access to dental services and oral health-related quality of life in the context of primary health care
Abstract The aim of the present study was to evaluate the association between access to oral health care in the Primary Health Care (PHC) and Oral Health-Related Quality of Life (OHRQoL). The present study was a cross-sectional study, and the sample was composed of 412 users living in the areas covered by the public PHC services who visited a health unit for an oral exam or treatment in the last 24 months. Participants in the study responded to a home-based interview with questions that addressed...
Brazilian Oral Research
9h

Demarcated opacity in primary teeth increases the prevalence of molar incisor hypomineralization
Abstract This cross-sectional study aimed to assess the prevalence of molar incisor hypomineralization (MIH) and its relationship with the number of primary teeth with developmental defects of enamel (DDE). A representative population-based sample of 731 schoolchildren was randomly selected from the public school system in Curitiba, Brazil. Schoolchildren aged 8 years with fully erupted permanent first molars and incisors were eligible for the study. MIH and DDE were classified by four calibrated...
Brazilian Oral Research
9h
Isolation and characterization of a human cementocyte-like cell line, HCY-23
Abstract Cementum is the mineralized tissue covering the tooth root that functions in tooth attachment and post-eruptive adjustment of tooth position. It has been reported to be highly similar to bone in several respects but remains poorly understood in terms of development and regeneration. Here, we investigate whether cementocytes, the residing cells in cellular cementum, have the potential to be protagonist in cementum homeostasis, responding to endocrine signals and directing local cementum metabolism....
Brazilian Oral Research
9h
Effect of iodonium salt and chitosan on the physical and antibacterial properties of experimental infiltrants
Abstract Resinous infiltrants are indicated in the treatment of incipient carious lesions, and further development of these materials may contribute to greater control of these lesions. The aim of this study was to analyze the physical and antibacterial properties of experimental infiltrants containing iodonium salt and chitosan. Nine experimental infiltrants were formulated by varying the concentration of the diphenyliodonium salt (DPI) at 0, 0.5 and 1 mol%; and chitosan at 0, 0.12 and 0.25 g%....
Brazilian Oral Research
9h
A national study on the use of opioid analgesics in dentistry
Abstract The aim of this study was to assess the frequency of opioid analgesics prescribed by Brazilian dentists, potential regional differences and their association with socioeconomic and health-related factors. Data for all opioid prescriptions by dentists was obtained from the 2012 database of the National Controlled Substances Management System, regulated by the Brazilian Health Surveillance Agency. The number of defined daily doses (DDD) and DDDs per 1,000 inhabitants per day for each Brazilian...
Brazilian Oral Research
9h
Users’ perceptions and preferences towards maxillary removable orthodontic retainers: a crossover randomized clinical trial
Abstract The aim of this study was to assess, correlate, and compare users’ perceptions and preference related to maxillary removable retainers. Volunteers were recruited to use four retainer types: conventional wrap-around (CWA), wrap-around with an anterior opening (OWA), “U” wrap-around (UWA), and clear thermoplastic retainer (CT). The main outcomes were the volunteers’ perceptions, evaluated with a 100-mm visual analogue scale, and their preferred retainer. The retainers were used for 21 days...
Brazilian Oral Research
9h
Epidemiology of Common Otologic Surgical Procedures in Pediatric Patients: A Population Based Birth Cohort Study
Publication date: Available online 14 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Mao-Che Wang, Chia-Huei Chu, Ying-Piao WangAbstractObjectiveIt is generally recognized the most common pediatric otologic surgical procedure is ventilation tube insertion (VTI). Tympanoplasty and mastoidectomy are more frequently performed on adults. In this study we examined the incidence and age distribution of these procedures by use of a population-based birth cohort design,...
Pediatric Otorhinolaryngology
17h
Quality of Life Outcomes Following Velopharyngeal Insufficiency Surgery
Publication date: Available online 14 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Lilun Li, David Strum, Stephen Larson, Diego PreciadoAbstractObjectivesVelopharyngeal insufficiency (VPI) may be due to functional or anatomic causes, and can lead to speech deficits, communication difficulty, and emotional strain on patients and their caregivers. The VPI Effects on Life Outcomes (VELO) instrument quantifies quality of life outcomes in VPI patients both before...
Pediatric Otorhinolaryngology
1d
The effectiveness of a specifically-designed language intervention protocol on the cochlear implanted children’s communication development
Publication date: Available online 14 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Leila Monshizadeh, Roshanak Vameghi, Mehdi Rahimi, Firoozeh Sajedi, Fariba Yadegari, Seyed Basir HashemiAbstractObjectiveAlthough various studies have depicted the importance of language intervention programs in facilitating language acquisition in cochlear implanted children, to this date rarely has a specific language intervention approach been recommended as better than the...
Pediatric Otorhinolaryngology
1d
Langsam progrediente Dysphonie
HNO
16h
Die obere Atemwegsstimulation bei obstruktiver Schlafapnoe – Kann die radiologische Lage des Stimulation-Cuff die Zungenbewegung vorhersagen?
Zusammenfassung Einleitung Zungenbewegungsmuster (ZBM) können die Ergebnisse der oberen Atemwegsstimulation (UAS) bei der Behandlung der obstruktiven Schlafapnoe (OSA) beeinflussen. Üblicherweise wird nach der Implantation eine Lagekontrolle mithilfe des konventionellen Röntgens durchgeführt. Wir erstellten ein mehrdimensionales Röntgenbeurteilungssystem und untersuchten, ob sich zwischen diesen Lagebeurteilungen und den ZBM ein Jahr nach...
HNO
18h
Radiological assessment of the vestibular system
Publication date: Available online 13 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Katherine L. Reinshagen, Hugh D. CurtinImaging is useful for the diagnosis, preoperative planning, and postoperative management for a number of vestibular pathologies. Computed tomography (CT) and magnetic resonance imaging (MRI) are the most commonly used modalities to assess the temporal bone. This review will discuss commonly used imaging techniques, review relevant anatomy...
Otolaryngology-Head and Neck Surgery
1d
Concordancia interevaluador en la elección de tratamiento profiláctico para la migraña vestibular y papel de un algoritmo asistido para la elección de dicho tratamiento
Publication date: Available online 13 August 2019Source: Acta Otorrinolaringológica EspañolaAuthor(s): Emilio Domínguez-Durán, Pablo Baños-López, Elena Martín-Castillo, Hugo Galera-RuizResumenAntecedentes y objetivoLa migraña vestibular (MV) es una de las causas de síndrome vestibular episódico. Existen muchos fármacos disponibles para su profilaxis y actualmente su elección se realiza mayoritariamente según las comorbilidades del paciente. El objetivo de este artículo es medir la concordancia de...
Acta Otorrinolaringológica Española
1d
Pain and Neck Dysfunction Following Dry Needling With and Without Intramuscular Electrical Stimulus.
Conditions:   Neck Pain;   Shoulder Pain;   Myofascial PainInterventions:   Procedure: Dry Needling (DN);   Procedure: Dry needling with Intramuscular electrical stimulation (DNES)Sponsor:   University of Mary Hardin-BaylorNot yet recruiting
ClinicalTrials
16h
A Phase II Study of AMD3100 in Combination With Pembrolizumab in Head and Neck Squamous Cell Carcinoma Patients Who Have Progressed on Immune Checkpoint Blockade Therapy
Condition:   Head and Neck CancerInterventions:   Drug: AMD3100;   Drug: PembrolizumabSponsors:   Massachusetts General Hospital;   Merck Sharp & Dohme Corp.;   AperiSys, IncNot yet recruiting
ClinicalTrials
16h
VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer
Conditions:   Glottis Tumor;   Larynx CancerInterventions:   Radiation: Single Vocal Cord Irradiation (SVCI);   Procedure: Arm A: Transoral CO2-Laser Microsurgical Cordectomy (TLM)Sponsors:   Olgun Elicin;   University of Bern;   The Netherlands Cancer Institute;   University of Lausanne Hospitals;   University Hospital, Geneva;   University of ZurichNot yet recruiting
ClinicalTrials
16h
Building Family Caregiver Skills Using a Simulation-Based Intervention for Care of Cancer Patients
Condition:   CancerInterventions:   Behavioral: One-on-one teaching sessions;   Behavioral: Telephone booster contactSponsor:   Case Comprehensive Cancer CenterNot yet recruiting
ClinicalTrials
1d
A Study of Single and Multiple Ascending Doses of KBL697 in Healthy Subjects
Condition:   Atopic Dermatitis (AD)Intervention:   Drug: KBL697Sponsors:   KoBioLabs;   Novotech (Australia) Pty LimitedNot yet recruiting
ClinicalTrials
1d
Prospective Observational Comparative Study of Response and Toxicities in Early Glottic Cancer Using Telecobalt Versus 3D-CRT
Abstract The study was performed with 50 patients, 24 patients in Arm A and 26 patients in Arm B. Arm A—Conventional Telecobalt RT 66 Gy/33 fraction in stage T1N0M0 and stage T2N0M0 and Arm B—3D-CRT 66 Gy/33 fraction in T1N0M0 and T2N0M0 used. At the end of RT, 6 weeks, 3 months acute and late toxicities were noted by RTOG/EORTC morbidity scoring criteria for skin reaction, dysphagia and laryngeal toxicity. Fiber optic Laryngoscopy clinical assessment criteria were used to assess...
Otolaryngology Indian
19h
Serious immune‐related adverse events in patients with head and neck cancer after checkpoint blockade: Systematic review
Abstract Background Immune checkpoint inhibitors confer significant clinical benefit by bolstering immune‐system activity, however, they also produce a spectrum of immune‐related adverse events (irAEs). Rapid recognition and timely treatment of these patients is essential for improved outcomes. Methods We conducted a systematic review of English‐language articles in MEDLINE, EMBASE, Web of Science, PubMed, and Cochrane CENTRAL databases on patients with head and neck cancer treated with...
Head & Neck
6h
Absence of disruptive TP53 mutations in high‐risk human papillomavirus‐driven neck squamous cell carcinoma of unknown primary
Abstract Background To enforce the evidence for causality between high‐risk human papillomavirus (hrHPV) infections and neck squamous cell carcinoma from unknown primary (NSCCUP) and provide biological basis for treatment de‐intensification, we searched for TP53 mutations in association with HPV status. Methods TP53 mutations were searched for by amplification of exons 4 to 10. Results Of the 70 NSCCUP, 27 (39%) harbored HPV infection. TP53 sequencing resulted in the identification...
Head & Neck
6h

The impact of treatment package time on locoregional control for HPV+ oropharyngeal squamous cell carcinoma treated with surgery and postoperative (chemo)radiation
Abstract Background For patients with head and neck squamous cell carcinoma (SCC) undergoing surgery followed by postoperative radiotherapy (PORT), time from surgery to completion of adjuvant therapy, “package time” impacts locoregional control (LRC). However, the significance of package time in HPV+ oropharyngeal SCC (OPSCC) is unknown. Methods We examined patients undergoing TORS resection with PORT for HPV+ OPSCC from January 2010 to December 2015 with ≥18 months follow‐up (n = 267)....
Head & Neck
20h
Front Cover
The cover image is based on the Original Article Parotidectomy by an endoscopic‐assisted postauricular‐groove approach, by Tiancheng Li et al., https://doi.org/10.1002/hed.25720.
Head & Neck
1d
Inside Back Cover
The cover image is based on the Original Article Efficacy of posttreatment radioiodine scanning in patients with differentiated thyroid cancer, by Shorook Na'ara et al., https://doi.org/10.1002/hed.25833. Cover Image © Nofar Rada.
Head & Neck
1d
Issue Information
Head & Neck
1d
Inside Front Cover
The cover image is based on the Original Article Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase‐specific oncolytic Sendai virus, by Yoshihiro Miyagawa et al., https://doi.org/10.1002/hed.25769.
Head & Neck
1d
Outside Back Cover
The cover image is based on the Original Article Novel technique for the direct closure of the radial forearm flap donor site defect with a local bilobed flap by Mubarak Ahmed Mashrah et al., https://doi.org/10.1002/hed.25839.
Head & Neck
1d

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