Contributors : Anna C Castelo Branco ; Maria Notomi SatoSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensTo evaluate the effect of histamine on LPS induced proinflammatory state of purified monocytes from healthy adults and newborns, we performed a qPCR for 84 genes related to toll-like receptor (TLR) signalling
2h
Contributor : Matthew J LozaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTNF-a is elevated in a variety of inflammatory disease involving epithelial tissues. To better understand the the impact of TNF-a on epithelial biology, 3 epithelial cell lines were cultured with and without TNFa and the transcriptomes compared using were profiled using Affymetrix GeneChip® HG-U133+2 array or HG-U133+PM arrays.
2h
Contributors : Aurélie Bousard ; Ana Raposo ; Jan J Zylicz ; Christel Picard ; Vanessa Borges Pires ; Yanyan Qi ; Laurène Syx ; Howard Chang ; Edith Heard ; Simão Teixeira da RochaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusXist RNA has been established as the master regulator of X-chromosome inactivation in female eutherian mammals but its mechanism of action remain unclear. By creating novel Xist mutants at the endogenous locus in mouse embryonic...
2h
Contributor : Bo ChenSeries Type : Expression profiling by arrayOrganism : Danio rerioWe employed DNA microarray to figure out the possible mechanism of BBR on zebrafish NAFLD model
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Contributors : Laura Garcia-Perez ; Frank StaalSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusT cell factor 1 (Tcf1) is the first T cell‒specific protein induced in multipotent progenitors following Notch signaling in the thymus, leading to the activation of two major target genes, Gata3 and Bcl11b. Tcf1 deficiency results in partial arrests in T cell development high apoptosis, and increased development of B cells and myeloid cells. Phenotypically,...
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Contributors : Irit Reichenstein ; Eran HornsteinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMotor-neuron specific microRNA-218 (miR-218) was recently put in the spotlight because of its striking roles in mouse development. However, miR-218 relevance to human motor neuron disease was not yet explored. Here, we demonstrate by neuropathology that miR-218 is abundant in healthy human motor neurons. However, in amyotrophic lateral sclerosis (ALS) motor neurons...
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Contributors : Joe Sorg ; Marc MonotSeries Type : Expression profiling by high throughput sequencingOrganism : Clostridioides difficileClostridium difficile epidemic strain R20291 was grown in presence of the two main bile acids, Deoxycholate and Cholate.
2h
Contributors : Jimmy Bell ; David Hendrix ; Christiane Löhr ; Massimo BionazSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Bos taurus ; Felis catusMicroRNAs are conserved, endogenous small RNAs with critical post-transcriptional regulatory functions throughout eukaryota, including prominent roles in development and disease. Despite much effort, microRNA annotations still contain errors and are incomplete due especially to challenges related to identifying valid...
16h
Contributors : Kristopher D Rawls ; Edik M Blais ; Bonnie V Dougherty ; Glynis L Kolling ; Kalyan C Vinnakota ; Venkat R Pannala ; Jason A PapinSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusContext-specific Genome-scale Metabolic Network Reconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically exposed rat hepatocytes to constrain a GENRE of rat...
16h
Contributors : Antonin Papin ; Benoit Tessoulin ; Céline Bellanger ; Anne Moreau ; Yannick Le Bris ; Hervé Maisonneuve ; Philippe Moreau ; Cyrille Touzeau ; Martine Amiot ; Catherine Pellat-Deceunynck ; Steven Le Gouill ; David ChironSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe microenvironment strongly influences mantle cell lymphoma (MCL) survival, proliferation and chemoresistance. However, little is known regarding the molecular characterization of lymphoma...
16h
Contributors : Steven Poser ; Mathias Lesche ; Andreas Dahl ; Yan Ge ; Carlo CannistraciSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer stem cells are responsible for the regenerative properties of tumors, manifested as recurrence and metastasis. They can adopt different states, some of which may not be sensitive to current therapies. Modeling distinct states in culture will contribute towards efficient drug discovery. We previously demonstrated...
16h
Contributors : Cyril Carvalho ; Regis Courbeyrette ; Celine Derbois ; Robert Olaso ; Jean-François Deleuze ; Carl Mann ; Jean-Yves ThuretSeries Type : Expression profiling by arrayOrganism : Homo sapiensAnalysis of the transcriptional response to treatment with glucocorticoids in human fibroblasts entering oncogene-induced senescence.
21h
Contributors : Cyril Carvalho ; Regis Courbeyrette ; Cyril Denby-Wilkes ; Carl Mann ; Jean-Yves ThuretSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of the differential binding of EGR1 to chromatin in human fibroblasts entering oncogene-induced senescence, with and without clobetasol.
21h
Contributors : Ya Gao ; Yifang Zhang ; Qingfeng LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHDFs were cultured for 24 hrs for adhesion and to reach 50-70% confluence before mechanical tension was applied. Cyclic mechanical stretch (CMS) with a 0.5-Hz sinusoidal curve at 10-20% elongation was applied using a Flexcell○RFX-5000TM Tension System during the stretching. Cells were harvested immediately after the application of CMS stimulation...
22h
Contributors : Sarah K Sasse ; Margaret Gruca ; Mary A Allen ; Vineela Kadiyala ; Tengyao Song ; Fabienne Gally ; Arnav Gupta ; Miles A Pufall ; Robin D Dowell ; Anthony N GerberSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis study combined ChIP-seq using two different GR antibodies and stable GR knockdown in Beas-2B airway epithelial cells to determine whether glucocorticoid-mediated repression of inflammatory enhancers requires local...
23h
Contributors : Sarah K Sasse ; Margaret Gruca ; Mary A Allen ; Vineela Kadiyala ; Tengyao Song ; Fabienne Gally ; Arnav Gupta ; Miles A Pufall ; Robin D Dowell ; Anthony N GerberSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis study combined ChIP-seq using two different GR antibodies and stable GR knockdown in Beas-2B airway epithelial cells to determine whether glucocorticoid-mediated repression of inflammatory enhancers requires local...
23h
Contributors : Sarah K Sasse ; Margaret Gruca ; Mary A Allen ; Vineela Kadiyala ; Tengyao Song ; Fabienne Gally ; Arnav Gupta ; Miles A Pufall ; Robin D Dowell ; Anthony N GerberSeries Type : OtherOrganism : Homo sapiensThis study addressed mechanisms through which glucocorticoids exert repressive effects on pro-inflammatory TNF signaling using Global Run-on Sequencing (GRO-seq) in Beas-2B airway epithelial cells treated with dexamethasone and/or TNF for 10 or 30 minutes.
23h
Contributors : Hui Chen ; Weiwei Feng ; Kun Chen ; Xuchun Qiu ; Hai Xu ; Guanghua Mao ; Ting Zhao ; Yangyang Ding ; Xiangyang WuSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPhthalate esters (PAEs), a notable plasticizer, could be prolific contaminants in the aquatic environment, and have been shown to induce reproductive toxicity. However, studies concerning the toxicity towards aquatic species are based upon individual chemicals and the combined...
23h
Series Type : Expression profiling by arrayOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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Contributors : Antwi-Boasiako Oteng ; Anke Loregger ; Michel van Weeghel ; Noam Zelcer ; Sander KerstenSeries Type : Expression profiling by arrayOrganism : Mus musculusScope: Consumption of industrial trans fatty acids unfavourably alters plasma cholesterol and has been linked to NAFLD. However, the mechanisms underlying these deleterious effects of trans fatty acids are unclear. Here, we aim to investigate the molecular mechanisms of action of industrial trans fatty acids. Methods & Results:...
1d
Contributors : Antwi-Boasiako Oteng ; Anke Loregger ; Michel van Weeghel ; Noam Zelcer ; Sander KerstenSeries Type : Expression profiling by arrayOrganism : Mus musculusScope: Consumption of industrial trans fatty acids unfavourably alters plasma cholesterol and has been linked to NAFLD. However, the mechanisms underlying these deleterious effects of trans fatty acids are unclear. Here, we aim to investigate the molecular mechanisms of action of industrial trans fatty acids. Methods & Results:...
1d
Contributors : Antwi-Boasiako Oteng ; Anke Loregger ; Michel van Weeghel ; Noam Zelcer ; Sander KerstenSeries Type : Expression profiling by arrayOrganism : Mus musculusScope: Consumption of industrial trans fatty acids unfavourably alters plasma cholesterol and has been linked to NAFLD. However, the mechanisms underlying these deleterious effects of trans fatty acids are unclear. Here, we aim to investigate the molecular mechanisms of action of industrial trans fatty acids. Methods & Results:...
1d
Objectives: This paper describes a school-based preventive dental program implemented in 14 rural schools within nine villages of Armenia. As part of the program, school-based toothbrushing stations (called Brushadromes) were installed in the participating schools. The intervention included school-based supervised toothbrushing with fluoride toothpaste and oral hygiene education. Methods: The study evaluates the prevalence and levels of dental caries among rural schoolchildren in 2013 (before...
3h
Whole genome sequencing (WGS) has become the new gold standard for bacterial outbreak investigation, due to the high resolution available for typing. While sequencing is currently predominantly performed on Illumina devices, the preceding library preparation can be performed using various protocols. Enzymatic fragmentation library preparation protocols are fast, have minimal hands-on time, and work with small quantities of DNA. The aim of our study was to compare three library preparation protocols...
17h
Journal of Neurotrauma, Ahead of Print.
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Heredity
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Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy
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International journal of technology assessment in health care
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Third Version of MBSAQIP Standards and Pathways Manual Embraces, Reflects Growth of Obesity Medicine
by John M. Morton, MD, MPH, MHA, FACS, FASMBS, ABOM Clinical Editor of Bariatric Times; Vice-Chair of Quality and Division Chief of Bariatric and Minimally Invasive Surgery in the Department of Surgery at Yale School of Medicine in New Haven, Connecticut. Dear Friends and Readers, As 2019 marks the five-year anniversary of the Metabolic and […]
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by Christopher D. Still, DO, FACN, FACP Co-Clinical Editor of Bariatric Times; Medical Director for the Center for Nutrition and Weight Management, and Director for Geisinger Obesity Research Institute at Geisinger Medical Center in Danville, Pennsylvania. Dear Friends and Readers, By now you know that one of my favorite and most frequently used take-home messages […]
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by Kasey P.S. Goodpaster, PhD Dr. Goodpaster is with the Cleveland Clinic Bariatric & Metabolic Institute in Cleveland, Ohio. Funding: No funding was provided Disclosures: The authors have no conflicts of interest relevant to the content of this article. Abstract: Bariatric surgery is the most durable and effective treatment option for morbid obesity, and patients […]
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by Dominick Gadaleta, MD, FACS, FASMBS; Martin Doerfler, MD; and Anthony T. Petrick, MD, FACS, FASMBS Dr. Gadaleta is Chair of the Department of Surgery at Southside Hospital and Director of Metabolic and Bariatric Surgery at North Shore University Hospital, Northwell Health in Manhasset, New York; and Associate Professor of Surgery at Zucker School of […]
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Click the cover below to access the August 2019 digital edition of Bariatric Times!
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Surgical Infections, Ahead of Print.
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