Biomolecules, Vol. 9, Pages 438: Design, Synthesis and Evaluation of Novel Trichloromethyl Dichlorophenyl Triazole Derivatives as Potential Safener Biomolecules doi: 10.3390/biom9090438 Authors: Ke-Liang Guo Li-Xia Zhao Zi-Wei Wang Shu-Zhe Rong Xiao-Lin Zhou Shuang Gao Ying Fu Fei Ye The dominance of safener can unite with herbicides acquiring the efficient protection of crop and qualifying control of weeds in agricultural fields. In order to solve the crop toxicity...
Sun Sep 01, 2019 03:00
Biomolecules, Vol. 9, Pages 435: Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice Biomolecules doi: 10.3390/biom9090435 Authors: Bihui Liu Jing Zhang Peng Sun Ruokun Yi Xiaoyan Han Xin Zhao A high-fat diet-induced C57BL/6N mouse model of non-alcoholic fatty liver disease (NAFLD) was established. The effect and mechanism of Raw Bowl Tea polyphenols (RBTP) on preventing NAFLD via regulating intestinal...
Sun Sep 01, 2019 03:00
Biomolecules, Vol. 9, Pages 433: Fusaricidin-Type Compounds Create Pores in Mitochondrial and Plasma Membranes of Mammalian Cells Biomolecules doi: 10.3390/biom9090433 Authors: Mikkola Andersson Kharechkina Kruglova Kruglov Fusaricidins and related LI-F compounds are effective bactericides and fungicides. Recently, we have found that they are highly toxic to mammalian cells. Here, we studied the effect of fusaricidin-type compounds (FTCs) on the membranes of mammalian...
Sun Sep 01, 2019 03:00
Biomolecules, Vol. 9, Pages 434: Development and Optimization of the Novel Fabrication Method of Highly Macroporous Chitosan/Agarose/Nanohydroxyapatite Bone Scaffold for Potential Regenerative Medicine Applications Biomolecules doi: 10.3390/biom9090434 Authors: Paulina Kazimierczak Krzysztof Palka Agata Przekora Bone scaffolds mimicking the three-dimensional bone structure are of essential importance for bone regeneration. The aim of this study was to develop and optimize the production...
Sun Sep 01, 2019 03:00
Biomolecules, Vol. 9, Pages 432: Comparative Analysis of MicroRNA and mRNA Profiles of Sperm with Different Freeze Tolerance Capacities in Boar (Sus scrofa) and Giant Panda (Ailuropoda melanoleuca) Biomolecules doi: 10.3390/biom9090432 Authors: Ran Zhou Liang Wang Zhang Zhang Yang Zhou Wu Wang Huang Luo Qazi Zhang Zeng Post-thawed sperm quality parameters vary across different species after cryopreservation. To date, the molecular...
Sun Sep 01, 2019 03:00
Biomolecules, Vol. 9, Pages 431: Severity of Dyskinesia and D3R Signaling Changes Induced by L-DOPA Treatment of Hemiparkinsonian Rats Are Features Inherent to the Treated Subjects Biomolecules doi: 10.3390/biom9090431 Authors: Albarrán-Bravo Ávalos-Fuentes Cortés Rodriguez-Sánchez Leyva-García Rangel-Barajas Erlij Florán Extensive damage to nigrostriatal dopaminergic neurons leads to Parkinson’s disease (PD). To date, the most effective treatment...
Sun Sep 01, 2019 03:00
Biomolecules, Vol. 9, Pages 430: Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels Biomolecules doi: 10.3390/biom9090430 Authors: AL-Ishaq Abotaleb Kubatka Kajo Büsselberg Diabetes mellitus (DM) is a prevailing global health metabolic disorder, with an alarming incidence rate and a huge burden on health care providers. DM is characterized by the elevation of blood glucose due either to a defect in insulin synthesis,...
Sun Sep 01, 2019 03:00
Biomolecules, Vol. 9, Pages 429: The Role of Circular RNA CDR1as/ciRS-7 in Regulating Tumor Microenvironment: A Pan-Cancer Analysis Biomolecules doi: 10.3390/biom9090429 Authors: Zou Zheng Deng Yang Xie Tang Xie Circular RNA CDR1as/ciRS-7 functions as an oncogenic regulator in various cancers. However, there has been a lack of systematic and comprehensive analysis to further elucidate its underlying role in cancer. In the current study, we firstly performed a...
Fri Aug 30, 2019 03:00
Biomolecules, Vol. 9, Pages 428: Interactions of Mycotoxin Alternariol with Cyclodextrins and its Removal from Aqueous Solution by Beta-Cyclodextrin Bead Polymer Biomolecules doi: 10.3390/biom9090428 Authors: Fliszár-Nyúl Lemli Kunsági-Máté Szente Poór Alternariol is an Alternaria mycotoxin that appears in fruits, tomatoes, oilseeds, and corresponding products. Chronic exposure to it can induce carcinogenic and xenoestrogenic effects. Cyclodextrins (CDs) are ring-shaped...
Fri Aug 30, 2019 03:00
Biomolecules, Vol. 9, Pages 427: Function, Regulation and Biological Roles of PI3Kγ Variants Biomolecules doi: 10.3390/biom9090427 Authors: Nürnberg Beer-Hammer Phosphatidylinositide 3-kinase (PI3K) γ is the only class IB PI3K member playing significant roles in the G-protein-dependent regulation of cell signaling in health and disease. Originally found in the immune system, increasing evidence suggest a wide array of functions in the whole organism. PI3Kγ occur...
Fri Aug 30, 2019 03:00
Biomolecules, Vol. 9, Pages 426: Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure Biomolecules doi: 10.3390/biom9090426 Authors: Bin Xu Li-Min Lang Shi-Ze Li Jing-Ru Guo Jian-Fa Wang Huan-Min Yang Shuai Lian Cold stress can induce neuroinflammation in the hippocampal dentate gyrus (DG), but the mechanism underlying neuronal apoptosis induced by cold stress is not well-understood....
Fri Aug 30, 2019 03:00
Biosensors, Vol. 9, Pages 105: Evaluation of In-Flow Magnetoresistive Chip Cell—Counter as a Diagnostic Tool Biosensors doi: 10.3390/bios9030105 Authors: Manon Giraud François-Damien Delapierre Anne Wijkhuisen Pierre Bonville Mathieu Thévenin Gregory Cannies Marc Plaisance Elodie Paul Eric Ezan Stéphanie Simon Claude Fermon Cécile Féraudet-Tarisse Guénaëlle Jasmin-Lebras Inexpensive simple medical devices allowing fast and reliable counting of whole...
Sat Aug 31, 2019 03:00
Brain Sciences, Vol. 9, Pages 221: Prediction of PD-L1 Expression in Neuroblastoma via Computational Modeling Brain Sciences doi: 10.3390/brainsci9090221 Authors: Lombardo Presti Mangano Petralia Basile Libra Candido Fagone Mazzon Nicoletti Bramanti Immunotherapy is a promising new therapeutic approach for neuroblastoma (NBM): an anti-GD2 vaccine combined with orally administered soluble beta-glucan is undergoing a phase II clinical trial and...
Sat Aug 31, 2019 03:00
Brain Sciences, Vol. 9, Pages 220: Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder Brain Sciences doi: 10.3390/brainsci9090220 Authors: Baldermann Bohn Hammes Schüller Visser-Vandewalle Drzezga Kuhn Recent approaches have suggested that deep brain stimulation (DBS) for obsessive-compulsive disorder relies on distributed networks rather than local brain modulation. However, there is insufficient data...
Fri Aug 30, 2019 03:00
Cancers, Vol. 11, Pages 1288: FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer Cancers doi: 10.3390/cancers11091288 Authors: Young-Ho Kim Hyun-Kyoung Kim Hee Yeon Kim HyeRan Gawk Seung-Hyun Bae Hye Won Sim Eun-Kyung Kang Ju-Young Seoh Hyonchol Jang Kyeong-Man Hong Background: Cancers with copy-gain drug-target genes are excellent candidates for targeted therapy. In order to search for new predictive marker genes, we investigated...
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Cancers, Vol. 11, Pages 1287: Influence of Cell Type and Culture Medium on Determining Cancer Selectivity of Cold Atmospheric Plasma Treatment Cancers doi: 10.3390/cancers11091287 Authors: Biscop Lin Boxem Loenhout Backer Deben Dewilde Smits Bogaerts Increasing the selectivity of cancer treatments is attractive, as it has the potential to reduce side-effects of therapy. Cold atmospheric plasma (CAP) is a novel cancer treatment that disrupts the intracellular...
Sun Sep 01, 2019 03:00
Cancers, Vol. 11, Pages 1286: Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy Cancers doi: 10.3390/cancers11091286 Authors: Lee Jung Jo Yang Koh Hyun Abstract: Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential...
Sun Sep 01, 2019 03:00
Cancers, Vol. 11, Pages 1285: KCa3.1 Channels Confer Radioresistance to Breast Cancer Cells Cancers doi: 10.3390/cancers11091285 Authors: Mohr Gross Sezgin Steudel Ruth Huber Lukowski KCa3.1 K+ channels reportedly contribute to the proliferation of breast tumor cells and may serve pro-tumor functions in the microenvironment. The putative interaction of KCa3.1 with major anti-cancer treatment strategies, which are based on cytotoxic drugs or radiotherapy, remains...
Sun Sep 01, 2019 03:00
Cancers, Vol. 11, Pages 1282: Exploring Tumor Heterogeneity Using PET Imaging: The Big Picture Cancers doi: 10.3390/cancers11091282 Authors: Clément Bailly Caroline Bodet-Milin Mickaël Bourgeois Sébastien Gouard Catherine Ansquer Matthieu Barbaud Jean-Charles Sébille Michel Chérel Françoise Kraeber-Bodéré Thomas Carlier Personalized medicine represents a major goal in oncology. It has its underpinning in the identification of biomarkers with diagnostic, prognostic,...
Sat Aug 31, 2019 03:00
Cancers, Vol. 11, Pages 1283: Unique Aberrations in Intimal Sarcoma Identified by Next-Generation Sequencing as Potential Therapy Targets Cancers doi: 10.3390/cancers11091283 Authors: Jason Roszik Abir Khan Anthony P. Conley J. Andrew Livingston Roman Groisberg Vinod Ravi Roberto Carmagnani Pestana Shiraj Sen Vivek Subbiah Intimal sarcomas are rare and histologically heterogeneous tumors, commonly arising from the pulmonary arteries. They have remained challenging...
Sat Aug 31, 2019 03:00
Cancers, Vol. 11, Pages 1284: Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature Cancers doi: 10.3390/cancers11091284 Authors: Guerini Triggiani Maddalo Bonù Frassine Baiguini Alghisi Tomasini Borghetti Pasinetti Bresciani Magrini Buglione Anticancer treatment efficacy is limited by the development of refractory tumor cells characterized by increased expression and activity of mechanisms...
Sat Aug 31, 2019 03:00
Cancers, Vol. 11, Pages 1281: Analysing Tumour Growth Delay Data from Animal Irradiation Experiments with Deviations from the Prescribed Dose Cancers doi: 10.3390/cancers11091281 Authors: Leonhard Karsch Elke Beyreuther Doreen Eger Passos Jörg Pawelke Steffen Löck The development of new radiotherapy technologies is a long-term process, which requires proof of the general concept. However, clinical requirements with respect to beam quality and controlled dose delivery may...
Sat Aug 31, 2019 03:00
Cancers, Vol. 11, Pages 1279: Ultra-Mutation in IDH Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment Cancers doi: 10.3390/cancers11091279 Authors: Barresi Simbolo Mafficini Piredda Caffo Cardali Germanò Cingarlini Ghimenton Scarpa Background: Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (IDH) mutants and IDH wild-types...
Fri Aug 30, 2019 03:00
Cancers, Vol. 11, Pages 1280: STAT3, a Master Regulator of Anti-Tumor Immune Response Cancers doi: 10.3390/cancers11091280 Authors: Rébé Ghiringhelli Immune cells in the tumor microenvironment regulate cancer growth. Thus cancer progression is dependent on the activation or repression of transcription programs involved in the proliferation/activation of lymphoid and myeloid cells. One of the main transcription factors involved in many of these pathways is the signal transducer and...
Fri Aug 30, 2019 03:00
Cancers, Vol. 11, Pages 1278: Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma Cancers doi: 10.3390/cancers11091278 Authors: Doherty Bryant Valluru Rennie Sisley Uveal melanoma (UM) is the most common primary intraocular tumour in adults, with a mean survival of six months following metastasis. The survival rates have not improved in over 30 years. This study has shown that sister chromatid exchange (SCE)...
Fri Aug 30, 2019 03:00
Cancers, Vol. 11, Pages 1276: Extracellular Vesicles from Human Advanced-Stage Prostate Cancer Cells Modify the Inflammatory Response of Microenvironment-Residing Cells Cancers doi: 10.3390/cancers11091276 Authors: Letizia Mezzasoma Egidia Costanzi Paolo Scarpelli Vincenzo Nicola Talesa Ilaria Bellezza Prostate cancer (PCa) progression is strictly associated with microenvironmental conditions, which can be modified by cancer-released extracellular vesicles (EVs), important...
Fri Aug 30, 2019 03:00
Cancers, Vol. 11, Pages 1275: High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study Cancers doi: 10.3390/cancers11091275 Authors: Miguel Cordova-Delgado Mauricio P. Pinto Ignacio N. Retamal Matías Muñoz-Medel María Loreto Bravo María F. Fernández Betzabé Cisternas Sebastián Mondaca César Sanchez Hector Galindo Bruno Nervi Carolina Ibáñez Francisco Acevedo Jorge Madrid José...
Fri Aug 30, 2019 03:00
Cancers, Vol. 11, Pages 1277: Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression Cancers doi: 10.3390/cancers11091277 Authors: Sara Matarazzo Laura Melocchi Sara Rezzola Elisabetta Grillo Federica Maccarinelli Arianna Giacomini Marta Turati Sara Taranto Luca Zammataro Marianna Cerasuolo Mattia Bugatti William Vermi Marco Presta Roberto Ronca Bladder tumors are a diffuse type of cancer. Long pentraxin-3 (PTX3) is a component of the...
Fri Aug 30, 2019 03:00
Cancers, Vol. 11, Pages 1274: Detection of Clinical Mesenchymal Cancer Cells from Bladder Wash Urine for Real-Time Detection and Prognosis Cancers doi: 10.3390/cancers11091274 Authors: Bee Luan Khoo Charlotte Bouquerel Pradeep Durai Sarannya Anil Benjamin Goh Bingcheng Wu Lata Raman Ratha Mahendran Thomas Thamboo Edmund Chiong Chwee Teck Lim Bladder cancer (BC) is a disease that requires lifelong surveillance due to its high recurrence rate. An efficient...
Fri Aug 30, 2019 03:00
Cancers, Vol. 11, Pages 1273: Etiology-Specific Analysis of Hepatocellular Carcinoma Transcriptome Reveals Genetic Dysregulation in Pathways Implicated in Immunotherapy Efficacy Cancers doi: 10.3390/cancers11091273 Authors: Wei Tse Li Angela E. Zou Christine O. Honda Hao Zheng Xiao Qi Wang Tatiana Kisseleva Eric Y. Chang Weg M. Ongkeko Immunotherapy has emerged in recent years as arguably the most effective treatment for advanced hepatocellular carcinoma (HCC), but...
Fri Aug 30, 2019 03:00
Cells, Vol. 8, Pages 1018: Effect of Chronic Corticosterone Treatment on Depression-Like Behavior and Sociability in Female and Male C57BL/6N Mice Cells doi: 10.3390/cells8091018 Authors: Berger Gureczny Reisinger Horvath Pollak Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men. Despite intense research efforts in recent decades, the neurobiological basis underlying...
Sun Sep 01, 2019 03:00
Cells, Vol. 8, Pages 1016: Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes Cells doi: 10.3390/cells8091016 Authors: Pablo Marasek Pozo-Rodrigálvarez Wilhelmsson Inagaki Pekna Pekny Vimentin (VIM) is an intermediate filament (nanofilament) protein expressed in multiple cell types, including astrocytes. Mice with VIM mutations of serine sites phosphorylated during mitosis (VIMSA/SA) show cytokinetic failure in fibroblasts and...
Sun Sep 01, 2019 03:00
Cells, Vol. 8, Pages 1017: Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation Cells doi: 10.3390/cells8091017 Authors: Vella Nicolosi Giuliano Morrione Malaguarnera Belfiore Previously published work has demonstrated that overexpression of the insulin receptor isoform A (IR-A) might play a role in cancer progression and metastasis. The IR has a predominant metabolic role in physiology, but...
Sun Sep 01, 2019 03:00
Cells, Vol. 8, Pages 1015: Long Non-Coding RNA in the Pathogenesis of Cancers Cells doi: 10.3390/cells8091015 Authors: Chi Wang Wang Yu Yang The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy,...
Sun Sep 01, 2019 03:00
Cells, Vol. 8, Pages 1013: Highlights in Resistance Mechanism Pathways for Combination Therapy Cells doi: 10.3390/cells8091013 Authors: Delou Souza Souza Borges Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review presents the most...
Fri Aug 30, 2019 03:00
Cells, Vol. 8, Pages 1014: Transport of Ca2+ and Ca2+-Dependent Permeability Transition in Rat Liver Mitochondria under the Streptozotocin-Induced Type I Diabetes Cells doi: 10.3390/cells8091014 Authors: Belosludtsev Talanov Starinets Agafonov Dubinin Belosludtseva Although diabetes mellitus is known to be a disease associated with mitochondrial dysfunction, not everything is clear about mitochondrial Ca2+ transport and Ca2+-induced permeability transition in diabetic...
Fri Aug 30, 2019 03:00
Cells, Vol. 8, Pages 1011: Wnt10b Participates in Regulating Fatty Acid Synthesis in the Muscle of Zebrafish Cells doi: 10.3390/cells8091011 Authors: Dongwu Liu Qiuxiang Pang Qiang Han Qilong Shi Qin Zhang Hairui Yu There are 19 Wnt genes in mammals that belong to 12 subfamilies. Wnt signaling pathways participate in regulating numerous homeostatic and developmental processes in animals. However, the function of Wnt10b in fatty acid synthesis remains unclear in fish species....
Fri Aug 30, 2019 03:00
Cells, Vol. 8, Pages 1012: Graph Convolutional Network and Convolutional Neural Network Based Method for Predicting lncRNA-Disease Associations Cells doi: 10.3390/cells8091012 Authors: Xuan Pan Zhang Liu Sun Aberrant expressions of long non-coding RNAs (lncRNAs) are often associated with diseases and identification of disease-related lncRNAs is helpful for elucidating complex pathogenesis. Recent methods for predicting associations between lncRNAs and diseases integrate...
Fri Aug 30, 2019 03:00
Cells, Vol. 8, Pages 1009: Melatonin Improves In Vitro Development of Vitrified-Warmed Mouse Germinal Vesicle Oocytes Potentially via Modulation of Spindle Assembly Checkpoint-Related Genes Cells doi: 10.3390/cells8091009 Authors: Wu Pan Qazi Yang Guo Yang Zhang Zeng Zhang Han Meng Zhou The present study aimed to investigate the effect of melatonin (MT) supplementation on in vitro maturation of vitrified mouse germinal vesicle (GV) oocytes....
Fri Aug 30, 2019 03:00
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